Mechanism of action of antiinflammatory drugs

International Journal of Tissue Reactions

Volumn 20, Issue 1, 1998, Pages 3-15

  Vane, J R ^a   Botting, R M ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (7 TERT BUTYL 2,3 DIHYDRO 3,3 DIMETHYLBENZO[B]FURAN 5 YL) 4 CYCLOPROPYL 1 BUTANONE; 5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CELECOXIB; CL 1004; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; DICLOFENAC; ETODOLAC; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; L 475337; LIPOXYGENASE INHIBITOR; MELOXICAM; N [5 (4 FLUOROPHENOXY) 2 THIENYL]METHANESULFONAMIDE; NAPROXEN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PD 098120003; PIROXICAM; PROSTAGLANDIN; ROFECOXIB; RS 57067000; SULINDAC; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; CANCER THERAPY; DRUG POTENCY; ENZYME BINDING; ENZYME INHIBITION; HUMAN; INFLAMMATION; KIDNEY; KIDNEY INJURY; LUNG; NONHUMAN; PREMATURE LABOR; PROSTAGLANDIN SYNTHESIS; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; REVIEW; STOMACH MUCOSA LESION; UTERUS;

ALZHEIMER DISEASE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HUMANS; INFLAMMATION; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0032452709     PISSN: 02500868     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (15)

1. Hemler M., Lands W.E.M., Smith W.L. Purification of the cyclooxygenase that forms prostaglandins: Demonstration of two forms of iron in the holoenzyme. J. Biol. Chem., 251, 5575, 1976.
2. Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs. Nature, 231, 232, 1971.
3. Higgs G.A., Vane J.R., Hart F.D., Wojtulewski J.A. Effects of antiinflammatory drugs on prostaglandins in rheumatoid arthritis. In: Robinson H.J., Vane J.R. (eds.). "Prostaglandin Synthase Inhibitors". Raven, New York, 1974, pp. 165-173.
4. 2 synthase-1. Nature, 367, 243, 1994.
5. Luong C., Miller A., Barnett J., Chow J., Ramesha C., Browner M.F. Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2. Nature Struct. Biol., 3, 927, 1996.
6. 523 to Val mutation. J. Biol. Chem., 272, 9280, 1997.
7. Moncada S., Gryglewski R., Bunting S., Vane J.R. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature, 263, 663, 1976.
8. Whittle B.J.R., Higgs G.A., Eakins K.E., Moncada S., Vane J.R. Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature, 284, 271, 1980.
9. Funk C.D., Funk LB., Kennedy M.E., Pong A.S., Fitzgerald, G.A. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J., 5, 2304, 1991.
10. Raz A., Wyche A., Needleman P. Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases. Proc. Natl. Acad. Sci. USA, 86, 1657, 1989.
11. 2 synthase (cyclooxygenase) in human monocytes. J. Biol. Chem., 265, 16737, 1990.
12. Masferrer J.L., Zweifel B.S., Seibert K., Needleman P. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J. Clin. Invest., 86, 1375, 1990.
13. Xie W, Chipman J.G., Robertson D.L., Erikson R.L., Simmons D.L. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl. Acad. Sci. USA, 88, 2692, 1991.
14. Xie W., Robertson D.L., Simmons D.L. Mitogen-inducible prostaglandin G/H synthase: a new target for nonsteroidal antiinflammatory drugs. Drug Devel. Res., 25, 249, 1992.
15. O'Banion M.K., Sadowski H.B., Winn V. Young D.A. A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J. Biol. Chem., 266, 23261, 1991.