A global genomic view on LNX siRNA-mediated cell cycle arrest

Molecular Biology Reports

Volumn 38, Issue 4, 2011, Pages 2771-2783

  Zheng, Dan ^a   Gu, Shaohua ^a   Li, Yao ^a   Ji, Chaoneng ^a   Xie, Yi ^a   Mao, Yumin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Cell cycle; LNX; Microarray; Pathway analysis; Ubiquitin ligase

Indexed keywords

BETA CATENIN; CELL PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; PROTEIN LNX; PROTEIN P53; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; LNX1 PROTEIN, HUMAN; OLIGONUCLEOTIDE; PRIMER DNA; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENOMICS; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; CELL CYCLE; CELL LINE; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENE SILENCING; GENE VECTOR; GENETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BETA CATENIN; CELL CYCLE; CELL LINE; DNA PRIMERS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 79960933930     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0422-6     Document Type: Article

References (85)

1. Lamprecht G, Seidler U (2006) The emerging role of PDZ adapter proteins for regulation of intestinal ion transport. Am J Physiol Gastrointest Liver Physiol 291:G766-G777
2. Bilder D (2001) PDZ proteins and polarity: functions from the fly. Trends Genet 17:511-519
3. Tsunoda S, Sierralta J, Sun Y et al (1997) A multivalent PDZdomain protein assembles signalling complexes in a G-proteincoupled cascade. Nature 388:243-249
4. Maudsley S, Zamah AM, Rahman N et al (2000) Platelet-derived growth factor receptor association with Na?/H? exchanger regulatory factor potentiates receptor activity. Mol Cell Biol 20:8352-8353
5. Voltz JW, Weinman EJ, Shenolikar S (2001) Expanding the role of NHERF, a PDZ-domain containing protein adapter to growth regulation. Oncogene 20:6309-6314
6. Park J-H, Lin M-L, Nishidate T et al (2006) PDZ-binding kinase/ T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer. Cancer Res 66:9186-9195
7. Gaudet S, Branton D, Lue RA (2000) Characterization of PDZbinding kinase, a mitotic kinase. Proc Natl Acad Sci 97:5167-5172
8. Abe Y, Matsumoto S, Kito K et al (2000) Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in testis and activated lymphoid cells. J Biol Chem 275:21525-21531
9. Reed JA, Lin Q, Chen D et al (2005) SKI pathways inducing progression of human melanoma. Cancer Metast Rev 24:265-272
10. Colmenares C, Stavnezer E (1989) The ski oncogene induces muscle differentiation in quail embryo cells. Cell 59:293-303
11. Chen W, Lam SS, Srinath H et al (2007) Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling. J Biol Chem 282: 11365-11376
12. Leong GM, Subramaniam N, Figueroa J et al (2001) Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-b-dependent transcription. J Biol Chem 276:18243-18248
13. Kansaku A, Hirabayashi S, Mori H et al (2006) Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule. Oncogene 25:5071-5084
14. Rhyu MS, Jan LY, Jan YN (1994) Asymmetric distribution of Numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76:477-491
15. Spana EP, Kopczynski C, Goodman CS et al (1995) Asymmetric localization of Numb autonomously determines sibling neuron identity in the Drosophila CNS. Development 121:3489-3494
16. Vervoort M, Dambly-Chaudiere C, Ghysen A (1997) Cell fate determination in Drosophila. Curr Opin Neurobiol 7:21-28
17. Guo M, Jan LY, Jan YN (1996) Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch. Neuron 17:27-41
18. Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284:770-776
19. Nie J, McGill MA, Dermer M et al (2002) LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO 21:93-102
20. Pray TR, Parlati F, Huang J et al (2002) Cell cycle regulatory E3 ubiquitin ligases as anticancer targets. Drug Resist Update 5:249-258
21. Liu L, Ji C, Chen J et al (2008) A global genomic view of MIF knockdown-mediated cell cycle arrest. Cell Cycle 7:1678-1692
22. Kleihues P, Burger PC, Scheithauer BW (1993) The new WHO classification of brain tumours. Brain Pathol 3:255-268
23. Chen J, Xu J, Zhao W et al (2005) Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. Int J Biochem Cell Biol 37:2273-2283
24. Liu W, Zhu FX, Wu QY et al (2007) Effects of ubiquitin ligase LNX on epithelial cell junction formation. Chin J Biochem Mol Biol 23:463-468
