Sildenafil citrate improves sperm motility but causes a premature acrosome reaction in vitro

Fertility and Sterility

Volumn 87, Issue 5, 2007, Pages 1064-1070

  Glenn, David R J ^a   McVicar, Carmel M ^a   McClure, Neil ^a   Lewis, Sheena E M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

acrosome reaction; Sildenafil citrate; sperm motility

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; PEANUT AGGLUTININ; SILDENAFIL;

ACROSOME REACTION; ADULT; ARTICLE; COMPUTER ANALYSIS; CONCEPTION; CONTROL GROUP; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; FERTILIZATION IN VITRO; HUMAN; INCUBATION TEMPERATURE; INCUBATION TIME; MALE; PRIORITY JOURNAL; SEMEN ANALYSIS; SPERMATOZOON MOTILITY;

ACROSOME REACTION; ADULT; HUMANS; INFERTILITY, MALE; MALE; PIPERAZINES; PURINES; SPERM MOTILITY; SULFONES;

EID: 34247499476     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2006.11.017     Document Type: Article

References (56)

1. Pfizer Ltd. www.viagra.com/whyViagra/provenSafety.asp, 2005.
2. Aldridge J., and Measham F. Sildenafil (Viagra) is used as a recreational drug in England. BMJ 318 (1999) 669
3. Smith K.M., and Romanelli F. Recreational use and misuse of phosphodieterase 5 inhibitors. J Am Pharm Assoc (Was DC) 45 (2005) 63-65
4. Monga M., Bernie J., and Rajasekaran M. Male infertility and erectile dysfunction in spinal cord injury: a review. Arch Phys Med Rehabil 80 (1999) 1331-1339
5. Glossmann H., Petrischor G., and Bartsch G. Molecular mechanisms of the effects of SC (VIAGRA). Exp Gerontol 34 (1999) 305-318
6. McKinney K.A., Lewis S.E., and Thompson W. Persistent effects of pentoxifylline on human sperm motility, after drug removal, in normozoospermic and asthenozoospermic individuals. Andrologia 26 (1994) 235-240
7. Koupparis A.J., Jeremy J.Y., Mazaffar S., Persad R., and Shukla N. Sildenafil inhibits the formation of superoxide and the expression of gp47(phox)NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells. B J Urol 96 (2005) 423-427
8. McKinney K.A., Lewis S.E.M., and Thompson W. The effects of pentoxifylline on the generation of reactive oxygen species and lipid peroxidation in human spermatozoa. Andrologia 28 (1996) 15-20
9. World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction (1999), Cambridge University Press, Cambridge
10. Biggers J.D., Whitten W.K., and Whittingham D.G. The culture of mouse embryos in vitro. In: Daniel J.C. (Ed). Methods in mammalian embryology (1971), Freeman, San Francisco 86-116
11. O'Connell M., McClure N., Powell L.A., Steele E.K., and Lewis S.E. Differences in mitochondrial and nuclear DNA status of high-density and low-density sperm fractions after density centrifugation preparation. Fertil Steril 79 Suppl 1 (2003) 754-762
12. Mortimer D. Sperm fertilizing ability testing. In: Mortimer D. (Ed). Practical laboratory andrology (1994), Oxford University Press, Oxford 199-240
13. Mortimer D., Curtis E.F., and Miller R.G. Specific labelling by peanut agglutinin of the outer acrosomal membrane of the human spermatozoon. J Reprod Fertil 81 (1987) 127-135
14. Morales A., Gingell C., Collins M., Wicker P.A., and Osterloh I.H. Clinical safety of oral sildenafil citrate (VIAGRA [TM]) in the treatment of erectile dysfunction. Int J Impotence Res 2 (1998) 69-73
15. Fabbri A., Aversa A., and Isidori A. Sildenafil and erectile dysfunction. J Endo Inv 6 (1999) 486-491
16. Goldstein I., Rosen R.C., and Steers E.D. Sildenafil in the treatment of erectile dysfunction (Reply). N Engl J Med 339 (1999) 701-702
