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Origin and specification of type II sensory neurons in Drosophila
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of outstanding interest. The authors use flp/FRT-generated lacZ-expressing clones to show that the embryonic sense organs are generated by several different lineages. Some precursors produce the complement of cells corresponding to one sense organ (including the monodendritic type I neuron), others produce one or more multidendritic type II neurons, yet others produce both type I and type II neurons. The authors also show that numb is involved in the sheath cell versus neuron choice.
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Brewster R, Bodmer R. Origin and specification of type II sensory neurons in Drosophila. of outstanding interest Development. 121:1995;2923-2936 The authors use flp/FRT-generated lacZ-expressing clones to show that the embryonic sense organs are generated by several different lineages. Some precursors produce the complement of cells corresponding to one sense organ (including the monodendritic type I neuron), others produce one or more multidendritic type II neurons, yet others produce both type I and type II neurons. The authors also show that numb is involved in the sheath cell versus neuron choice.
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Development
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Brewster, R.1
Bodmer, R.2
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Stem C. Two or three bristles. Am Sci. 42:1954;213-247.
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Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing
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Skeath JB, Carroll SB. Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes Dev. 5:1991;984-995.
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Skeath, J.B.1
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Cis-regulation of achaete and scute: Shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discs
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Gomez-Skarmeta JL, Rodriguez I, Martinez C, Culi J, Ferres-Marco D, Beamonte D, Modolell J. Cis-regulation of achaete and scute: shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discs. Genes Dev. 9:1995;1869-1883.
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Gomez-Skarmeta, J.L.1
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Skeath JB, Panganiban G, Selague J, Carroll SB. Gene regulation in two dimensions: the achaete- and scute genes are controlled by combinations of axis-patterning genes through a common intergenic control region. Genes Dev. 6:1993;2609-2619.
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Skeath, J.B.1
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Winglass expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development
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Phillips RG, Whittle JRS. winglass expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development. Development. 118:1993;427-438.
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Phillips, R.G.1
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Iroquois: A prepattern gene that controls the formation of bristles on the thorax of Drosophila
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of special interest. Describes the isolation of iroquois mutants and their genetic and phenotypic analyses, and demonstrates that iroquois is required for the expression of the gene scute in the lateral regions of the wing disc, suggesting that iroquois acts through the control of achaete - scute gene expression.
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Leyns L, Gomez-Skarmeta J-L, Dambly-Chaudière C. iroquois: a prepattern gene that controls the formation of bristles on the thorax of Drosophila. of special interest Mech Dev. 59:1996;63-72 Describes the isolation of iroquois mutants and their genetic and phenotypic analyses, and demonstrates that iroquois is required for the expression of the gene scute in the lateral regions of the wing disc, suggesting that iroquois acts through the control of achaete - scute gene expression.
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Leyns, L.1
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Dambly-Chaudière, C.3
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16
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0029919934
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Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes
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of special interest. Describes the molecular cloning of the iroquois complex. The two members of this complex are expressed in the same spatial pattern, which includes the lateral region of the wing disc, and they code for homeodomain proteins that bind to regulatory regions of the AS-C.
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Gomez-Skarmeta J-L, Del Corral RD, De la Calle-Mustienes E, Ferrès-Marco D, Modolell J. araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes. of special interest Cell. 85:1996;95-107 Describes the molecular cloning of the iroquois complex. The two members of this complex are expressed in the same spatial pattern, which includes the lateral region of the wing disc, and they code for homeodomain proteins that bind to regulatory regions of the AS-C.
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Cell
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Gomez-Skarmeta, J.-L.1
Del Corral, R.D.2
De La Calle-Mustienes, E.3
Ferrès-Marco, D.4
Modolell, J.5
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17
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0029809523
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Araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing
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Gomez-Skarmeta J-L, Modolell J. araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing. Genes Dev. 10:1996;2935-2946.
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Gomez-Skarmeta, J.-L.1
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18
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0027333320
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Pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1
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of special interest. See annotation [19].