25. Liu Y (2004) Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 15:1-12
26. Xia X, Su Q, Soriano S et al (2001) Loss of presenilin 1 is associated with enhanced b-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci USA 98:10863-10868
27. Huelsken J, Behrens J (2002) The Wnt signalling pathway. J Cell Sci 115:3977-3978
28. Katoh M, Katoh M (2006) Cross-talk of WNT and FGF signaling pathways at GSK3b to regulate b-catenin and SNAIL signaling cascades. Cancer Biol Ther 5:1059-1064
29. Hoffmans R, Basler K (2007) BCL9-2 binds Arm/b-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. Mech Dev 124:59-67
30. De D, Chen A, Wu Z, Lv S, He G, Qi Y (2009) Overexpression of Pygopus2 protects HeLa cells from vinblastine-induced apoptosis. Biol Chem 390:157-165
31. Lee Young-Ho, Stallcup MR (2006) Interplay of Fli-I and FLAP1 for regulation of b-catenin dependent transcription. Nucleic Acids Res 34:5052-5059
32. Ohshima R, Ohta T, WuW et al (2007) Putative tumor suppressor EDD interacts with and up-regulates APC. Genes Cells 12: 1339-1345
33. Kikuchi A (2000) Regulation of b-catenin signaling in the Wnt pathway. Biochem Biophys Res Commun 268:243-248
34. Vousden KH, Lu X (2002) Live or let die: the cell's response to p53. Nat Rev Cancer 2:594-604
35. Linke SP, Clarkin KC, Di LA, Tsou A, Wahl GM (1996) A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev 10:934-947
36. Le Cam L, Linares LK, Paul C, et al (2006) e4f1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell 127:775-788
37. Falck J, Coates J, Jackson SP (2005) Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434:605-611
38. Li H, Watts GS, Oshiro MM et al (2006) AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells. Oncogene 25:5405-5415
39. McPherson LA, Loktev AV, Weigel RJ (2002) Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53. J Biol Chem 277:45028-45033
40. Li Q, Dashwood RH (2004) Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits betacatenin/ T-cell factor transcriptional activity in colorectal cancer cells. J Biol Chem 279:45669-45675
41. Ihrie Rebecca A, Attardi Laura D (2004) Perp-etrating p53-dependent apoptosis. Cell Cycle 3:267-269
42. Li J, Lee B, Lee AS (2006) Endoplasmic reticulum stress-induced apoptosis. Multiple pathways and activation of p53-up-regulated modulator of apoptosis (Puma) and Noxa by p53. J Biol Chem 281:7260-7270
43. Myung K, Braastad C, He DM, Hendrickson EA (1998) KARP-1 is induced by DNA damage in a p53-and ataxia telangiectasia mutated-dependent fashion. Proc Natl Acad Sci USA 95: 7664-7669
44. Braasted CD, Leguia M, Hendrickson EA (2002) Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. Nucleic Acids Res 30:1713-1724
45. Anazawa Y, Arakawa H, Nakagawa H et al (2004) Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. Oncogene 23:7621-7627
46. Yoon H, Liyanarachchi S, Wright FA et al (2002) Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53. Proc Natl Acad Sci USA 99:15632-15637
47. Datto MB, Li Y, Panus JF et al (1995) Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 92:5545-5549
48. Kamesaki H, Nishizawa K, Michaud GY et al (1998) TGF-beta 1 induces the cyclin-dependent kinase inhibitor p27Kip1 mRNA and protein in murine B cells. J Immunol 160:770-777
49. Amati B (2001) Integrating Myc and TGF-beta signalling in cellcycle control. Nat Cell Biol 3:E112-E113
50. Yao X, Chen X, Cottonham C, Xu CL (2008) Preferential utilization of Imp7/8 in nuclear import of Smads. J Biol Chem 283:22867-22874
51. Kim T-D, Shin S, Janknecht R (2008) Repression of Smad3 activity by histone demethylase SMCX/JARID1C. Biochem Bioph Res Commun 366:563-567
52. Yamamura Y, Hua X, Bergelson S et al (2000) Critical role of Smads and AP-1 complex in transforming growth factor-bdependent apoptosis. J Biol Chem 275:36295-36302
53. Pulverer BJ, Hughes K, Franklin CC et al (1993) Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cells. Oncogene 8:407-415
54. Norris JL, Baldwin AS Jr (1999) Oncogenic Ras enhances NFkappaB transcriptional activity through Raf-dependent and Rafindependent mitogen-activated protein kinase signaling pathways. J Biol Chem 274:13841-13846
55. Baumann B, Weber CK, Troppmair J et al (2000) Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Proc Natl Acad Sci USA 97:4615-4620
