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Volumn 12, Issue 7, 2000, Pages 2215-2223

Role of the peroxisome proliferator-activated receptor-γ (PPAR-γ) and its natural ligand 15-deoxy-Δ(12,14)-prostaglandin J2 in the regulation of microglial functions

Author keywords

Brain macrophages; iNOS; MHC class II; NF B; STAT 1; TNF

Indexed keywords

CYCLIC AMP; DELTA12 PROSTAGLANDIN J2; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RECEPTOR SUBTYPE; STAT1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033944415     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00110.x     Document Type: Article
Times cited : (225)

References (56)
  • 2
    • 0029882579 scopus 로고    scopus 로고
    • Reversible inhibitory effects of interferon-γ and tumor necrosis factor-α on oligodendroglial lineage cell proliferation and differentiation in vitro
    • Agresti, C., D'Urso, D. & Levi, G. (1996) Reversible inhibitory effects of interferon-γ and tumor necrosis factor-α on oligodendroglial lineage cell proliferation and differentiation in vitro. Eur. J. Neurosci., 8, 1106-1116.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1106-1116
    • Agresti, C.1    D'Urso, D.2    Levi, G.3
  • 3
    • 0019412450 scopus 로고
    • Different reticular elements in rat lymphoid tissue identified by localization of Ia, Thy-1 and MRC OX 2 antigens
    • Barclay, A.N. (1981) Different reticular elements in rat lymphoid tissue identified by localization of Ia, Thy-1 and MRC OX 2 antigens. Immunology, 44, 727-736.
    • (1981) Immunology , vol.44 , pp. 727-736
    • Barclay, A.N.1
  • 4
    • 0019405689 scopus 로고
    • Bone marrow origin of ia-positive cells in the medulla rat thymus
    • Barclay, A.N. & Mayrhofer, G. (1981) Bone marrow origin of Ia-positive cells in the medulla rat thymus. J. Exp. Med., 153, 1668-1671.
    • (1981) J. Exp. Med. , vol.153 , pp. 1668-1671
    • Barclay, A.N.1    Mayrhofer, G.2
  • 5
    • 0031863452 scopus 로고    scopus 로고
    • Selective enhancement of LPS-induced serum TNF-α production by carrageenan pretreatment in mice
    • Blanque, R., Meakin, C., Millet, S. & Gardner, C.R. (1998) Selective enhancement of LPS-induced serum TNF-α production by carrageenan pretreatment in mice. Gen. Pharmacol., 31, 301-306.
    • (1998) Gen. Pharmacol. , vol.31 , pp. 301-306
    • Blanque, R.1    Meakin, C.2    Millet, S.3    Gardner, C.R.4
  • 7
    • 0031050035 scopus 로고    scopus 로고
    • Regulation of transcription of MHC class II genes
    • Boss, J.M. (1997) Regulation of transcription of MHC class II genes. Curr. Biol., 9, 107-113.
    • (1997) Curr. Biol. , vol.9 , pp. 107-113
    • Boss, J.M.1
  • 8
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPAR): Tissue distribution of PPAR-α-β and -γ in the adult rat
    • Braissant, O., Foufelle, F., Scotto, C., Dauca, M. & Wahli, W. (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α-β and -γ in the adult rat. Endocrinology, 137, 354-366.
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 9
    • 0028181539 scopus 로고
    • Function of NF-κb /rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-κb/rel subunits
    • Brown, A.M., Linhoff, M.W., Stein, B., Wright, K.L., Baldwin, A.S., Basta, P.V. & Ting, J.P.-T. (1994) Function of NF-κB /rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-κB/rel subunits. Mol. Cell. Biol., 14, 2926-2935.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2926-2935
    • Brown, A.M.1    Linhoff, M.W.2    Stein, B.3    Wright, K.L.4    Baldwin, A.S.5    Basta, P.V.6    Ting, J.P.-T.7
  • 10
  • 11
    • 0031930111 scopus 로고    scopus 로고
    • Distribution of mRNAs encoding the peroxisome proliferator-activated receptor α, β, and γ and the retinoid X receptor α, β, and γ in rat central nervous system
    • Cullingford, T.E., Bhakoo, D., Peuchen, S., Dolphin, C.T., Patel, R. & Clark, J.B. (1998) Distribution of mRNAs encoding the peroxisome proliferator-activated receptor α, β, and γ and the retinoid X receptor α, β, and γ in rat central nervous system. J. Neurochem., 70, 1366-1375.
