A unique transporter of S-adenosylmethionine in African trypanosomes

FASEB Journal

Volumn 11, Issue 4, 1997, Pages 256-260

  Goldberg, Burt ^a,b   Yarlett, Nigel ^a   Sufrin, Janice ^c   Lloyd, David ^b   Bacchi, Cyrus J ^a  

^a PACE UNIVERSITY   (United States)

^b UNIVERSITY OF WALES   (United Kingdom)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

purine uptake; S adenosylmethionine metabolism; trypanocidal agents

Indexed keywords

5' METHYLTHIOADENOSINE; 5' [(4 AMINO 2 BUTENYL)METHYLAMINO] 5' DEOXYADENOSINE; ADENOSINE; ANTITRYPANOSOMAL AGENT; CARRIER PROTEIN; DIMINAZENE ACETURATE; INOSINE; MELARSOPROL; MITOGUAZONE; PENTAMIDINE; S ADENOSYLMETHIONINE; SINEFUNGIN;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; METHYLATION; NONHUMAN; NUCLEOSIDE TRANSPORT; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; RAT; TRYPANOSOMA BRUCEI; TRYPANOSOMA RHODESIENSE;

ANIMALIA; MAMMALIA; TRYPANOSOMA; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 0030993577     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.11.4.9068614     Document Type: Article

References (30)

