-
1
-
-
0025887459
-
Microtubule dynamics: Mechanism, regulation, and function
-
Gelfand VI, Bershadsky AD. Microtubule dynamics: mechanism, regulation, and function. Annu Rev Cell Biol 1991;7:93-116.
-
(1991)
Annu Rev Cell Biol
, vol.7
, pp. 93-116
-
-
Gelfand, V.I.1
Bershadsky, A.D.2
-
2
-
-
33746471989
-
Novel agents that target tubulin and related elements
-
Rowinsky EK, Calvo E. Novel agents that target tubulin and related elements. Semin Oncol 2006;33:421-35.
-
(2006)
Semin Oncol
, vol.33
, pp. 421-435
-
-
Rowinsky, E.K.1
Calvo, E.2
-
3
-
-
17544366715
-
Localization of the vinblastine-binding site on β-tubulin
-
Rai SS, Wolff J. Localization of the vinblastine-binding site on β-tubulin. J Biol Chem 1996;271:14707-11.
-
(1996)
J Biol Chem
, vol.271
, pp. 14707-14711
-
-
Rai, S.S.1
Wolff, J.2
-
4
-
-
32944481043
-
Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies
-
Nyman DW, Campbell KJ, Hersh E, et al. Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies. J Clin Oncol 2005;23:7785-93.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7785-7793
-
-
Nyman, D.W.1
Campbell, K.J.2
Hersh, E.3
-
5
-
-
32944482677
-
Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
-
Gradishar WJ, Tjulandin S, Davidson N, et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol 2005;23:7794-803.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7794-7803
-
-
Gradishar, W.J.1
Tjulandin, S.2
Davidson, N.3
-
6
-
-
33747887418
-
Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer
-
Green MR, Manikhas GM, Orlov S, et al. Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer. Ann Oncol 2006;17:1263-8.
-
(2006)
Ann Oncol
, vol.17
, pp. 1263-1268
-
-
Green, M.R.1
Manikhas, G.M.2
Orlov, S.3
-
7
-
-
34547829077
-
Phase I and pharmacokinetic trial of carboplatin and albumin-bound paclitaxel, ABI-007 (Abraxane) on three treatment schedules in patients with solid tumors
-
Stinchcombe TE, Socinski MA, Walko CM, et al. Phase I and pharmacokinetic trial of carboplatin and albumin-bound paclitaxel, ABI-007 (Abraxane) on three treatment schedules in patients with solid tumors. Cancer Chemother Pharmacol 2007;60:759-66.
-
(2007)
Cancer Chemother Pharmacol
, vol.60
, pp. 759-766
-
-
Stinchcombe, T.E.1
Socinski, M.A.2
Walko, C.M.3
-
8
-
-
60849091438
-
Phase II study of weekly nanoparticle paclitaxel (ABI-007), carboplatin and trastuzumab as first-line therapy of HER2-positive metastatic breast cancer
-
Seidman A, Danso M, Bach A, et al. Phase II study of weekly nanoparticle paclitaxel (ABI-007), carboplatin and trastuzumab as first-line therapy of HER2-positive metastatic breast cancer. J Clin Oncol 2006 ASCO Annu Meet Proc 2006;24:10650.
-
(2006)
J Clin Oncol 2006 ASCO Annu Meet Proc
, vol.24
, pp. 10650
-
-
Seidman, A.1
Danso, M.2
Bach, A.3
-
9
-
-
73149091256
-
Adjuvant bevacizumab (B) plus dose-dense doxorubicin/cyclophosphamide (AC) followed by nanopar ticle albumin- bound paclitaxel (nab-p) in early stage breast cancer patients: Cardiac safety
-
Dickler M, Traina T, Panageas K, et al. Adjuvant bevacizumab (B) plus dose-dense doxorubicin/cyclophosphamide (AC) followed by nanopar ticle albumin- bound paclitaxel (nab-p) in early stage breast cancer patients: cardiac safety. J Clin Oncol 2007 ASCO Annu Meet Proc 2007;25:567.
