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Volumn 93, Issue 2, 2011, Pages 178-186

The immune response in glaucoma: A perspective on the roles of oxidative stress

Author keywords

Aging; Glaucoma; Glia; Immune system; Oxidative stress; Retinal ganglion cell

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CYTOKINE; HEAT SHOCK PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TOLL LIKE RECEPTOR;

EID: 80052807932     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2010.07.009     Document Type: Article
Times cited : (122)

References (138)
  • 1
    • 0035101187 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes
    • Agapova O.A., Ricard C.S., Salvador-Silva M., Hernandez M.R. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes. Glia 2001, 33:205-216.
    • (2001) Glia , vol.33 , pp. 205-216
    • Agapova, O.A.1    Ricard, C.S.2    Salvador-Silva, M.3    Hernandez, M.R.4
  • 2
    • 77954672049 scopus 로고    scopus 로고
    • Age-associated epigenetic modifications in human DNA increase its immunogenicity
    • Agrawal A., Tay J., Yang G.E., Agrawal S., Gupta S. Age-associated epigenetic modifications in human DNA increase its immunogenicity. Aging 2010, 2:93-100.
    • (2010) Aging , vol.2 , pp. 93-100
    • Agrawal, A.1    Tay, J.2    Yang, G.E.3    Agrawal, S.4    Gupta, S.5
  • 3
    • 2142810973 scopus 로고    scopus 로고
    • Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure
    • Ahmed F., Brown K.M., Stephan D.A., Morrison J.C., Johnson E.C., Tomarev S.I. Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure. Invest. Ophthalmol. Vis. Sci. 2004, 45:1247-1258.
    • (2004) Invest. Ophthalmol. Vis. Sci. , vol.45 , pp. 1247-1258
    • Ahmed, F.1    Brown, K.M.2    Stephan, D.A.3    Morrison, J.C.4    Johnson, E.C.5    Tomarev, S.I.6
  • 4
    • 70449529633 scopus 로고    scopus 로고
    • The blood-brain barrier and immune function and dysfunction
    • Banks W.A., Erickson M.A. The blood-brain barrier and immune function and dysfunction. Neurobiol. Dis. 2010, 37:26-32.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 26-32
    • Banks, W.A.1    Erickson, M.A.2
  • 6
    • 60349095684 scopus 로고    scopus 로고
    • The role of stress factors during aging of the immune system
    • Bauer M.E., Jeckel C.M., Luz C. The role of stress factors during aging of the immune system. Ann. N. Y. Acad. Sci. 2009, 1153:139-152.
    • (2009) Ann. N. Y. Acad. Sci. , vol.1153 , pp. 139-152
    • Bauer, M.E.1    Jeckel, C.M.2    Luz, C.3
  • 7
    • 67650388344 scopus 로고    scopus 로고
    • Retinal deimination in aging and disease
    • Bhattacharya S.K. Retinal deimination in aging and disease. IUBMB Life 2009, 61:504-509.
    • (2009) IUBMB Life , vol.61 , pp. 504-509
    • Bhattacharya, S.K.1
  • 9
    • 47749120638 scopus 로고    scopus 로고
    • Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head
    • Burgoyne C.F., Downs J.C. Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head. J. Glaucoma 2008, 17:318-328.
    • (2008) J. Glaucoma , vol.17 , pp. 318-328
    • Burgoyne, C.F.1    Downs, J.C.2
  • 10
    • 38449100535 scopus 로고    scopus 로고
    • Extracellular heat shock proteins in cell signaling and immunity
    • Calderwood S.K., Mambula S.S., Gray P.J. Extracellular heat shock proteins in cell signaling and immunity. Ann. N. Y. Acad. Sci. 2007, 1113:28-39.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1113 , pp. 28-39
    • Calderwood, S.K.1    Mambula, S.S.2    Gray, P.J.3
  • 11
    • 33748745741 scopus 로고    scopus 로고
    • Ocular autoimmunity: the price of privilege?
    • Caspi R.R. Ocular autoimmunity: the price of privilege?. Immunol. Rev. 2006, 213:23-35.
    • (2006) Immunol. Rev. , vol.213 , pp. 23-35
    • Caspi, R.R.1
  • 14
    • 0037435923 scopus 로고    scopus 로고
    • Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity
    • van Eden W., Koets A., van Kooten P., Prakken B., van der Zee R. Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity. Vaccine 2003, 21:897-901.
    • (2003) Vaccine , vol.21 , pp. 897-901
    • van Eden, W.1    Koets, A.2    van Kooten, P.3    Prakken, B.4    van der Zee, R.5
  • 15
    • 57149098020 scopus 로고    scopus 로고
    • Oxidative injury to blood vessels and glia of the pre-laminar optic nerve head in human glaucoma
    • Feilchenfeld Z., Yucel Y.H., Gupta N. Oxidative injury to blood vessels and glia of the pre-laminar optic nerve head in human glaucoma. Exp. Eye Res. 2008, 87:409-414.
    • (2008) Exp. Eye Res. , vol.87 , pp. 409-414
    • Feilchenfeld, Z.1    Yucel, Y.H.2    Gupta, N.3
  • 16
    • 65349094002 scopus 로고    scopus 로고
    • Privilege revisited: an evaluation of the eye's defence mechanisms
    • Forrester J.V. Privilege revisited: an evaluation of the eye's defence mechanisms. Eye 2009, 23:756-766.
    • (2009) Eye , vol.23 , pp. 756-766
    • Forrester, J.V.1
  • 19
    • 35848941181 scopus 로고    scopus 로고
    • Does the blood-brain barrier play a role in glaucoma?
    • Grieshaber M.C., Flammer J. Does the blood-brain barrier play a role in glaucoma?. Surv. Ophthalmol. 2007, 52(Suppl. 2):S115-S121.