    • (1998) J. Neurochem. , vol.70 , pp. 1366-1375
    • Cullingford, T.E.1    Bhakoo, D.2    Peuchen, S.3    Dolphin, C.T.4    Patel, R.5    Clark, J.B.6
  • 13
    • 0029616444 scopus 로고
    • NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression
    • Drew, P.D., Franzoso, G., Becker, K.G., Bours, V., Carlos, L.M., Siebenlist, U. & Ozato, K. (1995) NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression. J. Interferon Cytokine Res., 15, 1037-1045.
    • (1995) J. Interferon Cytokine Res. , vol.15 , pp. 1037-1045
    • Drew, P.D.1    Franzoso, G.2    Becker, K.G.3    Bours, V.4    Carlos, L.M.5    Siebenlist, U.6    Ozato, K.7
  • 14
    • 0025789094 scopus 로고
    • Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-α promoter in primary macrophages
    • Drouet, C., Shakhov, A.N. & Jongeneel, C.V. (1991) Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-α promoter in primary macrophages. J. Immunol., 147, 1694-1700.
    • (1991) J. Immunol. , vol.147 , pp. 1694-1700
    • Drouet, C.1    Shakhov, A.N.2    Jongeneel, C.V.3
  • 16
    • 0031022516 scopus 로고    scopus 로고
    • An interferon-γ-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-γ and lipopolysaccharide
    • Gao, J., Morrison, D.C., Parmely, T.J., Russell, S.W. & Murphy, W.J. (1997) An interferon-γ-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-γ and lipopolysaccharide. J. Biol. Chem., 272, 1226-1230.
    • (1997) J. Biol. Chem. , vol.272 , pp. 1226-1230
    • Gao, J.1    Morrison, D.C.2    Parmely, T.J.3    Russell, S.W.4    Murphy, W.J.5
  • 17
    • 0030789420 scopus 로고    scopus 로고
    • I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor
    • Heck, S, Bender, K., Kullmann, M., Gottlicher, M., Herrlich, P. & Cato, A.C.B. (1997) I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor. EMBO J., 16, 4698-4707.
    • (1997) EMBO J. , vol.16 , pp. 4698-4707
    • Heck, S.1    Bender, K.2    Kullmann, M.3    Gottlicher, M.4    Herrlich, P.5    Cato, A.C.B.6
  • 19
    • 0031136958 scopus 로고    scopus 로고
    • IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and n MHC genes in vivo
    • Hobart, M., Ramassar, V., Goes, N., Urmson, J. & Halloran, P.F. (1997) IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and n MHC genes in vivo. J. Immunol., 158, 4260-4269.
    • (1997) J. Immunol. , vol.158 , pp. 4260-4269
    • Hobart, M.1    Ramassar, V.2    Goes, N.3    Urmson, J.4    Halloran, P.F.5
  • 20
    • 0028970385 scopus 로고
    • The relocalization of ν-rel from the nucleus to the cytoplasm coincides with induction of expression of Ikbα and nfκb1 and stabilization of I kappa B-alpha
    • Hrdlickova, R., Nehyba, J., Roy, A., Humphries, E.H. & Bose, H.R. (1995) The relocalization of ν-Rel from the nucleus to the cytoplasm coincides with induction of expression of Ikbα and nfκb1 and stabilization of I kappa B-alpha. J. Virol., 69, 403-413.
    • (1995) J. Virol. , vol.69 , pp. 403-413
    • Hrdlickova, R.1    Nehyba, J.2    Roy, A.3    Humphries, E.H.4    Bose, H.R.5
  • 21
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C., Ting, A.T. & Seed, B. (1998) PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature, 391, 82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 23
    • 0032127465 scopus 로고    scopus 로고
    • STAT-1 combines signals derived from IFN-γ and LPS receptors during macrophage activation
    • Kovarik, P., Stoiber, D., Novy, M. & Decker, T. (1998) STAT-1 combines signals derived from IFN-γ and LPS receptors during macrophage activation. EMBO J., 17, 3660-3668.
    • (1998) EMBO J. , vol.17 , pp. 3660-3668
    • Kovarik, P.1    Stoiber, D.2    Novy, M.3    Decker, T.4
  • 24
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg, G.W. (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci., 19, 312-318.
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 25
    • 0029731662 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: A nuclear receptor signalling pathway in lipid physiology
    • Lemberger, T., Desvergne, B. & Wahli, W. (1996) Peroxisome proliferator-activated receptors: a nuclear receptor signalling pathway in lipid physiology. Ann. Rev. Cell Dev. Biol, 12, 335-363.
