-
1
-
-
5444272172
-
Causes of Parkinson's disease: genetics of DJ-1
-
Abou-Sleiman, P.M., Healy, D.G. and Wood, N.W. (2004) Causes of Parkinson's disease: genetics of DJ-1. Cell Tissue Res., 318, 185-188.
-
(2004)
Cell Tissue Res.
, vol.318
, pp. 185-188
-
-
Abou-Sleiman, P.M.1
Healy, D.G.2
Wood, N.W.3
-
2
-
-
1842611727
-
Alph-synuclein and Parkinson's disease
-
Recchia, A., Debetto, P., Negro, A., Guidolin, D., Skaper, S.D. and Giusti, P. (2004) Alph-synuclein and Parkinson's disease. Faseb. J., 18, 617-626.
-
(2004)
Faseb. J.
, vol.18
, pp. 617-626
-
-
Recchia, A.1
Debetto, P.2
Negro, A.3
Guidolin, D.4
Skaper, S.D.5
Giusti, P.6
-
3
-
-
20744435383
-
Molecular pathophysiology of Parkinson's disease
-
Moore, D.J., West, A.B., Dawson, V.L. and Dawson, T.M. (2005) Molecular pathophysiology of Parkinson's disease. Annu. Rev. Neurosci., 28, 57-87.
-
(2005)
Annu. Rev. Neurosci.
, vol.28
, pp. 57-87
-
-
Moore, D.J.1
West, A.B.2
Dawson, V.L.3
Dawson, T.M.4
-
4
-
-
0030882856
-
Alph-synuclein in Lewy bodies
-
Spillantini, M.G., Schmidt, M.L., Lee, V.M., Trojanowski, J.Q., Jakes, R. and Goedert, M. (1997) Alph-synuclein in Lewy bodies. Nature, 388, 839-840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
5
-
-
0030744876
-
Mutation in the alph-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M.H., Lavedan, C., Leroy, E., Ide, S.E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R. et al. (1997) Mutation in the alph-synuclein gene identified in families with Parkinson's disease. Science, 276, 2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
-
6
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alph-synuclein in Parkinson's disease
-
Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J.T., Schols, L. and Riess, O. (1998) Ala30Pro mutation in the gene encoding alph-synuclein in Parkinson's disease. Nat. Genet., 18, 106-108.
-
(1998)
Nat. Genet.
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
Przuntek, H.7
Epplen, J.T.8
Schols, L.9
Riess, O.10
-
7
-
-
10744230149
-
The new mutation, E46K, of alph-synuclein causes Parkinson and Lewy body dementia
-
Zarranz, J.J., Alegre, J., Gomez-Esteban, J.C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atares, B. et al. (2004) The new mutation, E46K, of alph-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol., 55, 164-173.
-
(2004)
Ann. Neurol.
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atares, B.10
-
8
-
-
0242300619
-
Alph-synuclein locus triplication causes Parkinson's disease
-
Singleton, A.B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R. et al. (2003) alph-synuclein locus triplication causes Parkinson's disease. Science, 302, 841.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
-
9
-
-
53949108957
-
N-terminal region of alph-synuclein is essential for the fatty acid-induced oligomerization of the molecules
-
Karube, H., Sakamoto, M., Arawaka, S., Hara, S., Sato, H., Ren, C.H., Goto, S., Koyama, S., Wada, M., Kawanami, T. et al. (2008) N-terminal region of alph-synuclein is essential for the fatty acid-induced oligomerization of the molecules. FEBS Lett., 582, 3693-3700.
-
(2008)
FEBS Lett.
, vol.582
, pp. 3693-3700
-
-
Karube, H.1
Sakamoto, M.2
Arawaka, S.3
Hara, S.4
Sato, H.5
Ren, C.H.6
Goto, S.7
Koyama, S.8
Wada, M.9
Kawanami, T.10
-
10
-
-
65549107985
-
The first N-terminal amino acids of Alph-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast
-
Vamvaca, K., Volles, M.J. and Lansbury, P.T. Jr (2009) The first N-terminal amino acids of Alph-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast. J. Mol. Biol., 389, 413-424.
-
(2009)
J. Mol. Biol.
, vol.389
, pp. 413-424
-
-
Vamvaca, K.1
Volles, M.J.2
Lansbury Jr., P.T.3
-
11
-
-
73549109861
-
Characterization of inhibitor-bound alph-synuclein dimer: role of Alph-synuclein N-terminal region in dimerization and inhibitor binding
-
Yamaguchi, Y., Masuda, M., Sasakawa, H., Nonaka, T., Hanashima, S., Hisanaga, S., Kato, K. and Hasegawa, M. (2010) Characterization of inhibitor-bound alph-synuclein dimer: role of Alph-synuclein N-terminal region in dimerization and inhibitor binding. J. Mol. Biol., 395, 445-456.