    • (2007) Surv. Ophthalmol. , vol.52 , Issue.SUPPL. 2
    • Grieshaber, M.C.1    Flammer, J.2
  • 21
    • 40949155215 scopus 로고    scopus 로고
    • Prevalence of serum autoantibodies and paraproteins in patients with glaucoma
    • Hammam T., Montgomery D., Morris D., Imrie F. Prevalence of serum autoantibodies and paraproteins in patients with glaucoma. Eye 2008, 22:349-353.
    • (2008) Eye , vol.22 , pp. 349-353
    • Hammam, T.1    Montgomery, D.2    Morris, D.3    Imrie, F.4
  • 22
    • 0033997806 scopus 로고    scopus 로고
    • The optic nerve head in glaucoma: role of astrocytes in tissue remodeling
    • Hernandez M.R. The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog. Retin. Eye Res. 2000, 19:297-321.
    • (2000) Prog. Retin. Eye Res. , vol.19 , pp. 297-321
    • Hernandez, M.R.1
  • 23
    • 0024344508 scopus 로고
    • Age-related changes in the extracellular matrix of the human optic nerve head
    • Hernandez M.R., Luo X.X., Andrzejewska W., Neufeld A.H. Age-related changes in the extracellular matrix of the human optic nerve head. Am. J. Ophthalmol. 1989, 107:476-484.
    • (1989) Am. J. Ophthalmol. , vol.107 , pp. 476-484
    • Hernandez, M.R.1    Luo, X.X.2    Andrzejewska, W.3    Neufeld, A.H.4
  • 24
    • 0036544647 scopus 로고    scopus 로고
    • Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray
    • Hernandez M.R., Agapova O.A., Yang P., Salvador-Silva M., Ricard C.S., Aoi S. Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray. Glia 2002, 38:45-64.
    • (2002) Glia , vol.38 , pp. 45-64
    • Hernandez, M.R.1    Agapova, O.A.2    Yang, P.3    Salvador-Silva, M.4    Ricard, C.S.5    Aoi, S.6
  • 25
    • 53049094645 scopus 로고    scopus 로고
    • Astrocytes in glaucomatous optic neuropathy
    • Hernandez M.R., Miao H., Lukas T. Astrocytes in glaucomatous optic neuropathy. Prog. Brain Res. 2008, 173:353-373.
    • (2008) Prog. Brain Res. , vol.173 , pp. 353-373
    • Hernandez, M.R.1    Miao, H.2    Lukas, T.3
  • 26
    • 0030896890 scopus 로고    scopus 로고
    • The optic nerve head in glaucomatous optic neuropathy
    • Hernandez M.R., Pena J.D. The optic nerve head in glaucomatous optic neuropathy. Arch. Ophthalmol. 1997, 115:389-395.
    • (1997) Arch. Ophthalmol. , vol.115 , pp. 389-395
    • Hernandez, M.R.1    Pena, J.D.2
  • 27
    • 0027275417 scopus 로고
    • Glaucoma: changes in extracellular matrix in the optic nerve head
    • Hernandez M.R., Ye H. Glaucoma: changes in extracellular matrix in the optic nerve head. Ann. Med. 1993, 25:309-315.
    • (1993) Ann. Med. , vol.25 , pp. 309-315
    • Hernandez, M.R.1    Ye, H.2
  • 28
    • 77954012304 scopus 로고    scopus 로고
    • Serum cytokine alteration is associated with optic neuropathy in human primary open angle glaucoma
    • Huang P., Qi Y., Xu Y.S., Liu J., Liao D., Zhang S.S., Zhang C. Serum cytokine alteration is associated with optic neuropathy in human primary open angle glaucoma. J. Glaucoma 2010, 19:324-330.
    • (2010) J. Glaucoma , vol.19 , pp. 324-330
    • Huang, P.1    Qi, Y.2    Xu, Y.S.3    Liu, J.4    Liao, D.5    Zhang, S.S.6    Zhang, C.7
  • 29
    • 34250171784 scopus 로고    scopus 로고
    • Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma
    • Inman D.M., Horner P.J. Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia 2007, 55:942-953.
    • (2007) Glia , vol.55 , pp. 942-953
    • Inman, D.M.1    Horner, P.J.2
  • 30
    • 34447118860 scopus 로고    scopus 로고
    • Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor
    • Joachim S.C., Bruns K., Lackner K.J., Pfeiffer N., Grus F.H. Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor. Curr. Eye Res. 2007, 32:501-509.
    • (2007) Curr. Eye Res. , vol.32 , pp. 501-509
    • Joachim, S.C.1    Bruns, K.2    Lackner, K.J.3    Pfeiffer, N.4    Grus, F.H.5
  • 31
    • 41449112785 scopus 로고    scopus 로고
    • Sera of glaucoma patients show autoantibodies against myelin basic protein and complex autoantibody profiles against human optic nerve antigens
    • Joachim S.C., Reichelt J., Berneiser S., Pfeiffer N., Grus F.H. Sera of glaucoma patients show autoantibodies against myelin basic protein and complex autoantibody profiles against human optic nerve antigens. Graefes Arch. Clin. Exp. Ophthalmol. 2008, 246:573-580.
    • (2008) Graefes Arch. Clin. Exp. Ophthalmol. , vol.246 , pp. 573-580
    • Joachim, S.C.1    Reichelt, J.2    Berneiser, S.3    Pfeiffer, N.4    Grus, F.H.5
  • 34
    • 34548070301 scopus 로고    scopus 로고
    • Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model
    • Johnson E.C., Jia L., Cepurna W.O., Doser T.A., Morrison J.C. Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 2007, 48:3161-3177.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 3161-3177
    • Johnson, E.C.1    Jia, L.2    Cepurna, W.O.3    Doser, T.A.4    Morrison, J.C.5
  • 35
    • 80052789857 scopus 로고    scopus 로고
    • Early optic nerve head astrocytic reaction to elevated intraocular pressure is characterized by dedifferentiation and proliferation
    • E-Abstract 5215. Available at:
    • Johnson E.C., Doser T.A., Dyck J.A., Guo Y., Lambert W.S., Cepurna W.O., Morrison J.C. Early optic nerve head astrocytic reaction to elevated intraocular pressure is characterized by dedifferentiation and proliferation. Invest. Ophthalmol. Vis. Sci. 2010, 51. E-Abstract 5215. Available at:. http://www.iovs.org.