    • (1996) Ann. Rev. Cell Dev. Biol , vol.12 , pp. 335-363
    • Lemberger, T.1    Desvergne, B.2    Wahli, W.3
  • 26
    • 0023604876 scopus 로고
    • Differentiation of cerebellar bipotential glial precursors into oligodendrocytes in primary cultures: Developmental profile of surface antigens and mitotic activity
    • Levi, G., Aloisi, F. & Wilkin, G.P. (1987) Differentiation of cerebellar bipotential glial precursors into oligodendrocytes in primary cultures: developmental profile of surface antigens and mitotic activity. J. Neurosci. Res., 18, 407-417.
    • (1987) J. Neurosci. Res. , vol.18 , pp. 407-417
    • Levi, G.1    Aloisi, F.2    Wilkin, G.P.3
  • 28
    • 0027409048 scopus 로고
    • Human immunodeficiency virus coat protein gp120 inhibits the β-adrenergic regulation of astroglial and microglial functions
    • Levi, G., Patrizio, M, Bernardo, A., Petrucci, T.C. & Agresti, C. (1993) Human immunodeficiency virus coat protein gp120 inhibits the β-adrenergic regulation of astroglial and microglial functions. Proc. Natl Acad. Sci. USA, 90, 1541-1545.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 1541-1545
    • Levi, G.1    Patrizio, M.2    Bernardo, A.3    Petrucci, T.C.4    Agresti, C.5
  • 29
    • 0030457034 scopus 로고    scopus 로고
    • The role of protein tyrosine phosphatase SHP-1 in the regulation of ifn-γ signaling in neural cells
    • Massa, P.T. & Wu, C. (1996) The role of protein tyrosine phosphatase SHP-1 in the regulation of IFN-γ signaling in neural cells. J. Immunol., 157, 5139-5144.
    • (1996) J. Immunol. , vol.157 , pp. 5139-5144
    • Massa, P.T.1    Wu, C.2
  • 30
    • 0031904583 scopus 로고    scopus 로고
    • Increased inducible activation of NF-kappaB and responsive genes in astrocytes deficient in the protein tyrosine phosphatase SHP-1
    • Massa, P.T. & Wu, C. (1998) Increased inducible activation of NF-kappaB and responsive genes in astrocytes deficient in the protein tyrosine phosphatase SHP-1. J. Interferon Cytokine Res., 18, 499-507.
    • (1998) J. Interferon Cytokine Res. , vol.18 , pp. 499-507
    • Massa, P.T.1    Wu, C.2
  • 31
    • 0032126180 scopus 로고    scopus 로고
    • Effects of interferons on tumor necrosis factor α production from human keratinocytes
    • Matsuura, K., Otsuka, F. & Fujisawa, H. (1998) Effects of interferons on tumor necrosis factor α production from human keratinocytes. Cytokine, 10, 500-505.
    • (1998) Cytokine , vol.10 , pp. 500-505
    • Matsuura, K.1    Otsuka, F.2    Fujisawa, H.3
  • 32
    • 0028805463 scopus 로고
    • Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures
    • Minghetti, L. & Levi, G. (1995) Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures. J. Neurochem., 65, 2690-2698.
    • (1995) J. Neurochem. , vol.65 , pp. 2690-2698
    • Minghetti, L.1    Levi, G.2
  • 33
    • 0031985513 scopus 로고    scopus 로고
    • Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide
    • Minghetti, L. & Levi, G. (1998) Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog. Neurobiol., 54, 99-125.
    • (1998) Prog. Neurobiol. , vol.54 , pp. 99-125
    • Minghetti, L.1    Levi, G.2
  • 34
    • 0031081781 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase expression in activated rat microglial culture is down-regulated by exogenous prostaglandin E2 and by cyclooxygenase inhibitors
    • Minghetti, L., Nicolini, A., Polazzi, E., Creminon, C., Maclouf, J. & Levi, G. (1997) Inducible nitric oxide synthase expression in activated rat microglial culture is down-regulated by exogenous prostaglandin E2 and by cyclooxygenase inhibitors. Glia, 19, 152-160.
    • (1997) Glia , vol.19 , pp. 152-160
    • Minghetti, L.1    Nicolini, A.2    Polazzi, E.3    Creminon, C.4    Maclouf, J.5    Levi, G.6
  • 35
    • 0029961125 scopus 로고    scopus 로고
    • Interferon-γ and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression
    • Minghetti, L., Polazzi, E., Nicolini, A., Creminon, C. & Levi, G. (1996) Interferon-γ and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression. J. Neurochem., 66, 1936-1970.
