Crystal structure of human spermine synthase: Implications of substrate binding and catalytic mechanism

Journal of Biological Chemistry

Volumn 283, Issue 23, 2008, Pages 16135-16146

  Wu, Hong ^a   Min, Jinrong ^a   Zeng, Hong ^a   McCloskey, Diane E ^b   Ikeguchi, Yoshihiko ^b,e   Loppnau, Peter ^a   Michael, Anthony J ^c   Pegg, Anthony E ^b   Plotnikov, Alexander N ^a,d,f  

^a UNIVERSITY OF TORONTO   (Canada)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^c INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^d UNIVERSITY OF TORONTO   (Canada)

^e JOSAI UNIVERSITY   (Japan)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVITY; MODEL STRUCTURES; PLANTS (BOTANY); PORT TERMINALS; QUANTUM CHEMISTRY; SUBSTRATES; TRACE ANALYSIS;

ACTIVE SITES; AMINOPROPYL; BINDING POCKETS; CATALYTIC MECHANISMS; DECARBOXYLASE; DO-MAINS; DONOR SUBSTRATES; EVOLUTIONARY ORIGINS; KEY PARTS; LARGER SUBSTRATES; PLAUSIBLE MODELS; POTENT INHIBITIONS; SPERMIDINE; SPERMIDINE SYNTHASE; STRUCTURAL SIMILARITIES; SUBSTRATE BINDINGS; SYNTHASE; SYNTHASES; TERMINAL DOMAINS; TERNARY COMPLEXES;

ENZYMES;

5' METHYLTHIOADENOSINE; ADENOSYLMETHIONINE DECARBOXYLASE; ASPARTIC ACID; DIMER; PROTEIN SUBUNIT; SPERMIDINE; SPERMIDINE SYNTHASE; SPERMINE; SPERMINE SYNTHASE; 5'-METHYLTHIOADENOSINE; DEOXYADENOSINE DERIVATIVE; NUCLEOSIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; GENE DELETION; GENETICS; HUMAN; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DEOXYADENOSINES; DIMERIZATION; HUMANS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; SPERMIDINE; SPERMIDINE SYNTHASE; SPERMINE SYNTHASE; STRUCTURAL HOMOLOGY, PROTEIN; THIONUCLEOSIDES;

EID: 47049102867     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M710323200     Document Type: Article

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