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51
    • Johnson, E.C.1    Doser, T.A.2    Dyck, J.A.3    Guo, Y.4    Lambert, W.S.5    Cepurna, W.O.6    Morrison, J.C.7
  • 36
    • 68249100026 scopus 로고    scopus 로고
    • Friend or foe? Resolving the impact of glial responses in glaucoma
    • Johnson E.C., Morrison J.C. Friend or foe? Resolving the impact of glial responses in glaucoma. J. Glaucoma 2009, 18:341-353.
    • (2009) J. Glaucoma , vol.18 , pp. 341-353
    • Johnson, E.C.1    Morrison, J.C.2
  • 38
    • 33750740077 scopus 로고    scopus 로고
    • Retinal glial cell responses and Fas/FasL activation in rats with chronic ocular hypertension
    • Ju K.R., Kim H.S., Kim J.H., Lee N.Y., Park C.K. Retinal glial cell responses and Fas/FasL activation in rats with chronic ocular hypertension. Brain Res. 2006, 1122:209-221.
    • (2006) Brain Res. , vol.1122 , pp. 209-221
    • Ju, K.R.1    Kim, H.S.2    Kim, J.H.3    Lee, N.Y.4    Park, C.K.5
  • 39
    • 64049099493 scopus 로고    scopus 로고
    • Telomere shortening and ageing of the immune system
    • Kaszubowska L. Telomere shortening and ageing of the immune system. J. Physiol. Pharmacol. 2008, 59(Suppl. 9):169-186.
    • (2008) J. Physiol. Pharmacol. , vol.59 , Issue.SUPPL. 9 , pp. 169-186
    • Kaszubowska, L.1
  • 40
    • 21344434614 scopus 로고    scopus 로고
    • Dynamic changes in reactive oxygen species and antioxidant levels in retinas in experimental glaucoma
    • Ko M.L., Peng P.H., Ma M.C., Ritch R., Chen C.F. Dynamic changes in reactive oxygen species and antioxidant levels in retinas in experimental glaucoma. Free Radic. Biol. Med. 2005, 39:365-373.
    • (2005) Free Radic. Biol. Med. , vol.39 , pp. 365-373
    • Ko, M.L.1    Peng, P.H.2    Ma, M.C.3    Ritch, R.4    Chen, C.F.5
  • 41
    • 54049094029 scopus 로고    scopus 로고
    • Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension
    • Kompass K.S., Agapova O.A., Li W., Kaufman P.L., Rasmussen C.A., Hernandez M.R. Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension. BMC Neurosci. 2008, 9:93.
    • (2008) BMC Neurosci. , vol.9 , pp. 93
    • Kompass, K.S.1    Agapova, O.A.2    Li, W.3    Kaufman, P.L.4    Rasmussen, C.A.5    Hernandez, M.R.6
  • 44
    • 0037310097 scopus 로고    scopus 로고
    • Early glial responses after acute elevated intraocular pressure in rats
    • Lam T.T., Kwong J.M., Tso M.O. Early glial responses after acute elevated intraocular pressure in rats. Invest. Ophthalmol. Vis. Sci. 2003, 44:638-645.
    • (2003) Invest. Ophthalmol. Vis. Sci. , vol.44 , pp. 638-645
    • Lam, T.T.1    Kwong, J.M.2    Tso, M.O.3
  • 46
    • 0032769075 scopus 로고    scopus 로고
    • Direct and indirect approaches to neuroprotective therapy of glaucomatous optic neuropathy
    • Levin L.A. Direct and indirect approaches to neuroprotective therapy of glaucomatous optic neuropathy. Surv. Ophthalmol. 1999, 43(Suppl. 1):S98-S101.
    • (1999) Surv. Ophthalmol. , vol.43 , Issue.SUPPL. 1
    • Levin, L.A.1
  • 47
    • 34250160687 scopus 로고    scopus 로고
    • RAGE on the toll road?
    • Lin L. RAGE on the toll road?. Cell. Mol. Immunol. 2006, 3:351-358.
    • (2006) Cell. Mol. Immunol. , vol.3 , pp. 351-358
    • Lin, L.1
  • 48
    • 0034118141 scopus 로고    scopus 로고
    • Expression of nitric oxide synthase-2 in reactive astrocytes of the human glaucomatous optic nerve head
    • Liu B., Neufeld A.H. Expression of nitric oxide synthase-2 in reactive astrocytes of the human glaucomatous optic nerve head. Glia 2000, 30:178-186.
    • (2000) Glia , vol.30 , pp. 178-186
    • Liu, B.1    Neufeld, A.H.2
  • 49
    • 80052815714 scopus 로고    scopus 로고
    • Serum biomarkers in glaucoma patients: oxidized proteins
    • E-Abstract 2670. Available at:
    • Luo C., Thornton I., Yang X., Soltau J.B., Tezel G. Serum biomarkers in glaucoma patients: oxidized proteins. Invest. Ophthalmol. Vis. Sci. 2010, 51. E-Abstract 2670. Available at:. http://www.iovs.org.
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51
    • Luo, C.1    Thornton, I.2    Yang, X.3    Soltau, J.B.4    Tezel, G.5
  • 50
    • 78149489635 scopus 로고    scopus 로고
    • Glaucomatous tissue stress and the regulation of immune response through the glial toll-like receptor signaling
    • 2010, doi:10.1167/iovs.10-540.
    • Luo, C., Yang, X., Kain, A., Powell, D., Kuehn, M.H., Tezel, G., 2010b. Glaucomatous tissue stress and the regulation of immune response through the glial toll-like receptor signaling. Invest. Ophthalmol. Vis. Sci. 51 (2010), doi:10.1167/iovs.10-540.
