Platelet-derived growth factor receptor association with Na+/H+ exchanger regulatory factor potentiates receptor activity

Molecular and Cellular Biology

Volumn 20, Issue 22, 2000, Pages 8352-8363

  Maudsley, S ^a   Zamah, A M ^a   Rahman, N ^a   Blitzer, J T ^a   Luttrell, L M ^a   Lefkowitz, R J ^a   Hall, R A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPORTER; BETA 2 ADRENERGIC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTON SODIUM EXCHANGE; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; ANIMALS; CHO CELLS; CRICETINAE; GENES, DOMINANT; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; POINT MUTATION; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SODIUM-HYDROGEN ANTIPORTER;

EID: 0033755880     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.22.8352-8363.2000     Document Type: Article

References (51)

1. Vascular endothelial growth factor and ptatelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer
2. Platelet-derived growth factor (PDGF) in plasma of breast cancer patients: Correlation with stage and rate of progression
3. Interaction of nitric oxide syntahse with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains
4. Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein
5. The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of ceil-cell contact in the brain
6. Crystal structure of a PDZ domain
7. 2-adrenergic receptor
8. + exchange and induces cytoplasmic alkalinization in NR6 cells
9. Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor subunit in human breast tissue and breast carcinoma
10. 2-adrenergic receptor to different G proteins by protein kinase A
11. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
12. Signal characteristics of G protein-transactivated EGF receptor
13. Crystal structure of a comptexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ domains
14. + exchange regulatory factor
15. PDZ domains: Fundamental building blocks in the organization of protein complexes at the plasma membrane
16. Frequent allelic toss at the TOC locus on 17q25.1 in primary breast cancers
17. + exchange
18. + exchanger regutatory factor family of PDZ proteins
19. Mutation of a Src phosphorytation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis hut decreased mitogenesis
20. Signal transduction via platelet-derived growth factor receptors
21. Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in tysophosphatidic acid-stimulated mitogenic activity in L cells
22. PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor
23. CAPON: A protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD-95
24. Detailed deletion analysis of sporadic breast tumors defines an interstitial region of allelic loss on 17q25
25. A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of toss in breast tumors
26. Antiestrogens: Mechanisms of action and resistance in breast cancer
27. Identification of a putative Syp substrate, the PDGF-β receptor
28. Angiotensin II stimulates ERK via two pathways in epithelial cells - Protein kinase C suppresses a G-protein coupled receptor EGF receptor transactivation pathway
29. Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells
30. Reconstitution of human epidermal growth factor receptor and its deletion mutants in cultured hamster cells
31. + exchange by platelet-derived growth factor involves phosphatidylinositol 3'-kinase and phospholipase C gamma
32. 2-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multireceptor complex with the epidermal growth factor receptor
33. Identification of a hydrophobic region in the carboxyl terminus of the platelet-derived growth factor β-receptor which is important ligand-mediated endocytosis
34. Ligand-induced ubiquitination of the platelet-derived growth factor β-receptor plays a negative regulatory role in its mitogenic signaling
35. + exchange, is a common interactor for Merlin and ERM (MERM) proteins
36. 17q21-q25 aberrations in breast cancer: Combined allelotyping and CGH analysis reveals 5 regions of allelic imbalance among which two correspond to DNA amplification
37. The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains
38. Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
39. Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: Involvement in the interaction with phospholipase C-gamma
40. Differential effects of carboxyl-terminal sequence deletions on platelet-derived growth factor receptor signaling activities and interactions with cellular substrates
41. Two different subunits associate to create isoform-specific platelet-derived growth factor receptors
42. Positive immunostaining for platelet-derived growth factor (PDGF) is an adverse prognostic factor in patients with advanced breast cancer
43. LET-23 receptor localization by the celt junction protein LIN-7 during C. elegans vulval induction
44. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP
45. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands
46. The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity
47. Peptide binding consensus of the NHE-RF PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)
48. + exchanger
49. Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF)
50. Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins
51. + exchanger, NHE3, requires an associated regulatory protein