Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element

Nucleic Acids Research

Volumn 30, Issue 8, 2002, Pages 1713-1724

  Braastad, Corey D ^a   Leguia, Mariana ^a   Hendrickson, Eric A ^b  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; DOUBLE STRANDED DNA; ENOYL COENZYME A HYDRATASE; KU ANTIGEN; PROTEIN KARP 1; PROTEIN P53; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ARTICLE; CHROMATIN; CONTROLLED STUDY; CPG ISLAND; DNA FLANKING REGION; DNA REPAIR; DNA RESPONSIVE ELEMENT; DNA STRAND BREAKAGE; ENZYME ACTIVE SITE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC CODE; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTRON; METHYLATION; PEROXISOME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; TRANSCRIPTION INITIATION;

EID: 0037089145     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/30.8.1713     Document Type: Article

References (89)

1. Genome maintenance mechanisms for preventing cancer
2. Spontaneous DNA damage, genome instability and cancer - When DNA replication escapes control
3. Cellular responses to DNA damage
4. Non-homologous end joining as a mechanism of DNA repair
5. The DNA-dependent protein kinase
6. Ku autoantigen: A multifunctional DNA-binding protein
7. Mechanism of interaction between Ku protein and DNA
8. EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA
9. Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA
10. Ku selectively transfers between DNA molecules with homologous ends
11. Ku proteins join DNA fragments as shown by atomic force microscopy
12. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
13. Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II
14. The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
15. DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA
16. Ku recruits the XRCC4-Ligase IV complex to DNA ends
17. Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks
18. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
19. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
20. Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
21. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
22. DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes
23. Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells
24. Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo
25. Ku70: A candidate tumor suppressor gene for murine T cell lymphoma
26. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
27. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
28. DNA-PKcs: A T-cell tumor suppressor encoded at the mouse scid locus
29. Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation
30. cs-null mutation reveals DNA-PK-independent functions for Ku in V(D)J recombination
31. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity
32. Deletion of Ku86 causes early onset of senescence in mice
33. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts
34. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
35. Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
36. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
37. Ku acts in a unique way at the mammalian telomere to prevent end joining
38. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
39. Ku86 is essential in human somatic cells
40. KARP-1: A novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity
41. KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion
42. The role of ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation
43. Evidence for DNA-PK dependent and independent DNA double strand break repair pathways in mammalian cells as a function of the cell cycle
44. Ku80 gene expression is Sp1-dependent and sensitive to CpG methylation within a novel cis element
45. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1
46. Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene
47. Regional methylation of the 5′ end CpG island of BRCA1 is associated with reduced gene expression in human somatic cells
48. The promoters for human DNA-PKcs (PRKDC) and MCM4: Divergently transcribed genes located at chromosome 8 band q11
49. A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: Amino acid sequence, structure and expression studies
50. Identification and characterization of a new gene physically linked to the ATM gene
51. 1 arrest in human cancer cells
52. 2 arrest after DNA damage
53. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation
54. Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element
55. The mouse albumin promoter and a distal upstream site are simultaneously DNase I hypersensitive in liver chromatin and bind similar liver-abundant factors in vivo
56. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer
57. Spreading of transcriptional repressor SIR3 from telomeric heterochromatin
58. An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice
59. Chromatin structure and gene expression
60. CpG islands as gene markers in the vertebrate nucleus
61. Number of CpG islands and genes in human and mouse
62. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer
63. Cancer. Death and methylation
64. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs
65. Generality of a functional initiator consensus sequence
66. DNA sequence requirements for transcriptional initiator activity in mammalian cells
67. Kinetics of p53 binding to promoter sites in vivo
68. Definition of a consensus binding site for p53
69. Interaction of p53 with its consensus DNA-binding site
70. Mapping DNA interaction sites of chromosomal proteins. Crosslinking studies in yeast
71. Mutations of GTBP in genetically unstable cells
72. Loss of DNA mismatch repair in acquired resistance to cisplatin
73. Enhanced phosphorylation of p53 by ATM in response to DNA damage
74. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
75. DNA damage activates p53 through a phosphorylation-acetylation cascade
76. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
77. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
78. Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases
79. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
80. A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed
81. Protein traffic on the heat shock promoter: Parking, stalling and trucking along
82. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
83. Coincident start sites for divergent transcripts at a randomly selected CpG-rich island of mouse
84. The organization and expression of histone gene families
85. Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter
86. Analysis of the chicken GPAT/AIRC bidirectional promoter for de novo purine nucleotide synthesis
87. Dual bidirectional promoters at the mouse dhfr locus: Cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene
88. Sequence of the WT1 upstream region including the Wit-1 gene
89. BRCA1 required for transcription-coupled repair of oxidative DNA damage