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Ramain P, Heitzler P, Haenlin M, Simpson P. pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1. of special interest Development. 119:1993;1277-1291 See annotation [19].
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Ramain, P.1
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0029888494
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A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila
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of special interest. This paper and [18] describe the genetic and molecular characterization of the pannier (pnr) gene, the product of which acts as a transregulator of the AS-C. The genetic and phenotypic analyses of a large series of mutants indicate that pnr can act both negatively and positively on AS-C expression. These papers also suggest the existence of a strong and specific genetic interaction of pnr with the gene extramacrochaete, an inhibitor of proneural activity.
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Heitzler P, Haenlin M, Ramain P, Simpson P. A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila. of special interest Genetics. 143:1996;1271-1286 This paper and [18] describe the genetic and molecular characterization of the pannier (pnr) gene, the product of which acts as a transregulator of the AS-C. The genetic and phenotypic analyses of a large series of mutants indicate that pnr can act both negatively and positively on AS-C expression. These papers also suggest the existence of a strong and specific genetic interaction of pnr with the gene extramacrochaete, an inhibitor of proneural activity.
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Genetics
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Heitzler, P.1
Haenlin, M.2
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Fortini, M.E.1
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21
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0028943243
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Notch signaling
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of special interest. An excellent review summarizing our current understanding of the 'Notch system', with essential information on the functioning of Notch as receptor, on its ligands, and on the way Notch signalling is transduced.
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Artavanis-Tsakonas S, Matsuno K, Fortini ME. Notch signaling. of special interest Science. 268:1995;225-232 An excellent review summarizing our current understanding of the 'Notch system', with essential information on the functioning of Notch as receptor, on its ligands, and on the way Notch signalling is transduced.
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Science
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Artavanis-Tsakonas, S.1
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M. Bate, Martinez-Arias A. Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Campos-Ortega, J.A.1
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Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN. Cell interactions and gene interactions in peripheral neurogenesis. Genes Dev. 7:1993;723-733.
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Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling
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Singson A, Leviten MW, Bang AG, Hua XH, Posakony JW. Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes Dev. 8:1994;2058-2071.
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Singson, A.1
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The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo
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Jennings B, Preiss A, Delidakis C, Bray S. The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development. 120:1994;3537-3548.
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Jennings, B.1
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Jennings B, Delidakis C, Preiss A, Bray S. Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins. Development. 121:1995;3745-3752.
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Jennings, B.1
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Nakao K, Campos-Ortega JA. Persistent expression of genes of the Enhancer of Split complex suppresses neural development in Drosophila. Neuron. 16:1996;275-286.
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Suppressor of Hairless directly activates transcription of Enhancer of split complex genes in response to Notch receptor activity
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of special interest. See annotation [31].
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Bailey AM, Posakony JW. Suppressor of Hairless directly activates transcription of Enhancer of split complex genes in response to Notch receptor activity. of special interest Genes Dev. 9:1995;2609-2622 See annotation [31].
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Bailey, A.M.1
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31
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0028973381
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The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling
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of special interest. This paper and [30] show that the protein encoded by the Suppressor of Hairless gene acts downstream of Notch and regulates the expression of Enhancer of split complex genes by binding to their regulatory regions.
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Lecourtois M, Schweisguth F. The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling. of special interest Genes Dev. 9:1995;2598-2608 This paper and [30] show that the protein encoded by the Suppressor of Hairless gene acts downstream of Notch and regulates the expression of Enhancer of split complex genes by binding to their regulatory regions.
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Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
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Heitzler, P.1
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Huang FZ, Weisblat DA. Cell fate determination in an annelid equivalence group. Development. 122:1996;1839-1847.
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Hartenstein, V.1
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of special interest. An analysis of the function of Notch in the embryonic sensory lineages and of its interactions with numb. A direct interaction between Notch and Numb is demonstrated by the yeast two-hybrid method.
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Guo M, Jan LY, Jan YN. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. of special interest Neuron. 17:1996;27-41 An analysis of the function of Notch in the embryonic sensory lineages and of its interactions with numb. A direct interaction between Notch and Numb is demonstrated by the yeast two-hybrid method.
