Helix 12 dynamics and thyroid hormone receptor activity: Experimental and molecular dynamics studies of ile280 mutants

Journal of Molecular Biology

Volumn 412, Issue 5, 2011, Pages 882-893

  Souza, Paulo C T ^a   Barra, Gustavo B ^b   Velasco, Lara F R ^b   Ribeiro, Isabel C J ^b   Simeoni, Luiz A ^b   Togashi, Marie ^b   Webb, Paul ^c   Neves, Francisco A R ^b   Skaf, Munir S ^a   Martínez, Leandro ^d   Polikarpov, Igor ^d  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF BRASILIA   (Brazil)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

cofactor recruitment; molecular dynamics simulations; nuclear hormone receptor; thyroid

Indexed keywords

THYROID HORMONE RECEPTOR;

ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; GENE MUTATION; HELIX 12; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

EID: 80051930688     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.04.014     Document Type: Article

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