Chemical validation of trypanothione synthetase: A potential drug target for human trypanosomiasis

Journal of Biological Chemistry

Volumn 284, Issue 52, 2009, Pages 36137-36145

  Torrie, Leah S ^a   Wyllie, Susan ^a   Spinks, Daniel ^a   Oza, Sandra L ^a   Thompson, Stephen ^a   Harrison, Justin R ^a   Gilbert, Ian H ^a   Wyatt, Paul G ^a   Fairlamb, Alan H ^a   Frearson, Julie A ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL LINES; COMPOUND LIBRARIES; DRUG TARGETS; ENZYME ASSAYS; GLUTATHIONES; HIGH THROUGHPUT SCREENING; IN-VITRO; INHIBITED GROWTH; KNOCK OUTS; NANOMOLAR; NOVEL SERIES; POTENTIAL DRUG; SPERMIDINE; TRYPANOSOMA BRUCEI; TRYPANOTHIONE; TRYPANOTHIONE SYNTHETASE; WILD TYPES;

CELL CULTURE; ELECTRIC CONDUCTIVITY MEASUREMENT; LEAD COMPOUNDS;

TARGETS;

ADENOSINE TRIPHOSPHATE; DDD 86243; GLUTATHIONE; ORGANOLEAD COMPOUND; SPERMIDINE; SYNTHETASE; TRYPANOTHIONE SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE TARGETING; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; KNOCKOUT GENE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; WILD TYPE;

ALLOSTERIC REGULATION; AMIDE SYNTHASES; ANIMALS; ANTIPROTOZOAL AGENTS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; PROTOZOAN PROTEINS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

TRYPANOSOMA BRUCEI;

EID: 73649125297     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.045336     Document Type: Article

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