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Volumn 7, Issue 11, 2010, Pages 603-609

An update on new oral PDE5 inhibitors for the treatment of erectile dysfunction

Author keywords

[No Author keywords available]

Indexed keywords

AVANAFIL; BREMELANOTIDE; CALCITONIN GENE RELATED PEPTIDE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LODENAFIL CARBONATE; MELANOCORTIN RECEPTOR AGONIST; MIRODENAFIL; NAKED DNA; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VI; PLACEBO; PLASMID DNA; SILDENAFIL; SLX 2101; SUPEROXIDE DISMUTASE; TADALAFIL; UDENAFIL; UNCLASSIFIED DRUG; VARDENAFIL; VASCULOTROPIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 78549285356     PISSN: 17594812     EISSN: 17594820     Source Type: Journal    
DOI: 10.1038/nrurol.2010.165     Document Type: Review
Times cited : (51)

References (44)
  • 1
    • 0033553509 scopus 로고    scopus 로고
    • Cyclic GMP phosphodiesterase-5: Target of sildenafil
    • Corbin, J. D. & Francis, S. H. Cyclic GMP phosphodiesterase-5: target of sildenafil. J. Biol. Chem. 274, 13729-13732 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 13729-13732
    • Corbin, J.D.1    Francis, S.H.2
  • 2
    • 0036332629 scopus 로고    scopus 로고
    • Pharmacology of phosphodiesterase-5 inhibitors
    • Corbin, J. D. & Francis, S. H. Pharmacology of phosphodiesterase-5 inhibitors. Int. J. Clin. Pract. 56, 453-459 (2002).
    • (2002) Int. J. Clin. Pract. , vol.56 , pp. 453-459
    • Corbin, J.D.1    Francis, S.H.2
  • 3
    • 74049143429 scopus 로고    scopus 로고
    • Pharmacotherapy for erectile dysfunction
    • Eardley, I. et al. Pharmacotherapy for erectile dysfunction. J. Sex. Med. 7 (1 Pt 2), 524-540 (2010).
    • (2010) J. Sex. Med. , vol.7 , Issue.1 PART 2 , pp. 524-540
    • Eardley, I.1
  • 4
    • 0038353576 scopus 로고    scopus 로고
    • Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: A randomized controlled trial
    • Porst, H. et al. Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial. Urology 62, 121-125 (2003).
    • (2003) Urology , vol.62 , pp. 121-125
    • Porst, H.1
  • 5
    • 43549087078 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of udenafil, a novel PDE-5 inhibitor, in healthy young Korean subjects
    • Kim, B. H. et al. Safety, tolerability, and pharmacokinetics of udenafil, a novel PDE-5 inhibitor, in healthy young Korean subjects. Br. J. Clin. Pharmacol. 65, 848-854 (2008).
    • (2008) Br. J. Clin. Pharmacol. , vol.65 , pp. 848-854
    • Kim, B.H.1
  • 6
    • 39749096953 scopus 로고    scopus 로고
    • SLx-2102, a new long-acting PDE5 inhibitor: Preliminary safety, tolerability, PK and endothelial function effects in healthy subjects
    • Prince, W. et al. SLx-2102, a new long-acting PDE5 inhibitor: preliminary safety, tolerability, PK and endothelial function effects in healthy subjects. J. Urol. 175 (Suppl. 4), 924 (2006).
    • (2006) J. Urol. , vol.175 , Issue.SUPPL. 4 , pp. 924
    • Prince, W.1
  • 7
    • 4043140681 scopus 로고    scopus 로고
    • Efficacy of sildenafil citrate at 12 hours after dosing: Re-exploring the therapeutic window
    • Moncada, I., Jara, J., Subirá, D., Castaño, I. & Hernández, C. Efficacy of sildenafil citrate at 12 hours after dosing: re-exploring the therapeutic window. Eur. Urol. 46, 357-360 (2004).
    • (2004) Eur. Urol. , vol.46 , pp. 357-360
    • Moncada, I.1    Jara, J.2    Subirá, D.3    Castaño, I.4    Hernández, C.5
  • 8
    • 33745866247 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5 mg and 10 mg in the treatment of erectile dysfunction: Results of a multicenter, randomized, double-blind, placebo-controlled trial
    • Porst, H. et al. Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5 mg and 10 mg in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial. Eur. Urol. 50, 351-359 (2006).
