A literature review and case reports series on the use of phosphodiesterase inhibitors in the treatment of female sexual dysfunction

International Journal of STD and AIDS

Volumn 20, Issue 3, 2009, Pages 152-157

  Foster, R ^a   Mears, A ^b   Goldmeier, D ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

Author keywords

Female sexual dysfunction; Phosphodiesterase inhibitors

Indexed keywords

ACETYLSALICYLIC ACID; ANASTROZOLE; ANDROGEN; ANTIDEPRESSANT AGENT; ATORVASTATIN; CARBAMAZEPINE; ESTROGEN; HYDROXYCHLOROQUINE; LITHIUM; LOFEPRAMINE; MIRTAZAPINE; OLANZAPINE; ORAL CONTRACEPTIVE AGENT; PERINDOPRIL; PHOSPHODIESTERASE V INHIBITOR; SEROTONIN UPTAKE INHIBITOR; SILDENAFIL; SULPIRIDE; TADALAFIL; TAMOXIFEN; VARDENAFIL;

ANORGASMIA; ANXIETY DISORDER; BLOOD FLOW; BREAST CANCER; CLITORIS; DEPRESSION; DYSPAREUNIA; FEMALE SEXUAL DYSFUNCTION; HUMAN; ORGASM DISORDER; PARANOIA; PATIENT SATISFACTION; POSTMENOPAUSE; PRIORITY JOURNAL; REVIEW; SCHIZOAFFECTIVE PSYCHOSIS; SEXUAL AROUSAL DISORDER; SEXUAL INTERCOURSE; SEXUAL SATISFACTION; TEMPORAL LOBE EPILEPSY; UNSPECIFIED SIDE EFFECT; VAGINISM;

ADULT; FEMALE; HUMANS; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL;

EID: 62249137799     PISSN: 09564624     EISSN: None     Source Type: Journal    
DOI: 10.1258/ijsa.2008.008336     Document Type: Review

References (42)

