Life in vacuoles - Nutrient acquisition by Leishmania amastigotes

International Journal for Parasitology

Volumn 31, Issue 12, 2001, Pages 1311-1320

  Burchmore, Richard J S ^a   Barrett, Michael P ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Amastigote; Leishmania mexicana; Nutrition; Parasitophorous vacuole; pH; Transporter

Indexed keywords

CARRIER PROTEIN;

LIFE CYCLE; NUTRIENT UPTAKE; PARASITE;

AMASTIGOTE; BINDING AFFINITY; CELL MEMBRANE TRANSPORT; CELL PH; CELL VACUOLE; ENDOSOME; GLUCOSE TRANSPORT; LEISHMANIA; MACROMOLECULE; NONHUMAN; NUTRIENT; PARASITE SURVIVAL; PHAGOCYTOSIS; PHAGOSOME; PROMASTIGOTE; PROTEIN DEGRADATION; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; HOST-PARASITE RELATIONS; HUMANS; HYDROGEN-ION CONCENTRATION; INSECT VECTORS; LEISHMANIA; LEISHMANIASIS; LIFE CYCLE STAGES; MEMBRANE TRANSPORT PROTEINS; PSYCHODIDAE; VACUOLES;

EID: 0034825692     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(01)00259-4     Document Type: Review

References (96)

