Sildenafil attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity

Toxicology

Volumn 257, Issue 3, 2009, Pages 137-143

  Lee, Kang Wook ^a   Jeong, Jin Young ^a   Lim, Beom Jin ^a   Chang, Yoon Kyung ^b   Lee, Sang Ju ^b   Na, Ki Ryang ^a   Shin, Young Tai ^a   Choi, Dae Eun ^a  

^a Chungnam National University College of Medicine   (South Korea)

^b Daejeon St Mary's Hospital   (South Korea)

Author keywords

Apoptosis; Cisplatin induced nephrotoxicity; Sildenafil

Indexed keywords

CASPASE 3; CISPLATIN; CREATININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; PROTEIN BAX; PROTEIN BCL 2; SILDENAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DENSITOMETRY; DRUG MECHANISM; ENZYME ACTIVATION; KIDNEY FUNCTION; KIDNEY INJURY; MALE; MICROPHOTOGRAPHY; NEPHROTOXICITY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; BCL-2-ASSOCIATED X PROTEIN; BLOOD UREA NITROGEN; BLOTTING, WESTERN; CASPASE 3; CISPLATIN; CREATININE; IN SITU NICK-END LABELING; KIDNEY; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; MALE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SULFONES;

ANIMALIA; RATTUS;

EID: 60249083033     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.12.017     Document Type: Article

References (23)

1. Boolell M., Allen M.J., Ballard S.A., Gepi-Attee S., Muirhead G.J., Naylor A.M., Osterloh I.H., and Gingell C. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int. J. Impot. Res. 8 (1996) 47-52
2. Das A., Ockaili R., Salloum F., and Kukreja R.C. Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits. Am. J. Physiol. Heart Circ. Physiol. 286 (2004) H1455-H1460
3. Elrod J.W., Greer J.J., and Lefer D.J. Sildenafil-mediated acute cardioprotection is independent of the NO/cGMP pathway. Am. J. Physiol. Heart Circ. Physiol. 292 (2007) H342-H347
4. Engineer M.S., Brown N.S., Ho D.H., Newman R.A., and Bulger R.E. A comparison of the effects of tetraplatin and cisplatin on renal function and gentamicin pharmacology in rats. Toxicology 59 (1989) 151-162
5. Evenepoel P. Acute toxic renal failure. Best Pract. Res. Clin. Anaesthesiol. 18 (2004) 37-52
6. Fisher P.W., Salloum F., Das A., Hyder H., and Kukreja R.C. Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity. Circulation 111 (2005) 1601-1610
7. Francescato H.D., Costa R.S., Scavone C., and Coimbra T.M. Parthenolide reduces cisplatin-induced renal damage. Toxicology 230 (2007) 64-75
8. Iseri S., Ercan F., Gedik N., Yuksel M., and Alican I. Simvastatin attenuates cisplatin-induced kidney and liver damage in rats. Toxicology 230 (2007) 256-264
9. Kang D.G., Lee A.S., Mun Y.J., Woo W.H., Kim Y.C., Sohn E.J., Moon M.K., and Lee H.S. Butein ameliorates renal concentrating ability in cisplatin-induced acute renal failure in rats. Biol. Pharm. Bull. 27 (2004) 366-370
10. Kiymaz N., Yilmaz N., Mumcu C., Anlar O., Ozen S., and Kayaoglu C.R. Protective effect of sildenafil (Viagra) in transient spinal cord ischemia. Pediatr. Neurosurg. 44 (2008) 22-28
11. Kone B.C. Nitric oxide synthesis in the kidney: isoforms, biosynthesis, and functions in health. Semin. Nephrol. 24 (2004) 299-315
12. Knight S., Snellen H., Humphreys M., and Baylis C. Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat. Am. J. Physiol. Renal. Physiol. 292 (2007) F655-F659
13. Lameire N., Van Biesen W., and Vanholder R. Acute renal failure. Lancet 365 (2005) 417-430
14. Lau A.H. Apoptosis induced by cisplatin nephrotoxic injury. Kidney Int. 56 (1999) 1295-1298
15. Lieberthal W., Triaca V., and Levine J. Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis. Am. J. Physiol. 270 (1996) F700-F708
16. Ockaili R., Salloum F., Hawkins J., and Kukreja R.C. Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H1263-H1269
17. Palmer R.M., Ashton D.S., and Moncada S. Vascular endothelial cells synthesize nitric oxide from l-arginine. Nature 333 (1988) 664-666
18. Ries F., and Klastersky J. Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity. Am. J. Kidney Dis. 8 (1986) 368-379
19. Rodriguez-Iturbe B., Ferrebuz A., Vanegas V., Quiroz Y., Espinoza F., Pons H., and Vaziri N.D. Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage. Kidney Int. 68 (2005) 2131-2142
20. Saleh S., and El-Demerdash E. Protective effects of l-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide. Basic Clin. Pharmacol. Toxicol. 97 (2005) 91-97
21. Srivastava R.C., Farookh A., Ahmad N., Misra M., Hasan S.K., and Husain M.M. Evidence for the involvement of nitric oxide in cisplatin-induced toxicity in rats. Biometals 9 (1996) 139-142
22. Tsuruya K., Ninomiya T., Tokumoto M., Hirakawa M., Masutani K., Taniguchi M., Fukuda K., Kanai H., Kishihara K., Hirakata H., and Iida M. Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death. Kidney Int. 63 (2003) 72-82
23. Yao X., Panichpisal K., Kurtzman N., and Nugent K. Cisplatin nephrotoxicity: a review. Am. J. Med. Sci. 334 (2007) 115-124