-
(2010)
J. Mol. Biol.
, vol.395
, pp. 445-456
-
-
Yamaguchi, Y.1
Masuda, M.2
Sasakawa, H.3
Nonaka, T.4
Hanashima, S.5
Hisanaga, S.6
Kato, K.7
Hasegawa, M.8
-
12
-
-
0030932673
-
Binding of Abeta to alpha- and beta-synucleins: identification of segments in alph-synuclein/NAC precursor that bind Abeta and NAC
-
Jensen, P.H., Hojrup, P., Hager, H., Nielsen, M.S., Jacobsen, L., Olesen, O.F., Gliemann, J. and Jakes, R. (1997) Binding of Abeta to alpha- and beta-synucleins: identification of segments in alph-synuclein/NAC precursor that bind Abeta and NAC. Biochem. J., 323, 539-546.
-
(1997)
Biochem. J.
, vol.323
, pp. 539-546
-
-
Jensen, P.H.1
Hojrup, P.2
Hager, H.3
Nielsen, M.S.4
Jacobsen, L.5
Olesen, O.F.6
Gliemann, J.7
Jakes, R.8
-
13
-
-
77957347060
-
Alph-synuclein promotes SNARE-complex assembly in vivo and in vitro
-
Burre, J., Sharma, M., Tsetsenis, T., Buchman, V., Etherton, M.R. and Sudhof, T.C. (2010) Alph-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science, 329, 1663-1667.
-
(2010)
Science
, vol.329
, pp. 1663-1667
-
-
Burre, J.1
Sharma, M.2
Tsetsenis, T.3
Buchman, V.4
Etherton, M.R.5
Sudhof, T.C.6
-
14
-
-
33745375279
-
Chaperone-like activities of alph-synuclein: alph-synuclein assists enzyme activities of esterases
-
Ahn, M., Kim, S., Kang, M., Ryu, Y. and Kim, T.D. (2006) Chaperone-like activities of alph-synuclein: alph-synuclein assists enzyme activities of esterases. Biochem. Biophys. Res. Commun., 346, 1142-1149.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.346
, pp. 1142-1149
-
-
Ahn, M.1
Kim, S.2
Kang, M.3
Ryu, Y.4
Kim, T.D.5
-
15
-
-
51349116429
-
Site-specific interactions of Cu(II) with alpha and betαuclein: bridging the molecular gap between metal binding and aggregation
-
Binolfi, A., Lamberto, G.R., Duran, R., Quintanar, L., Bertoncini, C.W., Souza, J.M., Cervenansky, C., Zweckstetter, M., Griesinger, C. and Fernandez, C.O. (2008) Site-specific interactions of Cu(II) with alpha and betαuclein: bridging the molecular gap between metal binding and aggregation. J. Am. Chem. Soc., 130, 11801-11812.
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 11801-11812
-
-
Binolfi, A.1
Lamberto, G.R.2
Duran, R.3
Quintanar, L.4
Bertoncini, C.W.5
Souza, J.M.6
Cervenansky, C.7
Zweckstetter, M.8
Griesinger, C.9
Fernandez, C.O.10
-
16
-
-
13444254033
-
Subcellular localisation of recombinant alpha- and gamma-synuclein
-
Specht, C.G., Tigaret, C.M., Rast, G.F., Thalhammer, A., Rudhard, Y. and Schoepfer, R. (2005) Subcellular localisation of recombinant alpha- and gamma-synuclein. Mol. Cell Neurosci., 28, 326-334.
-
(2005)
Mol. Cell Neurosci.
, vol.28
, pp. 326-334
-
-
Specht, C.G.1
Tigaret, C.M.2
Rast, G.F.3
Thalhammer, A.4
Rudhard, Y.5
Schoepfer, R.6
-
17
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both alph-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy
-
Conway, K.A., Lee, S.J., Rochet, J.C., Ding, T.T., Williamson, R.E. and Lansbury, P.T. Jr (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both alph-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc. Natl Acad. Sci. USA, 97, 571-576.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.J.2
Rochet, J.C.3
Ding, T.T.4
Williamson, R.E.5
Lansbury Jr., P.T.6
-
18
-
-
0032540327
-
Stabilization of Alph-synuclein secondary structure upon binding to synthetic membranes
-
Davidson, W.S., Jonas, A., Clayton, D.F. and George, J.M. (1998) Stabilization of Alph-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem., 273, 9443-9449.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9443-9449
-
-
Davidson, W.S.1
Jonas, A.2
Clayton, D.F.3
George, J.M.4
-
19
-
-
73549085595
-
Increased expression of Alph-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
-
Nemani, V.M., Lu, W., Berge, V., Nakamura, K., Onoa, B., Lee, M.K., Chaudhry, F.A., Nicoll, R.A. and Edwards, R.H. (2010) Increased expression of Alph-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron, 65, 66-79.
