Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

Molecular Microbiology

Volumn 74, Issue 3, 2009, Pages 529-540

  Wyllie, Susan ^a   Oza, Sandra L ^a   Patterson, Stephen ^a   Spinks, Daniel ^a   Thompson, Stephen ^a   Fairlamb, Alan H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDASE; GLUTATHIONE; SYNTHETASE; TRYPANOTHIONE; TRYS ENZYME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOLYSIS; ENZYME ACTIVITY; GROWTH INHIBITION; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RAT; TRYPANOSOMA BRUCEI;

AMIDE SYNTHASES; AMIDOHYDROLASES; ANIMALS; ENZYME INHIBITORS; GENE KNOCKOUT TECHNIQUES; GLUTATHIONE; MICE; OXIDATIVE STRESS; POLYAMINES; PROTOZOAN PROTEINS; SPERMIDINE; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS, AFRICAN;

MUS; TRYPANOSOMA BRUCEI; TRYPANOSOMATIDAE;

EID: 70350381791     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2009.06761.x     Document Type: Article

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