Polyamine homoeostasis as a drug target in pathogenic protozoa: Peculiarities and possibilities

Biochemical Journal

Volumn 438, Issue 2, 2011, Pages 229-244

  Birkholtz, Lyn Marie ^a   Williams, Marni ^a   Niemand, Jandeli ^a   Louw, Abraham I ^a   Persson, Lo ^b   Heby, Olle ^c  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b LUND UNIVERSITY   (Sweden)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

difluoromethylornithine; Leishmania; Malaria; Ornithine decarboxylase (ODC); Polyamine; S adenosylmethionine decarboxylase (AdoMetDC); Spermidine synthase; Trypanosoma

Indexed keywords

1,4 DIAMINO 2 BUTANONE; 3 AMINOOXYPROPYLAMINE; 5' [(4 AMINO 2 BUTENYL)METHYLAMINO] 5' DEOXYADENOSINE; ADENOSYLMETHIONINE DECARBOXYLASE; AMPHOTERICIN B; ANTIPROTOZOAL AGENT; BENZNIDAZOLE; CGC 11211; CGC 11226; CGC 11235; CGP 498664A; CPG 40215A; CYCLOHEXYLAMINE; DICYCLOHEXYLAMINE DERIVATIVE; EFLORNITHINE; MDL 27699; MDL 28302; MDL 29431; MEFLOQUINE; MITOGUAZONE; N,N' BIS(3 BENZYLAMINOPROPYL) 1,7 HEPTANEDIAMINE; NIFURTIMOX; ORNITHINE DECARBOXYLASE; POLYAMINE; PUTRESCINE; PUTRESCINE DERIVATIVE; PYRIMETHAMINE; SULFADOXINE; TRYPANOTHIONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AFRICAN TRYPANOSOMIASIS; ANTIPROTOZOAL ACTIVITY; CHAGAS DISEASE; DETOXIFICATION; DRUG COST; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HOMEOSTASIS; HUMAN; KINETOPLASTIDA; LEISHMANIASIS; MALARIA; MYXOGASTRIA; NONHUMAN; PARASITE VIRULENCE; POLYAMINE METABOLISM; PRIORITY JOURNAL; PROTON TRANSPORT; PROTOZOON; REVIEW; TRYPANOSOMA BRUCEI; UNSPECIFIED SIDE EFFECT;

ANIMALS; ANTIPROTOZOAL AGENTS; HOMEOSTASIS; HOST-PATHOGEN INTERACTIONS; HUMANS; PARASITES; POLYAMINES;

PROTOZOA; TRYPANOSOMA; TRYPANOSOMATIDAE;

EID: 80051673618     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110362     Document Type: Review

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