    • (1996) J. Neurochem. , vol.66 , pp. 1936-1970
    • Minghetti, L.1    Polazzi, E.2    Nicolini, A.3    Creminon, C.4    Levi, G.5
  • 36
    • 0029996739 scopus 로고    scopus 로고
    • The concept of microglia in relation to CNS disease and regeneration
    • Moore, S. & Thanos, S. (1996) The concept of microglia in relation to CNS disease and regeneration. Prog. Neurobiol., 48, 441-460.
    • (1996) Prog. Neurobiol. , vol.48 , pp. 441-460
    • Moore, S.1    Thanos, S.2
  • 37
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assay
    • Mosmann, T.R. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. J. Immunol. Meth., 65, 55-63.
    • (1983) J. Immunol. Meth. , vol.65 , pp. 55-63
    • Mosmann, T.R.1
  • 38
    • 0344157469 scopus 로고    scopus 로고
    • The role of tumor necrosis factor, interleukin 6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system
    • Munoz-Fernandez, M.A. & Fresno, M. (1998) The role of tumor necrosis factor, interleukin 6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system. Prog. Neurobiol., 56, 307-340.
    • (1998) Prog. Neurobiol. , vol.56 , pp. 307-340
    • Munoz-Fernandez, M.A.1    Fresno, M.2
  • 39
    • 0024256996 scopus 로고
    • Astrocytes as eicosanoid-producing cells
    • Murphy, S., Pearce, B., Jeremy, J. & Dandona, P. (1988) Astrocytes as eicosanoid-producing cells. Glia, 1, 241-245.
    • (1988) Glia , vol.1 , pp. 241-245
    • Murphy, S.1    Pearce, B.2    Jeremy, J.3    Dandona, P.4
  • 40
    • 0032515035 scopus 로고    scopus 로고
    • Role of IKK1 and IKK2 in lipopolysaccharide signalling in human monocytic cells
    • O'Connell, M.A., Bennett, B.L., Mercurio, F., Manning, A.M. & Nackman, N. (1998) Role of IKK1 and IKK2 in lipopolysaccharide signalling in human monocytic cells. J. Biol. Chem., 273, 30410-30414.
    • (1998) J. Biol. Chem. , vol.273 , pp. 30410-30414
    • O'Connell, M.A.1    Bennett, B.L.2    Mercurio, F.3    Manning, A.M.4    Nackman, N.5
  • 41
    • 0345294457 scopus 로고    scopus 로고
    • A revised view of the CNS microenvironment and major histocompatibility complex class II antigen presentation
    • Perry, V.H. (1998) A revised view of the CNS microenvironment and major histocompatibility complex class II antigen presentation. J. Neuroimmunol., 90, 113-121.
    • (1998) J. Neuroimmunol. , vol.90 , pp. 113-121
    • Perry, V.H.1
  • 43
    • 0030443838 scopus 로고    scopus 로고
    • Evidence for the in vivo role of class II transactivator in basal and IFN-γ induced class II expression in mouse tissue
    • Ramassar, V., Goes, N., Hortart, M. & Halloran, P.F. (1996) Evidence for the in vivo role of class II transactivator in basal and IFN-γ induced class II expression in mouse tissue. Transplantation, 62, 1901-1907.
    • (1996) Transplantation , vol.62 , pp. 1901-1907
    • Ramassar, V.1    Goes, N.2    Hortart, M.3    Halloran, P.F.4
  • 44
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • Ricote, M., Li, A.C., Willsons, T.M., Kelly, C.J. & Glass, C.K. (1998) The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature, 391, 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willsons, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 45
    • 0034610759 scopus 로고    scopus 로고
    • Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
    • Rossi, A., Kapahi, P., Natoli, G., Takahashi, T., Chen, Y., Karin, M. & Santoro, G. (2000) Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature, 403, 103-108.
    • (2000) Nature , vol.403 , pp. 103-108
    • Rossi, A.1    Kapahi, P.2    Natoli, G.3    Takahashi, T.4    Chen, Y.5    Karin, M.6    Santoro, G.7
  • 46
    • 0022451826 scopus 로고
    • Reversible staining and peptide mapping of proteins transferred to nitrocellulose after separation by sodium dodecylsulfate-polyacrylamide gel electrophoresis
    • Salinovich, O. & Montelaro, R.C. (1986) Reversible staining and peptide mapping of proteins transferred to nitrocellulose after separation by sodium dodecylsulfate-polyacrylamide gel electrophoresis. Anal. Biochem., 156, 341-347.
