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Volumn 250, Issue 7, 2003, Pages 788-792

Anti-inflammatory therapy in Alzheimer's disease: Is hope still alive?

Author keywords

Alzheimer's disease; Anti inflammatory drugs; Inflammation; Microglia; Therapy

Indexed keywords

ANTIINFLAMMATORY AGENT; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; HYDROXYCHLOROQUINE; INDOMETACIN; MISOPROSTOL; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE;

EID: 0042347804     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00415-003-1146-5     Document Type: Review
Times cited : (60)

References (34)
  • 1
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Akiyama H, Barger S, Barnum S, et al. (2002) Inflammation and Alzheimer's disease. Neurobiol Aging 21:383-421
    • (2002) Neurobiol Aging , vol.21 , pp. 383-421
    • Akiyama, H.1    Barger, S.2    Barnum, S.3
  • 3
    • 0028103819 scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: Implications for therapy
    • Aisen PS, Davis KL (1994) Inflammatory mechanisms in Alzheimer's disease: implications for therapy. Am J Psychiatry 15:1105-1113
    • (1994) Am J Psychiatry , vol.15 , pp. 1105-1113
    • Aisen, P.S.1    Davis, K.L.2
  • 4
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer PL, McGeer EG (1995) The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev 21:195-218
    • (1995) Brain Res Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 5
    • 0034948192 scopus 로고    scopus 로고
    • Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
    • Lue LF, Rydel R, Brigham EF, et al. (2001) Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia 35:72-79
    • (2001) Glia , vol.35 , pp. 72-79
    • Lue, L.F.1    Rydel, R.2    Brigham, E.F.3
  • 6
    • 0026447529 scopus 로고
    • Complement activation by beta-amyloid in Alzheimer disease
    • Rogers J, Cooper NR, Webster S, et al. (1992) Complement activation by beta-amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 89:10016-10020
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10016-10020
    • Rogers, J.1    Cooper, N.R.2    Webster, S.3
  • 7
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • McGeer PL, Schulzer M, McGeer EG (1996) Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 47:425-432
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 8
    • 0034620538 scopus 로고    scopus 로고
    • A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study
    • Aisen PS, Davis KL, Berg JD, et al. (2000) A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study. Neurology 54:588-593
    • (2000) Neurology , vol.54 , pp. 588-593
    • Aisen, P.S.1    Davis, K.L.2    Berg, J.D.3
  • 9
    • 0027268393 scopus 로고
    • Clinical trial of indomethacin in Alzheimer's disease
    • Rogers J, Kirby LC, Hempelman SR, et al. (1993) Clinical trial of indomethacin in Alzheimer's disease. Neurology 43:1609-1611
    • (1993) Neurology , vol.43 , pp. 1609-1611
    • Rogers, J.1    Kirby, L.C.2    Hempelman, S.R.3
  • 11
    • 0033551547 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease
    • Scharf S, Mander A, Ugoni A, Vajda F, Christophidis N (1999) A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology 53:197-201
    • (1999) Neurology , vol.53 , pp. 197-201
    • Scharf, S.1    Mander, A.2    Ugoni, A.3    Vajda, F.4    Christophidis, N.5
  • 12
    • 0035845325 scopus 로고    scopus 로고
    • Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: An 18-month randomised, double-blind, placebo-controlled study
    • van Gool WA, Weinstein HC, Scheltens PK, Walstra GJ (2001) Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study. Lancet 358:455-460
    • (2001) Lancet , vol.358 , pp. 455-460
    • Van Gool, W.A.1    Weinstein, H.C.2    Scheltens, P.K.3    Walstra, G.J.4
  • 13
    • 0025770795 scopus 로고
    • Cerebral amyloid plaques in Alzheimer's disease but not in scrapie-affected mice are closely associated with a local inflammatory process
    • Eikelenboom P, Rozemuller JM, Kraal G, et al. (1991) Cerebral amyloid plaques in Alzheimer's disease but not in scrapie-affected mice are closely associated with a local inflammatory process. Virchows Arch B Cell Pathol Incl Mol Pathol 60:329-336
    • (1991) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.60 , pp. 329-336
    • Eikelenboom, P.1    Rozemuller, J.M.2    Kraal, G.3
  • 14
    • 0030250852 scopus 로고    scopus 로고
    • The role of complement and activated microglia in the pathogenesis of Alzheimer's disease
    • Eikelenboom P, Veerhuis R (1996) The role of complement and activated microglia in the pathogenesis of Alzheimer's disease. Neurobiol Aging 17:673-680
    • (1996) Neurobiol Aging , vol.17 , pp. 673-680
    • Eikelenboom, P.1    Veerhuis, R.2
  • 15
    • 0027354484 scopus 로고
    • Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
    • Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C (1993) Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7:75-83
    • (1993) Glia , vol.7 , pp. 75-83
    • Dickson, D.W.1    Lee, S.C.2    Mattiace, L.A.3    Yen, S.H.4    Brosnan, C.5
  • 16
    • 0001360461 scopus 로고
    • Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