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51
    • Luo, C.1    Yang, X.2    Kain, A.3    Powell, D.4    Kuehn, M.H.5    Tezel, G.6
  • 51
    • 33846818874 scopus 로고    scopus 로고
    • 4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes
    • Malone P.E., Hernandez M.R. 4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes. Exp. Eye Res. 2007, 84:444-454.
    • (2007) Exp. Eye Res. , vol.84 , pp. 444-454
    • Malone, P.E.1    Hernandez, M.R.2
  • 53
    • 0034083161 scopus 로고    scopus 로고
    • Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients
    • Maruyama I., Ohguro H., Ikeda Y. Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2000, 41:1657-1665.
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , pp. 1657-1665
    • Maruyama, I.1    Ohguro, H.2    Ikeda, Y.3
  • 54
    • 0032742416 scopus 로고    scopus 로고
    • Retinal microglia differentially express phenotypic markers of antigen-presenting cells in vitro
    • Matsubara T., Pararajasegaram G., Wu G.S., Rao N.A. Retinal microglia differentially express phenotypic markers of antigen-presenting cells in vitro. Invest. Ophthalmol. Vis. Sci. 1999, 40:3186-3193.
    • (1999) Invest. Ophthalmol. Vis. Sci. , vol.40 , pp. 3186-3193
    • Matsubara, T.1    Pararajasegaram, G.2    Wu, G.S.3    Rao, N.A.4
  • 56
    • 80052792577 scopus 로고    scopus 로고
    • Severe B- and T-lymphocyte immunodeficiency caused by Rag1 knockout prevents optic nerve axon loss in a mouse glaucoma model
    • E-Abstract 2523. Available at:
    • McKinnon S.J., Kasmala L.T., Dixon A.L. Severe B- and T-lymphocyte immunodeficiency caused by Rag1 knockout prevents optic nerve axon loss in a mouse glaucoma model. Invest. Ophthalmol. Vis. Sci. 2010, 51. E-Abstract 2523. Available at:. http://www.iovs.org.
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51
    • McKinnon, S.J.1    Kasmala, L.T.2    Dixon, A.L.3
  • 57
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov R. Origin and physiological roles of inflammation. Nature 2008, 454:428-435.
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 62
    • 0033926963 scopus 로고    scopus 로고
    • Optic nerve head structure in glaucoma: astrocytes as mediators of axonal damage
    • Morgan J.E. Optic nerve head structure in glaucoma: astrocytes as mediators of axonal damage. Eye 2000, 14(Pt 3B):437-444.
    • (2000) Eye , vol.14 , Issue.PART 3B , pp. 437-444
    • Morgan, J.E.1
  • 64
    • 0036727499 scopus 로고    scopus 로고
    • Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma
    • Naskar R., Wissing M., Thanos S. Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2002, 43:2962-2968.
    • (2002) Invest. Ophthalmol. Vis. Sci. , vol.43 , pp. 2962-2968
    • Naskar, R.1    Wissing, M.2    Thanos, S.3
  • 65
    • 0032799983 scopus 로고    scopus 로고
    • Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucoma
    • Neufeld A.H. Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucoma. Surv. Ophthalmol. 1999, 43(Suppl. 1):S129-S135.
    • (1999) Surv. Ophthalmol. , vol.43 , Issue.SUPPL. 1
    • Neufeld, A.H.1
  • 66
    • 0032809910 scopus 로고    scopus 로고
    • Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma
    • Neufeld A.H. Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma. Arch. Ophthalmol. 1999, 117:1050-1056.
    • (1999) Arch. Ophthalmol. , vol.117 , pp. 1050-1056
    • Neufeld, A.H.1
  • 67
    • 0031434681 scopus 로고    scopus 로고
    • Cyclooxygenase-1 and cyclooxygenase-2 in the human optic nerve head
    • Neufeld A.H., Hernandez M.R., Gonzalez M., Geller A. Cyclooxygenase-1 and cyclooxygenase-2 in the human optic nerve head. Exp. Eye Res. 1997, 65:739-745.
    • (1997) Exp. Eye Res. , vol.65 , pp. 739-745
    • Neufeld, A.H.1    Hernandez, M.R.2    Gonzalez, M.3    Geller, A.4
  • 68
    • 0345016024 scopus 로고    scopus 로고
    • Glaucomatous optic neuropathy: when glia misbehave
    • Neufeld A.H., Liu B. Glaucomatous optic neuropathy: when glia misbehave. Neuroscientist 2003, 9:485-495.
    • (2003) Neuroscientist , vol.9 , pp. 485-495
    • Neufeld, A.H.1    Liu, B.2
  • 69
    • 0035149257 scopus 로고    scopus 로고
    • Control of glial immune function by neurons
    • Neumann H. Control of glial immune function by neurons. Glia 2001, 36:191-199.
    • (2001) Glia , vol.36 , pp. 191-199
    • Neumann, H.1
  • 70
    • 34248144933 scopus 로고    scopus 로고
    • From ocular hypertension to ganglion cell death: a theoretical sequence of events leading to glaucoma
    • Nickells R.W. From ocular hypertension to ganglion cell death: a theoretical sequence of events leading to glaucoma. Can. J. Ophthalmol. 2007, 42:278-287.
    • (2007) Can. J. Ophthalmol. , vol.42 , pp. 278-287
    • Nickells, R.W.1
  • 71
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 72
    • 77249128045 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells
    • Nishioku T., Matsumoto J., Dohgu S., Sumi N., Miyao K., Takata F., Shuto H., Yamauchi A., Kataoka Y. Tumor necrosis factor-alpha mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells. J. Pharmacol. Sci. 2010, 112:251-254.