-
(2010)
Neuron
, vol.65
, pp. 66-79
-
-
Nemani, V.M.1
Lu, W.2
Berge, V.3
Nakamura, K.4
Onoa, B.5
Lee, M.K.6
Chaudhry, F.A.7
Nicoll, R.A.8
Edwards, R.H.9
-
20
-
-
33746533924
-
Alph-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
-
Cooper, A.A., Gitler, A.D., Cashikar, A., Haynes, C.M., Hill, K.J., Bhullar, B., Liu, K., Xu, K., Strathearn, K.E., Liu, F. et al. (2006) Alph-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science, 313, 324-328.
-
(2006)
Science
, vol.313
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Hill, K.J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Liu, F.10
-
21
-
-
1842424791
-
Proteasomal inhibition by alph-synuclein filaments and oligomers
-
Lindersson, E., Beedholm, R., Hojrup, P., Moos, T., Gai, W., Hendil, K.B. and Jensen, P.H. (2004) Proteasomal inhibition by alph-synuclein filaments and oligomers. J. Biol. Chem., 279, 12924-12934.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12924-12934
-
-
Lindersson, E.1
Beedholm, R.2
Hojrup, P.3
Moos, T.4
Gai, W.5
Hendil, K.B.6
Jensen, P.H.7
-
22
-
-
11344262265
-
Ubiquitin-proteasome system and Parkinson's diseases
-
Betarbet, R., Sherer, T.B. and Greenamyre, J.T. (2005) Ubiquitin-proteasome system and Parkinson's diseases. Exp. Neurol., 191, (Suppl. 1), S17-S27.
-
(2005)
Exp. Neurol.
, vol.191
, Issue.SUPPL. 1
-
-
Betarbet, R.1
Sherer, T.B.2
Greenamyre, J.T.3
-
23
-
-
0036278335
-
Dopamine-dependent neurotoxicity of alph-synuclein: a mechanism for selective neurodegeneration in Parkinson disease
-
Xu, J., Kao, S.Y., Lee, F.J., Song, W., Jin, L.W. and Yankner, B.A. (2002) Dopamine-dependent neurotoxicity of alph-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat. Med., 8, 600-606.
-
(2002)
Nat. Med.
, vol.8
, pp. 600-606
-
-
Xu, J.1
Kao, S.Y.2
Lee, F.J.3
Song, W.4
Jin, L.W.5
Yankner, B.A.6
-
24
-
-
23644442282
-
Heat shock prevents Alph-synuclein-induced apoptosis in a yeast model of Parkinson's disease
-
Flower, T.R., Chesnokova, L.S., Froelich, C.A., Dixon, C. and Witt, S.N. (2005) Heat shock prevents Alph-synuclein-induced apoptosis in a yeast model of Parkinson's disease. J. Mol. Biol., 351, 1081-1100.
-
(2005)
J. Mol. Biol.
, vol.351
, pp. 1081-1100
-
-
Flower, T.R.1
Chesnokova, L.S.2
Froelich, C.A.3
Dixon, C.4
Witt, S.N.5
-
25
-
-
0037130174
-
Neurodegenerative disease: amyloid pores from pathogenic mutations
-
Lashuel, H.A., Hartley, D., Petre, B.M., Walz, T. and Lansbury, P.T. Jr (2002) Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature, 418, 291.
-
(2002)
Nature
, vol.418
, pp. 291
-
-
Lashuel, H.A.1
Hartley, D.2
Petre, B.M.3
Walz, T.4
Lansbury Jr., P.T.5
-
26
-
-
0037046163
-
Vesicle permeabilization by protofibrillar Alph-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism
-
Volles, M.J. and Lansbury, P.T. Jr (2002) Vesicle permeabilization by protofibrillar Alph-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism. Biochemistry, 41, 4595-4602.
-
(2002)
Biochemistry
, vol.41
, pp. 4595-4602
-
-
Volles, M.J.1
Lansbury Jr., P.T.2
-
27
-
-
0038334899
-
Alph-synuclein overexpression protects against paraquat-induced neurodegeneration
-
Manning-Bog, A.B., McCormack, A.L., Purisai, M.G., Bolin, L.M. and Di Monte, D.A. (2003) Alph-synuclein overexpression protects against paraquat-induced neurodegeneration. J. Neurosci., 23, 3095-3099.
-
(2003)
J. Neurosci.
, vol.23
, pp. 3095-3099
-
-
Manning-Bog, A.B.1
McCormack, A.L.2
Purisai, M.G.3
Bolin, L.M.4
Di Monte, D.A.5
-
28
-
-
77950864743
-
Prosurvival effect of human wild-type Alph-synuclein on MPTP-induced toxicity to central but not peripheral catecholaminergic neurons isolated from transgenic mice
-
Perez-Sanchez, F., Milan, M., Buendia, P., Cano-Jaimez, M., Ambrosio, S., Rosenthal, A. and Farinas, I. (2010) Prosurvival effect of human wild-type Alph-synuclein on MPTP-induced toxicity to central but not peripheral catecholaminergic neurons isolated from transgenic mice. Neuroscience, 167, 261-276.
