Phosphorylation-dependent interaction with 14-3-3 in the regulation of bad trafficking in retinal ganglion cells

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 6, 2008, Pages 2483-2494

  Yang, Xiangjun ^a   Luo, Cheng ^a   Cai, Jian ^a   Pierce, William M ^a   Tezel, Gülgün ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; DJNKI; DTAT PEPTIDE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN 14 3 3; PROTEIN BAD; PROTEIN BCL 2; RECOMBINANT PROTEIN; SCAFFOLD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TACROLIMUS; UNCLASSIFIED DRUG; BAD PROTEIN, HUMAN; BAD PROTEIN, RAT; PHOSPHOPROTEIN;

ANIMAL MODEL; ANTIBODY LABELING; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; EYE; GENE TRANSLOCATION; GLAUCOMA; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VIVO STUDY; INTRAOCULAR HYPERTENSION; MASS SPECTROMETRY; MITOCHONDRIAL MEMBRANE; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEOMICS; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BROWN NORWAY RAT; CELL COUNT; DISEASE MODEL; FLUORESCENT ANTIBODY TECHNIQUE; MALE; METABOLISM; NERVE FIBER; NICK END LABELING; OPTIC NERVE DISEASE; PATHOLOGY; PHOSPHORYLATION; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION;

14-3-3 PROTEINS; ANIMALS; APOPTOSIS; AXONS; BCL-ASSOCIATED DEATH PROTEIN; BLOTTING, WESTERN; CELL COUNT; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLAUCOMA; HUMANS; IN SITU NICK-END LABELING; MALE; MASS SPECTROMETRY; OPTIC NERVE DISEASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEOMICS; RATS; RATS, INBRED BN; RETINAL GANGLION CELLS; UP-REGULATION;

EID: 47249120101     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-1344     Document Type: Article

References (43)