    • (2006) Eur. Urol. , vol.50 , pp. 351-359
    • Porst, H.1
  • 9
    • 33846073648 scopus 로고    scopus 로고
    • Tadalafil dosed once a day in men with erectile dysfunction: A randomized, double blind, placebo-controlled study in the US
    • Rajfer, J. et al. Tadalafil dosed once a day in men with erectile dysfunction: a randomized, double blind, placebo-controlled study in the US. Int. J. Impot. Res. 19, 95-103 (2007).
    • (2007) Int. J. Impot. Res. , vol.19 , pp. 95-103
    • Rajfer, J.1
  • 10
    • 51349111890 scopus 로고    scopus 로고
    • Long-term safety and efficacy of tadalafil 5 mg dosed once daily in men with erectile dysfunction
    • Porst, H. et al. Long-term safety and efficacy of tadalafil 5 mg dosed once daily in men with erectile dysfunction. J. Sex. Med. 5, 2160-2169 (2008).
    • (2008) J. Sex. Med. , vol.5 , pp. 2160-2169
    • Porst, H.1
  • 11
    • 28544444480 scopus 로고    scopus 로고
    • An open-label, multicentre, randomized, crossover study comparing sildenafil citrate and tadalafil for treating erectile dysfunction in men naive to phosphodiesterase 5 inhibitor therapy
    • Eardley, I. et al. An open-label, multicentre, randomized, crossover study comparing sildenafil citrate and tadalafil for treating erectile dysfunction in men naive to phosphodiesterase 5 inhibitor therapy. BJU Int. 96, 1323-1332 (2005).
    • (2005) BJU Int. , vol.96 , pp. 1323-1332
    • Eardley, I.1
  • 12
    • 33747694337 scopus 로고    scopus 로고
    • Prospective randomized, open-label, fixed-dose, crossover study to establish preference of patients with erectile dysfunction after taking the three PDE-5 inhibitors
    • Tolrà, J. R., Campaña, J. M., Ciutat, L. F. & Miranda, E. F. Prospective, randomized, open-label, fixed-dose, crossover study to establish preference of patients with erectile dysfunction after taking the three PDE-5 inhibitors. J. Sex. Med. 3, 901-909 (2006).
    • (2006) J. Sex. Med. , vol.3 , pp. 901-909
    • Tolrà, J.R.1    Campaña, J.M.2    Ciutat, L.F.3    Miranda, E.F.4
  • 13
    • 33750484649 scopus 로고    scopus 로고
    • Comparing vardenafil and sildenafil in the treatment of men with erectile dysfunction and risk factors for cardiovascular disease: A randomized, double-blind, pooled crossover study
    • Rubio-Aurioles, E. et al. Comparing vardenafil and sildenafil in the treatment of men with erectile dysfunction and risk factors for cardiovascular disease: a randomized, double-blind, pooled crossover study. J. Sex. Med. 3, 1037-1049 (2006).
    • (2006) J. Sex. Med. , vol.3 , pp. 1037-1049
    • Rubio-Aurioles, E.1
  • 14
    • 0038003861 scopus 로고    scopus 로고
    • Mechanism of erectogenic effect of the selective phosphodiesterase type 5 inhibitor DA-8159
    • DOh, H. et al. Mechanism of erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159. Arch. Pharm. Res. 25, 873-878 (2002)
    • (2002) Arch. Pharm. Res. , vol.25 , pp. 873-878
    • Doh, H.1
  • 15
    • 41549146877 scopus 로고    scopus 로고
    • The efficacy and safety of udenafil, a new selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction
    • Paick, J. S. et al. The efficacy and safety of udenafil, a new selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction. J. Sex. Med. 5, 946-953 (2008).
    • (2008) J. Sex. Med. , vol.5 , pp. 946-953
    • Paick, J.S.1
  • 16
    • 38149020893 scopus 로고    scopus 로고
    • Efficacy of udenafil for the treatment of erectile dysfunction up to 12 hours after dosing: A randomized controlled trial [abstract PS-02-013]
    • Park, N. C., Min, K. S. & Paick, J. S. Efficacy of udenafil for the treatment of erectile dysfunction up to 12 hours after dosing: a randomized controlled trial [abstract PS-02-013]. J. Sex. Med. 3 (Suppl. 3), 180 (2006).
