The role of glia, mitochondria, and the immune system in glaucoma

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 3, 2009, Pages 1001-1012

  Tezel, Gülgün ^a   Ben Hur, Tamir ^b   Gibson, Gary E ^c   Stevens, Beth ^d   Streit, Wolfgang J ^e   Wekerle, Hartmut ^f   Bhattacharya, Sanjoy K ^g   Borras, Terete ^h   Burgoyne, Claude F ⁱ   Caspi, Rachel R ^j   Chauhan, Balwantray C ^k   Clark, Abbot F ^l   Crowston, Jonathan ^m   Danias, John ⁿ   Dick, Andrew D ^o   Flammer, Josef ^p   Foster, C Stephen ^q   Grosskreutz, Cynthia L ^r   Grus, Franz H ^s   Guy, John ^e   Hernandez, M Rosario ^t   Johnson, Elaine ^u   Kaplan, Henry J ^a   Kuehn, Markus H ^v   Lenaers, Guy ^w   Levin, Leonard A ^x   Lindsey, James D ^y   Malina, Halina ^z   Nickells, Robert W ^aa   Osborne, Neville ^ab   Quigley, Harry A ^ac   Rao, Narsing ^ad   Rosenbaum, James T ^u   Sadun, Alfredo A ^ad   Schwartz, Michal ^ae   Sun, Deming ^ad   Trounce, Ian ^af   Wax, Martin B ^ag   Yorio, Thomas ^l   Abrams, Gary W ^ah   Atherton, Sally S ^ai   Boatright, Jeffrey H ^aj   Chu, Jesse ^ak   Dowling, John ^al   Ferris, Frederick L ^am   Garway Heath, David ^an   Gregory, Meredith ^ao   Grzybowski, Deborah M ^ap   Gupta, Neeru ^aq   Inman, Denise ^ar   Ju, Won Kyu ^y   Kang, KuiDong ^ab   Kaufman, Herbert E ^as   Kaufman, Paul L ^aa   Larssen, Lill Inger ^ak   Liebmann, Jeffrey ^at   Lupien, Caroline ^ar   Miller, Robert F ^au   Niesman, Mike ^ak   O'Brien, Colm ^av   Petrash, J Mark ^aw   Prasanna, Granesh ^ak   Ritch, Robert ^at   Shestopalov, Valery ^g   Wirostko, Barbara ^ak   WoldeMussie, Elizabeth ^am   Yue, Beatrice ^ax   Zimmerman, Thom J ^a   more..

^a University of Louisville School of Medicine   (United States)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d STANFORD UNIVERSITY   (United States)

^e UNIVERSITY OF FLORIDA   (United States)

^f MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^g UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

ⁱ DEVERS EYE INSTITUTE   (United States)

^j NATIONAL INSTITUTES OF HEALTH   (United States)

^k DALHOUSIE UNIVERSITY   (Canada)

^l UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^m CENTRE FOR EYE RESEARCH AUSTRALIA   (Australia)

ⁿ MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^o UNIVERSITY OF BRISTOL   (United Kingdom)

^p UNIVERSITY EYE CLINIC   (Switzerland)

^q MASSACHUSETTS EYE RESEARCH AND SURGERY INSTITUTION   (United States)

^r MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^s JOHANNES GUTENBERG UNIVERSITY   (Germany)

^t NORTHWESTERN UNIVERSITY   (United States)

^u OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^v UNIVERSITY OF IOWA   (United States)

^w INSERM   (France)

^x UNIVERSITÉ DE MONTRÉAL   (Canada)

^y UNIVERSITY OF CALIFORNIA   (United States)

^z UNIVERSITY OF BERN   (Switzerland)

^aa UNIVERSITY OF WISCONSIN MADISON   (United States)

^ab UNIVERSITY OF OXFORD   (United Kingdom)

^ac JOHNS HOPKINS UNIVERSITY   (United States)

