Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 20, 2007, Pages 8275-8280

  Willert, Erin K ^a   Fitzpatrick, Richard ^b   Phillips, Margaret A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Chemistry Research Department   (United States)

Author keywords

Gene duplication; Prozyme; S adenyosylmethionine decarboxylase; Trypanosoma brucei

Indexed keywords

ADENOSYLMETHIONINE DECARBOXYLASE; POLYAMINE; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

ALLOSTERISM; ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME REGULATION; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; AMINO ACID SEQUENCE; ANIMAL; CATALYSIS; CHEMISTRY; DIMERIZATION; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; GENOME; KINETICS; METABOLISM; MOLECULAR GENETICS; PARASITE; PHYLOGENY; SEQUENCE HOMOLOGY;

PROTOZOA; TRYPANOSOMA BRUCEI; TRYPANOSOMATIDAE;

ADENOSYLMETHIONINE DECARBOXYLASE; ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; DIMERIZATION; ENZYME ACTIVATION; GENOME, PROTOZOAN; KINETICS; MOLECULAR SEQUENCE DATA; PARASITES; PHYLOGENY; POLYAMINES; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA BRUCEI BRUCEI;

EID: 34347207243     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0701111104     Document Type: Article

References (45)

1. Word Health Organization (2004) World Health Report (WHO, Geneva).
2. Fries D, Fairlamb AH (2003) in Burger's Medicinal Chemistry and Drug Discovery, ed Abraham D (Wiley, New York), Vol 5, pp 1033-1087.
3. Childs AC, Mehta DJ, Gerner EW (2003) Cell Mol Life Sci 60:1394-1406.
4. Pegg AE (2006) J Biol Chem 281:14529-14532.
5. Tabor C, Tabor H (1984) Annu Rev Biochem 53:749-790.
6. Gerner EW, Meyskens FL, Jr (2004) Nat Rev Cancer 4:781-792.
7. Fairlamb AH, Blackburn P, Chait BT, Cerami A (1985) Science 227:1485-1487.
8. Marton LJ, Pegg AE (1995) Annu Rev Pharmacol Toxicol 35:55-91.
9. Bacchi CJ, Nathan HC, Hunter SN (1980) Science 210:332-334.
10. Pegg AE, Xiong H, Feith DJ, Shantz LM (1998) Biochem Soc Trans 26:580-586.
11. Roberts SC, Scott J, Gasteier JE, Jiang Y, Brooks B, Jardim A, Carter NS, Heby O, Ullman B (2002) J Biol Chem 277:5902-5909.
12. Bacchi CJ, Nathan HC, Yarlett N, Goldberg B, McCann PP, Bitonti A, Sjoerdsma A (1992) Antimicrob Agents Chemother 36:2736-2740.
13. Yakubu MA, Majumder S, Kierszenbaum F (1993) J Parasitol 79:525-532.
14. Ekstrom JL, Tolbert WD, Xiong H, Pegg AE, Ealick SE (2001) Biochemistry 40:9495-9504.
15. Tolbert WD, Zhang Y, Cottet SE, Bennett EM, Ekstrom JL, Pegg AE, Ealick SE (2003) Biochemistry 42:2386-2395.
16. Ekstrom JL, Mathews II, Stanley B, Pegg AE, Ealick SE (1999) Structure (London) 7:583-595.
17. Tolbert WD, Ekstrom JL, Mathews II, Secrist JA, III, Kapoor P, Pegg AE, Ealick SE (2001) Biochemistry 40:9484-9494.
18. Bennett EM, Eckstrom JL, Pegg AE, Ealick SE (2002) Biochemistry 41:14509-14517.
19. Kinch LN, Scott J, Ullman B, Phillips MA (1999) Mol Biochem Parasitol 101:1-11.
20. Kinch LN, Phillips MA (2000) Biochemistry 39:3336-3343.
21. Persson K, Aslund L, Grahn B, Hanke J, Heby O (1998) Biochem J 333:527-537.
22. Clyne T, Kinch LN, Phillips MA (2002) Biochemistry 41:13207-13261.
23. Beswick TC, Willert EK, Phillips MA (2006) Biochemistry 45:7797-7807.
24. Hanfrey C, Elliott KA, Franceschetti M, Mayer MJ, Illingworth C, Michael AJ (2005) J Biol Chem 280:39229-39237.
25. Heller JS, Fong WF, Canellakis ES (1976) Proc Natl Acad Sci USA 73:1858-1862.
26. Casara P, Marchal P, Wagner J, Danzin C (1989) J Am Chem Soc 111:9111-9113.
27. Danzin C, Marchal P, Casara P (1990) Biochem Pharmacol 40:1499-1503.
28. Pils B, Schultz J (2004) J Mol Biol 340:399-404.
29. Arkin MR, Wells JA (2004) Nat Rev Drug Discov 3:301-317.
30. Noble ME, Endicott JA, Johnson LN (2004) Science 303:1800-1805.
31. Scheer JM, Romanowski MJ, Wells JA (2006) Proc Natl Acad Sci USA 103:7595-7600.
32. Toms AV, Kinsland C, McCloskey DE, Pegg AE, Ealick SE (2004) J Biol Chem 279:33837-33846.
33. Korhonen VP, Halmekyto M, Kauppinen L, Myohanen S, Wahlfors J, Keinanen T, Hyvonen T, Alhonen L, Eloranta T, Janne J (1995) DNA Cell Biol 14:841-847.
34. Shah R, Akella R, Goldsmith EJ, Phillips MA (2007) Biochemistry 46:2831-2841.
35. Hoffman DW, Carroll D, Martinez N, Hackert ML (2005) Biochemistry 44:11777-11785.
36. Mangold U (2006) Cell Mol Life Sci 63:2095-2101.
37. Adachi J, Hasegawa M (1992) Jpn J Genet 67:187-197.
38. Jones D, Taylor W, Thornton J (1992) Comput Appl Biosci 8:275-283.
39. Saitou N, Nei M (1987) Mol Biol Evol 4:406-425.
40. Kishino H, Hasegawa M (1990) Methods Enzymol 183:550-570.
41. Hirumi H, Hirumi K (1989) J Parasitol 75:985-989.
42. Brun R, Schonenberger M (1979) Acta Trap 36:289-292.
43. Wirtz E, Leal S, Ochatt C, Cross GA (1999) Mol Biochem Parasitol 99:89-101.
44. Copeland R (1996) Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis (Wiley-VCH, New York).
45. Lebowitz J, Lewis M, Schuck P (2002) Protein Sci 11:2067-2079.