Does the Blood-brain Barrier Play a Role in Glaucoma?

Survey of Ophthalmology

Volumn 52, Issue 6 SUPPL., 2007, Pages

  Grieshaber, Matthias C ^a   Flammer, Josef ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

basement membrane; blood brain barrier; endothelin 1; glaucoma; matrix metalloproteinase; optic disk hemorrhage; optic nerve head; tight junction; vascular dysregulation

Indexed keywords

ENDOTHELIN 1; GELATINASE B;

ARTICLE; BLOOD BRAIN BARRIER; BLOOD EYE BARRIER; ERYTHROCYTE; GLAUCOMA; HUMAN; OPTIC DISK; OPTIC NERVE; PERICYTE; PRIORITY JOURNAL; RETINA; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VEIN OCCLUSION;

BLOOD-BRAIN BARRIER; GLAUCOMA; HUMANS; OPTIC DISK; PERIPHERAL VASCULAR DISEASES;

EID: 35848941181     PISSN: 00396257     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.survophthal.2007.08.005     Document Type: Article

References (88)

1. Abbott N.J., and Revest P.A. Control of brain endothelial permeability. Cerebrovasc Brain Metab Rev 3 (1991) 39-72
2. Agapova O.A., Ricard C.S., Salvador-Silva M., et al. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes. Glia 33 (2001) 205-216
3. Ahn J.K., Kang J.H., and Park K.H. Correlation between a disc hemorrhage and peripapillary atrophy in glaucoma patients with a unilateral disc hemorrhage. J Glaucoma 13 (2004) 9-14
4. Ahn J.K., and Park K.H. Morphometric change analysis of the optic nerve head in unilateral disk hemorrhage cases. Am J Ophthalmol 134 (2002) 920-922
5. Airaksinen P.J., and Heijl A. Visual field and retinal nerve fibre layer in early glaucoma after optic disc haemorrhage. Acta Ophthalmol (Copenh) 61 (1983) 186-194
6. Arend O., Remky A., Plange N., et al. Fluorescein leakage of the optic disc in glaucomatous optic neuropathy. Graefes Arch Clin Exp Ophthalmol 243 (2005) 659-664
7. Beltrame J.F., Sasayama S., and Maseri A. Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and Caucasian patients. J Am Coll Cardiol 33 (1999) 1442-1452
8. Bengtsson B., Holmin C., and Krakau C.E. Disc haemorrhage and glaucoma. Acta Ophthalmol (Copenh) 59 (1981) 1-14
9. Ben-Sira I., and Riva C.E. Fluorescein diffusion in the human optic disc. Invest Ophthalmol 14 (1975) 205-211
10. Bhattacherjee P., Mukhopadhyay P., Tilley S.L., et al. Blood-aqueous barrier in prostaglandin EP2 receptor knockout mice. Ocul Immunol Inflamm 10 (2002) 187-196
11. Bito L.Z. Impact of intraocular pressure on venous outflow from the globe: a hypothesis regarding IOP-dependent vascular damage in normal-tension and hypertensive glaucoma. J Glaucoma 5 (1996) 127-134
12. Browning D.J., and Fraser C.M. Retinal vein occlusions in patients taking warfarin. Ophthalmology 111 (2004) 1196-1200
13. Chen Y., McCarron R.M., Azzam N., et al. Endothelin-1 and nitric oxide affect human cerebromicrovascular endothelial responses and signal transduction. Acta Neurochir 76 Suppl (2000) 131-135
14. Cleary C., Buckley C.H., Henry E., et al. Enhanced endothelium derived hyperpolarising factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye. Br J Ophthalmol 89 (2005) 223-228
15. Cohen A.I. Is there a potential defect in the blood-retinal barrier at the choroidal level of the optic nerve canal?. Invest Ophthalmol 12 (1973) 513-519
16. Cunha-Vaz J.G., Shakib M., and Ashton N. Studies on the permeability of the blood-retinal barrier. I. On the existence, development, and site of a blood-retinal barrier. Br J Ophthalmol 50 (1966) 441-453
17. Derevjanik N.L., Vinores S.A., Xiao W.H., et al. Quantitative assessment of the integrity of the blood-retinal barrier in mice. Invest Ophthalmol Vis Sci 43 (2002) 2462-2467