    • (2010) J. Pharmacol. Sci. , vol.112 , pp. 251-254
    • Nishioku, T.1    Matsumoto, J.2    Dohgu, S.3    Sumi, N.4    Miyao, K.5    Takata, F.6    Shuto, H.7    Yamauchi, A.8    Kataoka, Y.9
  • 74
    • 36749001706 scopus 로고    scopus 로고
    • Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease
    • Odoardi F., Kawakami N., Klinkert W.E., Wekerle H., Flugel A. Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:18625-18630.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 18625-18630
    • Odoardi, F.1    Kawakami, N.2    Klinkert, W.E.3    Wekerle, H.4    Flugel, A.5
  • 75
    • 53049110307 scopus 로고    scopus 로고
    • Pathogenesis of ganglion " cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria
    • Osborne N.N. Pathogenesis of ganglion " cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria. Prog. Brain Res. 2008, 173:339-352.
    • (2008) Prog. Brain Res. , vol.173 , pp. 339-352
    • Osborne, N.N.1
  • 76
    • 77952765906 scopus 로고    scopus 로고
    • Mitochondria: their role in ganglion cell death and survival in primary open angle glaucoma
    • Osborne N.N. Mitochondria: their role in ganglion cell death and survival in primary open angle glaucoma. Exp. Eye Res. 2010, 90:750-757.
    • (2010) Exp. Eye Res. , vol.90 , pp. 750-757
    • Osborne, N.N.1
  • 77
    • 77951248779 scopus 로고    scopus 로고
    • Gene expression changes in areas of focal loss of retinal ganglion cells in the retina of DBA/2J mice
    • Panagis L., Zhao X., Ge Y., Ren L., Mittag T.W., Danias J. Gene expression changes in areas of focal loss of retinal ganglion cells in the retina of DBA/2J mice. Invest. Ophthalmol. Vis. Sci. 2010, 51:2024-2034.
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51 , pp. 2024-2034
    • Panagis, L.1    Zhao, X.2    Ge, Y.3    Ren, L.4    Mittag, T.W.5    Danias, J.6
  • 79
    • 0035157681 scopus 로고    scopus 로고
    • Apoptosis of inflammatory cells in immune control of the nervous system: role of glia
    • Pender M.P., Rist M.J. Apoptosis of inflammatory cells in immune control of the nervous system: role of glia. Glia 2001, 36:137-144.
    • (2001) Glia , vol.36 , pp. 137-144
    • Pender, M.P.1    Rist, M.J.2
  • 80
    • 67650153191 scopus 로고    scopus 로고
    • Involvement of ROS in BBB dysfunction
    • Pun P.B., Lu J., Moochhala S. Involvement of ROS in BBB dysfunction. Free Radic. Res. 2009, 43:348-364.
    • (2009) Free Radic. Res. , vol.43 , pp. 348-364
    • Pun, P.B.1    Lu, J.2    Moochhala, S.3
  • 81
    • 24644516739 scopus 로고    scopus 로고
    • Glaucoma: macrocosm to microcosm the Friedenwald lecture
    • Quigley H.A. Glaucoma: macrocosm to microcosm the Friedenwald lecture. Invest. Ophthalmol. Vis. Sci. 2005, 46:2662-2670.
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 2662-2670
    • Quigley, H.A.1
  • 82
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: unique stimuli, specialized responses
    • Ransohoff R.M., Perry V.H. Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 2009, 27:119-145.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 83
  • 84
    • 44049084401 scopus 로고    scopus 로고
    • Analysis of autoantibodies against human retinal antigens in sera of patients with glaucoma and ocular hypertension
    • Reichelt J., Joachim S.C., Pfeiffer N., Grus F.H. Analysis of autoantibodies against human retinal antigens in sera of patients with glaucoma and ocular hypertension. Curr. Eye Res. 2008, 33:253-261.
    • (2008) Curr. Eye Res. , vol.33 , pp. 253-261
    • Reichelt, J.1    Joachim, S.C.2    Pfeiffer, N.3    Grus, F.H.4
  • 85
    • 0024495094 scopus 로고
    • The effect of age on normal human optic nerve fiber number and diameter
    • Repka M.X., Quigley H.A. The effect of age on normal human optic nerve fiber number and diameter. Ophthalmology 1989, 96:26-32.
    • (1989) Ophthalmology , vol.96 , pp. 26-32
    • Repka, M.X.1    Quigley, H.A.2
  • 86
    • 0037385159 scopus 로고    scopus 로고
    • Macrophages and microglia in central nervous system injury: are they helpful or harmful?
    • Schwartz M. Macrophages and microglia in central nervous system injury: are they helpful or harmful?. J. Cereb. Blood Flow Metab. 2003, 23:385-394.
    • (2003) J. Cereb. Blood Flow Metab. , vol.23 , pp. 385-394
    • Schwartz, M.1
  • 87
    • 0037377893 scopus 로고    scopus 로고
    • Neurodegeneration and neuroprotection in glaucoma: development of a therapeutic neuroprotective vaccine: the Friedenwald lecture
    • Schwartz M. Neurodegeneration and neuroprotection in glaucoma: development of a therapeutic neuroprotective vaccine: the Friedenwald lecture. Invest. Ophthalmol. Vis. Sci. 2003, 44:1407-1411.
    • (2003) Invest. Ophthalmol. Vis. Sci. , vol.44 , pp. 1407-1411
    • Schwartz, M.1
  • 88
    • 0036839021 scopus 로고    scopus 로고
    • Autoimmunity on alert: naturally occurring regulatory CD4(+)CD25(+) T cells as part of the evolutionary compromise between a 'need' and a 'risk'
    • Schwartz M., Kipnis J. Autoimmunity on alert: naturally occurring regulatory CD4(+)CD25(+) T cells as part of the evolutionary compromise between a 'need' and a 'risk'. Trends Immunol. 2002, 23:530-534.
    • (2002) Trends Immunol. , vol.23 , pp. 530-534
    • Schwartz, M.1    Kipnis, J.2
  • 89
    • 42749097973 scopus 로고    scopus 로고
    • Immunity to self and self-maintenance: a unified theory of brain pathologies
    • Schwartz M., Ziv Y. Immunity to self and self-maintenance: a unified theory of brain pathologies. Trends Immunol. 2008, 29:211-219.