    • Griffin WS, Stanley LC, Ling C, et al. (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A 86:7611-7615
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 7611-7615
    • Griffin, W.S.1    Stanley, L.C.2    Ling, C.3
  • 17
    • 0035696282 scopus 로고    scopus 로고
    • The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease
    • Mrak RE, Griffinbc WS (2001) The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease. Neurobiol Aging 22:915-922
    • (2001) Neurobiol Aging , vol.22 , pp. 915-922
    • Mrak, R.E.1    Griffinbc, W.S.2
  • 18
    • 17644438751 scopus 로고    scopus 로고
    • Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism
    • Grimaldi LM, Casadei VM, Ferri C, et al. (2000) Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism. Ann Neurol 47:361-365
    • (2000) Ann Neurol , vol.47 , pp. 361-365
    • Grimaldi, L.M.1    Casadei, V.M.2    Ferri, C.3
  • 19
    • 0034053173 scopus 로고    scopus 로고
    • Association of interleukin-1 gene polymorphisms with Alzheimer's disease
    • Nicoll JA, Mrak RE, Graham DI, et al. (2000) Association of interleukin-1 gene polymorphisms with Alzheimer's disease. Ann Neurol 47:365-368
    • (2000) Ann Neurol , vol.47 , pp. 365-368
    • Nicoll, J.A.1    Mrak, R.E.2    Graham, D.I.3
  • 20
    • 84984755327 scopus 로고    scopus 로고
    • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D, Diamond DM, Gottschall PE, et al. (2000) A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408:982-985
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3
  • 21
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloidbeta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, Barbour R, Dunn W, et al. (1999) Immunization with amyloidbeta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400:173-177
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 23
    • 0035100231 scopus 로고    scopus 로고
    • Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease
    • Ho L, Purohit D, Haroutunian V, et al. (2001) Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. Arch Neurol 58:487-492
    • (2001) Arch Neurol , vol.58 , pp. 487-492
    • Ho, L.1    Purohit, D.2    Haroutunian, V.3
  • 24
    • 0032551633 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain
    • Pasinetti GM, Aisen PS (1998) Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience 87:319-324
    • (1998) Neuroscience , vol.87 , pp. 319-324
    • Pasinetti, G.M.1    Aisen, P.S.2
  • 25
    • 0035887744 scopus 로고    scopus 로고
    • Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice
    • Andreasson KI, Savonenko A, Vidensky S, et al. (2001) Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. J Neurosci 21:8198-8209
    • (2001) J Neurosci , vol.21 , pp. 8198-8209
    • Andreasson, K.I.1    Savonenko, A.2    Vidensky, S.3
  • 26
    • 0032887341 scopus 로고    scopus 로고
    • Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2
    • Kelley KA, Ho L, Winger D, et al. (1999) Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am J Pathol 155:995-1004
    • (1999) Am J Pathol , vol.155 , pp. 995-1004
    • Kelley, K.A.1    Ho, L.2    Winger, D.3
  • 27
    • 0035693506 scopus 로고    scopus 로고
    • Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease
    • Landreth GE, Heneka MT (2001) Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease. Neurobiol Aging 22:937-944
    • (2001) Neurobiol Aging , vol.22 , pp. 937-944
    • Landreth, G.E.1    Heneka, M.T.2
  • 28
    • 0035691115 scopus 로고    scopus 로고
    • Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
    • Lim GP, Yang F, Chu T, et al. (2001) Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging 22:983-991
    • (2001) Neurobiol Aging , vol.22 , pp. 983-991
    • Lim, G.P.1    Yang, F.2    Chu, T.3
  • 29
    • 0035829592 scopus 로고    scopus 로고
    • A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
    • Weggen S, Eriksen JL, Das P, et al. (2001) A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414:212-216
    • (2001) Nature , vol.414 , pp. 212-216
    • Weggen, S.1    Eriksen, J.L.2    Das, P.3
  • 31
    • 0035936004 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
    • In 't Veld BA, Ruitenberg A, Hofman A, et al. (2001) Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 345:1515-1521
    • (2001) N Engl J Med , vol.345 , pp. 1515-1521
    • In 't Veld, B.A.1    Ruitenberg, A.2    Hofman, A.3
  • 32
    • 0035936009 scopus 로고    scopus 로고
    • Do non-steroidal antiinflammatory drugs reduce the risk of Alzheimer's disease?
    • Breitner JC, Zandi PP (2001) Do non-steroidal antiinflammatory drugs reduce the risk of Alzheimer's disease? N Engl J Med 345:1567-1568
    • (2001) N Engl J Med , vol.345 , pp. 1567-1568
    • Breitner, J.C.1    Zandi, P.P.2
  • 34
    • 0035845283 scopus 로고    scopus 로고
    • In-vivo measurement of activated microglia in dementia
    • Cagnin A, Brooks DJ, Kennedy AM, et al. (2001) In-vivo measurement of activated microglia in dementia. Lancet 358:461-467
    • (2001) Lancet , vol.358 , pp. 461-467
    • Cagnin, A.1    Brooks, D.J.2    Kennedy, A.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.