^ad UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^ae WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^af ST VINCENT S HOSPITAL   (Australia)

^ag ALCON RESEARCH LTD   (United States)

^ah WAYNE STATE UNIVERSITY   (United States)

^ai MEDICAL COLLEGE OF GEORGIA   (United States)

^aj EMORY EYE CENTER   (United States)

^ak PFIZER INC   (United States)

^al HARVARD UNIVERSITY   (United States)

^am NATIONAL EYE INSTITUTE   (United States)

^an MOORFIELDS EYE HOSPITAL   (United Kingdom)

^ao SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^ap OHIO STATE UNIVERSITY   (United States)

^aq ST MICHAEL'S HOSPITAL   (Canada)

^ar UNIVERSITY OF WASHINGTON   (United States)

^as LSU EYE CENTER   (United States)

^at NEW YORK EYE AND EAR INFIRMARY   (United States)

^au UNIVERSITY OF MINNESOTA   (United States)

^av MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^aw WASHINGTON UNIVERSITY   (United States)

^ax UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; IMMUNOSUPPRESSIVE AGENT;

CONFERENCE PAPER; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA IMMUNIZATION; EYE DISEASE; GLAUCOMA; GLIA; HUMAN; IMMUNE SYSTEM; MEDICAL RESEARCH; MITOCHONDRION; NERVE DEGENERATION; NEUROPROTECTION; PRIORITY JOURNAL; CONSENSUS DEVELOPMENT; NERVE FIBER; OPTIC NERVE DISEASE; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA GANGLION CELL;

AXONS; GLAUCOMA; HUMANS; IMMUNE SYSTEM; MITOCHONDRIA; MITOCHONDRIAL DISEASES; NEUROGLIA; OPTIC NERVE DISEASES; RETINAL GANGLION CELLS;

EID: 62649132149     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2717     Document Type: Conference Paper

References (58)