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Guo, M.1
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Schweisguth F, Posakony JW. Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Cell. 69:1992;1166-1212.
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Lyman DF, Yedvobnick B. Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development. Genetics. 141:1995;1491-1505.
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Doe, C.Q.1
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47
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Numb antagonizes Notch signaling to specify sibling neuron cell fates
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of outstanding interest. Analyzes the function of Notch and Delta during the MP2 lineage. Based on the expression pattern of the two genes and on in vitro cultures of dissociated embryos, the authors conclude that the inhibitory signal comes from outside of the lineage.
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Spana EP, Doe CQ. Numb antagonizes Notch signaling to specify sibling neuron cell fates. of outstanding interest Neuron. 17:1996;21-26 Analyzes the function of Notch and Delta during the MP2 lineage. Based on the expression pattern of the two genes and on in vitro cultures of dissociated embryos, the authors conclude that the inhibitory signal comes from outside of the lineage.
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Spana, E.P.1
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Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question
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Horvitz HR, Herskovitz I. Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question. Cell. 68:1992;237-255.
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Cell
, vol.68
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Horvitz, H.R.1
Herskovitz, I.2
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49
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0024980213
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Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos
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Uemura T, Shepherd S, Ackerman L, Jan LY, Jan YN. numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell. 58:1989;349-360.
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(1989)
Cell
, vol.58
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Uemura, T.1
Shepherd, S.2
Ackerman, L.3
Jan, L.Y.4
Jan, Y.N.5
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50
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0027947609
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Asymmetric distribution of Numb protein during division of sensory organ precursor cell confers distinct fates to daughter cells
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Rhyu MS, Jan LY, Jan YN. Asymmetric distribution of Numb protein during division of sensory organ precursor cell confers distinct fates to daughter cells. Cell. 76:1994;477-491.
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(1994)
Cell
, vol.76
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Rhyu, M.S.1
Jan, L.Y.2
Jan, Y.N.3
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51
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0028802562
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Asymmetric localization of Numb autonomously determines sibling neuron identity in the Drosophila CNS
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of special interest. See annotation [52].
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Spana EP, Kopczynsky C, Goodman CS, Doe CQ. Asymmetric localization of Numb autonomously determines sibling neuron identity in the Drosophila CNS. of special interest Development. 121:1995;3489-3494 See annotation [52].
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(1995)
Development
, vol.121
, pp. 3489-3494
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Spana, E.P.1
Kopczynsky, C.2
Goodman, C.S.3
Doe, C.Q.4
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52
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0028818805
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Asymmetric segregation of Numb and Prospero during cell division
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of special interest. This paper and [51] present evidence that during the prophase of the neuroblasts, the asymmetric localization of Numb and of the product of the prospero gene is correlated with the position of one the two centrosomes and is thereby tightly linked to the axis of division.
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Knoblich JA, Jan LY, Jan YN. Asymmetric segregation of Numb and Prospero during cell division. of special interest Nature. 377:1995;624-627 This paper and [51] present evidence that during the prophase of the neuroblasts, the asymmetric localization of Numb and of the product of the prospero gene is correlated with the position of one the two centrosomes and is thereby tightly linked to the axis of division.
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(1995)
Nature
, vol.377
, pp. 624-627
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Knoblich, J.A.1
Jan, L.Y.2
Jan, Y.N.3
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53
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0029821914
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Role of inscuteable in orienting asymmetric cell divisions in Drosophila
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of special interest. Shows that the product of the inscuteable gene is required for the localization of Numb and Prospero in dividing neuroblasts. This localization may depend on the control of spindle orientation, a process for which inscuteable is both necessary and sufficient.
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Kraut R, Chia W, Jan LY, Jan YN, Knoblich JA. Role of inscuteable in orienting asymmetric cell divisions in Drosophila. of special interest Nature. 383:1996;50-55 Shows that the product of the inscuteable gene is required for the localization of Numb and Prospero in dividing neuroblasts. This localization may depend on the control of spindle orientation, a process for which inscuteable is both necessary and sufficient.