-
(2007)
J Clin Oncol 2007 ASCO Annu Meet Proc
, vol.25
, pp. 567
-
-
Dickler, M.1
Traina, T.2
Panageas, K.3
-
10
-
-
60849104892
-
Phase II study of xyotax (PPX) for androgen independent prostate cancer (AIPC)
-
Khan M, Sharef S, Amato RJ. Phase II study of xyotax (PPX) for androgen independent prostate cancer (AIPC). J Clin Oncol 2006 ASCO Annu Meet Proc 2006;24:14624.
-
(2006)
J Clin Oncol 2006 ASCO Annu Meet Proc
, vol.24
, pp. 14624
-
-
Khan, M.1
Sharef, S.2
Amato, R.J.3
-
11
-
-
33645266024
-
Paclitaxel poliglumex (PPX) in combination with carboplatin (carb) for the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC): Preliminary data
-
Nemunaitis JJ, Leighl N, Miller W, Cormier Y, Bernareggi A, Oldham F. Paclitaxel poliglumex (PPX) in combination with carboplatin (carb) for the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC): preliminary data. J Clin Oncol 2005 ASCO Annu Meet Proc 2005;23:7230.
-
(2005)
J Clin Oncol 2005 ASCO Annu Meet Proc
, vol.23
, pp. 7230
-
-
Nemunaitis, J.J.1
Leighl, N.2
Miller, W.3
Cormier, Y.4
Bernareggi, A.5
Oldham, F.6
-
12
-
-
33746799835
-
Paclitaxel poliglumex (PPX-Xyotax) and concurrent radiation for esophageal and gastric cancer: A phase I study
-
Dipetrillo T, Milas L, Evans D, et al. Paclitaxel poliglumex (PPX-Xyotax) and concurrent radiation for esophageal and gastric cancer: a phase I study. Am J Clin Oncol 2006;29:376-9.
-
(2006)
Am J Clin Oncol
, vol.29
, pp. 376-379
-
-
Dipetrillo, T.1
Milas, L.2
Evans, D.3
-
13
-
-
12744278961
-
Phase II study of CT-2103 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma
-
Sabbatini P, Aghajanian C, Dizon D, et al. Phase II study of CT-2103 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. J Clin Oncol 2004;22:4523-31.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4523-4531
-
-
Sabbatini, P.1
Aghajanian, C.2
Dizon, D.3
-
14
-
-
17644364728
-
Phase I study of the novel taxane CT-2103 in patients with advanced solid tumors
-
Veronese ML, Flaherty K, Kramer A, et al. Phase I study of the novel taxane CT-2103 in patients with advanced solid tumors. Cancer Chemother Pharmacol 2005;55:497-501.
-
(2005)
Cancer Chemother Pharmacol
, vol.55
, pp. 497-501
-
-
Veronese, M.L.1
Flaherty, K.2
Kramer, A.3
-
15
-
-
34250612643
-
Phase II study of CT-2103 as first- or second-line chemotherapy in patients with metastatic breast cancer: Unexpected incidence of hypersensitivity reactions
-
Lin NU, Parker LM, Come SE, et al. Phase II study of CT-2103 as first- or second-line chemotherapy in patients with metastatic breast cancer: unexpected incidence of hypersensitivity reactions. Invest New Drugs 2007;25:369-75.
-
(2007)
Invest New Drugs
, vol.25
, pp. 369-375
-
-
Lin, N.U.1
Parker, L.M.2
Come, S.E.3
-
16
-
-
0030018666
-
Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (myxobacteria). Production, physico-chemical and biological properties
-
Gerth K, Bedorf N, Höfle G, Irschik H, Reichenbach H. Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (myxobacteria). Production, physico-chemical and biological properties. J Antibiot (Tokyo) 1996;49:560-3.
