In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 6, 1996, Pages 1448-1453

  Bacchi, Cyrus J ^a   Brun, Reto ^b   Croft, Simon L ^c   Alicea, Karen ^a   Bühler, Yvonne ^b  

^a PACE UNIVERSITY   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSYLMETHIONINE DECARBOXYLASE INHIBITOR; ANTITRYPANOSOMAL AGENT; CGP 40215A; EFLORNITHINE; MITOGUAZONE; PUTRESCINE; SPERMIDINE; UNCLASSIFIED DRUG; DECARBOXYLASE INHIBITOR; DIMINAZENE; DIMINAZENE ACETURATE; MELARSOPROL; SURAMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; OSMOTIC PUMP; PARASITE ISOLATION; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; SPECIES DIFFERENTIATION; SUBCUTANEOUS DRUG ADMINISTRATION; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS; CONCENTRATION RESPONSE; DOSE TIME EFFECT RELATION; HUMAN; HUMAN CELL; INCUBATION TIME; MULTIDRUG RESISTANCE; STRUCTURE ACTIVITY RELATION;

ADENOCARCINOMA; ADENOSYLMETHIONINE DECARBOXYLASE; ANIMALS; HUMANS; MITOGUAZONE; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRYPANOCIDAL AGENTS; TRYPANOSOMA; TUMOR CELLS, CULTURED;

EID: 0029937062     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.6.1448     Document Type: Article

References (31)

