Prolonged mitosis versus tetraploid checkpoint: How p53 measures the duration of mitosis

Cell Cycle

Volumn 5, Issue 9, 2006, Pages 971-975

  Blagosklonny, Mikhail V ^a  

^a ORDWAY RESEARCH INSTITUTE   (United States)

Author keywords

Cell cycle; Checkpoint; Mdm 2; Mitosis; p21; p53; Tetraploidy; Transcription

Indexed keywords

ALPHA AMANITIN; AMANITIN; ANTINEOPLASTIC AGENT; DACTINOMYCIN; DEMECOLCINE; DOCETAXEL; DOXORUBICIN; FLAVOPIRIDOL; GELDANAMYCIN; NOCODAZOLE; PACLITAXEL; PROTEIN P21; PROTEIN P53; VINBLASTINE; VINCA ALKALOID; VINCRISTINE; VINFLUNINE;

ARTICLE; CHROMOSOME; DEPOLYMERIZATION; DNA DAMAGE; HUMAN; MITOSIS; MITOSIS INHIBITION; PROTEIN DEGRADATION; PROTEIN FUNCTION; TETRAPLOIDY;

VINCA;

EID: 33646437275     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.9.2711     Document Type: Article

References (61)

1. Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RL, Raskind WH, Reid BJ. A p53-dependent mouse spindle checkpoint. Science 1995; 267:1353-6.
2. Fukasawa K, Vande Woude GF. Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability. Mol Cell Biol 1997; 17:506-18.
3. Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res 1997; 57:1013-9.
4. Khan SH, Wahl GM. p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G, arrest. Cancer Res 1998; 58:396-401.
5. Lanni JS, Jacks T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol 1998; 18:1055-64.
6. Casenghi M, Mangiacasale R, Tuynder M, Caillet-Fauquet P, Elhajouji A, Lavia P, Mousset S, Kirsch-Volders M, Cundari E. p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells. Exp Cell Res 1999; 250:339-50.
7. 1. Mol Biol Cell 2001; 12:1315-28.
8. Sphyris N, Harrison DJ. p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells. Oncogene 2005; 24:2184-94.
9. Margolis RL. Tetraploidy and tumor development. Cancer Cell 2005; 8:353-4.
10. Stukenberg PT. Triggering p53 after cytokinesis failure. J Cell Biol 2004; 165:607-8.
11. Uetake Y, Sluder G. Cell cycle progression after cleavage failure: Mammalian somatic cells do not possess a "tetraploidy checkpoint". J Cell Biol 2004; 165:609-15.
12. Wong C, Stearns T. Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure. BMC Cell Biol 2005; 6:6.
13. Nakamura Y, Takaira M, Sato E, Kawano K, Miyoshi O, Niikawa N. A tetraploid liveborn neonate: Cytogenetic and autopsy findings. Arch Pathol Lab Med 2003; 127:1612-4.
14. Guc-Scekic M, Milasin J, Stevanovic M, Stojanov LJ, Djordjevic M. Tetraploidy in a 26-month-old girl (cytogenetic and molecular studies). Clin Genet 2002; 61:62-5.
15. 2 cell cycle arrest instead of mitotic arrest: Molecular determinants of paclitaxel-induced cytotoxicity. Oncogene 2001; 20:3806-13.
16. Ikui AE, Yang CP, Matsumoto T, Horwitz SB. Low concentrations of taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy. Cell Cycle 2005; 4:1385-8.
17. Torres K, Horwitz SB. Mechanisms of Taxol-induced cell death are concentration dependent. Cancer Res 1998; 58:3620-3626.
18. 1 arrest following transient inhibition of the mitotic spindle. J Biol Chem 2001; 276:19205-13.
19. Rowinsky EK, Donehower RC. Paclitaxel (Taxol). N Engl J Med 1995; 332:1004-14.
20. Blagosklonny MV, Fojo T. Molecular effects of paclitaxel: Myths and reality. Int J Cancer 1999; 83:151-6.
21. Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 2004; 4:253-65.
22. Jordan MA, Wilson L. Microtubules and actin filaments: Dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 1998; 10:123-30.
23. Jordan MA, Toso RJ, Thrower D, Wilson L. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci USA 1993; 90:9552-6.
24. Blagosklonny MV, Schulte TW, Nguyen P, Mimnaugh EG, Trepel J, Neckers L. Taxol induction of p21Waf1 and p53 requires c-raf-1. Cancer Res 1995; 55:4623-6.
25. Tishler RB, Lamppu DM, Park S, Price BD. Microtubule-active drugs, Taxol, vinblastine and nocodazole increase the levels of transcriptionally active p53. Cancer Res 1995; 55:6021-5.
26. Debernardis D, Sire EG, De Feudis P, Vikhanskaya F, Valenti M, Parodi S, D'Incalci M, Broggini M. p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel. Cancer Res 1997; 57:870-4.
27. Sablina AA, Chumakov PM, Levine AJ, Kopnin BP. p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling. Oncogene 2001; 20:899-909.
28. Heliez C, Baricault L, Barboule N, Valette A. Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells. Oncogene 2003; 22:3260-8.
29. Giannakakou P, Sackett DL, Ward Y, Webster KR, Blagosklonny MV, Fojo T. p53 is associated with cellular microtubules and is transported to the nucleus by dynein. Nat Cell Biol 2000; 2:709-17.