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(1996)
Nature
, vol.383
, pp. 50-55
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Kraut, R.1
Chia, W.2
Jan, L.Y.3
Jan, Y.N.4
Knoblich, J.A.5
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54
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0029909203
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The Drosophila Numb protein inhibits signaling of the Notch receptor during cell - cell interaction in sensory organ lineage
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Frise E, Knoblich JA, Younger-Shepherd S, Jan LY, Jan YN. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell - cell interaction in sensory organ lineage. Proc Natl Acad Sci USA. 93:1996;11925-11932.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 11925-11932
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Frise, E.1
Knoblich, J.A.2
Younger-Shepherd, S.3
Jan, L.Y.4
Jan, Y.N.5
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55
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0029058493
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Tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS
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of special interest. Analyzes the function of ramtrack (ttk) during sense organ lineages. Shows that ttk is instrumental in directing the cells to a non-neural fate and that it is expressed in cells with non-neural fates. Also demonstrates that ttk acts downstream of numb.
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Guo M, Bier E, Jan LY, Jan YN. tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS. of special interest Neuron. 14:1995;913-925 Analyzes the function of ramtrack (ttk) during sense organ lineages. Shows that ttk is instrumental in directing the cells to a non-neural fate and that it is expressed in cells with non-neural fates. Also demonstrates that ttk acts downstream of numb.
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(1995)
Neuron
, vol.14
, pp. 913-925
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Guo, M.1
Bier, E.2
Jan, L.Y.3
Jan, Y.N.4
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56
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0027956411
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Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development
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Salzberg A, D'Evelyn D, Schulze K, Lee J-K, Strumpf D, Tsai L, Bellen HJ. Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron. 13:1994;269-287.
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Neuron
, vol.13
, pp. 269-287
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Salzberg, A.1
D'Evelyn, D.2
Schulze, K.3
Lee, J.-K.4
Strumpf, D.5
Tsai, L.6
Bellen, H.J.7
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57
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0027159969
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Tramtrack is transcriptional repressor required for cell fate determination in the Drosophila eye
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Xiong W-C, Montell C. tramtrack is transcriptional repressor required for cell fate determination in the Drosophila eye. Genes Dev. 7:1993;1085-1096.
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(1993)
Genes Dev
, vol.7
, pp. 1085-1096
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Xiong, W.-C.1
Montell, C.2
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58
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0027518828
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Repression of Drosophila pair-rule segmentation genes by ectopic expression of tramtrack
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Brown JL, Wu C. Repression of Drosophila pair-rule segmentation genes by ectopic expression of tramtrack. Development. 117:1993;45-58.
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(1993)
Development
, vol.117
, pp. 45-58
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Brown, J.L.1
Wu, C.2
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59
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0025215857
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Sensillum development in the absence of cell division: The sensillum phenotype of the Drosophila mutant string
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Hartenstein V, Posakony JW. Sensillum development in the absence of cell division: the sensillum phenotype of the Drosophila mutant string. Dev Biol. 138:1990;147-158.
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(1990)
Dev Biol
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Hartenstein, V.1
Posakony, J.W.2
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60
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0029080346
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Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila
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of special interest. An excellent clonal analysis of the function of Notch during wing margin neurogenesis, showing convincingly that Notch is required to set up the expression of wingless but is not involved in the mechanism by which wingless, subsequently, activates the expression of the genes of the AS-C.
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Rulifson EJ, Blair SS. Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila. of special interest Development. 121:1995;2813-2824 An excellent clonal analysis of the function of Notch during wing margin neurogenesis, showing convincingly that Notch is required to set up the expression of wingless but is not involved in the mechanism by which wingless, subsequently, activates the expression of the genes of the AS-C.
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(1995)
Development
, vol.121
, pp. 2813-2824
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Rulifson, E.J.1
Blair, S.S.2
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61
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0029585601
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Serrate signals through Notch to establish a wingless-dependent organizer at the dorso-ventral compartments boundary of the Drosophila wing
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of special interest. See annotation [63].
