Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 5, 2009, Pages 2052-2058

  Barker Jr , Robert H ^a   Liu, Hanlan ^a   Hirth, Bradford ^a   Celatka, Cassandra A ^a   Fitzpatrick, Richard ^a   Xiang, Yibin ^a   Willert, Erin K ^b   Phillips, Margaret A ^b   Kaiser, Marcel ^c   Bacchi, Cyrus J ^d   Rodriguez, Aixa ^d   Yarlett, Nigel ^d   Klinger, Jeffrey D ^a   Sybertz, Edmund ^a  

^a GENZYME CORPORATION   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d PACE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' [(4 AMINO 2 BUTENYL)METHYLAMINO] 5' DEOXYADENOSINE; ADENOSYLMETHIONINE DECARBOXYLASE; CYTOCHROME P450; DEOXYADENOSINE DERIVATIVE; ENZYME INHIBITOR; GENZ 644131; PENTAMIDINE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL STRAIN CACO 2; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG MECHANISM; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; HALF LIFE TIME; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SURVIVAL; TRYPANOSOMA RHODESIENSE;

ADENOSYLMETHIONINE DECARBOXYLASE; ANIMALS; BRAIN; CACO-2 CELLS; DEOXYADENOSINES; HUMANS; KINETICS; MICE; PARASITIC SENSITIVITY TESTS; RATS; TREATMENT OUTCOME; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 66149136395     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01674-08     Document Type: Article

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