-
(2010)
Neuroscience
, vol.167
, pp. 261-276
-
-
Perez-Sanchez, F.1
Milan, M.2
Buendia, P.3
Cano-Jaimez, M.4
Ambrosio, S.5
Rosenthal, A.6
Farinas, I.7
-
29
-
-
77649181035
-
Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by Alph-synuclein
-
Cano-Jaimez, M., Perez-Sanchez, F., Milan, M., Buendia, P., Ambrosio, S. and Farinas, I. (2010) Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by Alph-synuclein. Neurobiol. Dis., 38, 92-103.
-
(2010)
Neurobiol. Dis.
, vol.38
, pp. 92-103
-
-
Cano-Jaimez, M.1
Perez-Sanchez, F.2
Milan, M.3
Buendia, P.4
Ambrosio, S.5
Farinas, I.6
-
30
-
-
77955176216
-
In vivo RNAi-mediated alph-synuclein silencing induces nigrostriatal degeneration
-
Gorbatyuk, O.S., Li, S., Nash, K., Gorbatyuk, M., Lewin, A.S., Sullivan, L.F., Mandel, R.J., Chen, W., Meyers, C., Manfredsson, F.P. et al. (2010) In vivo RNAi-mediated alph-synuclein silencing induces nigrostriatal degeneration. Mol. Ther., 18, 1450-1457.
-
(2010)
Mol. Ther.
, vol.18
, pp. 1450-1457
-
-
Gorbatyuk, O.S.1
Li, S.2
Nash, K.3
Gorbatyuk, M.4
Lewin, A.S.5
Sullivan, L.F.6
Mandel, R.J.7
Chen, W.8
Meyers, C.9
Manfredsson, F.P.10
-
31
-
-
27544507306
-
Alph-synuclein cooperates with CSPalpha in preventing neurodegeneration
-
Chandra, S., Gallardo, G., Fernandez-Chacon, R., Schluter, O.M. and Sudhof, T.C. (2005) Alph-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell, 123, 383-396.
-
(2005)
Cell
, vol.123
, pp. 383-396
-
-
Chandra, S.1
Gallardo, G.2
Fernandez-Chacon, R.3
Schluter, O.M.4
Sudhof, T.C.5
-
32
-
-
67650156461
-
Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease
-
Bayir, H., Kapralov, A.A., Jiang, J., Huang, Z., Tyurina, Y.Y., Tyurin, V.A., Zhao, Q., Belikova, N.A., Vlasova, I.I., Maeda, A. et al. (2009) Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease. J. Biol. Chem., 284, 15951-15969.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 15951-15969
-
-
Bayir, H.1
Kapralov, A.A.2
Jiang, J.3
Huang, Z.4
Tyurina, Y.Y.5
Tyurin, V.A.6
Zhao, Q.7
Belikova, N.A.8
Vlasova, I.I.9
Maeda, A.10
-
33
-
-
79251572323
-
Alph-synuclein is a cellular ferrireductase
-
Davies, P., Moualla, D. and Brown, D.R. (2011) Alph-synuclein is a cellular ferrireductase. PLoS ONE, 6, e15814.
-
(2011)
PLoS ONE
, vol.6
-
-
Davies, P.1
Moualla, D.2
Brown, D.R.3
-
34
-
-
0345189364
-
Yeast cells provide insight into alph-synuclein biology and pathobiology
-
Outeiro, T.F. and Lindquist, S. (2003) Yeast cells provide insight into alph-synuclein biology and pathobiology. Science, 302, 1772-1775.
-
(2003)
Science
, vol.302
, pp. 1772-1775
-
-
Outeiro, T.F.1
Lindquist, S.2
-
35
-
-
0031587849
-
14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae
-
Roberts, R.L., Mosch, H.U. and Fink, G.R. (1997) 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae. Cell, 89, 1055-1065.
-
(1997)
Cell
, vol.89
, pp. 1055-1065
-
-
Roberts, R.L.1
Mosch, H.U.2
Fink, G.R.3
-
36
-
-
77951530523
-
Genotype to phenotype: a complex problem
-
Dowell, R.D., Ryan, O., Jansen, A., Cheung, D., Agarwala, S., Danford, T., Bernstein, D.A., Rolfe, P.A., Heisler, L.E., Chin, B. et al. (2010) Genotype to phenotype: a complex problem. Science, 328, 469.
-
(2010)
Science
, vol.328
, pp. 469
-
-
Dowell, R.D.1
Ryan, O.2
Jansen, A.3
Cheung, D.4
Agarwala, S.5
Danford, T.6
Bernstein, D.A.7
Rolfe, P.A.8
Heisler, L.E.9
Chin, B.10
-
37
-
-
33749583553
-
{alpha}-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
-
Kontopoulos, E., Parvin, J.D. and Feany, M.B. (2006) {alpha}-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum. Mol. Genet., 15, 3012-3023.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 3012-3023
-
-
Kontopoulos, E.1
Parvin, J.D.2
Feany, M.B.3
-
38
-
-
79952754637
-
Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase
-
Tatchell, K., Makrantoni, V., Stark, M.J. and Robinson, L.C. (2011) Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase. Proc. Natl Acad. Sci. USA, 108, 3994-3999.