1. Leishmania species: Models of intracellular parasitism
2. Biochemical and immunochemical characterization of a P-type ATPase from Leishmania donovani promastigote plasma membrane
3. Parasitophorous vacuoles of L. amazoniensis-infected macrophages maintain an acidic pH
4. The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophages
5. Two high affinity nucleoside transporters in Leishmania donovani
6. Trypanosome glucose transporters
7. Putrescine and spermidine transport in Leishmania
8. Leishmania mexicana: Induction of metacyclogenesis by cultivation of promastigotes at acidic p
9. Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms
10. Understanding the multiple functions of Nramp1
11. Subverted transferrin trafficking in Leishmania-infected macrophages
12. Differential regulation of two distinct families of glucose transporter genes in Trypanosoma brucei
13. Glucose transport in amastigotes and promastigotes of Leishmania mexicana mexicana
14. Differential regulation of multiple glucose transporter genes in Leishmania mexicana
15. Developmentally regulated gene from Leishmania encodes a putative membrane transport protein
16. Heavy metal resistance: A new role for P-glycoprotein in Leishmania
17. Leishmania pifanoi: Kinetics of messenger RNA expression during amastigote to promastigote transformation in vitro
18. Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant
19. Cloning and functional characterisation of an extrachromasomally amplified multidrug resistance-like gene in Leishmania enriettii
20. In vitro reversible transformation of Leishmania braziliensis panamensis between promastigote and ellipsoidal forms
21. The low density lipoprotein receptor: Identification of amino acids in cytoplasmic domain required for rapid endocytosis
22. Intracellular L. amazonensis amastigotes internalize and degrade MHC class II molecules of their hosts
23. Inhibition of phagolysosomal biogenesis by the Leishmania lipophosphoglycan
24. Leishmania donovani: Long-term culture of axenic amastigotes at 37°C
25. + symporter from L. donovani
26. The biosynthesis, processing and immunolocalization of Leishmania pifanoi amastigote cysteine proteinases
27. Extracellular cultivation and morphological characterization of amastigote-like forms of Leishmania panamensis and Leishmania braziliensis
28. The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence
29. Stage-specific development of a novel adenosine transporter in Leishmania donovani amastigotes
30. pH homeostasis in L. donovani amastigotes and promastigotes
31. Lutzomyia longipalpis: pH in the gut, digestive glycosidases, and some speculations upon Leishmania development
32. Leishmania mexicana: Purine metabolism in promastigotes, axenic amastigotes and amastigotes derived from Vero cells
33. Leishmania mexicana: Energy metabolism of amastigotes and promastigotes
34. Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene
35. Molecular characterisation of the ldmdr1 multidrug resistance gene from Leishmania donovani
36. Temperature-induced in vitro transformation of Leishmania mexicana. I. Ultrastructural comparison of culture-transformed and intracellular amastigotes
37. Phosphoglycan repeat-deficient Leishmania mexicana parasites remain infectious to macrophages and mice
38. Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana
39. Natural resistance to intracellular infections: Natural resistance-associated macrophage protein (nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane
40. Plasma membrane (K+/H+)-ATPase from Leishmania donovani
41. Cloning and characterization of differentially expressed genes from in vitro-grown 'amastigotes' of Leishmania donovani
42. The apical membrane glycocalyx of MDCK cells
43. Proline metabolism in L. donovani promastigotes
44. Role of substrate binding forces in exchange only transport systems: I. Transition state theory
45. Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae
46. Molecular characterization of two genes encoding members of the glucose transporter superfamily in the parasitic protozoan Leishmania donovani
47. Functional expression of two glucose transporter isoforms from the parasitic protozoan Leishmania enriettii
48. Functional expression and subcellular localization of a high-Km hexose transporter from Leishmania donovani
49. Amino acid and hormonal control of macromolecular turnover in perfused rat liver. Evidence for selective autophagy
50. The P-glycoprotein-related gene family in Leishmania tarentolae
51. The Leishmania donovani LD1 locus ORFG encodes a biopterin transporter (BT1)
52. Determinants of the phagosomal pH in macrophages
53. Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family
54. Developmental regulation of proline transport in Leishmania donovani
55. Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani
56. + symport protein (GalP) from E. coli
57. Structure and expression of a tandem gene pair in Leishmania donovani that encodes a protein structurally homologous to eukaryotic cation-transporting ATPases
58. A tandem pair of Leishmania donovani cation transporting ATPase genes encode isoforms that are differentially expressed
59. +-antiporter involved in glucose symport: Studies with sealed ghosts and vesicles of opposite polarity
60. Delayed in vitro utilization of glucose by Leishmania tropica promastigotes
61. Enhanced metabolism of Leishmania donovani amastigotes at acid pH: An adaptation for intracellular growth
62. Amplification of ABC transporter gene pgpA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption
63. Leishmania mexicana: Serial cultivation of intracellular stages in a cell-free medium
64. Analysis of the antigenic relationships among promastigotes and amastigotes by gel diffusion, immunoelectrophoresis, and immunoprecipitation
65. Leishmania mexicana pifanoi: In vivo and in vitro interactions between amastigotes and macrophages
66. Leishmania mexicana: Comparative fine structure of amastigotes and promastigotes in vitro and in vivo
67. Contribution of Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance
68. Identification and characterization of a ribose transport system in Leishmania donovani promastigotes
69. Leishmania mexicana amazonensis: Surface charge of amastigote and promastigote forms
70. 2-terminal domain
71. The transport systems of mammalian lysosomes
72. Localization and activity of various lysosomal proteases in Leishmania amazonensis infected macrophages
73. Biochemical and molecular characterization of Leishmania pifanoi amastigotes in continuous axenic culture
74. Transmembrane orientation of hydrophobic alpha-helices is regulated both by the relationship of helix length to bilayer thickness and by the cholesterol concentration
75. Intraparasitophorous vacuolar pH of Leishmania mexicana infected macrophages
76. Intracellular trafficking and the parasitorphorous vacuole of Leishmania mexicana-infected macrophages
77. Unraveling the mechanism of the lactose permease of Escherichia coli
78. Parasitophorous vacuoles of Leishmania mexicana acquire macromolecules from the host cell cytosol via two independent routes
79. Sandfly diet and Leishmania
80. Cytoskeletal association is important for differential targetting of glucose transporter isoforms in Leishmania
81. Morphology of Leishmania braziliensis: Changes during reversible heat-induced transformation from promastigote to an ellipsoidal form
82. Characterization of glucose transport and cloning of a hexose transporter gene in Trypanosoma cruzi
83. The surface membrane of Leishmania mexicana mexicana: Comparison of amastigote and promastigote using freeze-fracture cytochemistry
84. Identification and characterization of a membrane protein (y(+)L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y(+)L - A candidate gene for lysinuric protein intolerance
85. Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant
86. The structure-function relationship of functionally distinct but structurally similar hexose transporter from Trypanosoma congolense
87. Transfer of zymosan (yeast cell walls) to the parasitophorous vacuoles of macrophages infected with Leishmania amazonensis
88. Fusion between large phagocytic vesicles: Targeting of yeast and other particulates to phagolysosomes which shelter the bacterium Coxiella burnetii or the protozoan Leishmania amazonensis in Chinese hamster ovary cells
89. Entry and survival of Leishmania amazonensis amastigotes within phagolysosome-like vacuoles that shelter Coxiella burnettii in Chinese hamster ovary cells
90. New glycoprotein-associated amino acid transporters
91. Glucose uptake in Trypanosoma vivax and molecular characterisation of its transporter gene
92. + symporters by mutations and construction of chimeras
93. Protonmotive force-driven active transport of D-glucose and L-proline in the protozoan parasite Leishmania donovani
94. Regulation of L-proline transport in Leishmania donovani by extracellular pH
95. The role of pH and temperature in the development of Leishmania parasites
96. Growth at acidic pH induces an amastigote stage-specific protein in Leishmania promastigotes