1. Kuzoe, F. (1993) African Trypanosomiasis, Twelfth Annual Report, Tropical Disease Research, pp. 115-123, World Health Organization, Geneva, Switzerland
2. 2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei. J. Biol. Chem. 270, 28153-28157
3. 2 purine transporter with reduced substrate affinity. Mol. Biochem. Parasitol. 73, 223-229
4. Carter, N. S., and Fairlamb, A. H. (1993) Arsenical-resistant trypanosomes lack an unusual adenosine transporter. Nature (London) 361, 173-175
5. Berens, R. L., Krug, E. C., and Marr, J. J. (1995) Purine and pyrimidine metabolism. In Biochemistry and Molecular Biology of Parasites (Marr, J. J., and Müller, M., eds) pp. 89-117, Academic Press, New York
6. James, D. M., and Born, G. V. R. (1980) Uptake of purine bases and nucleosides in African trypanosomes. Parasitology 81, 383-393
7. Stramentinoli, C. (1987) Pharmacologic aspects of S-adenosylmethionine pharmacokinitics and pharmacodynamics. Am. J. Med. 83 (Suppl. 5A), 35-42
8. Yarlett, N., Garofalo, J., Ciminelli, M. A., Ruggerio, V., Goldberg, B., and Bacchi, C. J. (1993) S-Adenosylmethionine synthetase in bloodstream Trypanosoma brucei. Biochem. Biophys. Acta 1181, 68-76
9. Fairlamb, A. H., and Cerami, A. (1992) Metabolism and functions of trypanothione in the Kinetoplastida. Annu. Rev. Microbiol. 46, 695-729
10. Bacchi, C. J., Goldberg, B., Garofalo-Hannan, J., Rattendi, D., Lyte, P., and Yarlett, N. (1995) Fale of soluble methionine in African trypanosomes: effects of metabolic inhibitors. Biochem. J. 309, 737-743
11. Bacchi, C. J., Nathan, H. C., Livingston, T., Valladares, G., Saric, M., Sayer, P. D., Njogu, A. R., and Clarkson, Jr., A. B. (1990) Differential susceptibility to DL-α-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense. Antimicrob. Agents Chemother. 34, 1183-1188
12. Sufrin, J. R., Spiess, A. I., Kramer, D. L., Libby, P. R., Miller, J. T., Bernacki, R. J., Lee, Y., Borchardt, R. T., and Porter, C. W. (1991) Targeting 5′-deoxy-5′-(methylthio)adenosine phosphorylase by 5′-haloalkyl analogues of 5′-deoxy-5′-(methylthio)adenosine. J. Med. Chem. 34, 2600-2606
13. L'Hostis, C., Geindre, M., and Deshusses, J. (1993) Active transport of L-proline in the protozan parasite Trypanosoma brucei brucei. Biochem. J. 291, 297-301
14. Aronow, B., Kaur, K., McCartan, K., and Ullman, B. (1987) Two high affinity nucleoside transporters in Leishmainia donovani. Mol. Biochem. Parasitol. 22, 29-31
15. Yarlett, N., Goldberg, B., Nathan, H. C., Garofalo, J., and Bacchi, C. J. (1991) Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals. Exp. Parasitol. 72, 205-215
16. Clarkson, A. B., Jr., Bienen, E. J., Pollakis, G., and Grady, R. W. (1989) Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase. J. Biol. Chem. 264, 17770-17776
17. Bacchi, C. J., Sufrin, J. R., Nathan, H. C., Spiess, A. J., Hannan, T., Garofalo, J., Alicea, K., Katz, L., and Yarlett, N. (1991) 5′-Alkyl-substituted analogs of 5′-methylthioadenosine as trypanocides. Antimicrob. Agents Chemother. 35, 1315-1320
18. Cantoni, G. L. (1953) S-Adenosylmethionine: a new intermediate formed enzymatically from L-methionine and ATP. J. Biol. Chem. 204, 403-410
19. de la Haba, G., Jamisson, G. A., Mudd, S. H., and Richards, H. H. (1959) S-Adenosylmethionine: the relation of configuration at the sulfonium center to enzymatic activity. J. Am. Chem. Soc. 81, 3975-3980
20. Cornforth, J. N., Carrell, H. L., Gluskiv, J. P., and Talalay, P. (1979) The absolute configuration at the sulfonium center of S-adenosylmethionine. In Transmethylation (Usdin, E., Borchardt, R. T., and Creveling, C. R., eds) pp. 19-25, Elsevier North Holland, New York
21. Yarlett, N., Quamina, A., and Bacchi, C. J. (1991) Protein methylases in Trypanosoma brucei brucei: activities and responses to DL-α-difluoromethylornithine. J. Gen. Microbiol. 137, 717-724
22. Phelouzat, M.-A., Basselin, M., Lawrence, F., and Robert-Gero, M. (1995) Sinefungin shares AdoMet-uptake system to enter Leishmania donovoni promastigotes. Biochem. J. 305, 133-137
23. Mozier, N. M., and Hoffman, J. L. (1990) Biosynthesis and urinary excretion of methyl sulfonium derrivatives of the sulfur mustard analog, 2-chloroethyl ethyl sulfide, and other thio ethers. FASEB J. 4, 3329-3333
24. Pezzoli, C., Stramentinoli, G., Galli-Kienle, M., and Pfaff, E. (1978) Uptake and metabolism of S-adenosyl-L-methionine by isolated rat hepatocytes. Biochem. Biophys. Res. Commun. 85, 1031-1038
25. Stramentinoli, G., Gualano, M., and Ideo, G. (1978) Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats. Biochem. Pharmacol. 27, 323-326
26. Duce, A. M., Ortiz, P., Cabrero, C., and Mato, J. M. (1988) S-Adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrosis. Hepatology 8, 65-68
27. Alleman, M. M., Mann, V. H., Bacchi, C. J., Yarlett, N., Gottlieb, M., and Dwyer, D. (1995) Crithidia lucilliae: effect of purine starvation an S-adenosyl-L-methionine uptake and protein methylation. Exp. Parasitol. 81, 519-528
28. Bacchi, C. J., Nathan, H. C., Hutner, S. H., McCann, P. P., and Sjoerdsma, A. (1980) Polyamine metabolism: A potential therapeutic target in trypanosomes. Science 210, 332-334
29. Bitonti, A. J., Dumont, J. A., Bush, T. L., Edwards, M. L., Stemerick, D. M., McCann, P. P., and Sjoerdsma, A. (1989) Bis(benzyl) polyamine analogs inhibit the growth of chloroquin-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with α-difluoromethylornithine cure murine malaria. Proc. Natl. Acad. Sci. USA. 86, 651-655
30. Bitonti, A. J., Byers, T. L., Bush, T. L., Casara, P. J., Bacchi, C. J. Clarkson, A. B., Jr., McCann, P. P., and Sjoerdsma, A. (1990) Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesienae infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase. Antimicrob. Agents Chemother. 34, 1485-1490