Central Role of Fas-associated Death Domain Protein in Apoptosis Induction by the Mitogen-activated Protein Kinase Kinase Inhibitor CI-1040 (PD184352) in Acute Lymphocytic Leukemia Cells in Vitro

Journal of Biological Chemistry

Volumn 278, Issue 47, 2003, Pages 47326-47339

  Meng, Xue Wei ^a   Chandra, Joya ^a,d   Loegering, David ^a   Van Becelaere, Keri ^b   Kottke, Timothy J ^a   Gore, Steven D ^c   Karp, Judith E ^c   Sebolt Leopold, Judy ^b   Kaufmann, Scott H ^a  

^a MAYO CLINIC   (United States)

^b PFIZER INC   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHEMICAL ACTIVATION; DNA; ENZYME INHIBITION; GENETIC ENGINEERING; PROTEINS; TUMORS;

APOPTOSIS; PHOSPHORYLATION; THERAPEUTICS;

BIOCHEMISTRY;

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; ANTIBODY; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; COMPLEMENTARY DNA; ESTER DERIVATIVE; FAS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN BCL 2; PROTEIN MCL 1; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LYMPHOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; BONE MARROW; CELL TYPE; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; LEUKEMIA CELL LINE; LYMPHOID CELL LINE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SOLUBILITY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; BENZAMIDES; CARRIER PROTEINS; CASPASE 8; CASPASE 9; CASPASES; CELL LINE, TUMOR; DIMERIZATION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION;

CUCURBITA;

EID: 0344443643     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304793200     Document Type: Article

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