1. Hernandez MR, Pena JD. The optic nerve head in glaucomatous optic neuropathy. Arch Ophthalmol. 1997;115:389-395.
2. Tezel G, Chauhan BC, LeBlanc RP, Wax MB. Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma. Invest Ophthalmol Vis Sci. 2003;44:3025-3033.
3. Hernandez MR, Agapova OA, Yang P, Salvador-Silva M, Ricard CS, Aoi S. Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray. Glia. 2002;38:45-64.
4. Martin KR, Levkovitch-Verbin H, Valenta D, Baumrind L, Pease ME, Quigley HA. Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat. Invest Ophthalmol Vis Sci. 2002;43:2236-2243.
5. Tezel G, Wax MB. Increased production of tumor necrosis factoralpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J Neurosci. 2000;20:8693-8700.
6. Bechmann I, Galea I, Perry VH. What is the blood-brain barrier (not)? Trends Immunol. 2007;28:5-11.
7. Prasanna G, Narayan S, Krishnamoorthy RR, Yorio T. Eyeing endothelins: a cellular perspective. Mol Cell Biochem. 2003;253:71-88.
8. Yan X, Tezel G, Wax MB, Edward DP. Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head. Arch Ophthalmol. 2000;118:666-673.
9. Guo L, Moss SE, Alexander RA, Ali RR, Fitzke FW, Cordeiro MF. Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix. Invest Ophthalmol Vis Sci. 2005;46:175-182.
10. Grieshaber MC, Flammer J. Does the blood-brain barrier play a role in glaucoma? Surv Ophthalmol. 2007;52 Suppl 2:S115-121.
11. Matsubara T, Pararajasegaram G, Wu GS, Rao NA. Retinal microglia differentially express phenotypic markers of antigen-presenting cells in vitro. Invest Ophthalmol Vis Sci. 1999;40:3186-3193.
12. Streit WJ. Microglial senescence: does the brain's immune system have an expiration date? Trends Neurosci. 2006;29:506-510.
13. Levkovitch-Verbin H, Quigley HA, Martin KR, Zack DJ, Pease ME, Valenta DF. A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transection. Invest Ophthalmol Vis Sci. 2003;44:3388-3393.
14. Obrenovitch TP. Molecular physiology of preconditioning-induced brain tolerance to ischemia. Physiol Rev. 2008;88:211-247.
15. Morrison JC, Johnson EC, Cepurna W, Jia L. Understanding mechanisms of pressure-induced optic nerve damage. Prog Retin Eye Res. 2005;24:217-240.
16. Pang IH, Clark AF. Rodent models for glaucoma retinopathy and optic neuropathy. J Glaucoma. 2007;16:483-505.
17. Tezel G. Oxidative stress in glaucomatous neurodegeneration: Mechanisms and consequences. Prog Retin Eye Res. 2006;25:490-513.
18. Tezel G, Yang X. Caspase-independent component of retinal ganglion cell death, in vitro. Invest Ophthalmol Vis Sci. 2004;45:4049-4059.
19. Tezel G, Yang X, Cai J. Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma. Invest Ophthalmol Vis Sci. 2005;46:3177-3187.
20. Tezel G, Luo C, Yang X. Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head. Invest Ophthalmol Vis Sci. 2007;48:1201-1211.
21. Osborne NN, Li GY, Ji D, Mortiboys HJ, Jackson S. Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies. J Neurochem. 2008;105:2013-2028.
22. Ju WK, Kim KY, Lindsey JD, et al. Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2008;49(11):4903-4911.
23. Lieven CJ, Hoegger MJ, Schlieve CR, Levin LA. Retinal ganglion cell axotomy induces an increase in intracellular superoxide anion. Invest Ophthalmol Vis Sci. 2006;47:1477-1485.
24. Hoegger MJ, Lieven CJ, Levin LA. Differential production of superoxide by neuronal mitochondria. BMC Neurosci. 2008;9:4.
25. Libby RT, Li Y, Savinova OV, et al. Susceptibility to neurodegeneration in a glaucoma is modified by bax gene dosage. PLoS Genet. 2005;1:e4.
26. Huang W, Fileta JB, Dobberfuhl A, et al. Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma. Proc Natl Acad Sci U S A. 2005;102:12242-12247.
27. Yang X, Luo C, Cai J, Pierce WM, Tezel G. Phosphorylation-dependent interaction with 14-3-3 in the regulation of bad trafficking in retinal ganglion cells. Invest Ophthalmol Vis Sci. 2008;49:2483-2494.
28. Tezel G, Hernandez MR, Wax MB. Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch Ophthalmol. 2000;118:511-518.
29. Tezel G, Yang X. Comparative gene array analysis of TNF-alpha-induced MAPK and NF-kappaB signaling pathways between retinal ganglion cells and glial cells. Exp Eye Res. 2005;81:207-217.