    • (2006) J. Sex. Med. , vol.3 , Issue.SUPPL. 3 , pp. 180
    • Park, N.C.1    Min, K.S.2    Paick, J.S.3
  • 17
    • 38149127413 scopus 로고    scopus 로고
    • Efficacy and safety of fixed-dose Udenafil (Zydena®) in men with diabetes and erectile dysfunction [abstract P-06-056]
    • Kim, J. J. Efficacy and safety of fixed-dose Udenafil (Zydena®) in men with diabetes and erectile dysfunction [abstract P-06-056]. J. Sex. Med. 5 (Suppl. 2); 63(2008).
    • (2008) J. Sex. Med. , vol.5 , Issue.63 SUPPL. 2
    • Kim, J.J.1
  • 18
    • 78549237752 scopus 로고    scopus 로고
    • The efficacy and safety of once-a-day dosing of udenafil in men with erectile dysfunction: A randomized double-blind placebo-controlled study [abstract PD-056]
    • Kangwon, K. et al. The efficacy and safety of once-a-day dosing of udenafil in men with erectile dysfunction: a randomized, double-blind, placebo-controlled study [abstract PD-056]. J. Sex. Med. 6 (Suppl. 2), 65 (2009).
    • (2009) J. Sex. Med. , vol.6 , Issue.SUPPL. 2 , pp. 65
    • Kangwon, K.1
  • 19
    • 37549016427 scopus 로고    scopus 로고
    • Identification of cytochrome P450 enzymes responsible for N-dealkylation of a new oral erectogenic, mirodenafil
    • Lee, H. S. et al. Identification of cytochrome P450 enzymes responsible for N-dealkylation of a new oral erectogenic, mirodenafil. Xenobiotica 38, 21-33 (2008).
    • (2008) Xenobiotica , vol.38 , pp. 21-33
    • Lee, H.S.1
  • 20
    • 55849098428 scopus 로고    scopus 로고
    • Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction
    • Paick, J. S. et al. Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction. J. Sex. Med. 5, 2672-2680 (2008).
    • (2008) J. Sex. Med. , vol.5 , pp. 2672-2680
    • Paick, J.S.1
  • 21
    • 71749097768 scopus 로고    scopus 로고
    • Efficacy and safety of oral mirodenafil in the treatment of erectile dysfunction in men with diabetes: A multi-center, randomized, double blind, placebo-controlled, fixed dose, parallel group clinical trial [abstract 370]
    • Park, N. C. et al. Efficacy and safety of oral mirodenafil in the treatment of erectile dysfunction in men with diabetes: a multi-center, randomized, double blind, placebo-controlled, fixed dose, parallel group clinical trial [abstract 370]. Eur. Urol. Suppl. 8, 213 (2009).
    • (2009) Eur. Urol. Suppl. , vol.8 , pp. 213
    • Park, N.C.1
  • 22
    • 42949161851 scopus 로고    scopus 로고
    • Pharmacological characterization of a novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum
    • Toque, H. A. et al. Pharmacological characterization of a novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum. Eur. J. Pharmacol. 591, 189-195 (2008).
    • (2008) Eur. J. Pharmacol. , vol.591 , pp. 189-195
    • Toque, H.A.1
  • 23
    • 59349105555 scopus 로고    scopus 로고
    • Efficacy and tolerability of lodenafil carbonate for oral therapy in erectile dysfunction: A phase II clinical trial
    • Glina, S. et al. Efficacy and tolerability of lodenafil carbonate for oral therapy in erectile dysfunction: a phase II clinical trial. J. Sex. Med. 6, 553-557 (2009).
    • (2009) J. Sex. Med. , vol.6 , pp. 553-557
    • Glina, S.1
  • 24
    • 33750842639 scopus 로고    scopus 로고
    • Safety and efficacy of avanafil, a new PDE5 inhibitor for treating erectile dysfunction [abstract 923]
    • Kaufman, J. & Dietrich, J. Safety and efficacy of avanafil, a new PDE5 inhibitor for treating erectile dysfunction [abstract 923]. J. Urol. 175 (Suppl. 4), 299 (2006).
