Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 10, 2011, Pages 3994-3999

  Tatchell, Kelly ^a   Makrantoni, Vasso ^b   Stark, Michael J R ^b   Robinson, Lucy C ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; HISTONE H3; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATASE; PROTEIN GLC 7; PROTEIN KINASE; PROTEIN LPL 1; PROTEIN PP 1; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CHROMOSOME SEGREGATION; ENZYME ACTIVITY; ENZYME REPRESSION; GENE INTERACTION; GENE MUTATION; HEAT SENSITIVITY; NONHUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; TEMPERATURE SENSITIVITY;

CELL NUCLEUS; CHROMOSOME DELETION; CHROMOSOMES, FUNGAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN PHOSPHATASE 1; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 79952754637     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1014406108     Document Type: Article

References (46)

1. Ruchaud S, Carmena M, Earnshaw WC (2007) Chromosomal passengers: Conducting cell division. Nat Rev Mol Cell Biol 8:798-812. (Pubitemid 47462135)
2. He X, Rines DR, Espelin CW, Sorger PK (2001) Molecular analysis of kinetochoremicrotubule attachment in budding yeast. Cell 106:195-206. (Pubitemid 32772630)
3. Biggins S, et al. (1999) The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev 13:532-544. (Pubitemid 29131878)
4. Tanaka TU, et al. (2002) Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108:317-329. (Pubitemid 34178397)
5. Lampson MA, Renduchitala K, Khodjakov A, Kapoor TM (2004) Correcting improper chromosome-spindle attachments during cell division. Nat Cell Biol 6:232-237. (Pubitemid 38344361)
6. Hauf S, et al. (2003) The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 161:281-294. (Pubitemid 36529847)
7. Tanaka TU, Stark MJ, Tanaka K (2005) Kinetochore capture and bi-orientation on the mitotic spindle. Nat Rev Mol Cell Biol 6:929-942. (Pubitemid 41778712)
8. Gestaut DR, et al. (2008) Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation. Nat Cell Biol 10:407-414.
9. Lampert F, Hornung P, Westermann S (2010) The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex. J Cell Biol 189:641-649.
10. Tien JF, et al. (2010) Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by Aurora B. J Cell Biol 189:713-723.
11. Keating P, Rachidi N, Tanaka TU, Stark MJ (2009) Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores. J Cell Sci 122:4375-4382.
12. Francisco L, Wang W, Chan CSM (1994) Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Mol Cell Biol 14:4731-4740. (Pubitemid 24196823)
13. Hsu J-Y, et al. (2000) Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102:279-291.
14. Pinsky BA, Kotwaliwale CV, Tatsutani SY, Breed CA, Biggins S (2006) Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Mol Cell Biol 26:2648-2660.
15. Bloecher A, Tatchell K (1999) Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpoint. Genes Dev 13:517-522. (Pubitemid 29131876)
16. Sassoon I, et al. (1999) Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. Genes Dev 13:545-555. (Pubitemid 29131879)
17. Emanuele MJ, et al. (2008) Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly. J Cell Biol 181:241-254. (Pubitemid 351574550)
18. Bollen M, Peti W, Ragusa MJ, Beullens M (2010) The extended PP1 toolkit: Designed to create specificity. Trends Biochem Sci 35:450-458.
19. Liu D, et al. (2010) Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J Cell Biol 188:809-820.
20. Kim Y, Holland AJ, Lan W, Cleveland DW (2010) Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell 142:444-455.
21. Akiyoshi B, Nelson CR, Ranish JA, Biggins S (2009) Analysis of Ipl1-mediated phosphorylation of the Ndc80 kinetochore protein in Saccharomyces cerevisiae. Genetics 183:1591-1595.
22. Woodbury EL, Morgan DO (2007) Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol 9:106-112. (Pubitemid 46024204)
23. Tung HY, Wang W, Chan CS (1995) Regulation of chromosome segregation by Glc8p, a structural homolog of mammalian inhibitor 2 that functions as both an activator and an inhibitor of yeast protein phosphatase 1. Mol Cell Biol 15:6064-6074.
24. Peggie MW, et al. (2002) Essential functions of Sds22p in chromosome stability and nuclear localization of PP1. J Cell Sci 115:195-206. (Pubitemid 34105542)
25. Bharucha JP, Larson JR, Gao L, Daves LK, Tatchell K (2008) Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae. Mol Biol Cell 19:1032-1045. (Pubitemid 351481817)
26. Cheng YL, Chen RH (2010) The AAA-ATPase Cdc48 and cofactor Shp1 promote chromosome bi-orientation by balancing Aurora B activity. J Cell Sci 123:2025-2034.
27. Chan CS, Botstein D (1993) Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics 135:677-691. (Pubitemid 23324813)
28. Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279:14752-14762. (Pubitemid 38618865)
29. Soulard A, Cohen A, Hall MN (2009) TOR signaling in invertebrates. Curr Opin Cell Biol 21:825-836.
30. Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10:457-468. (Pubitemid 35284167)
31. Reinke A, Chen JC, Aronova S, Powers T (2006) Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p. J Biol Chem 281:31616-31626.
32. Wanke V, et al. (2008) Caffeine extends yeast lifespan by targeting TORC1. Mol Microbiol 69:277-285. (Pubitemid 351832771)
33. Straight AF, Marshall WF, Sedat JW, Murray AW (1997) Mitosis in living budding yeast: Anaphase A but no metaphase plate. Science 277:574-578. (Pubitemid 27369007)
34. Zhang K, et al. (2005) The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell 122:723-734. (Pubitemid 41242637)
35. Bloecher A, Tatchell K (2000) Dynamic localization of protein phosphatase type 1 in the mitotic cell cycle of Saccharomyces cerevisiae. J Cell Biol 149:125-140. (Pubitemid 30196704)
36. Huber A, et al. (2009) Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev 23:1929-1943.
37. Urban J, et al. (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 26:663-674. (Pubitemid 46856238)
38. De Virgilio C, Loewith R (2006) Cell growth control: Little eukaryotes make big contributions. Oncogene 25:6392-6415. (Pubitemid 44582284)
39. Soulard A, et al. (2010) The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates. Mol Biol Cell 21:3475-3486.
40. Zhang S, Guha S, Volkert FC (1995) The Saccharomyces SHP1 gene, which encodes a regulator of phosphoprotein phosphatase 1 with differential effects on glycogen metabolism, meiotic differentiation, and mitotic cell cycle progression. Mol Cell Biol 15:2037-2050.
41. Jentsch S, Rumpf S (2007) Cdc48 (p97): A "molecular gearbox" in the ubiquitin pathway? Trends Biochem Sci 32:6-11.
42. Ramadan K, et al. (2007) Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature 450:1258-1262.
43. McCartney RR, Schmidt MC (2001) Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit. J Biol Chem 276:36460-36466. (Pubitemid 37384256)
44. Hedbacker K, Carlson M (2008) SNF1/AMPK pathways in yeast. Front Biosci 13:2408-2420. (Pubitemid 351599694)
45. Song J, Salek-Ardakani S, So T, Croft M (2007) The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat Immunol 8:64-73. (Pubitemid 46242360)
46. Cannon JF, Tatchell K (1987) Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase. Mol Cell Biol 7:2653-2663.