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 3994-3999
-
-
Tatchell, K.1
Makrantoni, V.2
Stark, M.J.3
Robinson, L.C.4
-
39
-
-
0038456964
-
Nuclear localization of alph-synuclein and its interaction with histones
-
Goers, J., Manning-Bog, A.B., McCormack, A.L., Millett, I.S., Doniach, S., Di Monte, D.A., Uversky, V.N. and Fink, A.L. (2003) Nuclear localization of alph-synuclein and its interaction with histones. Biochemistry, 42, 8465-8471.
-
(2003)
Biochemistry
, vol.42
, pp. 8465-8471
-
-
Goers, J.1
Manning-Bog, A.B.2
McCormack, A.L.3
Millett, I.S.4
Doniach, S.5
Di Monte, D.A.6
Uversky, V.N.7
Fink, A.L.8
-
40
-
-
0023011595
-
Changes in nuclear protein acetylation in u.v-damaged human cells
-
Ramanathan, B. and Smerdon, M.J. (1986) Changes in nuclear protein acetylation in u.v.-damaged human cells. Carcinogenesis, 7, 1087-1094.
-
(1986)
Carcinogenesis
, vol.7
, pp. 1087-1094
-
-
Ramanathan, B.1
Smerdon, M.J.2
-
41
-
-
0035577668
-
Histone H3 specific acetyltransferases are essential for cell cycle progression
-
Howe, L., Auston, D., Grant, P., John, S., Cook, R.G., Workman, J.L. and Pillus, L. (2001) Histone H3 specific acetyltransferases are essential for cell cycle progression. Genes Dev., 15, 3144-3154.
-
(2001)
Genes Dev.
, vol.15
, pp. 3144-3154
-
-
Howe, L.1
Auston, D.2
Grant, P.3
John, S.4
Cook, R.G.5
Workman, J.L.6
Pillus, L.7
-
42
-
-
0029808466
-
Cell cycle checkpoints: preventing an identity crisis
-
Elledge, S.J. (1996) Cell cycle checkpoints: preventing an identity crisis. Science, 274, 1664-1672.
-
(1996)
Science
, vol.274
, pp. 1664-1672
-
-
Elledge, S.J.1
-
43
-
-
0035797383
-
The DNA replication checkpoint response stabilizes stalled replication forks
-
Lopes, M., Cotta-Ramusino, C., Pellicioli, A., Liberi, G., Plevani, P., Muzi-Falconi, M., Newlon, C.S. and Foiani, M. (2001) The DNA replication checkpoint response stabilizes stalled replication forks. Nature, 412, 557-561.
-
(2001)
Nature
, vol.412
, pp. 557-561
-
-
Lopes, M.1
Cotta-Ramusino, C.2
Pellicioli, A.3
Liberi, G.4
Plevani, P.5
Muzi-Falconi, M.6
Newlon, C.S.7
Foiani, M.8
-
44
-
-
0035796505
-
The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/ Rad53 kinase cascade during growth and in response to DNA damage
-
Zhao, X., Chabes, A., Domkin, V., Thelander, L. and Rothstein, R. (2001) The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/ Rad53 kinase cascade during growth and in response to DNA damage. EMBO J., 20, 3544-3553.
-
(2001)
EMBO J.
, vol.20
, pp. 3544-3553
-
-
Zhao, X.1
Chabes, A.2
Domkin, V.3
Thelander, L.4
Rothstein, R.5
-
45
-
-
78049369559
-
The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage
-
Andreson, B.L., Gupta, A., Georgieva, B.P. and Rothstein, R. (2010) The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage. Nucleic Acids Res., 38, 6490-6501.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 6490-6501
-
-
Andreson, B.L.1
Gupta, A.2
Georgieva, B.P.3
Rothstein, R.4
-
46
-
-
48849102186
-
The Saccharomyces cerevisiae checkpoint genes RAD9 CHK1 and PDS1 are required for elevated homologous recombination in a mec1 (ATR) hypomorphic mutant
-
Fasullo, M. and Sun, M. (2008) The Saccharomyces cerevisiae checkpoint genes RAD9, CHK1 and PDS1 are required for elevated homologous recombination in a mec1 (ATR) hypomorphic mutant. Cell Cycle, 7, 2418-2426.
-
(2008)
Cell Cycle
, vol.7
, pp. 2418-2426
-
-
Fasullo, M.1
Sun, M.2
-
47
-
-
37249025795
-
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress
-
Ge, X.Q., Jackson, D.A. and Blow, J.J. (2007) Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev., 21, 3331-3341.
-
(2007)
Genes Dev.