17. Fisch J.D., Behr B., and Conti M. Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors. Hum Reprod 13 (1998) 1248-1254
18. Beavo J.A. Cyclic-nucleotide phosphodiesterases-functional implications of multiple isoforms. Phys Rev 75 (1995) 725-748
19. Conti M., Nemoz G., Sette C., and Vicini E. Recent progress in understanding the hormonal-regulation of phosphodiesterases. Endo Rev 16 (1995) 370-389
20. Lewis S.E., Moohan J.M., and Thompson W.I. Effects of pentoxifylline on human sperm motility in normospermic individuals using computer assisted analysis. Fertil Steril 59 (1993) 418-423
21. McKinney K.A., Lewis S.E.M., and Thompson W. The effect of pentoxifylline on human sperm motility and its persistence after drug removal in normozoospermic and asthenozoospermic individuals. Andrologia 26 (1994) 235-240
22. Lewis S.E.M., McKinney K., and Thompson. The influence of pentoxifylline on human sperm motility in asthenozoospermic individuals using computer assisted analysis. Arch Androl 32 (1994) 175-183
23. Fisch J.D., Behr B., and Conti M. Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors. Hum Reprod 13 (1998) 1248-1254
24. Cuadra D.L., Chan P.J., Patton W.C., Stewart S.C., and King A. Type 5 phosphodiesterase regulation of human sperm motility. Am J Obstet Gynecol 182 (2000) 1013-1015
25. Lefievre L., De Lamirande E., and Gagnon C. The cyclic GMP-specific phosphodiesterase inhibitor, SC, stimulates human sperm motility and capacitation but not acrosome reaction. J Androl 21 (2000) 929-937
26. Burger M., Sikka S.C., Bivalacqua T.J., Lamb D.J., and Hellstrom W.J. The effect of SC on human sperm motion and function from normal and infertile men. Int J Impot Res 12 (2000) 229-234
27. Aversa A., Mazzilli F., Rossi T., Delfino M., Isidori A.M., and Fabbri A. Effects of SC (Viagra) administration on seminal parameters and post-ejaculatory refractory time in normal males. Hum Reprod 15 (2000) 131-134
28. Hellstrom W.J.G., Overstreet J.W., Yu A., Saikal K., Shen W., Beasley C.M., et al. Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones. J Urol 170 (2003) 887-891
29. Andrade J.R., Traboulsi A., Hussain A., and Dubin N.H. In vitro effects of SC and phentolamine, drugs used for erectile dysfunction, on human sperm motility. Am J Obstet Gynecol 182 (2000) 1093-1095
30. Pfizer Ltd. www.emc.medicines.org.uk, 2002.
31. Winningham D.G., Nemoy N.J., and Stamey T.A. Diffusion of antibiotics from plasma into prostatic fluid. Nature 219 (1968) 139-143
32. Pichini S., Zuccaro P., and Pacifici R. Drugs in semen. Clin Pharmacokinet 26 (1994) 356-373
33. Jones R. Sperm survival versus degradation in the mammalian epididymis: a hypothesis. Biol Reprod 72 (2004) 1405-1411
34. Tur-Kaspa I., Segal S., Moffa F., Massobrio M., and Meltzer S. Viagra for temporary erectile dysfunction during treatments with assisted reproductive technologies. Hum Reprod 14 (1999) 1783-1784
35. Tesarik J., Mendoza C., and Carreras A. Effects of phosphodiesterase inhibitors caffeine and pentoxifylline on spontaneous and stimulus-induced acrosome reactions in human sperm. Fertil Steril 58 (1992) 1185-1190
36. Lanzafame F., Chapman M.G., Guglielmino A., Gearon C.M., and Forman R.G. Pharmacological stimulation of sperm motility. Hum Reprod 9 (1994) 192-199
37. Lefievre L., De Lamirande E., and Gagnon C. The cyclic GMP-specific phosphodiesterase inhibitor, sildenafil, stimulates human sperm motility and capacitation but not acrosome reaction. J Androl 21 (2000) 929-937
38. du Plessis S.S., de Jongh P.S., and Franken D.R. Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function. Fertil Steril 81 (2004) 1026-1033