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Diaz-Benjumea FJ, Cohen SM. Serrate signals through Notch to establish a wingless-dependent organizer at the dorso-ventral compartments boundary of the Drosophila wing. of special interest Development. 121:1995;4215-4225 See annotation [63].
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(1995)
Development
, vol.121
, pp. 4215-4225
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Diaz-Benjumea, F.J.1
Cohen, S.M.2
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62
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0030052457
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Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc
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of special interest. See annotation [63].
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De Celis JF, Garcia-Bellido A, Bray SJ. Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. of special interest Development. 122:1996;359-369 See annotation [63].
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(1996)
Development
, vol.122
, pp. 359-369
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De Celis, J.F.1
Garcia-Bellido, A.2
Bray, S.J.3
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63
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0029960107
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Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation
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of special interest. Three recent papers [61-63] show that the expression of wingless at the dorsoventral (D/V) boundary depends on two different signals acting through the same receptor, Notch. One ligand, Serrate, is produced by the dorsal cells and signals ventral cells abutting the D/V compartment boundary; these, in turn, produce another ligand, Delta, to signal the dorsal cells abutting the same boundary. As a result of this mutual induction, the two rows of signalled cells flanking the D/V boundary express the wing margin organizer wingless.
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Doherty D, Feger G, Younger-Shepherd S, Jan LY, Jan YN. Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. of special interest Genes Dev. 10:1996;421-435 Three recent papers [61-63] show that the expression of wingless at the dorsoventral (D/V) boundary depends on two different signals acting through the same receptor, Notch. One ligand, Serrate, is produced by the dorsal cells and signals ventral cells abutting the D/V compartment boundary; these, in turn, produce another ligand, Delta, to signal the dorsal cells abutting the same boundary. As a result of this mutual induction, the two rows of signalled cells flanking the D/V boundary express the wing margin organizer wingless.
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(1996)
Genes Dev
, vol.10
, pp. 421-435
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Doherty, D.1
Feger, G.2
Younger-Shepherd, S.3
Jan, L.Y.4
Jan, Y.N.5
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64
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0029080470
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Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis
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of outstanding interest. Shows that, depending on the orientation of the division axis, precursor cells in the mouse cortex either divide symmetrically (and produce two new precursors) or divide asymmetrically. In the asymmetric divisions, mouse Notch (M-Notch1) segregates in one of the two daughter cells, which will then migrate and differentiates as a neuron.
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Chen A, McConnell SK. Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis. of outstanding interest Cell. 82:1995;631-641 Shows that, depending on the orientation of the division axis, precursor cells in the mouse cortex either divide symmetrically (and produce two new precursors) or divide asymmetrically. In the asymmetric divisions, mouse Notch (M-Notch1) segregates in one of the two daughter cells, which will then migrate and differentiates as a neuron.
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(1995)
Cell
, vol.82
, pp. 631-641
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Chen, A.1
McConnell, S.K.2
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65
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0030200217
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Asymmetric localisation of a mammalian Numb homolog during mouse cortical neurogenesis
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Zhong W, Feder JN, Jiang M-M, Jan LY, Jan YN. Asymmetric localisation of a mammalian Numb homolog during mouse cortical neurogenesis. Neuron. 7:1996;43-53.
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(1996)
Neuron
, vol.7
, pp. 43-53
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Zhong, W.1
Feder, J.N.2
Jiang, M.-M.3
Jan, L.Y.4
Jan, Y.N.5
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66
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0029945359
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An inductive interaction in 4-cells stage C. elegans embryos involves APX-1 expression in the signalling cell
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Mickey K, Mello CC, Montgomery MK, Fire A, Priess JR. An inductive interaction in 4-cells stage C. elegans embryos involves APX-1 expression in the signalling cell. Development. 122:1996;1791-1798.
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(1996)
Development
, vol.122
, pp. 1791-1798
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Mickey, K.1
Mello, C.C.2
Montgomery, M.K.3
Fire, A.4
Priess, J.R.5
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