Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: A randomized trial

BJU International

Volumn 106, Issue 8, 2010, Pages 1181-1185

  Dimitriadis, Fotios ^a,b   Tsambalas, Stavros ^b   Tsounapi, Panagiota ^a   Kawamura, Hiroshi ^b   Vlachopoulou, Evlalia ^b   Haliasos, Nikolaos ^b   Gratsias, Stavros ^b   Watanabe, Takeshi ^a   Saito, Motoaki ^a   Miyagawa, Ikuo ^a   Sofikitis, Nikolaos ^b  

^a TOTTORI UNIVERSITY   (Japan)

^b UNIVERSITY OF IOANNINA   (Greece)

Author keywords

Leydig cell; PDE5 inhibitors; sperm quality; testis

Indexed keywords

CARNITINE; FOLLITROPIN; INSULIN LIKE 3 PEPTIDE; LUTEINIZING HORMONE; PHOSPHODIESTERASE V INHIBITOR; RELAXIN LIKE FACTOR; SILDENAFIL; TESTOSTERONE; UNCLASSIFIED DRUG; VARDENAFIL;

ADULT; ARTICLE; CELL STRUCTURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FOLLITROPIN BLOOD LEVEL; HUMAN; LEYDIG CELL; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; OLIGOSPERMIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; STATISTICAL SIGNIFICANCE; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; TREATMENT RESPONSE;

ANALYSIS OF VARIANCE; CARNITINE; HUMANS; IMIDAZOLES; INSULIN; LEYDIG CELLS; MALE; OLIGOSPERMIA; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PROTEINS; PURINES; SPERM COUNT; SPERM MOTILITY; SULFONES; TREATMENT OUTCOME; TRIAZINES;

EID: 77957583427     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2010.09243.x     Document Type: Article

References (28)

1. Sofikitis N, Miyagawa I, Dimitriadis D, Zavos P, Sikka S, Hellstrom W. Effects of smoking on testicular function, semen quality and sperm fertilizing capacity. J Urol 1995 154 : 1030 4
2. Sofikitis N, Takahashi C, Kadowaki H et al. Surgical repair versus medical treatment of varicocele in the rat: pharmacological manipulation of the varicocelized testicle. Eur Urol 1992 22 : 44 52
3. Sofikitis N, Giotitsas N, Tsounapi P, Baltogiannis D, Giannakis D, Pardalidis N. Hormonal regulation of spermatogenesis and spermiogenesis. J Steroid Biochem Mol Biol 2008 109 : 323 30
4. Scipioni A, Stefanini S, Santone R, Giorgi M. Immunohistochemical localisation of PDE5 in Leydig and myoid cells of prepubertal and adult rat testis. Histochem Cell Biol 2005 124 : 401 7
5. Vasta V, Shimizu-Albergine M, Beavo JA. Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A. Proc Natl Acad Sci USA 2006 103 : 19925 30
6. Dimitriadis F, Giannakis D, Pardalidis N et al. Effects of phosphodiesterase-5 inhibitors on sperm parameters and fertilizing capacity. Asian J Androl 2008 10 : 115 33
7. Purvis K, Muirhead GJ, Harness JA. The effects of sildenafil on human sperm function in healthy volunteers. Br J Clin Pharmacol 2002 53 (Suppl. 1 53S 60S
8. Aversa A, Mazzilli F, Rossi T, Delfino M, Isidori AM, Fabbri A. Effects of sildenafil (Viagra) administration on seminal parameters and post-ejaculatory refractory time in normal males. Hum Reprod 2000 15 : 131 4
9. Jarvi K, Dula E, Drehobl M, Pryor J, Shapiro J, Seger M. Daily vardenafil for 6 months has no detrimental effects on semen characteristics or reproductive hormones in men with normal baseline levels. J Urol 2008 179 : 1060 5
10. WHO. WHO Laboratory Manual for the Examination of Human Semen and Sperm +- Cervical Mucus Interaction.
11. Bay K, Hartung S, Ivell R et al. Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders: relationship to the luteinizing hormone-testosterone axis. J Clin Endocrinol Metab 2005 90 : 3410 8
12. Coyotupa J, Parlow AF, Abraham GE. Simultaneous radioimmunoassay of plasma testosterone and dihydrotestosterone. Anal Lett 1972 5 : 329 40
13. Sofikitis NV, Miyagawa I. Endocrinological, biophysical, and biochemical parameters of semen collected via masturbation versus sexual intercourse. J Androl 1993 14 : 366 73
14. Dimitriadis F, Giannakis D, Giotitsas N et al. Post-fertilization effects of chronic renal failure in male rats. Int J Androl 2008 32 : 675 86
15. Hellstrom WJ, Overstreet JW, Yu A et al. Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones. J Urol 2003 170 : 887 91
16. Hellstrom WJ, Gittelman M, Jarow J et al. An evaluation of semen characteristics in men 45 years of age or older after daily dosing with tadalafil 20mg: results of a multicenter, randomized, double-blind, placebo-controlled, 9-month study. Eur Urol 2008 53 : 1058 65
17. Weiss DB, Rodriguez-Rigau LJ, Smith KD, Steinberger E. Leydig cell function in oligospermic men with varicocele. J Urol 1978 120 : 427 30
18. Sofikitis N, Kaponis A, Mio Y et al. Germ cell transplantation: a review and progress report on ICSI from spermatozoa generated in xenogeneic testes. Hum Reprod Update 2003 9 : 291 307
19. Holstein AF, Maekawa M, Nagano T, Davidoff MS. Myofibroblasts in the lamina propria of human seminiferous tubules are dynamic structures of heterogeneous phenotype. Arch Histol Cytol 1996 59 : 109 25
20. Morley DJ, Hawley DM, Ulbright TM, Butler LG, Culp JS, Hodes ME. Distribution of phosphodiesterase I in normal human tissues. J Histochem Cytochem 1987 35 : 75 82
21. Mochida H, Inoue H, Takagi M, Noto T, Yano K, Kikkawa K. Sildenafil and T-1032, phosphodiesterase type 5 inhibitors, showed a different vasorelaxant property in the isolated rat aorta. Eur J Pharmacol 2002 440 : 45 52
22. Kotera J, Fujishige K, Imai Y et al. Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases. Eur J Biochem 1999 262 : 866 73
23. du Plessis SS, de Jongh PS, Franken DR. Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function. Fertil Steril 2004 81 : 1026 33
24. Jannini EA, Lombardo F, Salacone P, Gandini L, Lenzi A. Treatment of sexual dysfunctions secondary to male infertility with sildenafil citrate. Fertil Steril 2004 81 : 705 7
25. Ali ST, Rakkah NI. Neurophysiological role of sildenafil citrate (Viagra) on seminal parameters in diabetic males with and without neuropathy. Pak J Pharm Sci 2007 20 : 36 42
26. Pomara G, Morelli G, Canale D et al. Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men. Fertil Steril 2007 88 : 860 5
27. Su YH, Vacquier VD. Cyclic GMP-specific phosphodiesterase-5 regulates motility of sea urchin spermatozoa. Mol Biol Cell 2006 17 : 114 21
28. Wayman C, Phillips S, Lunny C et al. Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology. Int J Impot Res 2005 17 : 216 23