18. Drance S.M., and Begg I.S. Sector haemorrhage-a probable acute ischaemic disc change in chronic simple glaucoma. Can J Ophthalmol 5 (1970) 137-141
19. Ducos de Lahitte G., Quintyn J.C., Leparmentier A., et al. [Retinal vein occlusions in patients treated with anticoagulant and/or platelet aggregation inhibitors. Five case studies]. J Fr Ophtalmol 30 (2007) 145-149
20. Emre M., Orgül S., Haufschild T., et al. Increased plasma endothelin-1 levels in patients with progressive open angle glaucoma. Br J Ophthalmol 89 (2005) 60-63
21. Farkas E., and Luiten P.G. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol 64 (2001) 575-611
22. Fenstermacher J., Gross P., Sposito N., et al. Structural and functional variations in capillary systems within the brain. Ann NY Acad Sci 529 (1988) 21-30
23. Flage T. Permeability properties of the tissues in the optic nerve head region in the rabbit and the monkey. An ultrastructural study. Acta Ophthalmol (Copenh) 55 (1977) 652-664
24. Flage T. The distribution of intravenously administered peroxidase in the optic nerve head of rabbit and monkey. Acta Ophthalmol (Copenh) 53 (1975) 801-808
25. Flammer J., Orgül S., Costa V.P., et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 21 (2002) 359-393
26. Flammer J., Pache M., and Resink T. Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye. Prog Retin Eye Res 20 (2001) 319-349
27. Furuse M., Fujita K., Hiiragi T., et al. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 141 (1998) 1539-1550
28. Gasser P., and Meienberg O. Finger microcirculation in classical migraine. A video-microscopic study of nailfold capillaries. Eur Neurol 31 (1991) 168-171
29. Golubnitschaja O., Yeghiazaryan K., Liu R., et al. Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients. J Glaucoma 13 (2004) 66-72
30. Grayson M.C., and Laties A.M. Ocular localization of sodium fluorescein. Effects of administration in rabbit and monkey. Arch Ophthalmol 85 (1971) 600-603
31. Grieshaber M.C., Mozaffarieh M., and Flammer J. What is the link between vascular dysregulation and glaucoma?. Surv Ophthalmol 52 Suppl 2 (2007) S144-S154
32. Grieshaber M.C., Terhorst T., and Flammer J. The pathogenesis of optic disc splinter haemorrhages: a new hypothesis. Acta Ophthalmol Scand 84 (2006) 62-68
33. Hamann G.F., Okada Y., and del Zoppo G.J. Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion. J Cereb Blood Flow Metab 16 (1996) 1373-1378
34. Haufschild T., Prünte C., Messerli J., et al. Increased endothelin-1 plasma level in young adults with retinal vascular occlusive diseases. Klin Monatsbl Augenheilkd 221 (2004) 357-359
35. Hayreh S.S. Fluids in the anterior part of the optic nerve in health and disease. Surv Ophthalmol 23 (1978) 1-25
36. Healey P.R., Mitchell P., Smith W., et al. Optic disc hemorrhages in a population with and without signs of glaucoma. Ophthalmology 105 (1998) 216-223
37. Hegyalijai T., Meienberg O., Dubler B., et al. Cold-induced acral vasospasm in migraine as assessed by nailfold video-microscopy: prevalence and response to migraine prophylaxis. Angiology 48 (1997) 345-349
38. Hirase T., Staddon J.M., Saitou M., et al. Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci 110 Pt 14 (1997) 1603-1613
39. Hofman P., Hoyng P., vanderWerf F., et al. Lack of blood-brain barrier properties in microvessels of the prelaminar optic nerve head. Invest Ophthalmol Vis Sci 42 (2001) 895-901
40. Huber J.D., Egleton R.D., and Davis T.P. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci 24 (2001) 719-725
41. Hudspeth A.J., and Yee A.G. The intercellular junctional complexes of retinal pigment epithelia. Invest Ophthalmol 12 (1973) 354-365
42. Iannaccone A., Letizia C., Pazzaglia S., et al. Plasma endothelin-1 concentrations in patients with retinal vein occlusions. Br J Ophthalmol 82 (1998) 498-503