, vol.21
, pp. 3331-3341
-
-
Ge, X.Q.1
Jackson, D.A.2
Blow, J.J.3
-
48
-
-
48249084972
-
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
-
Ibarra, A., Schwob, E. and Mendez, J. (2008) Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc. Natl Acad. Sci. USA, 105, 8956-8961.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 8956-8961
-
-
Ibarra, A.1
Schwob, E.2
Mendez, J.3
-
49
-
-
70350103981
-
The S-phase checkpoint: targeting the replication fork
-
Segurado, M. and Tercero, J.A. (2009) The S-phase checkpoint: targeting the replication fork. Biol. Cell, 101, 617-627.
-
(2009)
Biol. Cell
, vol.101
, pp. 617-627
-
-
Segurado, M.1
Tercero, J.A.2
-
50
-
-
33747432986
-
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress
-
Woodward, A.M., Gohler, T., Luciani, M.G., Oehlmann, M., Ge, X., Gartner, A., Jackson, D.A. and Blow, J.J. (2006) Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J. Cell Biol., 173, 673-683.
-
(2006)
J. Cell Biol.
, vol.173
, pp. 673-683
-
-
Woodward, A.M.1
Gohler, T.2
Luciani, M.G.3
Oehlmann, M.4
Ge, X.5
Gartner, A.6
Jackson, D.A.7
Blow, J.J.8
-
51
-
-
33846818840
-
Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56
-
Driscoll, R., Hudson, A. and Jackson, S.P. (2007) Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science, 315, 649-652.
-
(2007)
Science
, vol.315
, pp. 649-652
-
-
Driscoll, R.1
Hudson, A.2
Jackson, S.P.3
-
52
-
-
34347258162
-
The Rtt109-Vps75 histone acetyltransferase complex acetylates non-nucleosomal histone H3
-
Han, J., Zhou, H., Li, Z., Xu, R.M. and Zhang, Z. (2007) The Rtt109-Vps75 histone acetyltransferase complex acetylates non-nucleosomal histone H3. J. Biol. Chem., 282, 14158-14164.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14158-14164
-
-
Han, J.1
Zhou, H.2
Li, Z.3
Xu, R.M.4
Zhang, Z.5
-
53
-
-
0027501142
-
A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase
-
Koch, C., Moll, T., Neuberg, M., Ahorn, H. and Nasmyth, K. (1993) A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase. Science, 261, 1551-1557.
-
(1993)
Science
, vol.261
, pp. 1551-1557
-
-
Koch, C.1
Moll, T.2
Neuberg, M.3
Ahorn, H.4
Nasmyth, K.5
-
54
-
-
28544441180
-
DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex
-
Mulder, K.W., Winkler, G.S. and Timmers, H.T. (2005) DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex. Nucleic Acids Res., 33, 6384-6392.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 6384-6392
-
-
Mulder, K.W.1
Winkler, G.S.2
Timmers, H.T.3
-
55
-
-
71249158149
-
SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast
-
Mimura, S., Komata, M., Kishi, T., Shirahige, K. and Kamura, T. (2009) SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast. EMBO J., 28, 3693-3705.
-
(2009)
EMBO J.
, vol.28
, pp. 3693-3705
-
-
Mimura, S.1
Komata, M.2
Kishi, T.3
Shirahige, K.4
Kamura, T.5
-
56
-
-
77956660837
-
Ubc4 and Not4 regulate steady-state levels of DNA polymerase-alpha to promote efficient and accurate DNA replication
-
Haworth, J., Alver, R.C., Anderson, M. and Bielinsky, A.K. (2010) Ubc4 and Not4 regulate steady-state levels of DNA polymerase-alpha to promote efficient and accurate DNA replication. Mol. Biol. Cell, 21, 3205-3219.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 3205-3219
-
-
Haworth, J.1
Alver, R.C.2
Anderson, M.3
Bielinsky, A.K.4
-
57
-
-
71149107246
-
Hydroxyurea triggers cellular responses that actively cause bacterial cell death
-
Bollenbach, T. and Kishony, R. (2009) Hydroxyurea triggers cellular responses that actively cause bacterial cell death. Mol. Cell, 36, 728-729.
-
(2009)
Mol. Cell
, vol.36
, pp. 728-729
-
-
Bollenbach, T.1
Kishony, R.2
-
58
-
-
71149083755
-
Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli
-
Davies, B.W., Kohanski, M.A., Simmons, L.A., Winkler, J.A., Collins, J.J. and Walker, G.C. (2009) Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli. Mol. Cell, 36, 845-860.
-
(2009)
Mol. Cell
, vol.36
, pp. 845-860
-
-
Davies, B.W.1
Kohanski, M.A.2
Simmons, L.A.3
Winkler, J.A.4
Collins, J.J.5
Walker, G.C.6
-
59
-
-
31644442907
-
Production of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast
-
Marchetti, M.A., Weinberger, M., Murakami, Y., Burhans, W.C. and Huberman, J.A. (2006) Production of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast. J. Cell Sci., 119, 124-131.