    • (2008) Trends Immunol. , vol.29 , pp. 211-219
    • Schwartz, M.1    Ziv, Y.2
  • 90
    • 0742288565 scopus 로고    scopus 로고
    • Regeneration beyond the glial scar
    • Silver J., Miller J.H. Regeneration beyond the glial scar. Nat. Rev. Neurosci. 2004, 5:146-156.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 146-156
    • Silver, J.1    Miller, J.H.2
  • 91
    • 77952578018 scopus 로고    scopus 로고
    • Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss
    • Son J.L., Soto I., Oglesby E., Lopez-Roca T., Pease M.E., Quigley H.A., Marsh-Armstrong N. Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia 2010, 58:780-789.
    • (2010) Glia , vol.58 , pp. 780-789
    • Son, J.L.1    Soto, I.2    Oglesby, E.3    Lopez-Roca, T.4    Pease, M.E.5    Quigley, H.A.6    Marsh-Armstrong, N.7
  • 95
    • 0032937860 scopus 로고    scopus 로고
    • The role of microglia and macrophages in the pathophysiology of the CNS
    • Stoll G., Jander S. The role of microglia and macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 1999, 58:233-247.
    • (1999) Prog. Neurobiol. , vol.58 , pp. 233-247
    • Stoll, G.1    Jander, S.2
  • 96
    • 0030433695 scopus 로고    scopus 로고
    • The role of microglia in brain injury
    • Streit W.J. The role of microglia in brain injury. Neurotoxicology 1996, 17:671-678.
    • (1996) Neurotoxicology , vol.17 , pp. 671-678
    • Streit, W.J.1
  • 97
    • 33747877627 scopus 로고    scopus 로고
    • Microglial senescence: does the brain's immune system have an expiration date?
    • Streit W.J. Microglial senescence: does the brain's immune system have an expiration date?. Trends Neurosci. 2006, 29:506-510.
    • (2006) Trends Neurosci. , vol.29 , pp. 506-510
    • Streit, W.J.1
  • 98
    • 34247191566 scopus 로고    scopus 로고
    • Systemic high-sensitivity C-reactive protein levels in normal-tension glaucoma and primary open-angle glaucoma
    • Su W.W., Ho W.J., Cheng S.T., Chang S.H., Wu S.C. Systemic high-sensitivity C-reactive protein levels in normal-tension glaucoma and primary open-angle glaucoma. J. Glaucoma 2007, 16:320-323.
    • (2007) J. Glaucoma , vol.16 , pp. 320-323
    • Su, W.W.1    Ho, W.J.2    Cheng, S.T.3    Chang, S.H.4    Wu, S.C.5
  • 99
    • 33748677104 scopus 로고    scopus 로고
    • Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences
    • Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog. Retin. Eye Res. 2006, 25:490-513.
    • (2006) Prog. Retin. Eye Res. , vol.25 , pp. 490-513
    • Tezel, G.1
  • 100
    • 53049095216 scopus 로고    scopus 로고
    • TNF-alpha signaling in glaucomatous neurodegeneration
    • Tezel G. TNF-alpha signaling in glaucomatous neurodegeneration. Prog. Brain Res. 2008, 173:409-421.
    • (2008) Prog. Brain Res. , vol.173 , pp. 409-421
    • Tezel, G.1
  • 101
    • 62649132149 scopus 로고    scopus 로고
    • The role of glia, mitochondria, and the immune system in glaucoma
    • Tezel G. The role of glia, mitochondria, and the immune system in glaucoma. Invest. Ophthalmol. Vis. Sci. 2009, 50:1001-1012.
    • (2009) Invest. Ophthalmol. Vis. Sci. , vol.50 , pp. 1001-1012
    • Tezel, G.1
  • 102
    • 0031789541 scopus 로고    scopus 로고
    • Autoantibodies to small heat shock proteins in glaucoma
    • Tezel G., Seigel G.M., Wax M.B. Autoantibodies to small heat shock proteins in glaucoma. Invest. Ophthalmol. Vis. Sci. 1998, 39:2277-2287.
    • (1998) Invest. Ophthalmol. Vis. Sci. , vol.39 , pp. 2277-2287
    • Tezel, G.1    Seigel, G.M.2    Wax, M.B.3
  • 103
    • 0034071397 scopus 로고    scopus 로고
    • Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes
    • Tezel G., Hernandez M.R., Wax M.B. Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch. Ophthalmol. 2000, 118:511-518.
    • (2000) Arch. Ophthalmol. , vol.118 , pp. 511-518
    • Tezel, G.1    Hernandez, M.R.2    Wax, M.B.3
  • 104
    • 0034934110 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and its receptor-1 in the retina of normal and glaucomatous eyes
    • Tezel G., Li L.Y., Patil R.V., Wax M.B. Tumor necrosis factor-alpha and its receptor-1 in the retina of normal and glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 2001, 42:1787-1794.
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 1787-1794
    • Tezel, G.1    Li, L.Y.2    Patil, R.V.3    Wax, M.B.4
  • 105
    • 0038576896 scopus 로고    scopus 로고
    • Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma
    • Tezel G., Chauhan B.C., LeBlanc R.P., Wax M.B. Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma. Invest. Ophthalmol. Vis. Sci. 2003, 44:3025-3033.
    • (2003) Invest. Ophthalmol. Vis. Sci. , vol.44 , pp. 3025-3033
    • Tezel, G.1    Chauhan, B.C.2    LeBlanc, R.P.3    Wax, M.B.4
  • 106
    • 27244444388 scopus 로고    scopus 로고
    • Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma
    • Tezel G., Yang X., Cai J. Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2005, 46:3177-3187.