    • (2006) J. Urol. , vol.175 , Issue.SUPPL. 4 , pp. 299
    • Kaufman, J.1    Dietrich, J.2
  • 25
    • 45749125401 scopus 로고    scopus 로고
    • SLx-2101 a novel long-acting phosphodiesterase-5 (PDE5) inhibitor for erectile dysfunction: In vivo and in vitro studies [abstract 51]
    • Sweetnam, P. et al. SLx-2101, a novel long-acting phosphodiesterase-5 (PDE5) inhibitor for erectile dysfunction: in vivo and in vitro studies [abstract 51]. J. Sex. Med. 3 (Suppl. 1), 30 (2006).
    • (2006) J. Sex. Med. , vol.3 , Issue.SUPPL. 1 , pp. 30
    • Sweetnam, P.1
  • 26
    • 78549257026 scopus 로고    scopus 로고
    • SLx-2101 a new long-acting PDE5 inhibitor: Preliminary safety tolerability PK and endothelial function effects in healthy subjects [abstract MP-03-102]
    • Donabedian, D. et al. SLx-2101, a new long-acting PDE5 inhibitor: preliminary safety, tolerability, PK and endothelial function effects in healthy subjects [abstract MP-03-102]. J. Sex. Med. 3 (Suppl. 3), 209 (2006).
    • (2006) J. Sex. Med. , vol.3 , Issue.SUPPL. 3 , pp. 209
    • Donabedian, D.1
  • 27
    • 0037143744 scopus 로고    scopus 로고
    • A role for the melanocortin 4 receptor in sexual function
    • Van der Ploeg, L. H. et al. A role for the melanocortin 4 receptor in sexual function. Proc. Natl Acad. Sci. USA 99, 11381-11386 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 11381-11386
    • Van Der Ploeg, L.H.1
  • 28
    • 2342453337 scopus 로고    scopus 로고
    • Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra
    • Rosen, R. C., Diamond, L. E., Earle, D. C., Shadiack, A. M. & Molinoff, P. B. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int. J. Impot. Res. 16, 135-142 (2004).
    • (2004) Int. J. Impot. Res. , vol.16 , pp. 135-142
    • Rosen, R.C.1    Diamond, L.E.2    Earle, D.C.3    Shadiack, A.M.4    Molinoff, P.B.5
  • 29
    • 37149047447 scopus 로고    scopus 로고
    • Phase IIB study of bremelanotide in the treatment of ED in non-diabetic males [abstract 1042]
    • KAminetsky, J. et al. Phase IIB study of bremelanotide in the treatment of ED in non-diabetic males [abstract 1042]. J. Urol. 177 (4 Suppl.), 345 (2007).
    • (2007) J. Urol. , vol.177 , Issue.4 SUPPL. , pp. 345
    • Kaminetsky, J.1
  • 30
    • 78549274673 scopus 로고    scopus 로고
    • Phase IIB study of bremelanotide in the treatment of ED in diabetic males [abstract 1177]
    • Steidle, C. P. et al. Phase IIB study of bremelanotide in the treatment of ED in diabetic males [abstract 1177]. J. Urol. 177 (4 Suppl.), 388 (2007).
    • (2007) J. Urol. , vol.177 , Issue.4 SUPPL. , pp. 388
    • Steidle, C.P.1
  • 31
    • 0031834590 scopus 로고    scopus 로고
    • The application of gene therapy to the treatment of erectile dysfunction
    • Christ, G. J. & Melman, A. The application of gene therapy to the treatment of erectile dysfunction. Int. J. Impot. Res. 10, 111-112 (1998).
    • (1998) Int. J. Impot. Res. , vol.10 , pp. 111-112
    • Christ, G.J.1    Melman, A.2
  • 33
    • 33947515906 scopus 로고    scopus 로고
    • Plasmid based gene transfer for treatment of erectile dysfunction and overactive bladder: Results of a phase i trial
    • Melman, A., Bar-Chama, N., McCullough, A., Davies, K. & Christ, G. Plasmid based gene transfer for treatment of erectile dysfunction and overactive bladder: results of a phase I trial. Isr. Med. Assoc. J. 9, 143-146 (2007).
