Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development

Fertility and Sterility

Volumn 78, Issue 5, 2002, Pages 1073-1076

  Sher, Geoffrey ^a,b,c   Fisch, Jeffrey D ^a  

^a Sher Institute for Reproductive Medicine   (United States)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

Endometrium; In vitro fertilization; Sildenafil

Indexed keywords

GONADORELIN AGONIST; LEUPRORELIN; RECOMBINANT FOLLITROPIN; SILDENAFIL;

ADULT; ARTICLE; COHORT ANALYSIS; CONCEPTION; CONTROLLED STUDY; DRUG EFFECT; EMBRYO TRANSFER; ENDOMETRITIS; ENDOMETRIUM; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; MAJOR CLINICAL STUDY; MENSTRUATION; PREGNANCY RATE; PRIORITY JOURNAL; PROGNOSIS; SPONTANEOUS ABORTION; THICKNESS; TREATMENT FAILURE; TREATMENT OUTCOME;

ADMINISTRATION, INTRAVAGINAL; ADULT; COHORT STUDIES; EMBRYO IMPLANTATION; ENDOMETRIUM; FEMALE; FERTILIZATION IN VITRO; HUMANS; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PREGNANCY; PREGNANCY RATE; RETREATMENT; RETROSPECTIVE STUDIES; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 0036842412     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(02)03375-7     Document Type: Article

References (11)

1. Ballard S.A., Gingell C.J., Tang K., Turner L.A., Price M.E., Naylor A.M. Effects of Sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isoenzymes. J Urol. 159:1998;2164-2171.
2. Telfer J.F., Irvine G.A., Kohnen G., Cambell S., Cameron I.T. Expression of endothelial and inducible nitric oxide synthase in non-pregnant and decidualized human endometrium. Mol Hum Reprod. 3:1997;69-75.
3. Fisch J.D., Behr B., Conti M. Enhancement of motility and acrosome reaction in human spermatozoa differential activation by type-specific phosphodiesterase inhibitors . Hum Reprod. 5:1998;1248-1254.
4. Boolell M., Gepi-Attee S., Gingell J.C., Allen M.J. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol. 78:1996;257-261.
5. Sher G., Fisch J.D. Vaginal sildenafil (Viagra) a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF . Hum Reprod. 15:2000;806-809.
6. Gonen Y., Casper R.F. Prediction of implantation by sonographic appearance during controlled ovarian stimulation for in vitro fertilization (IVF). J In Vitro Fert Embryo Transfer. 7:1990;146-152.
7. Sher G., Herbert C., Jacobs M., Maassarani G. Assessment of the late proliferative phase endometrium by ultrasonography in patients undergoing in vitro fertilization and embryo transfer (IVF-ET). Hum Reprod. 6:1991;232-237.
8. Sher G., Dodge S., Maassarani G., Knutzen V., Zouves C. Management of suboptimal sonographic endometrial patterns in patients undergoing in vitro fertilization and embryo transfer. Hum Reprod. 8:1993;374-379.
9. Weckstein L.N., Jacobson A., Galen D., Hampton K., Hammel J. Low-dose aspirin for oocyte donation recipients with a thin endometrium prospective, randomized study . Fertil Steril. 68:1997;927-930.
10. Cameron I.T., Cambell S. Nitric oxide in the endometrium. Hum Reprod Update. 4:1998;565-569.
11. Amit A., Thaler I., Paz Y., Itskovitz-Eldor J. The effect of a nitric oxide donor on doppler flow velocity waveforms in the uterine artery during the first trimester of pregnancy. Ultrasound Obstet Gynecol. 11:1998;94-98.