A systematic review of experimental and clinical studies of sildenafil citrate for intrauterine growth restriction and pre-term labour

Journal of Obstetrics and Gynaecology

Volumn 27, Issue 3, 2007, Pages 255-259

  Villanueva Garcia D ^a   Mota Rojas, D ^b   Hernandez Gonzalez R ^c   Sanchez Aparicio P ^b,d   Alonso Spilsbury, M ^b   Trujillo Ortega, M E ^d   Necoechea, R Ramírez ^b   Nava Ocampo, A A ^e,f  

^a HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^b DEPARTAMENTO DE SISTEMAS BIOLÓGICOS   (Mexico)

^c INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^d UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

^f PharmaReasons   (Canada)

Author keywords

Fetal growth; Phosphodiesterase inhibitors; Sildenafil citrate; Tocolytic agents

Indexed keywords

ARGININE; BOSENTAN; DEXAMETHASONE; DILTIAZEM; OXYGEN; PROGESTERONE; SILDENAFIL;

ABSENCE OF SIDE EFFECTS; DRUG EFFICACY; DRUG INFORMATION; HUMAN; INFORMATION RETRIEVAL; INTRAUTERINE GROWTH RETARDATION; MEDICAL INFORMATION; NONHUMAN; PREMATURE LABOR; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW; SYSTEMATIC REVIEW; THERAPY EFFECT; TOCOLYSIS; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; FETAL GROWTH RETARDATION; HUMANS; OBSTETRIC LABOR, PREMATURE; PIPERAZINES; PREGNANCY; PURINES; SULFONES; TOCOLYTIC AGENTS;

EID: 34247596449     PISSN: 01443615     EISSN: 13646893     Source Type: Journal    
DOI: 10.1080/01443610701194978     Document Type: Review

References (33)

