Biochemical role of intravaginal sildenafil citrate as a novel antiabortive agent in unexplained recurrent spontaneous miscarriage: First clinical study of four case reports from Egypt

Clinical Chemistry and Laboratory Medicine

Volumn 47, Issue 11, 2009, Pages 1433-1438

  El Far, Mohamed ^a   El Motwally, Abd El Gawad ^b   Hashem, Ikbal Abou ^b   Bakry, Nadia ^b  

^a Mansoura University   (Egypt)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Antiabortive agent; Antioxidants; Intravaginal sildenafil; Tumor necrosis factor ; Unexplained recurrent spontaneous abortion

Indexed keywords

ANTIOXIDANT; CATALASE; CD3 ANTIGEN; CD56 ANTIGEN; FOLIC ACID; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; NITRIC OXIDE; SILDENAFIL; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTERY DILATATION; ARTICLE; BLOOD FLOW; CASE REPORT; EGYPT; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; LABIA SWELLING; LYMPHOCYTE DIFFERENTIATION; NATURAL KILLER CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PULSE WAVE; SPONTANEOUS ABORTION; T LYMPHOCYTE; UTERINE ARTERY; UTERINE ARTERY PULSATILITY INDEX; VAGINA DISEASE; VAGINAL IRRITATION; VASOCONSTRICTION;

ABORTION, HABITUAL; ADMINISTRATION, INTRAVAGINAL; ADULT; EGYPT; FEMALE; HUMANS; PIPERAZINES; PREGNANCY; PURINES; SULFONES; TABLETS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 73349102184     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2009.311     Document Type: Article

References (17)

1. Farquharson RG, Quenby S, Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet Gynecol 2002;100:408-413
2. El-Far M, El-Sayed IH, El-Motwally Ael-G, Hashem IA, Bakry N. Tumor necrosis factor-a and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions. Clin Chem Lab Med 2007;45: 879-883
3. El-Far M, El-Sayed IH, El-Motwally Ael-G, Hashem IA, Bakry N. Serum levels of TNF-alpha and antioxidant enzymes and placental TNF-alpha expression in unexplained recurrent spontaneous miscarriage. J Physiol Biochem 2009;65:175-182
4. Vassiliadou N, Bulmer JN. Functional studies of human deciduas in spontaneous early pregnancy loss: effect of soluble factors and purified CD56q lymphocytes on killing of natural killer-and lymphokine-activated killer-sensitive targets. Biol Reprod 1998;58:982-987
5. Boolell M, Gepi-Attee S, Gingell JC, Allen MJ. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol 1998;78:257-261
6. Green LC, Wagner DA, Glokowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrite, nitrate, and w15Nx nitrite in biological fluids. Anal Biochem 1981; 126:131-138
7. Stocks J, Donnandy J. The autoxidation of human red cell lipids induced by hydrogen peroxide. Br J Haematol 1971;20:95-111.
8. Dechatelet LR, McCall CE, McPhial LC, Johnston RB. Superoxide dismutase activity in leukocytes. J Clin Invest 1974;53:1197-1201
9. Koupparis AJ, Jeremy JY, Muzaffar S, Persad R, Shukla N. Sildenafil inhibits the formation of superoxide and the expression of gp47phos NAD(P)H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells. Br J Urol Int 2005;96:423-427
10. Redecha P, Van Rooijen N, Torry D, Giradi G. Pravastatin prevents miscarriages in mice: role of tissue factor in placenta and fetal injury. Blood 2009;113:4101-4109
11. Quenby S, Nik H, Innes B, Lash G, Turner M, Drury J, et al. Uterine natural killer cells and angiogenesis in recurrent reproductive failure. Hum Reprod 2008;24:45-54.
12. Jerzak M, Kniotek M, Mrozek J, Górski A, Baranowski W. Sildenafil citrate decreased natural killer cell activity and enhanced chance of successful pregnancy in women with a history of recurrent miscarriage. Fertil Steril 2008;90:1848-1853
13. Kim SH, Doppler US. Evaluation of erectile dysfunction. Abdom Imaging 2002;27:578-587
14. Geoffrey Sher, Jeffrey D. Vaginal sildenafil (Viagra): a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF. Hum Reprod 2000;15:806-809
15. Burnett AL, Calvin DC, Silver RI, Peppas DS, Docimo SG. Immunohistochemical description of nitric oxide syntheses isoforms in human clitoris. J Urol 1997;158:75-78
16. D'Amati G, Di Gioia CR, Bologna M, Giordano D, Giorgi M, Dolci S, et al. Type 5 phosphodiesterase expression in the human vagina. Urology 2000;60:191-195
17. Sanchez-Aparicio P, Mota-rojas D, Ramirez Necoechea R, Olmos-Hernandez A, Alonso-Spilsbury M, Villanueva-Garcia S, et al. Systemic effects of sildenafil citrate on pregnancy and perinatal periods. J Anim Verter Advan 2007;6:267-271