-
(2006)
J. Cell Sci.
, vol.119
, pp. 124-131
-
-
Marchetti, M.A.1
Weinberger, M.2
Murakami, Y.3
Burhans, W.C.4
Huberman, J.A.5
-
60
-
-
59649096230
-
Microarray expression analysis of human dopaminergic neuroblastoma cells after RNA interference of SNCA-a key player in the pathogenesis of Parkinson's disease
-
Habig, K., Walter, M., Stappert, H., Riess, O. and Bonin, M. (2009) Microarray expression analysis of human dopaminergic neuroblastoma cells after RNA interference of SNCA-a key player in the pathogenesis of Parkinson's disease. Brain Res., 1256, 19-33.
-
(2009)
Brain Res.
, vol.1256
, pp. 19-33
-
-
Habig, K.1
Walter, M.2
Stappert, H.3
Riess, O.4
Bonin, M.5
-
61
-
-
0033681149
-
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
-
Betarbet, R., Sherer, T.B., MacKenzie, G., Garcia-Osuna, M., Panov, A.V. and Greenamyre, J.T. (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci., 3, 1301-1306.
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 1301-1306
-
-
Betarbet, R.1
Sherer, T.B.2
MacKenzie, G.3
Garcia-Osuna, M.4
Panov, A.V.5
Greenamyre, J.T.6
-
62
-
-
79955557808
-
Rotenone Paraquat and Parkinson's Disease
-
doi: 10. 1289/ehp.1002839
-
Tanner, C.M., Kamel, F., Ross, G.W., Hoppin, J.A., Goldman, S.M., Korell, M., Marras, C., Bhudhikanok, G.S., Kasten, M., Chade, A.R. et al. (2011) Rotenone, Paraquat and Parkinson's Disease. Environ. Health Perspect, 119, 866-872. doi: 10.1289/ehp.1002839.
-
(2011)
Environ. Health Perspect
, vol.119
, pp. 866-872
-
-
Tanner, C.M.1
Kamel, F.2
Ross, G.W.3
Hoppin, J.A.4
Goldman, S.M.5
Korell, M.6
Marras, C.7
Bhudhikanok, G.S.8
Kasten, M.9
Chade, A.R.10
-
63
-
-
29644434199
-
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alph-synuclein-induced toxicity
-
Smith, W.W., Jiang, H., Pei, Z., Tanaka, Y., Morita, H., Sawa, A., Dawson, V.L., Dawson, T.M. and Ross, C.A. (2005) Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alph-synuclein-induced toxicity. Hum. Mol. Genet., 14, 3801-3811.
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 3801-3811
-
-
Smith, W.W.1
Jiang, H.2
Pei, Z.3
Tanaka, Y.4
Morita, H.5
Sawa, A.6
Dawson, V.L.7
Dawson, T.M.8
Ross, C.A.9
-
64
-
-
15744362063
-
Structure and dynamics of micelle-bound human alph-synuclein
-
Ulmer, T.S., Bax, A., Cole, N.B. and Nussbaum, R.L. (2005) Structure and dynamics of micelle-bound human alph-synuclein. J. Biol. Chem., 280, 9595-9603.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 9595-9603
-
-
Ulmer, T.S.1
Bax, A.2
Cole, N.B.3
Nussbaum, R.L.4
-
65
-
-
0038386274
-
Zeroing in on the pathogenic form of alph-synuclein and its mechanism of neurotoxicity in Parkinson's disease
-
Volles, M.J. and Lansbury, P.T. Jr (2003) Zeroing in on the pathogenic form of alph-synuclein and its mechanism of neurotoxicity in Parkinson's disease. Biochemistry, 42, 7871-7878.
-
(2003)
Biochemistry
, vol.42
, pp. 7871-7878
-
-
Volles, M.J.1
Lansbury Jr., P.T.2
-
66
-
-
78650872712
-
The synucleins are a family of redox-active copper binding proteins
-
Davies, P., Wang, X., Sarell, C.J., Drewett, A., Marken, F., Viles, J.H. and Brown, D.R. (2010) The synucleins are a family of redox-active copper binding proteins. Biochemistry, 50, 37-47.
-
(2010)
Biochemistry
, vol.50
, pp. 37-47
-
-
Davies, P.1
Wang, X.2
Sarell, C.J.3
Drewett, A.4
Marken, F.5
Viles, J.H.6
Brown, D.R.7
-
67
-
-
79952493196
-
Copper(ii) enhances membrane-bound alph-synuclein helix formation
-
Lucas, H.R. and Lee, J.C. (2011) Copper(ii) enhances membrane-bound alph-synuclein helix formation. Metallomics, 3, 280-283.
-
(2011)
Metallomics
, vol.3
, pp. 280-283
-
-
Lucas, H.R.1
Lee, J.C.2
-
68
-
-
0023853637
-
Treatment of medulloblastoma with procarbazine, hydroxyurea, and reduced radiation doses to whole brain and spine
-
Levin, V.A., Rodriguez, L.A., Edwards, M.S., Wara, W., Liu, H.C., Fulton, D., Davis, R.L., Wilson, C.B. and Silver, P. (1988) Treatment of medulloblastoma with procarbazine, hydroxyurea, and reduced radiation doses to whole brain and spine. J. Neurosurg., 68, 383-387.