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 3177-3187
    • Tezel, G.1    Yang, X.2    Cai, J.3
  • 107
    • 34047259033 scopus 로고    scopus 로고
    • Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head
    • Tezel G., Luo C., Yang X. Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head. Invest. Ophthalmol. Vis. Sci. 2007, 48:1201-1211.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 1201-1211
    • Tezel, G.1    Luo, C.2    Yang, X.3
  • 108
    • 33847724321 scopus 로고    scopus 로고
    • Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia
    • Tezel G., Yang X., Luo C., Peng Y., Sun S.L., Sun D. Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia. Invest. Ophthalmol. Vis. Sci. 2007, 48:705-714.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 705-714
    • Tezel, G.1    Yang, X.2    Luo, C.3    Peng, Y.4    Sun, S.L.5    Sun, D.6
  • 109
    • 64249083385 scopus 로고    scopus 로고
    • T cell-mediated autoimmune component of glaucomatous neurodegeneration in a chronic pressure-induced rat model of glaucoma
    • E-Abstract 3699. Available at:
    • Tezel G., Yang X., Luo C., Peng Y., Sun D., Kaplan H.J. T cell-mediated autoimmune component of glaucomatous neurodegeneration in a chronic pressure-induced rat model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2008, 49. E-Abstract 3699. Available at:. http://www.iovs.org.
    • (2008) Invest. Ophthalmol. Vis. Sci. , vol.49
    • Tezel, G.1    Yang, X.2    Luo, C.3    Peng, Y.4    Sun, D.5    Kaplan, H.J.6
  • 111
    • 0034657707 scopus 로고    scopus 로고
    • The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells
    • Tezel G., Wax M.B. The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J. Neurosci. 2000, 20:3552-3562.
    • (2000) J. Neurosci. , vol.20 , pp. 3552-3562
    • Tezel, G.1    Wax, M.B.2
  • 112
    • 0034548875 scopus 로고    scopus 로고
    • Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells
    • Tezel G., Wax M.B. Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J. Neurosci. 2000, 20:8693-8700.
    • (2000) J. Neurosci. , vol.20 , pp. 8693-8700
    • Tezel, G.1    Wax, M.B.2
  • 115
    • 6944234914 scopus 로고    scopus 로고
    • Caspase-independent component of retinal ganglion cell death, in vitro
    • Tezel G., Yang X. Caspase-independent component of retinal ganglion cell death, in vitro. Invest. Ophthalmol. Vis. Sci. 2004, 45:4049-4059.
    • (2004) Invest. Ophthalmol. Vis. Sci. , vol.45 , pp. 4049-4059
    • Tezel, G.1    Yang, X.2
  • 116
    • 23144454127 scopus 로고    scopus 로고
    • Comparative gene array analysis of TNF-alpha-induced MAPK and NF-kappaB signaling pathways between retinal ganglion cells and glial cells
    • Tezel G., Yang X. Comparative gene array analysis of TNF-alpha-induced MAPK and NF-kappaB signaling pathways between retinal ganglion cells and glial cells. Exp. Eye Res. 2005, 81:207-217.
    • (2005) Exp. Eye Res. , vol.81 , pp. 207-217
    • Tezel, G.1    Yang, X.2
  • 117
    • 80052789049 scopus 로고    scopus 로고
    • Immunoproteomic analysis of glaucomatous patient serum and aqueous humor antibodies: differential immunoreactivity against glaucomatous versus non-glaucomatous retinal proteins
    • E-Abstract 2673. Available at:
    • Thornton I., Luo C., Yang X., Soltau J.B., Tezel G. Immunoproteomic analysis of glaucomatous patient serum and aqueous humor antibodies: differential immunoreactivity against glaucomatous versus non-glaucomatous retinal proteins. Invest. Ophthalmol. Vis. Sci. 2010, 51. E-Abstract 2673. Available at:. http://www.iovs.org.
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51
    • Thornton, I.1    Luo, C.2    Yang, X.3    Soltau, J.B.4    Tezel, G.5
  • 118
    • 34547652325 scopus 로고    scopus 로고
    • Why is Wallerian degeneration in the CNS so slow?
    • Vargas M.E., Barres B.A. Why is Wallerian degeneration in the CNS so slow?. Annu. Rev. Neurosci. 2007, 30:153-179.
    • (2007) Annu. Rev. Neurosci. , vol.30 , pp. 153-179
    • Vargas, M.E.1    Barres, B.A.2
  • 119
    • 0034118273 scopus 로고    scopus 로고
    • An immunohistochemical study of neuronal and glial cell reactions in retinae of rats with experimental glaucoma
    • Wang X., Tay S.S., Ng Y.K. An immunohistochemical study of neuronal and glial cell reactions in retinae of rats with experimental glaucoma. Exp. Brain Res. 2000, 132:476-484.
    • (2000) Exp. Brain Res. , vol.132 , pp. 476-484
    • Wang, X.1    Tay, S.S.2    Ng, Y.K.3
  • 121
    • 34247578812 scopus 로고    scopus 로고
    • Age-related changes in neuronal susceptibility to damage: comparison of the retinal ganglion cells of young and old mice before and after optic nerve crush
    • Wang A.L., Yuan M., Neufeld A.H. Age-related changes in neuronal susceptibility to damage: comparison of the retinal ganglion cells of young and old mice before and after optic nerve crush. Ann. N. Y. Acad. Sci. 2007, 1097:64-66.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1097 , pp. 64-66
    • Wang, A.L.1    Yuan, M.2    Neufeld, A.H.3
  • 122
    • 0028332131 scopus 로고
    • Increased incidence of paraproteinemia and autoantibodies in patients with normal-pressure glaucoma
    • Wax M.B., Barrett D.A., Pestronk A. Increased incidence of paraproteinemia and autoantibodies in patients with normal-pressure glaucoma. Am. J. Ophthalmol. 1994, 117:561-568.
    • (1994) Am. J. Ophthalmol. , vol.117 , pp. 561-568
    • Wax, M.B.1    Barrett, D.A.2    Pestronk, A.3
  • 123
    • 0032461801 scopus 로고    scopus 로고
    • Clinical and ocular histopathological findings in a patient with normal-pressure glaucoma
    • Wax M.B., Tezel G., Edward P.D. Clinical and ocular histopathological findings in a patient with normal-pressure glaucoma. Arch. Ophthalmol. 1998, 116:993-1001.