1. Tezel G, Wax MB. Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J Neurosci. 2000;20:8693-8700.
2. Tezel G, Yang X. Caspase-independent component of retinal ganglion cell death, in vitro. Invest Ophthalmol Vis Sci. 2004;45:4049-4059. (Pubitemid 39411160)
3. Tezel G, Yang X, Cai J. Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma. Invest Ophthalmol Vis Sci. 2005;46:3177-3187. (Pubitemid 44264303)
4. Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res. 2006;25:490-513. (Pubitemid 44389961)
5. Nickells RW. Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death. Surv Ophthalmol. 1999;43(suppl 1):S151-S161. (Pubitemid 29328590)
6. Li Y, Schlamp CL, Poulsen KP, Nickells RW. Bax-dependent and independent pathways of retinal ganglion cell death induced by different damaging stimuli. Exp Eye Res. 2000;71:209-213.
7. Whitmore AV, Lindsten T, Raff MC, Thompson CB. The proapoptotic proteins Bax and Bak are not involved in Wallerian degeneration. Cell Death Differ. 2003;10:260-261. (Pubitemid 36553469)
8. Libby RT, Li Y, Savinova OV, et al. Susceptibility to neurodegeneration in a glaucoma is modified by bax gene dosage. PLoS Genet. 2005;1:e4.
9. Ji J, Chang P, Pennesi ME, et al. Effects of elevated intraocular pressure on mouse retinal ganglion cells. Vision Res. 2005;45:169-179. (Pubitemid 39575750)
10. Kim HS, Park CK. Retinal ganglion cell death is delayed by activation of retinal intrinsic cell survival program. Brain Res. 2005;1057:17-28. (Pubitemid 41338083)
11. Huang W, Fileta JB, Dobberfuhl A, et al. Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma. Proc Natl Acad Sci U S A. 2005;102:12242-12247. (Pubitemid 41291159)
12. Tezel G, Chauhan BC, LeBlanc RP, Wax MB. Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma. Invest Ophthalmol Vis Sci. 2003;44:3025-3033. (Pubitemid 36759769)
13. Tezel G, Yang X. Comparative gene array analysis of TNF-α-induced MAPK and NF-κB signaling pathways between retinal ganglion cells and glial cells. Exp Eye Res. 2005;81:207-217. (Pubitemid 41080103)
14. Ivanov D, Dvoriantchikova G, Nathanson L, McKinnon SJ, Shestopalov VI. Microarray analysis of gene expression in adult retinal ganglion cells. FEBS Lett. 2006;580:331-335. (Pubitemid 43005357)
15. Skoulakis EM, Davis RL. 14-3-3 proteins in neuronal development and function. Mol Neurobiol. 1998;16:269-284. (Pubitemid 28268546)
16. Muslin AJ, Tanner JW, Allen PM, Shaw AS. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell. 1996;84:889-897. (Pubitemid 26106858)
17. Yaffe MB, Rittinger K, Volinia S, et al. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell. 1997;91:961-971. (Pubitemid 28027829)
18. Xing H, Zhang S, Weinheimer C, Kovacs A, Muslin AJ. 14-3-3 proteins block apoptosis and differentially regulate MAPK cascades. EMBO J. 2000;19:349-358. (Pubitemid 30072605)
19. Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes. 2001;50:77-82. (Pubitemid 32047984)
20. Morrison JC, Moore CG, Deppmeier LM, Gold BG, Meshul CK, Johnson EC. A rat model of chronic pressure-induced optic nerve damage. Exp Eye Res. 1997;64:85-96. (Pubitemid 27096643)
21. Schulenberg B, Aggeler R, Beechem JM, Capaldi RA, Patton WF. Analysis of steady-state protein phosphorylation in mitochondria using a novel fluorescent phosphosensor dye. J Biol Chem. 2003;278:27251-27255. (Pubitemid 36876882)
22. Schulenberg B, Goodman TN, Aggeler R, Capaldi RA, Patton WF. Characterization of dynamic and steady-state protein phosphorylation using a fluorescent phosphoprotein gel stain and mass spectrometry. Electrophoresis. 2004;25:2526-2532. (Pubitemid 39193662)
23. Tezel G, Wax MB. The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J Neurosci. 2000;20:3552-3562. (Pubitemid 30266217)
24. Tezel G, Yang X, Yang J, Wax MB. Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice. Brain Res. 2004;996:202-212. (Pubitemid 38022017)
25. Tezel G, Wax MB. Hypoxia-inducible factor 1α in the glaucomatous retina and optic nerve head. Arch Ophthalmol. 2004;122:1348-1356. (Pubitemid 39180857)
26. Levkovitch-Verbin H, Quigley HA, Martin KR, et al. The transcription factor c-jun is activated in retinal ganglion cells in experimental rat glaucoma. Exp Eye Res. 2005;80:663-670. (Pubitemid 40602967)
27. Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell. 1996;87:619-628. (Pubitemid 26386936)
28. Franke TF, Cantley LC. Apoptosis: a Bad kinase makes good. Nature. 1997;390:116-117. (Pubitemid 27507959)
29. Hsu YT, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A. 1997;94:3668-3672. (Pubitemid 27180430)
30. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ. Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol. 1997;139:1281-1292. (Pubitemid 27523214)
31. Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997;91:231-241. (Pubitemid 27456390)
32. del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science. 1997;278:687-689. (Pubitemid 27464966)
33. Davare MA, Saneyoshi T, Guire ES, Nygaard SC, Soderling TR. Inhibition of calcium/calmodulin-dependent protein kinase kinase by protein 14-3-3. J Biol Chem. 2004;279:52191-52199. (Pubitemid 39656593)
34. Shen YH, Godlewski J, Bronisz A, et al. Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol Biol Cell. 2003;14:4721-4733. (Pubitemid 37444669)
35. Woodcock JM, Murphy J, Stomski FC, Berndt MC, Lopez AF. The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface. J Biol Chem. 2003;278:36323-36327. (Pubitemid 37139958)
36. Powell DW, Rane MJ, Joughin BA, et al. Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol. 2003;23:5376-5387. (Pubitemid 36950892)
37. Sunayama J, Tsuruta F, Masuyama N, Gotoh Y. JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J Cell Biol. 2005;170:295-304. (Pubitemid 41043811)
38. Tsuruta F, Sunayama J, Mori Y, et al. JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J. 2004;23:1889-1899. (Pubitemid 38649651)
39. Gao Y, Signore AP, Yin W, et al. Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway. J Cereb Blood Flow Metab. 2005;25:694-712. (Pubitemid 40705605)
40. Chiang CW, Kanies C, Kim KW, et al. Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol Cell Biol. 2003;23:6350-6362. (Pubitemid 37075749)
41. Donovan N, Becker EB, Konishi Y, Bonni A. JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem. 2002;277:40944-40949. (Pubitemid 35215682)
42. Konishi Y, Lehtinen M, Donovan N, Bonni A. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell. 2002;9:1005-1016. (Pubitemid 34626670)
43. Sawyer TK, Shakespeare WC, Wang Y, et al. Protein phosphorylation and signal transduction modulation: chemistry perspectives for small-molecule drug discovery. Med Chem. 2005;1:293-319.