    • (1986) Anal. Biochem. , vol.156 , pp. 341-347
    • Salinovich, O.1    Montelaro, R.C.2
  • 48
    • 0025358788 scopus 로고
    • Arachidonic acid cascade and signal transduction
    • Shimizu, T. & Wolfe, L.S. (1990) Arachidonic acid cascade and signal transduction. J. Neurochem., 55, 1-15.
    • (1990) J. Neurochem. , vol.55 , pp. 1-15
    • Shimizu, T.1    Wolfe, L.S.2
  • 49
    • 0028972008 scopus 로고
    • Augmentation or inhibition of IFN-γ-induced MHC class II expression by lipopolysaccharides
    • Sicher, S.C., Chung, G.W., Vazquez, M.A. & Lu, C.Y. (1995) Augmentation or inhibition of IFN-γ-induced MHC class II expression by lipopolysaccharides. J. Immunol., 155, 5826-5834.
    • (1995) J. Immunol. , vol.155 , pp. 5826-5834
    • Sicher, S.C.1    Chung, G.W.2    Vazquez, M.A.3    Lu, C.Y.4
  • 50
    • 0030608706 scopus 로고    scopus 로고
    • Peroxisomal proliferator-activated receptors and the regulation of lipid oxidation and adipogenesis
    • Smith, S.A. (1997) Peroxisomal proliferator-activated receptors and the regulation of lipid oxidation and adipogenesis. Biochem. Soc. Trans., 25, 1242-1248.
    • (1997) Biochem. Soc. Trans. , vol.25 , pp. 1242-1248
    • Smith, S.A.1
  • 51
    • 0030759196 scopus 로고    scopus 로고
    • PPAR gamma and the control of adipogenesis
    • Spiegelman, B.M., Hu, E. & Brun, K.R. (1997) PPAR gamma and the control of adipogenesis. Biochimie, 79, 111-112.
    • (1997) Biochimie , vol.79 , pp. 111-112
    • Spiegelman, B.M.1    Hu, E.2    Brun, K.R.3
  • 52
    • 0027135061 scopus 로고
    • Regulation of murine macrophage function by IL-4: IL-4 and IFN-γ differentially regulate macrophage tumoricidal activation
    • Suk, K., Somers, S.D. & Erickson, K.L. (1993) Regulation of murine macrophage function by IL-4: IL-4 and IFN-γ differentially regulate macrophage tumoricidal activation. Immunology, 80, 617-624.
    • (1993) Immunology , vol.80 , pp. 617-624
    • Suk, K.1    Somers, S.D.2    Erickson, K.L.3
  • 53
    • 0032007308 scopus 로고    scopus 로고
    • The role of endogeneous IFN-γ, TNF-α and IL-10 in LPS-induced nitric oxide release in a mouse model
    • ter Steege, J.C.A., Van de Ven, M.W.C.M., Forget, P., Brouckaert, P. & Buurman, W.A. (1998) The role of endogeneous IFN-γ, TNF-α and IL-10 in LPS-induced nitric oxide release in a mouse model. Cytokine, 10, 115-123.
    • (1998) Cytokine , vol.10 , pp. 115-123
    • Ter Steege, J.C.A.1    Van De Ven, M.W.C.M.2    Forget, P.3    Brouckaert, P.4    Buurman, W.A.5
  • 55
    • 0000950084 scopus 로고
    • Spectrophotometric determination of nitrogen oxides using azo dyes
    • Tracey, W.R. (1992) Spectrophotometric determination of nitrogen oxides using azo dyes. Neuroprotocols, 1, 125-131.
    • (1992) Neuroprotocols , vol.1 , pp. 125-131
    • Tracey, W.R.1
  • 56
    • 0029886747 scopus 로고    scopus 로고
    • Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-γ
    • Zhang, X., Laubach, V.E., Alley, E.W., Edwards, K.A., Sherman, P.A., Russell, S.W. & Murphy, W.J. (1996) Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-γ. J. Leukoc. Biol., 59, 575-585.
    • (1996) J. Leukoc. Biol. , vol.59 , pp. 575-585
    • Zhang, X.1    Laubach, V.E.2    Alley, E.W.3    Edwards, K.A.4    Sherman, P.A.5    Russell, S.W.6    Murphy, W.J.7


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