-
(1996)
J Antibiot (Tokyo)
, vol.49
, pp. 560-563
-
-
Gerth, K.1
Bedorf, N.2
Höfle, G.3
Irschik, H.4
Reichenbach, H.5
-
17
-
-
0034895987
-
BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
-
Lee FY, Borzilleri R, Fairchild CR, et al. BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res 2001;7:1429-37.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1429-1437
-
-
Lee, F.Y.1
Borzilleri, R.2
Fairchild, C.R.3
-
18
-
-
0038811741
-
Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days
-
Abraham J, Agrawal M, Bakke S, et al. Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days. J Clin Oncol 2003;21:1866-73.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1866-1873
-
-
Abraham, J.1
Agrawal, M.2
Bakke, S.3
-
19
-
-
12144285977
-
Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors
-
Mani S, McDaid H, Hamilton A, et al. Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clin Cancer Res 2004;10:1289-98.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1289-1298
-
-
Mani, S.1
McDaid, H.2
Hamilton, A.3
-
20
-
-
39749126801
-
Phase I clinical and pharmacokinetic study of 3-weekly, 3-h infusion of ixabepilone (BMS-247550), an epothilone B analog, in Japanese patients with refractory solid tumors
-
Shimizu T, Yamamoto N, Yamada Y, et al. Phase I clinical and pharmacokinetic study of 3-weekly, 3-h infusion of ixabepilone (BMS-247550), an epothilone B analog, in Japanese patients with refractory solid tumors. Cancer Chemother Pharmacol 2008;61:751-8.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 751-758
-
-
Shimizu, T.1
Yamamoto, N.2
Yamada, Y.3
-
21
-
-
33747689092
-
A phase II trial of epothilone B analogue BMS-247550 (NSC #710428) ixabepilone, in patients with advanced pancreas cancer: A Southwest Oncology Group study
-
Whitehead RP, McCoy S, Rivkin SE, et al. A phase II trial of epothilone B analogue BMS-247550 (NSC #710428) ixabepilone, in patients with advanced pancreas cancer: a Southwest Oncology Group study. Invest New Drugs 2006;24:515-20.
-
(2006)
Invest New Drugs
, vol.24
, pp. 515-520
-
-
Whitehead, R.P.1
McCoy, S.2
Rivkin, S.E.3
-
22
-
-
34548158974
-
Phase II clinical trial of the epothilone B analog, ixabepilone, in patients with non small-cell lung cancer whose tumors have failed first-line platinum-based chemotherapy
-
Vansteenkiste J, Lara PN, Jr., Le Chevalier T, et al. Phase II clinical trial of the epothilone B analog, ixabepilone, in patients with non small-cell lung cancer whose tumors have failed first-line platinum-based chemotherapy. J Clin Oncol 2007;25:3448-55.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3448-3455
-
-
Vansteenkiste, J.1
Lara Jr., P.N.2
Le Chevalier, T.3
-
23
-
-
33644843604
-
Ixabepilone (epothilone B analogue BMS-247550) is active in chemotherapy-naive patients with hormone-refractory prostate cancer: A Southwest Oncology Group trial S0111
-
Hussain M, Tangen CM, Lara PN, Jr., et al. Ixabepilone (epothilone B analogue BMS-247550) is active in chemotherapy-naive patients with hormone-refractory prostate cancer: a Southwest Oncology Group trial S0111. J Clin Oncol 2005;23:8724-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8724-8729
-
-
Hussain, M.1
Tangen, C.M.2
Lara Jr., P.N.3
-
24
-
-
0026808448
-
Combined antimicrotubule activity of estramustine and Taxol in human prostatic carcinoma cell lines
-
Speicher LA, Barone L, Tew KD. Combined antimicrotubule activity of estramustine and Taxol in human prostatic carcinoma cell lines. Cancer Res 1992;52:4433-40.