    • (2007) Isr. Med. Assoc. J. , vol.9 , pp. 143-146
    • Melman, A.1    Bar-Chama, N.2    McCullough, A.3    Davies, K.4    Christ, G.5
  • 34
    • 33845774784 scopus 로고    scopus 로고
    • HMaxi-K gene transfer in males with erectile dysfunction: Results of the first human trial
    • Melman, A., Bar-Chama, N., McCullough, A., Davies, K. & Christ, G. hMaxi-K gene transfer in males with erectile dysfunction: results of the first human trial. Hum. Gene Ther. 17, 1165-1176 (2006).
    • (2006) Hum. Gene Ther. , vol.17 , pp. 1165-1176
    • Melman, A.1    Bar-Chama, N.2    McCullough, A.3    Davies, K.4    Christ, G.5
  • 35
    • 0037376430 scopus 로고    scopus 로고
    • The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia
    • Gholami, S. S. et al. The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia. J. Urol. 169, 1577-1581 (2003).
    • (2003) J. Urol. , vol.169 , pp. 1577-1581
    • Gholami, S.S.1
  • 36
    • 0037300192 scopus 로고    scopus 로고
    • Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats
    • Rogers, R. S., Graziottin, T. M., Lin, C. S., Kan, Y. W. & Lue, T. F. Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats. Int. J. Impot. Res. 15, 26-37 (2003).
    • (2003) Int. J. Impot. Res. , vol.15 , pp. 26-37
    • Rogers, R.S.1    Graziottin, T.M.2    Lin, C.S.3    Kan, Y.W.4    Lue, T.F.5
  • 37
    • 29244473849 scopus 로고    scopus 로고
    • Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats
    • Liu, W. J. et al. Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian J. Androl. 7, 381-388 (2005).
    • (2005) Asian J. Androl. , vol.7 , pp. 381-388
    • Liu, W.J.1
  • 38
    • 77449138341 scopus 로고    scopus 로고
    • Superoxide dismutase\a target for gene therapeutic approach to reduce oxidative stress in erectile dysfunction
    • Eng, W. et al. Superoxide dismutase\a target for gene therapeutic approach to reduce oxidative stress in erectile dysfunction. Methods Mol. 610, 213-227 (2010).
    • (2010) Methods Mol. , vol.610 , pp. 213-227
    • Eng, W.1
  • 40
    • 17444373469 scopus 로고    scopus 로고
    • Gene transfer of vasoactive intestinal polypeptide into the penis improves erectile response in the diabetic rat
    • Shen, Z. J. et al. Gene transfer of vasoactive intestinal polypeptide into the penis improves erectile response in the diabetic rat. BJU Int. 95, 890-894 (2005).
    • (2005) BJU Int. , vol.95 , pp. 890-894
    • Shen, Z.J.1
  • 41
    • 0034762419 scopus 로고    scopus 로고
    • Gene transfer of prepro-calcitonin gene-related peptide restores erectile function in the aged rat
    • Bivalacqua, T. J., Champion, H. C., Abdel-Mageed, A. B., Kadowitz, P. J. & Hellstrom, W. J. Gene transfer of prepro-calcitonin gene-related peptide restores erectile function in the aged rat. Biol. Reprod. 65, 1371-1377 (2001).
    • (2001) Biol. Reprod. , vol.65 , pp. 1371-1377
    • Bivalacqua, T.J.1    Champion, H.C.2    Abdel-Mageed, A.B.3    Kadowitz, P.J.4    Hellstrom, W.J.5
  • 42
    • 9644299891 scopus 로고    scopus 로고
    • Molecular pathophysiology and gene therapy of aging-related erectile dysfunction
    • Gonzalez-Cadavid, N. F. & Rajfer, J. Molecular pathophysiology and gene therapy of aging-related erectile dysfunction. Exp. Gerontol. 39, 1705-1712 (2004).
    • (2004) Exp. Gerontol. , vol.39 , pp. 1705-1712
    • Gonzalez-Cadavid, N.F.1    Rajfer, J.2
  • 43
    • 33847711835 scopus 로고    scopus 로고
    • Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction
    • Bivalacqua, T. J. et al. Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. Am. J. Physiol. Heart Circ. Physiol. 292, H1278-H1290 (2007).
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292
    • Bivalacqua, T.J.1
  • 44
    • 41849111684 scopus 로고    scopus 로고
    • Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat
    • Nolazco, G. et al. Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int. 101, 1156-1164 (2008).
    • (2008) BJU Int. , vol.101 , pp. 1156-1164
    • Nolazco, G.1


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