-
(1988)
J. Neurosurg.
, vol.68
, pp. 383-387
-
-
Levin, V.A.1
Rodriguez, L.A.2
Edwards, M.S.3
Wara, W.4
Liu, H.C.5
Fulton, D.6
Davis, R.L.7
Wilson, C.B.8
Silver, P.9
-
69
-
-
77950657921
-
Hydroxyurea enhances sickle survival
-
Eckman, J.R. (2010) Hydroxyurea enhances sickle survival. Blood, 115, 2331-2332.
-
(2010)
Blood
, vol.115
, pp. 2331-2332
-
-
Eckman, J.R.1
-
70
-
-
0003559611
-
-
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
-
Burke, D., Dawson, D. and Stearns, T. (2000) Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
-
(2000)
Methods in Yeast Genetics
-
-
Burke, D.1
Dawson, D.2
Stearns, T.3
-
72
-
-
0037469147
-
The N-terminal repeat domain of Alph-synuclein inhibits beta-sheet and amyloid fibril formation
-
Kessler, J.C., Rochet, J.C. and Lansbury, P.T. Jr (2003) The N-terminal repeat domain of Alph-synuclein inhibits beta-sheet and amyloid fibril formation. Biochemistry, 42, 672-678.
-
(2003)
Biochemistry
, vol.42
, pp. 672-678
-
-
Kessler, J.C.1
Rochet, J.C.2
Lansbury Jr., P.T.3
-
73
-
-
0035692022
-
Relationship between the function and the location of G1 cyclins in S. cerevisiae
-
Edgington, N.P. and Futcher, B. (2001) Relationship between the function and the location of G1 cyclins in S. cerevisiae. J. Cell Sci., 114, 4599-4611.
-
(2001)
J. Cell Sci.
, vol.114
, pp. 4599-4611
-
-
Edgington, N.P.1
Futcher, B.2
-
74
-
-
34250723888
-
YGR198w (YPP1) targets A30P alph-synuclein to the vacuole for degradation
-
Flower, T.R., Clark-Dixon, C., Metoyer, C., Yang, H., Shi, R., Zhang, Z. and Witt, S.N. (2007) YGR198w (YPP1) targets A30P alph-synuclein to the vacuole for degradation. J. Cell Biol., 177, 1091-1104.
-
(2007)
J. Cell Biol.
, vol.177
, pp. 1091-1104
-
-
Flower, T.R.1
Clark-Dixon, C.2
Metoyer, C.3
Yang, H.4
Shi, R.5
Zhang, Z.6
Witt, S.N.7
-
75
-
-
0031437883
-
Estimation of oxidative stress in Saccharomyces cerevisae with fluorescent probes
-
Jakubowski, W. and Bartosz, G. (1997) Estimation of oxidative stress in Saccharomyces cerevisae with fluorescent probes. Int. J. Biochem. Cell Biol., 29, 1297-1301.
-
(1997)
Int. J. Biochem. Cell Biol.
, vol.29
, pp. 1297-1301
-
-
Jakubowski, W.1
Bartosz, G.2
-
76
-
-
33846361805
-
Programmed cell death-involved aluminum toxicity in yeast alleviated by antiapoptotic members with decreased calcium signals
-
Zheng, K., Pan, J.W., Ye, L., Fu, Y., Peng, H.Z., Wan, B.Y., Gu, Q., Bian, H.W., Han, N., Wang, J.H. et al. (2007) Programmed cell death-involved aluminum toxicity in yeast alleviated by antiapoptotic members with decreased calcium signals. Plant Physiol., 143, 38-49.
-
(2007)
Plant Physiol.
, vol.143
, pp. 38-49
-
-
Zheng, K.1
Pan, J.W.2
Ye, L.3
Fu, Y.4
Peng, H.Z.5
Wan, B.Y.6
Gu, Q.7
Bian, H.W.8
Han, N.9
Wang, J.H.10
-
77
-
-
38149041804
-
Immunogold quantification of amino acids and proteins in complex subcellular compartments
-
Bergersen, L.H., Storm-Mathisen, J. and Gundersen, V. (2008) Immunogold quantification of amino acids and proteins in complex subcellular compartments. Nat. Protoc., 3, 144-152.
-
(2008)
Nat. Protoc.
, vol.3
, pp. 144-152
-
-
Bergersen, L.H.1
Storm-Mathisen, J.2
Gundersen, V.3
-
78
-
-
0034460153
-
Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality
-
Zhao, X., Georgieva, B., Chabes, A., Domkin, V., Ippel, J.H., Schleucher, J., Wijmenga, S., Thelander, L. and Rothstein, R. (2000) Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality. Mol. Cell Biol., 20, 9076-9083.
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 9076-9083
-
-
Zhao, X.1
Georgieva, B.2
Chabes, A.3
Domkin, V.4
Ippel, J.H.5
Schleucher, J.6
Wijmenga, S.7
Thelander, L.8
Rothstein, R.9
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