A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane

Biochemical Journal

Volumn 405, Issue 2, 2007, Pages 261-268

  Dufe, Veronica T ^a   Ingner, Daniel ^a   Heby, Olle ^b   Khomutov, Alex R ^c   Persson, Lo ^d   Al Karadaghi, Salam ^a  

^a LUND UNIVERSITY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^d LUND UNIVERSITY   (Sweden)

Author keywords

Cancer; Drug target; Inhibitor complex; Polyamine synthesis; Tropical parasite

Indexed keywords

DRUG TARGETS; INHIBITOR COMPLEXS; POLYAMINE SYNTHESIS; TROPICAL PARASITES;

BINDING SITES; CELL GROWTH; DRUG PRODUCTS; ONCOLOGY; SYNTHESIS (CHEMICAL);

ENZYME INHIBITION;

1 AMINO OXY 3 AMINOPROPANE; CADAVERINE; EFLORNITHINE; ORNITHINE DECARBOXYLASE; OXIME; PROPANE; PROTEINASE; PYRIDOXAL 5 PHOSPHATE; UNCLASSIFIED DRUG; 1-AMINOOXY-3-AMINOPROPANE; 3 AMINOOXYPROPYLAMINE; PROPYLAMINE;

ARTICLE; BINDING SITE; BIOSYNTHESIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; HUMAN; KINETICS; LEISHMANIA DONOVANI; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; ANIMAL; CHEMICAL STRUCTURE; CRYSTALLIZATION; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY;

LEISHMANIA DONOVANI;

ANIMALS; CADAVERINE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; LEISHMANIA DONOVANI; MODELS, MOLECULAR; ORNITHINE DECARBOXYLASE; PROPYLAMINES; PROTEIN BINDING; PYRIDOXAL PHOSPHATE;

EID: 34447117522     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070188     Document Type: Article

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