1. Bacchi, C. J., J. Garofalo, M. A. Ciminelli, D. Rattendi, B. Goldberg, P. P. McCann, and N. Yarlett. 1993 Resistance to DL-α-difluoromethylomithine by clinical isolates of Trypanosoma brucei rhodesiense. Biochem. Pharmacol. 46:471-481.
2. Bacchi, C. J., and P. P. McCann. 1987 Parasitic protozoa and polyamines, p. 317-344. In P. P. McCann, A E Pegg, and A. Sjoerdsma (ed.), Inhibition of polyamine metabolism. Academic Press, Inc., New York.
3. Bacchi, C. J., P. P. McCann, H. C. Nathan, S. H. Hutner, and A. Sjoerdsma. 1983. Antagonism of polyamine metabolism - a critical factor in chemotherapy of African trypanosomiasis, p. 221-231. In U. Bachrach, A. Kaye, and R. Chayen (ed.), Advances in polyamine research, vol 4 Raven Press, New York.
4. Bacchi, C. J., H. C. Nathan, A. B. Clarkson, Jr., E. J. Bienen, A. J. Bitonti, P. P. McCann, and A. Sjoerdsma. 1987. Effects of the ornithine decarboxylase inhibitors DL-α-difluoromethylornithine and α-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models. Am. J Trop. Med. Hyg. 36:46-52.
5. Bacchi, C. J., H. C. Nathan, T. Livingston, G. Valladares, M. Saric, P. D. Sayer, A. R. Njogu, and A. B. Clarkson, Jr. 1990. Differential susceptibility to DL-α-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense. Antimicrob. Agents Chemother. 34:1183-1188.
6. Bacchi, C. J., H. C. Nathan, N. Yarlett, B. Goldberg, P. P. McCann, A. Sjoerdsma, M. Saric, and A. B. Clarkson, Jr. 1994. Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-α-difluoromethylornithine and standard trypanocides Antimicrob. Agents Chemother. 38:563-569.
7. Bayles, J. D., S. M. Harrison, D. L. Mbwabi, and P. J. Schechter. 1989. Treatment of arsenical refractory Rhodesian sleeping sickness in Kenya Ann Trop. Med. Parasitol. 83(Suppl.):111-114.
8. Bitonti, A. J., C. J. Bacchi, P. P. McCann, and A. Sjoerdsma. 1985. Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis Biochem. Pharmacol. 34:1773-1777.
9. Bitonti, A. J., T. L. Byers, T. L. Bush, P. J. Cosara, C. J. Bacchi, A. B. Clarkson, Jr., P. P. McCann, and A. Sjoerdsma. 1990. Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase Antimicrob. Agents Chemother. 34:1485-1490.
10. Brun, R., Y. Bühler, U. Sandmeier, R. Kaminsky, C. J. Bacchi, D. Rattendi, S. Lane, S. L. Croft, D. Snowdon, V. Yardley, G. Caravatti, J. Frei, J. Stanek, and H. Mett. 1996. In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors. Antimicrob. Agents Chemother 40:1442-1447.
11. 2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei. J. Biol. Chem. 270:28153-28157.
12. Clarkson, A. B., Jr., E. J. Bienen, C. J. Bacchi, P. P. McCann, S. H. Hutner, and A. Sjoerdsma. 1984. A new drug combination for experimental late stage African trypanosomiasis: DFMO with suramin. Am. J. Trop. Med Hyg. 33:1073-1077.
13. Cunningham, M. P., and K. Vickerman. 1962. Antigenic analysis in Trypanosoma brucei group using an agglutination reaction Trans. R Soc. Trop. Med. Hyg. 56:48-59.
14. Fairlamb, A. H., N. S. Carter, M. Cunningham, and K. Smith. 1992 Characterization of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism. Mol. Biochem. Parasitol. 53:213-222.
15. Holtta, E., P. Hannonen, J. Pispa, and J. Janne. 1973. Effect of methylglyoxal bis(guanylhydrazone) on polyamine metabolism in normal and regenerating rat liver and in rat thymus Biochem. J. 136:669-676.
16. Jennings, F. W. 1988 The potentiation of arsenicals with difluoromethylornithme (DFMO). experimental studies in murine trypanosomiasis Bull. Soc. Pathol. Exot. 81:595-607.
17. Jennings, F. W. 1992 Chemotherapy of CNS-trypanosomiasis, this combined use of diminazene aceturate or pentamidine with DL-α-difluoromethylomithine. Trop. Med. Parasitol. 43:106-109.
18. Jennings, F. W., and A. R. Gray. 1983. Relapsed parasitemia following chemotherapy of chrome Trypanosoma brucei infections in mice and its relationship to cerebral trypanosomes. Contrib Microbiol. Immunol. 7:147-154.
19. Jennings, F. W., D. D. Whitelaw, and G. M. Urquhart. 1977 The relationship between duration of infection with Trypanosoma brucei in mice and the erficacy of chemotherapy. Parasitology 75:143-153
20. Mehlitz, D., U. Brinkman, and L. Heller. 1981. Epidemiological studies on the animal reservoir of gambiense sleeping sickness. Part I. Review of literature and description of study areas Z Tropenmed Parasitenkd 32:129-133.
21. Mihich, E. 1975. Bis-guanyl-hydrazones, p. 766-788 In A. C. Sartorelli and D. G Johns (ed.), Handbook of experimental pharmacology, new series, vol. 38. Springer-Verlag, New York.
22. Pegg, A. E. 1988. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res. 48:759-774.
23. Porter, C. W., U. Regenass, and R. J. Bergeron. 1992. Polyamine inhibitors and analogs as potential anticancer agents, p. 301-322 In R. H. Dowling, U R Folsch, and C H. R Löser (ed.), Polyamines in the gastrointestinal tract Klüwer Academic Publishing, Dordrecht, The Netherlands
24. Regenass, U., G. Carvatti, H. Mett, J. Stanek, P. Schneider, M. Müller, A. Matter, P. Vertino, and C. W. Porter. 1992. New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity. Cancer Res. 52: 4712-4718.
25. Regenass, U., H. Mett, J. Stanek, M. Muller, D. Kramer, and C. W. Porter. 1994. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity Cancer Res 54: 3210-3217.
26. Schechter, P. J., and A. Sjoerdsma. 1989. Therapeutic utility of selected enzyme activated inhibitors, p. 201-210. In M. G. Palfreyman, P. P. McCann, A. Sjoerdsma, and W. Lovenberg (ed.), Enzymes as targets for drug design. Academic Press, New York.
27. Stanek, J., G. Caravatti, II.-G. Capraro, P. Furet, H. Mett, P. Schneider, and U. Regenass. 1993. S-Adenosylmethionine decarboxylase inhibitors, new aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone). J. Med. Chem. 36:46-54.
28. Van Nieuwenhove, S. 1992. Advances in sleeping sickness therapy. Ann Soc. Belge Med. Trop. 72(Suppl 1):39-51.
29. Warrell, R. P., Jr., and J. H. Burchenal. 1983. Methylglyoxal bis(guanylhydrazone): current status and future prospects, J. Clin. Oncol. 1:52-65.
30. Williamson, J. 1970. Review of chemotherapeutic and chemoprophylactic agents, p. 125-221. In H. W. Mulligan (ed.), The African trypanosomiasis Allen and Unwin, Ltd., London.
31. World Health Organization. 1995. Tropical disease research. Twelfth Programme Report. World Health Organization, Geneva.