30. Huang W, Fileta JB, Filippopoulos T, Ray A, Dobberfuhl A, Grosskreutz CL. Hsp27 phosphorylation in experimental glaucoma. Invest Ophthalmol Vis Sci. 2007;48:4129-4135.
31. McKinnon SJ. Glaucoma: ocular Alzheimer's disease? Front Biosci. 2003;8:S1140-S1156.
32. Gibson GE, Blass JP, Beal MF, Bunik V. The alpha-ketoglutarate- dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Mol Neurobiol. 2005;31:43-63.
33. Quigley HA. Glaucoma: macrocosm to microcosm the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2005;46:2662-2670.
34. Qi X, Sun L, Hauswirth WW, Lewin AS, Guy J. Use of mitochondrial antioxidant defenses for rescue of cells with a Leber hereditary optic neuropathy-causing mutation. Arch Ophthalmol. 2007;125:268-272.
35. Miller TM, Moulder KL, Knudson CM, et al. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol. 1997;139:205-217.
36. Schlamp CL, Johnson EC, Li Y, Morrison JC, Nickells RW. Changes in Thy1 gene expression associated with damaged retinal ganglion cells. Mol Vis. 2001;7:192-201.
37. Schwartz M, Ziv Y. Immunity to self and self-maintenance: a unified theory of brain pathologies. Trends Immunol. 2008;29:211-219.
38. Tezel G, Wax MB. Glaucoma. Chem Immunol Allergy. 2007;92:221-227.
39. Wax MB, Tezel G, Yang J, et al. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T cell-derived Fas-ligand. J Neurosci. 2008;28(46):12085-12096.
40. Yang J, Yang P, Tezel G, Patil RV, Hernandez MR, Wax MB. Induction of HLA-DR expression in human lamina cribrosa astrocytes by cytokines and simulated ischemia. Invest Ophthalmol Vis Sci. 2001;42:365-371.
41. Tezel G, Yang X, Luo C, Peng Y, Sun SL, Sun D. Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia. Invest Ophthalmol Vis Sci. 2007;48:705-714.
42. Odoardi F, Kawakami N, Klinkert WE, Wekerle H, Flugel A. Bloodborne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proc Natl Acad Sci U S A. 2007;104:18625-18630.
43. Shao H, Kaplan HJ, Sun D. Major histocompatibility complex molecules on parenchymal cells of the target organ protect against autoimmune disease. Chem Immunol Allergy. 2007;92:94-104.
44. Khan N, Huang JJ, Foster CS. Cancer associated retinopathy (CAR): An autoimmune-mediated paraneoplastic syndrome. Semin Ophthalmol. 2006;21:135-141.
45. Grus FH, Joachim SC, Wuenschig D, Rieck J, Pfeiffer N. Autoimmunity and glaucoma. J Glaucoma. 2008;17:79-84.
46. Tezel G, Wax MB. The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J Neurosci. 2000;20:3552-3562.
47. Wax MB, Tezel G, Edward PD. Clinical and ocular histopathological findings in a patient with normal-pressure glaucoma. Arch Ophthalmol. 1998;116:993-1001.
48. Romano C, Li Z, Arendt A, Hargrave PA, Wax MB. Epitope mapping of anti-rhodopsin antibodies from patients with normal pressure glaucoma. Invest Ophthalmol Vis Sci. 1999;40:1275-1280.
49. Joachim SC, Wuenschig D, Pfeiffer N, Grus FH. IgG antibody patterns in aqueous humor of patients with primary open angle glaucoma and pseudoexfoliation glaucoma. Mol Vis. 2007;13:1573-1579.
50. Stasi K, Nagel D, Yang X, et al. Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes. Invest Ophthalmol Vis Sci. 2006;47:1024-1029.
51. Kuehn MH, Kim CY, Ostojic J, et al. Retinal synthesis and deposition of complement components induced by ocular hypertension. Exp Eye Res. 2006;83:620-628.
52. Stevens B, Allen NJ, Vazquez LE, et al. The classic complement cascade mediates CNS synapse elimination. Cell. 2007;131:1164-1178.
53. Smith JR, Rosenbaum JT. Management of immune-mediated uveitis. BioDrugs. 2000;13:9-20.
54. Silver PB, Agarwal RK, Su SB, et al. Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells. J Immunol. 2007;179:5146-5158.
55. Ben-Hur T. Immunomodulation by neural stem cells. J Neurol Sci. 2008;265:102-104.
56. Ziv Y, Schwartz M. Immune-based regulation of adult neurogenesis: implications for learning and memory. Brain Behav Immun. 2008;22:167-176.
57. Calder CJ, Nicholson LB, Dick AD. A selective role for the TNF p55 receptor in autocrine signaling following IFN-gamma stimulation in experimental autoimmune uveoretinitis. J Immunol. 2005;175:6286-6293.
58. Bora PS, Hu Z, Tezel TH, et al. Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc Natl Acad Sci U S A. 2003;100:2679-2684.