1. Nazareth I, Boynton P, King M. Problems with sexual function in people attending London general practitioners: cross sectional study. BMJ 2003;327:423
2. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States. JAMA 1999;281:537-45
3. Dunn KM, Croft PR, Hackett GI. Sexual Problems: a study of the prevalence and need for health care in the general population. Fam Pract 1998;15:519-24
4. Mercer CH, Fenton KA, Johnson AM, et al. Sexual function problems and help seeking behaviour in Britain: national probability sample survey. BMJ 2003;327:426-7
5. Hayes RD, Dennerstein L, Bennett CM, Fairley CK. What is the true prevalence of female sexual dysfunctions and does the way we assess these conditions have an impact? J Sex Med 2008;5:777-87
6. Basson R, Leiblum S, Brotto L, et al. Revised definitions of women's sexual dysfunction. J Sex Med 2004;1:40-8
7. Kaplan HS. Disorders of Sexual Desire. New York: Brunner/Mazel, 1979
8. Park K, Moreland RB, Goldstein I, Atala A, Traish A. Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernous smooth muscle. Biochem Biophys Res Commun 1998;249:612-7
9. Uckert S, Mayer ME, Jonas U, Stief CG. Immunohistochemical presence of cyclic AMP and cyclic GMP phosphodiesterase isoenzymes in the human clitoris (abstract). Eur Urol 2003;1:118
10. D'amati G, diGioia CRT, Bologna M, et al. Type 5 phosphodiesterase expression in the human vagina. Urology 2002;60:191-5
11. Burnett AL, Calvin DC, Silver RI, Peppas DS, Docimo SG. Immunohistochemical description of nitric oxide synthetase isoforms in the human clitoris. JUrol1997;158:75-8
12. Leiblum SR, Chivers ML. Normal and persistent genital arousal in women:new perspectives. J Sex Mar Ther 2007;33:357-73
13. Kaplan SA, Reis RB, John IJ, et al. Safety and Efficacy of sildenafil in postmenopausal women with sexual dysfunction. Urology 1999;53:481-6
14. Nurnberg HG, Lauriello J, Hensley PL, Parker LM, Keith SJ. Sildenafil for sexual dysfunction in women taking antidepressants. Am J Psychiatry 1999;156:1664-5
15. Berman JR, Berman LA, Lin H, Flaherty E, Lahey N, Goldstein I. Effect of sildenafil on subjective and physiologic parameters of the female sexual response in women with sexual arousal disorder. J Sex Mar Ther 2001;28:411-20
16. Berman LA, Berman JR, Bruck D, Pawar RV, Goldstein I. Pharmacotherapy or psychotherapy?: Effective treatment for FSD related to unresolved childhood sexual abuse. J Sex Mar Ther 2001;27:421-5
17. Atalas E, Yagci B. The effect of sildenafil citrate on uterine and clitoral arterial blood flow in postmenopausal women. Med Gen Med 2004;6:51
18. Richardson D, Goldmeier D, Kocsis A. PDE5 inhibitors may help some women with sexual problems. Sex Relations Ther 2005;20:65-9
19. Ferrara D, Zaslau S. Success of sildenafil treatment in neurogenic female sexual dysfunction caused by L5-S1 intervertebral disk rupture: a case report. Int J Urol 2007;14:566-8
20. Rosen RC. Sexual function assessment and the role of vasoactive drugs in female sexual dysfunction. Arch Sex Behav 2002;31:439-43
21. Goldstein I, Lue TF, Padma-Nathan H, et al. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998;338:1397-404
22. Sipski ML, Rosen RC, Alexander CJ, Hamer RM. Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury. Urology 2000;55:812-5
23. Caruso S, Intelisano G, Lupo L, Agnello C. Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, cross-over, placebo-controlled study. Br J Obstet Gynaecol 2001;108:623-8
24. Laan E, Van Lunsin RHW, Everaerd W, et al. The enhancement of vaginal vasocongestion by sildenafil in healthy premenopausal women. J Women Health Gender Based Med 2002;11:357-65
25. Basson R, McInnes R, Smith MD, Hodgson G, Koppiker N. Efficacy and safety of sildenafil citrate in women with sexual dysfunction associated with female sexual arousal disorder. J Women Health Gender Based Med 2002;11:367-77
26. Caruso S, Intelisano G, Farina M, Di Mari L, Agnello C. The function of sildenafil on female sexual pathways: a double-blind, cross-over, placebo-controlled study. Eur J Obstet Gynaecol Reprod Biol 2003;110:201-6
27. Basson R, Brotto LA. Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: a randomised controlled trial. Br J Obstet Gynaecol 2003;110:1014-24
28. Berman JR, Berman LA, Toler SM, Gill J, Haughie S. Safety and Efficacy of sildenafil citrate for the treatment of female sexual arousal disorder. JUrol2003;170:2333-8
29. Dasgupta R, Wisemn G, Kanabar G, Fowler C. Efficacy of sildenafil in the treatment of female sexual dysfunction due to multiple sclerosis. J Urol 2004;171:1189-93
30. Caruso S, Rugolo S, Agnello C, Intelisano G, Di Mari L, Cianci A. Sildenafil improves sexual functioning in premenopausal women with type 1 diabetes who are affected by sexual arousal disorder: a double-blind, crossover, placebo-controlled pilot study. Fertil Steril 2006;85:1496-501
31. Claret L, Cox EH, McFayden L, et al. Modeling and simulation of sexual activity daily diary data of patients with female sexual arousal disorder treated with sildenafil citrate. Pharm Res 2006;23:1756-64
32. Yang CC, Cao YY, Guan QY, et al. Influence of PDE5 inhibitor on MRI measurement of clitoral volume response in women with FSAD: a feasibility study of a potential technique for evaluating a drug response. Int J Impot Res 2008;20:105-10
33. Nurnberg HG, Hensley PL, Heinman JR, Croft HA, Debattista C, Paine S. Sildenafil treatment of women with antidepressant-associated sexual dysfunction. JAMA 2008;300:395 - 404
34. Moynihan R. The making of a disease: female sexual dysfunction. BMJ 2003;326:45-7
35. Bancroft J, Loftus J. Scott Long. Distress about sex: a national survey of women in heterosexual relationships. Arch Sex Behav 2003;32:193-208
36. Brink CB, Clapton JD, Eagar BE, Harvey BH. Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies. J Neural Transm 2008;115:117-25
37. Orr G, Seidman SN, Weiser M, Gershon AA, Dubrov Y, Klein DF. An open-label pilot study to evaluate the efficacy of sildenafil citrate in middle-aged men with late-onset dysthymia. J Nerv Ment Dis 2008;196:496-500
38. Kaya C, Yilmaz G, Nurkalem Z, Ilktac A, Karaman MI. Sexual function in women with coronary artery disease: a preliminary study. Int J Impot Res 2007;19:326-9
39. Derzko C, Elliott S, Lam W. Management of sexual dysfunction in postmenopausal breast cancer patients taking adjuvant aromatase inhibitor therapy. Curr Oncol 2007;14:S20-40
40. Fava M, Nurnberg HG, Seidman SN, et al. Efficacy and safety of sildenafil in men with serotonergic antidepressant-associated erectile dysfunction: results from a randomized, double-blind, placebo-controlled trial. J Cl n Psych atry 2006;67:240-6
41. Labbate LA, Croft HA, Oleshansky MA. Antidepressant-related erectile dysfunction: management via avoidance, switching antidepressants, antidotes, and adaptation. J Cl n Psych atry 2003;64:11 -9
42. Berner MM, Hagen M, Kriston L. Management of sexual dysfunction due to antipsychotic drug therapy. Cochrane Database Syst Rev 2007;24:CD003546