39. Esteves S.C., Spaine D.M., Cedenho A.P., and Srougi M. Cryopreservation of sperm from oligo-asthenozoospermic men with pentoxifylline improves the post-thaw agonist-induced acrosome reaction rate. J Urology 167 Suppl S (2002) 318
40. Ain R., Uma Devi K.U., Shivaji S., and Seshagiri P.B. Pentoxifylline-stimulated capacitation and acrosome reaction in hamster spermatozoa: involvement of intracellular signalling molecules. Mol Hum Reprod 5 (1999) 618-626
41. Tesarik J., Mendoza C., and Carreras A. Effects of phosphodiesterase inhibitors caffeine and pentoxifylline on spontaneous and stimulus-induced acrosome reactions in human sperm. Fertil Steril 58 (1992) 1185-1190
42. Tasdemir M., Tasdemir I., Kodama H., and Tanaka T. Pentoxifylline-enhanced acrosome reaction correlates with fertilization in vitro. Hum Reprod 8 (1993) 2102-2107
43. Yovich J.L. Pentosifylline: actions and applications in assisted reproduction. Hum Reprod 8 (1993) 1986-1991
44. Francis S.H. Phosphodiesterase 11 (PDE11): is it a player in human testicular function?. Int J of Imp Res 17 (2005) 467-468
45. Wayman C., Phillips S., Lunny C., Webb T., Fawcett L., Baxendale R., and Burges G. Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology. Int J Impot Res 17 (2005) 216-223
46. Omote M. Pharmacological profiles of SC (VIAGRA) in the treatment of erectile dysfunction: efficacy and drug interaction with nitrate. Nippon Yakurigaku Zasshi 114 (1999) 213-218
47. Middendorff R., Davidoff M.S., Behrends S., Mewe M., Miethens A., and Muller D. Multiple roles of the messenger molecule cGMP in testicular function. Andrologia 32 (2000) 55-59
48. Rossato M., Di Virgilio F., Rizzuto R., Galeazzi C., and Foresta C. Intracellular calcium store depletion and acrosome reaction in human spermatozoa: role of calcium and plasma membrance potential. Mol Hum Reprod 7 (2001) 119-128
49. Kim N.Y., Pae H.O., Kim Y.C., Choi C.K., Rim J.S., Lee H.S., et al. Pentoxifylline potentiates nitric oxide production in interleukin-1beta-stimulated vascular smooth muscle cells through cyclic AMP-dependent protein kinase A pathway. Gen Pharmacol 35 (2000) 205-211
50. Lewis S.E., Donnelly E.T., Sterling E.S., Kennedy M.S., Thomson W., and Chakravarthy U. Nitric oxide synthase and nitrite production in human spermatozoa: evidence that endogenous nitric oxide is beneficial to sperm motility. Mol Hum Reprod 2 (1996) 873-878
51. Donnelly E.T., Lewis S.E., Thompson W., and Chakravarthy U. Sperm nitric oxide and motility: the effects of nitric oxide synthase stimulation and inhibition. Mol Hum Reprod 3 (1997) 755-762
52. Lacham-Kaplan O., and Trounson A.O. Embryo development capacity of oocytes fertilized by immature sperm and sperm treated with motility stimulants. Reprod Fertil Dev 6 (1994) 113-116
53. Scott L., and Smith S. Human sperm motility-enhancing agents have detrimental effects on mouse oocytes and embryos. Fertil Steril 63 (1995) 166-175
54. Tournaye H., Van der Linden M., Van den Abbeel E., Devroey P., and Van Steirteghem A. Effect of pentoxifylline on implantation and post-implantation development of mouse embryos in vitro. Hum Reprod 8 (1993) 1948-1954
55. Siracusa G., De Felici M., and Salustri A. Meiotic maturation of the mammalian oocyte. In: Asch R.H., Balmaceda J.P., and Johnston I. (Eds). Gamete physiology (1990), Serono Symposia USA, Norwell, MA 129-144
56. Morales A., Gingell C., Collins M., Wicker P.A., and Osterloh I.H. Clinical safety of oral sildenafil citrate (VIAGRA (TM)) in the treatment of erectile dysfunction. Int J Impo Res 10 (1998) 69-73