Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase

Journal of Biological Chemistry

Volumn 285, Issue 22, 2010, Pages 16771-16781

  Smithson, David C ^a,b   Lee, Jeongmi ^c   Shelat, Anang A ^a   Phillips, Margaret A ^c   Guy, R Kiplin ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC SITE; BINDING MODES; CENTRAL AFRICA; HIGH THROUGHPUT; MOLECULAR TARGETS; ORNITHINE DECARBOXYLASE; PARASITE-; POLYAMINE METABOLISM; SELECTIVE INHIBITORS; TRYPANOSOMA BRUCEI;

BINDING ENERGY; ENZYMES;

BINDING SITES;

ALEXIDINE; AMIDINE; BENZTHIAZOLE; BISBIGUANIDE DERIVATIVE; DITHIOAMIDINE; INDOLE DERIVATIVE; ORNITHINE DECARBOXYLASE; ORNITHINE DECARBOXYLASE INHIBITOR; PENTAMIDINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; HIGH THROUGHPUT SCREENING; MOLECULAR DOCKING; MUTAGENESIS; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

ALLOSTERIC SITE; ANIMALS; AUTOMATION; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MALATE DEHYDROGENASE; MUTAGENESIS, SITE-DIRECTED; ORNITHINE DECARBOXYLASE; PHOSPHOENOLPYRUVATE CARBOXYLASE; PROTEIN BINDING; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EUKARYOTA; TRYPANOSOMA BRUCEI;

EID: 77952759972     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.081588     Document Type: Article

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