    • (1998) Arch. Ophthalmol. , vol.116 , pp. 993-1001
    • Wax, M.B.1    Tezel, G.2    Edward, P.D.3
  • 124
    • 0032006268 scopus 로고    scopus 로고
    • Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma
    • Wax M.B., Tezel G., Saito I., Gupta R.S., Harley J.B., Li Z., Romano C. Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma. Am. J. Ophthalmol. 1998, 125:145-157.
    • (1998) Am. J. Ophthalmol. , vol.125 , pp. 145-157
    • Wax, M.B.1    Tezel, G.2    Saito, I.3    Gupta, R.S.4    Harley, J.B.5    Li, Z.6    Romano, C.7
  • 125
    • 58149345559 scopus 로고    scopus 로고
    • Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand
    • Wax M.B., Tezel G., Yang J., Peng G., Patil R.V., Agarwal N., Sappington R.M., Calkins D.J. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J. Neurosci. 2008, 28:12085-12096.
    • (2008) J. Neurosci. , vol.28 , pp. 12085-12096
    • Wax, M.B.1    Tezel, G.2    Yang, J.3    Peng, G.4    Patil, R.V.5    Agarwal, N.6    Sappington, R.M.7    Calkins, D.J.8
  • 126
    • 64249089968 scopus 로고    scopus 로고
    • Immunoregulation of retinal ganglion cell fate in glaucoma
    • Wax M.B., Tezel G. Immunoregulation of retinal ganglion cell fate in glaucoma. Exp. Eye Res. 2009, 88:825-830.
    • (2009) Exp. Eye Res. , vol.88 , pp. 825-830
    • Wax, M.B.1    Tezel, G.2
  • 127
    • 2442643730 scopus 로고    scopus 로고
    • Primary open-angle glaucoma
    • Weinreb R.N., Khaw P.T. Primary open-angle glaucoma. Lancet 2004, 363:1711-1720.
    • (2004) Lancet , vol.363 , pp. 1711-1720
    • Weinreb, R.N.1    Khaw, P.T.2
  • 128
    • 0023413923 scopus 로고
    • Immune reactivity in the nervous system: modulation of T-lymphocyte activation by glial cells
    • Wekerle H., Sun D., Oropeza-Wekerle R.L., Meyermann R. Immune reactivity in the nervous system: modulation of T-lymphocyte activation by glial cells. J. Exp. Biol. 1987, 132:43-57.
    • (1987) J. Exp. Biol. , vol.132 , pp. 43-57
    • Wekerle, H.1    Sun, D.2    Oropeza-Wekerle, R.L.3    Meyermann, R.4
  • 129
    • 3943081270 scopus 로고    scopus 로고
    • Muller cell response to laser-induced increase in intraocular pressure in rats
    • Woldemussie E., Wijono M., Ruiz G. Muller cell response to laser-induced increase in intraocular pressure in rats. Glia 2004, 47:109-119.
    • (2004) Glia , vol.47 , pp. 109-119
    • Woldemussie, E.1    Wijono, M.2    Ruiz, G.3
  • 131
    • 0034128172 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head
    • Yan X., Tezel G., Wax M.B., Edward D.P. Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head. Arch. Ophthalmol. 2000, 118:666-673.
    • (2000) Arch. Ophthalmol. , vol.118 , pp. 666-673
    • Yan, X.1    Tezel, G.2    Wax, M.B.3    Edward, D.P.4
  • 132
    • 0035062239 scopus 로고    scopus 로고
    • T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma
    • Yang J., Patil R.V., Yu H., Gordon M., Wax M.B. T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma. Am. J. Ophthalmol. 2001, 131:421-426.
    • (2001) Am. J. Ophthalmol. , vol.131 , pp. 421-426
    • Yang, J.1    Patil, R.V.2    Yu, H.3    Gordon, M.4    Wax, M.B.5
  • 133
    • 0035142571 scopus 로고    scopus 로고
    • Induction of HLA-DR expression in human lamina cribrosa astrocytes by cytokines and simulated ischemia
    • Yang J., Yang P., Tezel G., Patil R.V., Hernandez M.R., Wax M.B. Induction of HLA-DR expression in human lamina cribrosa astrocytes by cytokines and simulated ischemia. Invest. Ophthalmol. Vis. Sci. 2001, 42:365-371.
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 365-371
    • Yang, J.1    Yang, P.2    Tezel, G.3    Patil, R.V.4    Hernandez, M.R.5    Wax, M.B.6
  • 134
    • 47249120101 scopus 로고    scopus 로고
    • Phosphorylation-dependent interaction with 14-3-3 in the regulation of bad trafficking in retinal ganglion cells
    • Yang X., Luo C., Cai J., Pierce W.M., Tezel G. Phosphorylation-dependent interaction with 14-3-3 in the regulation of bad trafficking in retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 2008, 49:2483-2494.
    • (2008) Invest. Ophthalmol. Vis. Sci. , vol.49 , pp. 2483-2494
    • Yang, X.1    Luo, C.2    Cai, J.3    Pierce, W.M.4    Tezel, G.5
  • 135
    • 0026793261 scopus 로고
    • Heat-shock proteins: immunity and autoimmunity
    • Young D.B. Heat-shock proteins: immunity and autoimmunity. Curr. Opin. Immunol. 1992, 4:396-400.
    • (1992) Curr. Opin. Immunol. , vol.4 , pp. 396-400
    • Young, D.B.1
  • 136
    • 0033781980 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head
    • Yuan L., Neufeld A.H. Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia 2000, 32:42-50.
    • (2000) Glia , vol.32 , pp. 42-50
    • Yuan, L.1    Neufeld, A.H.2
  • 137
    • 42649104802 scopus 로고    scopus 로고
    • Epigenetics, aging, and autoimmunity
    • Yung R.L., Julius A. Epigenetics, aging, and autoimmunity. Autoimmunity 2008, 41:329-335.
    • (2008) Autoimmunity , vol.41 , pp. 329-335
    • Yung, R.L.1    Julius, A.2
  • 138
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57:178-201.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.