43. Ishida K., Yamamoto T., Sugiyama K., et al. Disk hemorrhage is a significantly negative prognostic factor in normal-tension glaucoma. Am J Ophthalmol 129 (2000) 707-714
44. Kim S.H., and Park K.H. The relationship between recurrent optic disc hemorrhage and glaucoma progression. Ophthalmology 113 (2006) 598-602
45. Kitazawa Y., Shirato S., and Yamamoto T. Optic disc hemorrhage in low-tension glaucoma. Ophthalmology 93 (1986) 853-857
46. Kniesel U., and Wolburg H. Tight junctions of the blood-brain barrier. Cell Mol Neurobiol 20 (2000) 57-76
47. Kurata H., Takaoka M., Kubo Y., et al. Protective effect of nitric oxide on ischemia/reperfusion-induced renal injury and endothelin-1 overproduction. Eur J Pharmacol 517 (2005) 232-239
48. Liu C., Herold J., Sciscio A., et al. Osteon-odonto-keratoprosthesis surgery. Br J Ophthalmol 83 (1999) 127
49. Messerli J., and Flammer J. [Central vein thrombosis in younger patients]. Klin Monatsbl Augenheilkd 208 (1996) 303-305
50. Miceli F., Minici F., Garcia Pardo M., et al. Endothelins enhance prostaglandin (PGE(2) and PGF(2alpha)) biosynthesis and release by human luteal cells: evidence of a new paracrine/autocrine regulation of luteal function. J Clin Endocrinol Metab 86 (2001) 811-817
51. Mocco J., Zacharia B.E., Komotar R.J., et al. A review of current and future medical therapies for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Neurosurg Focus 21 (2006) e9
52. Morgan W.H., Balaratnasingam C., Hazelton M.L., et al. The force required to induce hemivein pulsation is associated with the site of maximum field loss in glaucoma. Invest Ophthalmol Vis Sci 46 (2005) 1307-1312
53. Morgan W.H., Hazelton M.L., Azar S.L., et al. Retinal venous pulsation in glaucoma and glaucoma suspects. Ophthalmology 111 (2004) 1489-1494
54. Nagy Z., Vastag M., Kolev K., et al. Human cerebral microvessel endothelial cell culture as a model system to study the blood-brain interface in ischemic/hypoxic conditions. Cell Mol Neurobiol 25 (2005) 201-210
55. Narushima I., Kita T., Kubo K., et al. Highly enhanced permeability of blood-brain barrier induced by repeated administration of endothelin-1 in dogs and rats. Pharmacol Toxicol 92 (2003) 21-26
56. Narushima I., Kita T., Kubo K., et al. Contribution of endothelin-1 to disruption of blood-brain barrier permeability in dogs. Naunyn Schmiedebergs Arch Pharmacol 360 (1999) 639-645
57. Olsson Y., and Kristensson K. Permeability of blood vessels and connective tissue sheaths in retina and optic nerve. Acta Neuropathol (Berl) 26 (1973) 147-156
58. Orgül S., Kaiser H.J., Flammer J., et al. Systemic blood pressure and capillary blood-cell velocity in glaucoma patients: a preliminary study. Eur J Ophthalmol 5 (1995) 88-91
59. Pache M., Kräuchi K., Cajochen C., et al. Cold feet and prolonged sleep-onset latency in vasospastic syndrome. Lancet 358 (2001) 125-126
60. Pagès N., Gogly B., Godeau G., et al. Structural alterations of the vascular wall in magnesium-deficient mice. A possible role of gelatinases A (MMP-2) and B (MMP-9). Magnes Res 16 (2003) 43-48
61. Pardridge W.M. Molecular biology of the blood-brain barrier. Mol Biotechnol 30 (2005) 57-70
62. Peyman G.A., and Apple D. Peroxidase diffusion processes in the optic nerve. Arch Ophthalmol 88 (1972) 650-654
63. Prünte-Glowazki A., and Flammer J. [Ocular vasospasm. 4: Clinical examples]. Klin Monatsbl Augenheilkd 198 (1991) 415-418
64. Rader J., Feuer W.J., and Anderson D.R. Peripapillary vasoconstriction in the glaucomas and the anterior ischemic optic neuropathies. Am J Ophthalmol 117 (1994) 72-80