1. Abbott D, Comby P, Charuel C, Graepel P, Hanton G, Leblanc B et al. 2004. Preclinical safety profile of sildenafil. International Journal of Impotence Research 16:498-504.
2. Agha AM, Taha RA. 2001. Sildenafil inhibits agonist-evoked rat uterine contractility: influence of guanylyl cyclase inhibition. European Journal of Pharmacology 428:343-348.
3. Al-Omari WR, Al-Shammaa HB, Al-Tikriti EM, Ahmed KW. 2006. Atosiban and nifedipine in acute tocolysis: a comparative study. European Journal of Obstetrics, Gynecology and Reproductive Biology 128:129-134.
4. Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. 1998. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. Journal of Urology 159:2164-2171.
5. Belik J. 2005. Sildenafil administration during pregnancy increases fetal rat weight gain. FASEB Journal 19:A1248.
6. Brar HS, Rutherford SE. 1988. Classification of intrauterine growth retardation. Seminars in Perinatology 12:2-10.
7. Buhimschi CS, Garfield RE, Weiner CP, Buhimschi IA. 2004. The presence and function of phosphodiesterase type 5 in the rat myometrium. American Journal of Obstetrics and Gynecology 190:268-274.
8. Check JH, Graziano V, Lee G, Nazari A, Choe JK, Dietterich C. 2004. Neither sildenafil nor vaginal estradiol improves endometrial thickness in women with thin endometria after taking oral estradiol in graduating dosages. Clinical and Experimental Obstetrics and Gynecology 31:99-102.
9. Corbin JD, Francis SH. 1999. Cyclic GMP phosphodiesterase-5: target of sildenafil. Journal of Biological Chemistry 274:13729-13732.
10. Durlach J, Guiet-Bara A, Pages N, Bac P, Bara M. 2005. Magnesium chloride or magnesium sulfate: a genuine question. Magnesium Research 18:187-192.
11. Ghofrani HA, Osterloh IH, Grimminger F. 2006. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nature Reviews Drug Discovery 5:689-702.
12. Gluckman PD, Pinal CS. 2003. Regulation of fetal growth by the somatotrophic axis. Journal of Nutrition 133:1741-1746.
13. Hernandez-Hernandez D, Vargas-Rivera M, Nava-Ocampo AA, Palma-Aguirre J, Sumano-Lopez H. 2002. Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women. BMC Pregnancy and Childbirth 2:3.
14. Hoekstra RE, Ferrara TB, Couser RJ, Payne NR, Connett JE. 2004. Survival and long-term neurodevelopmental outcome of extremely premature infants born at 23-26 weeks' gestational age at a tertiary center. Pediatrics 113:e1-e6.
15. Jackson G, Gillies H, Osterloh I. 2005. Past, present, and future: a 7-year update of Viagra (sildenafil citrate). International Journal of Clinical Practice 59:680-691.
16. Kane LB, Klings ES. 2006. Present and future treatment strategies for pulmonary arterial hypertension: focus on phosphodiesterase-5 inhibitors. Treatments in Respiratory Medicine 5:271-282.
17. Khan RN, Hamoud H, Warren A, Wong LF, Arulkumaran S. 2004. Relaxant action of sildenafil citrate (Viagra) on human myometrium of pregnancy. American Journal of Obstetrics and Gynecology 191:315-321.
18. Lacassie HJ, Germain AM, Valdes G, Fernandez MS, Allamand F, Lopez H. 2004. Management of Eisenmenger syndrome in pregnancy with sildenafil and L-arginine. Obstetrics and Gynecology 103:1118-1120.
19. Lang U, Baker RS, Braems G, Zygmunt M, Kunzel W, Clark KE. 2003. Uterine blood flow: a determinant of fetal growth. European Journal of Obstetrics, Gynecology, and Reproductive Biology 110:S55-S61.
20. Mayor S. 2004. Pfizer will not apply for a licence for sildenafil for women. British Medical Journal 328:542.
21. Molelekwa V, Akhter P, McKenna P, Bowen M, Walsh K. 2005. Eisenmenger's syndrome in a 27 week pregnancy: management with bosentan and sildenafil. Irish Medical Journal 98:87-88.
22. Paulus WE, Strehler E, Zhang M, Jelinkova L, El-Danasouri I, Sterzik K. 2002. Benefits of vaginal sildenafil citrate in assisted reproduction therapy. Fertility and Sterility 77:846-847.
23. Raymajhi R, Pratap K. 2003. A comparative study between nifedipine and isoxsuprine in the suppression of preterm labour. Kathmandu University Medical Journal 1:85-90.
24. Refuerzo JS, Sokol RJ, Aranda JV, Hallak M, Hotra JW, Kruger M et al. 2006. Sildenafil citrate and fetal outcome in pregnant rats. Fetal Diagnosis and Therapy 21:259-263.
25. Sanchez-Aparicio P, Villanueva-Garcia D, Mota-Rojas D, Alonso-Spilsbury M, Nava-Ocampo A, Arch-Tirado E et al. 2006. Systemic effects of sildenafil citrate in gestation and perinatal period (in Spanish). In: Mota-Rojas D, Nava-Ocampo A, Villanueva-Garcia D, Alonso-Spilsbury, M, editors. Animal perinatology: clinical and experimental aspects (in Spanish). 1st edn. México: B M Editores, SA de CV, México DF. pp 59-70.
26. Sher G, Fisch JD. 2000. Vaginal sildenafil (Viagra): a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF. Human Reproduction 15:806-809.
27. Sher G, Fisch JD. 2002. Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development. Fertility and Sterility 78:1073-1076.
28. Shields KM, Hrometz SL. 2006. Use of sildenafil for female sexual dysfunction. Annals of Pharmacotherapy 40:931-934.
29. Trujillo-Ortega ME, Mota-Rojas D, Hernandez-Gonzalez R, Velazquez-Armenta EY, Nava-Ocampo AA, Ramirez-Necoechea R et al. 2006. Obstetric and neonatal outcomes to recombinant porcine somatotropin administered in the last third of pregnancy to primiparous sows. Journal of Endocrinology 189:575-582.
30. van Veen AJ, Pelinck MJ, van Pampus MG, Erwich JJ. 2005. Severe hypotension and fetal death due to tocolysis with nifedipine. British Journal of Obstetrics and Gynaecology 112:509-510.
31. Wareing M, Myers JE, O'Hara M, Baker PN. 2005. Sildenafil citrate (Viagra) enhances vasodilatation in fetal growth restriction. Journal of Clinical Endocrinology and Metabolism 90:2550-2555.
32. Yanney M, Marlow N. 2004. Paediatric consequences of fetal growth restriction. Seminars in Fetal and Neonatal Medicine 9:411-418.
33. Zoma WD, Baker RS, Friedman A, Clark KE. 2001. Sildenafil citrate (Viagra) increases uterine blood flow and potentiates estrogen-induced vasodilation (A814). Journal of the Society for Gynecologic Investigation 8:286A.