30. Andera L, Wasylyk B. Transcription abnormalities potentiate apoptosis of normal human fibroblasts. Mol Medicine 1997; 3:852-63.
31. An WG, Chuman Y, Fojo T, Blagosklonny MV. Inhibitors of transcription, proteasome inhibitors, and DNA-damaging drugs differentially affect feedback of p53 degradation. Exp Cell Res 1998; 244:54-60.
32. Poele RHT, Okorokov AL, Joel SP. RNA synthesis block by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene 1999; 18:5765-72.
33. Demidenko ZN, Blagosklonny MV. Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor. Cancer Res 2004; 64:3653-60.
34. Ljungman M, DP L. Opinion: Transcription - Guarding the genome by sensing DNA damage. Nat Rev Cancer 2004; 4:727-737.
35. Blagosklonny MV, Demidenko ZN, Fojo T. Inhibition of transcription results in accumulation of Wt p53 followed by delayed outburst of p53-inducible proteins: p53 as a sensor of transcriptional integrity. Cell Cycle 2002; 1:67-74.
36. Bar-Or RL, Maya R, Segel LA, Alon U, Levine AJ, Oren M. Generation of oscillations by the p53-mdm2 feedback loop: A theoretical and experimental study. Proc Natl Acad Sci USA 2000; 97:11250-5.
37. Ciliberto A, Novak B, Tyson JJ. Steady states and oscillations in the p53/Mdm2 network. Cell Cycle 2005; 4:488-93.
38. Ma L, Wagner J, Rice JJ, Hu W, Levine AJ, Stolovitzky GA. A plausible model for the digital response of p53 to DNA damage. Proc Natl Acad Sci USA 2005; 102:14266-71.
39. Taylor JH. Nucleic acid synthesis in relation to the cell division cycle. Ann NY Acad Sci 1960; 90:409-21.
40. Prescott DM, Bender MA. Synthesis of RNA and protein during mitosis in mammalian tissue culture cells. Exp Cell Res 1962; 26:260-8.
41. Hartl P, Gottesfeld J, Forbes DJ. Mitotic repression of transcription in vitro. J Cell Biol 1993; 120:613-24.
42. Martinez-Balbas MA, Dey A, Rabindran SK, Ozato K, Wu C. Displacement of sequence-specific transcription factors from mitotic chromatin. Cell 1995; 83:29-38.
43. Gottesfeld JM, Forbes DJ. Mitotic repression of the transcriptional machinery. Trends Biochem Sci 1997; 22:197-202.
44. Spencer CA, Kruhlak MJ, Jenkins HL, Sun X, Bazett-Jones DP. Mitotic transcription repression in vivo in the absence of nucleosomal chromatin condensation. J Cell Biol 2000; 150:13-26.
45. Chen D, Dundr M, Wang C, Leung A, Lamond A, Misteli T, Huang S. Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins. J Cell Biol 2005; 168:41-54.
46. Martin W, Koonin EV. Introns and the origin of nucleus-cytosol compartmentalization. Nature 2006; 440:41-5.
47. Rieder CL, Maiato H. Stuck in division or passing through: What happens when cells cannot satisfy the spindle assembly checkpoint. Dev Cell 2004; 7:637-651.
48. Lee LF, Schuerer-Maly CC, Lofquist AK, van Haaften-Day C, Ting JPY, White CM, Martin BK, Haskill JS. Taxol-dependent transcriptional activation of IL-8 expression in a subset of human ovarian cancer. Cancer Res 1996; 56:1303-8.
49. Manthey CL, Qureshi N, Stutz PL, Vogel SN. Lipopolysaccharide antagonists block taxol-induced signaling in murine macrophages. J Exp Med 1993; 178:695-702.
50. Giannakakou P, Nakano M, Nicolaou KC, O'Brate A, Yu J, Blagosklonny MV, Greber UF, Fojo T. Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Natl Acad Sci USA 2002; 99:10855-60.
51. 1 arrest and a mitochondrial pathway. Mol Pharmacol 2004; 66:580-91.
52. Vogel C, Kienitz A, Hofmann I, Muller R, Bastians H. Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy. Oncogene 2004; 23:6845-53.
53. Tritarelli A, Oricchio E, Ciciarello M, Mangiacasale R, Palena A, Lavia P, Soddu S, Cundari E. p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation. Mol Biol Cell 2004; 15:3751-7.
54. Oricchio E, Saladino C, Iacovelli S, Soddu S, Cundari E. ATM is Activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity. Cell Cycle 2006; 5:88-92.
55. Taylor SS, McKeon F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 1997; 69:727-35.
56. Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 2001; 409:355-9.
57. Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 2005; 437:1043-7.
58. Giannakakou P, Poy G, Zhan Z, Knutsen T, Blagosklonny MV, Fojo T. Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer. Oncogene 2000; 19:3078-85.
59. Modi DN, Sane S, Bhartiya D. Accelerated germ cell apoptosis in sex chromosome aneuploid fetal human gonads. Mol Hum Reprod 2003; 9:219-2=25.
60. Yin Y, Stahl BC, DeWolf WC, Morgentaler A. p53-mediated germ cell quality control in spermatogenesis. Dev Biol 1998; 204:165-71.
61. Einhorn LH. Curing metastatic testicular cancer. Proc Natl Acad Sci USA 2002; 99:4592-5.