65. Rankin S.J., and Drance S.M. Peripapillary focal retinal arteriolar narrowing in open angle glaucoma. J Glaucoma 5 (1996) 22-28
66. Rodriquez-Peralta L. The blood-optic nerve barrier. Anat Rec (1963) 277-291
67. Rosenberg G.A., Estrada E.Y., and Dencoff J.E. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke 29 (1998) 2189-2195
68. Schlingemann R.O., Hofman P., Anderson L., et al. Vascular expression of endothelial antigen PAL-E indicates absence of blood-ocular barriers in the normal eye. Ophthalmic Res 29 (1997) 130-138
69. Schlingemann RO B.G., Van Duinen S.G., Dingjan G.M., et al. Differential expression of endothelial-specific antigen PAL-E in vasculature of brain tumors and preexistent brain capillaries. Ann NY Acad Sci 466 (1986) 111-114
70. Schwartz B. Circulatory defects of the optic disk and retina in ocular hypertension and high pressure open-angle glaucoma. Surv Ophthalmol 38 Suppl (1994) S23-S34
71. Schwartz B., Rieser J.C., and Fishbein S.L. Fluorescein angiographic defects of the optic disc in glaucoma. Arch Ophthalmol 95 (1977) 1961-1974
72. Sedlakova R., Shivers R.R., and Del Maestro R.F. Ultrastructure of the blood-brain barrier in the rabbit. J Submicrosc Cytol Pathol 31 (1999) 149-161
73. Shabo A.L., and Maxwell D.S. The structure of the trabecular meshwork of the primate eye: a light and electron microscopic study with peroxidase. Microvasc Res 4 (1972) 384-398
74. Shimada K., Kita T., Yonetani Y., et al. The effect of endothelin-1 on lipopolysaccharide-induced cyclooxygenase 2 expression in association with prostaglandin E(2). Eur J Pharmacol 388 (2000) 187-194
75. Shiose Y. [Morphological study on the permeability of the blood aqueous barrier]. Nippon Ganka Gakkai Zasshi 74 (1970) 1248-1255
76. Siegner S.W., and Netland P.A. Optic disc hemorrhages and progression of glaucoma. Ophthalmology 103 (1996) 1014-1024
77. Sonnsjö B., Dokmo Y., and Krakau T. Disc haemorrhages, precursors of open angle glaucoma. Prog Retin Eye Res 21 (2002) 35-56
78. Spaeth G.L. Fluorescein angiography: its contributions towards understanding the mechanisms of visual loss in glaucoma. Trans Am Ophthalmol Soc 73 (1975) 491-553
79. Su E.N., Cringle S.J., and Yu D.Y. Vasoconstrictive effects of sodium fluorescein on retinal vessels is increased by light exposure. Curr Eye Res 32 (2007) 77-81
80. Teuchner B., Orgül S., Ulmer H., et al. Reduced thirst in patients with a vasospastic syndrome. Acta Ophthalmol Scand 82 (2004) 738-740
81. Tso M.O., Shih C.Y., and McLean I.W. Is there a blood-brain barrier at the optic nerve head?. Arch Ophthalmol 93 (1975) 815-825
82. Tsukahara S. Hyperpermeable disc capillaries in glaucoma. Adv Ophthalmol 35 (1978) 65-72
83. Vágó H., Soós P., Zima E., et al. Changes of endothelin-1 and big endothelin-1 levels and action potential duration during myocardial ischemia-reperfusion in dogs with and without ventricular fibrillation. J Cardiovasc Pharmacol 44 Suppl 1 (2004) S376-S379
84. Vegge T. A blood-aqueous barrier to small molecules in the ciliary processes of the vervet monkey (Cercopithecus aethiops). Z Zellforsch Mikrosk Anat 135 (1972) 483-499
85. Waldmann E., Gasser P., Dubler B., et al. Silent myocardial ischemia in glaucoma and cataract patients. Graefes Arch Clin Exp Ophthalmol 234 (1996) 595-598
86. Williamson T.H. A throttle mechanism in the central retinal vein in the region of the lamina cribrosa. Br J Ophthalmol (2006)
87. Wunderlich K., Zimmerman C., Gutmann H., et al. Vasospastic persons exhibit differential expression of ABC-transport proteins. Mol Vis 9 (2003) 756-761
88. Yan X., Tezel G., Wax M.B., et al. Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head. Arch Ophthalmol 118 (2000) 666-673