Vaginal sildenafil (Viagra): A preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF

Human Reproduction

Volumn 15, Issue 4, 2000, Pages 806-809

  Sher, Geoffrey ^a,b   Jeffrey, D Fisch ^a  

^a Sher Institute for Reproductive Medicine   (United States)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Endometrium; In vitro fertilization; Sildenafil; Uterine artery blood flow

Indexed keywords

CHORIONIC GONADOTROPIN; CYCLIC GMP; ESTRADIOL VALERATE; GONADOTROPIN; LEUPRORELIN; NITRIC OXIDE; RECOMBINANT FOLLITROPIN; SILDENAFIL;

ADULT; ARTICLE; CASE REPORT; CLINICAL TRIAL; ENDOMETRIUM; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; TISSUE REGENERATION; TREATMENT OUTCOME; UTERUS BLOOD FLOW;

EID: 0034027145     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/15.4.806     Document Type: Article

References (12)

1. Amit, A., Thaler, I., Paz, Y. and Itskovitz-Eldor, J. (1998) The effect of a nitric oxide donor on doppler flow velocity waveforms in the uterine artery during the first trimester of pregnancy. Ultrasound Obstet. Gynecol., 11, 94-98.
2. Ballard, S.A., Gingell, C.J., Tang, K. et al. (1998) Effects of Sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isoenzymes. J. Urol., 159, 2164-2171.
3. Barroso, R.P., Osuampke, C., Nagamani, M. and Yallampalli, C. (1998) Nitric oxide inhibits development of embryos and implantation in mice. Mol. Hum. Reprod., 4, 503-507.
4. Boolell, M., Gepi-Attee, S., Gingell, J.C. and Allen, M.J. (1996) Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br. J. Urol., 78, 257-261.
5. Cameron, I.T. and Cambell, S. (1998) Nitric oxide in the endometrium. Hum. Reprod. Update, 4, 565-569.
6. Fisch, J.D., Behr, B. and Conti, M. (1998) Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by typespecific phosphodiesterase inhibitors. Hum. Reprod., 5, 1248-154.
7. Gonen, Y. and Casper, R.F. (1990) Prediction of implantation by sonographic appearance during controlled ovarian stimulation for in vitro fertilization (IVF). J. In Vitro Fertil. Embryo Transfer, 7, 146-152.
8. Sher, G., Herbert, C., Jacobs, M. and Maassarani, G. (1991) Assessment of the late proliferative phase endometrium by ultrasonography in patients undergoing m vitro fertilization and embryo transfer (IVF-ET). Hum. Reprod., 6, 232-237.
9. Sher, G., Dodge, S., Maassarani, G. et al. (1993) Management of suboptimal sonographic endometrial patterns in patients undergoing m vitro fertilization and embryo transfer. Hum. Reprod., 8, 374-379.
10. Smith, G.N. and Brien, J.F. (1998) Use of nitroglycerin for uterine relaxation. Obstet. Gynecol. Surv:, 53, 559-565.
11. Telfer, J.F., Irvine, O.A., Kohnen, G. et al. (1997) Expression of endothelial and inducible nitric oxide synthase in non-pregnant and decidualized human endometrium. Mol. Hum. Reprod., 3, 69-75.
12. Weckstein, L.N., Jacobson, A., Galen, D. et al. (1997) Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study. Fertil. Steril, 68, 927-930.