56. Chang F, Steelman LS, Shelton JG et al (2003) Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway. Int J Oncol 22:469-480
57. Zhu Y, Wang Y, Xia C et al (2004) WDR26: a novel Gb-like protein, suppresses MAPK signaling pathway. J Cell Biochem 93:579-587
58. Treisman R (1996) Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8:205-215
59. Maekawa M, Nishida E, Tanoue T (2002) Identification of the anti-proliferative protein Tob as a MAPK substrate. J Biol Chem 277:37783-37787
60. Shaulian E, Karin M (2001) AP-1 in cell proliferation and survival. Oncogene 20:2390-2400
61. Whitmarsh AJ, Davis RJ (1996) Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 74:589-607
62. Frigo DE, Tang Y, Beckman BS et al (2004) Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway. Carcinogenesis 25:249-261
63. Lu A, Zhang F, Gupta A et al (2002) Blockade of AP1 transactivation abrogates the abnormal expression of breast cancerspecific Gene 1 in breast cancer cells. J Biol Chem 277: 31364-31372
64. Lu A, Gupta A, Li C et al (2001) Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: control of transcription by DNA methylation and intronic sequences. Oncogene 20:5173-5185
65. Piva R, Belardo G, Santoro MG (2006) NFkappaB: a stressregulated switch for cell survival. Antioxid Redox Signal 8: 478-486
66. Van Waes C (2007) Nuclear factor-kappaB in development, prevention and therapy of cancer. Clin Cancer Res 13:1076-1082
67. Baldwin AS Jr, Azizkhan JC, Jensen DE, Beg AA, Coodly LR (1991) Induction of NFkappaB DNA-binding activity during the G0-to-G1 transition in mouse fibroblasts. Mol Cell Biol 11: 4943-4951
68. Kaltschmidt B Kaltschmidt C, Hehner SP, Dröge W, Schmitz ML (1999) Repression of NFkappaB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators. Oncogene 18:3213-3225
69. Mauro C, Pacifico F, Lavorgna A et al (2006) ABIN-1 binds to NEMO/IKKc and co-operates with A20 in inhibiting NF-jB. J Biol Chem 281:18482-18488
70. Dai P, Jeong SY, Yu Y, Leng T, Wu W, Xie L, Chen X (2009) Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. J Immunol 182:3450-3460
71. Pelengaris S, Khan M, Evan G (2002) c-MYC: more than just a matter of life and death. Nat Rev Cancer 2:764-776
72. Perez-Roger I, Kim SH, Griffiths B et al (1999) Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27Kip1 and p21Cip1. EMBO 18:5310-5320
73. Vlach J, Hennecke S, Alevizopoulos K et al (1996) Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO 15:6595-6604
74. Staller P, Peukert K, Kiermaier A et al (2001) Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol 3:392-399
75. Claassen GF, Hann SR (2000) A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta-induced cell cycle arrest. Proc Natl Acad Sci USA 97:9498-9503
76. Bossone SA, Asselin C, Patel AJ et al (1992) MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. Proc Natl Acad Sci USA 89:7452-7456
77. Komatsu M, Li H-O, Tsutsui H et al (1997) MAZ, a Myc-associated zinc finger protein, is essential for the ME1a1-mediated expression of the c-myc gene during neuroectodermal differentiation of P19 cells. Oncogene 15:1123-1131
78. Wessely R, Hengst L, Jaschke B et al (2003) A central role of interferon regulatory factor-1 for the limitation of neointimal hyperplasia. Hum Mol Genet 12:177-187
79. Rizvi IA, Robinson K, McFadden DW, Riggs DR, Jackson BJ, Vona-Davis L (2006) Peptide YY reverses TNF-alpha induced transcription factor binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells. J Surg Res 136:25-30
80. Pamment J, Ramsay E, Kelleher M, Dornan D, Ball KL (2002) Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway. Oncogene 21:7776-7785
81. Xie RL, Gupta S, Miele A, Shiffman D, Stein JL, Stein GS, van Wijnen AJ (2003) The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter. J Biol Chem 278:26589-26596
82. Shu F, Lv S, Qin Y et al (2007) Functional characterization of human PFTK1 as a cyclin-dependent kinase. Proc Natl Acad Sci USA 104:9248-9253
83. Han SH, Jeon JH, Ju HR et al (2003) VDUP1 upregulated by TGF-b1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene 22: 4035-4046
84. Jeon JH, Lee KN, Hwang CY, Kwon KSKH, You KH, Choi I (2005) Tumor suppressor VDUP1 increases p27(kip1) stability by inhibiting JAB1. Cancer Res 65:4485-4489
85. Jung P, Menssen A, Mayr D et al (2008) AP4 encodes a c-MYCinducible repressor of p21. Proc Natl Acad Sci USA 105: 15046-15051