-
(1992)
Cancer Res
, vol.52
, pp. 4433-4440
-
-
Speicher, L.A.1
Barone, L.2
Tew, K.D.3
-
25
-
-
20144377696
-
Multi-institutional randomized phase II trial of the epothilone B analog ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer
-
Galsky MD, Small EJ, Oh WK, et al. Multi-institutional randomized phase II trial of the epothilone B analog ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer. J Clin Oncol 2005;23:1439-46.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1439-1446
-
-
Galsky, M.D.1
Small, E.J.2
Oh, W.K.3
-
26
-
-
34547119271
-
Activity of second-line chemotherapy in docetaxel-refractory hormone-refractory prostate cancer patients: Randomized phase 2 study of ixabepilone or mitoxantrone and prednisone
-
Rosenberg JE, Weinberg VK, Kelly WK, et al. Activity of second-line chemotherapy in docetaxel-refractory hormone-refractory prostate cancer patients: randomized phase 2 study of ixabepilone or mitoxantrone and prednisone. Cancer 2007;110:556-63.
-
(2007)
Cancer
, vol.110
, pp. 556-563
-
-
Rosenberg, J.E.1
Weinberg, V.K.2
Kelly, W.K.3
-
27
-
-
29844447100
-
A retrospective evaluation of second-line chemotherapy response in hormone-refractory prostate carcinoma: Second line taxane-based therapy after first-line epothilone-B analog ixabepilone (BMS-247550) therapy
-
Rosenberg JE, Galsky MD, Rohs NC, et al. A retrospective evaluation of second-line chemotherapy response in hormone-refractory prostate carcinoma: second line taxane-based therapy after first-line epothilone-B analog ixabepilone (BMS-247550) therapy. Cancer 2006;106:58-62.
-
(2006)
Cancer
, vol.106
, pp. 58-62
-
-
Rosenberg, J.E.1
Galsky, M.D.2
Rohs, N.C.3
-
28
-
-
21044441003
-
Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer
-
Low JA, Wedam SB, Lee JJ, et al. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer. J Clin Oncol 2005;23:2726-34.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2726-2734
-
-
Low, J.A.1
Wedam, S.B.2
Lee, J.J.3
-
29
-
-
34548179878
-
Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy
-
Roché H, Yelle L, Cognetti F, et al. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy. J Clin Oncol 2007;25:3415-20.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3415-3420
-
-
Roché, H.1
Yelle, L.2
Cognetti, F.3
-
30
-
-
34548169630
-
Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes
-
Denduluri N, Low JA, Lee JJ, et al. Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes. J Clin Oncol 2007;25:3421-7.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3421-3427
-
-
Denduluri, N.1
Low, J.A.2
Lee, J.J.3
-
31
-
-
34548157209
-
Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine
-
Perez EA, Lerzo G, Pivot X, et al. Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine. J Clin Oncol 2007;25:3407-14.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3407-3414
-
-
Perez, E.A.1
Lerzo, G.2
Pivot, X.3
-
32
-
-
34548187738
-
Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer
-
Thomas E, Tabernero J, Fornier M, et al. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer. J Clin Oncol 2007;25:3399-406.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3399-3406
-
-
Thomas, E.1
Tabernero, J.2
Fornier, M.3
-
33
-
-
36849071808
-
Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
-
Thomas ES, Gomez HL, Li RK, et al. Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J Clin Oncol 2007;25:5210-7.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5210-5217
-
-
Thomas, E.S.1
Gomez, H.L.2
Li, R.K.3
-
34
-
-
3042701597
-
Epothilones: Mechanism of action and biologic activity
-
Goodin S, Kane MP, Rubin EH. Epothilones: mechanism of action and biologic activity. J Clin Oncol 2004;22:2015-25.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2015-2025
-
-
Goodin, S.1
Kane, M.P.2
Rubin, E.H.3
-
35
-
-
45349106522
-
Activity of patupilone for the treatment of recurrent or progressive brain metastases in patients (pts) with non-small cell lung cancer (NSCLC): An open-label, multicenter, phase II study
-
Abrey L, Wen P, Govindan R, et al. Activity of patupilone for the treatment of recurrent or progressive brain metastases in patients (pts) with non-small cell lung cancer (NSCLC): an open-label, multicenter, phase II study. J Clin Oncol 2007 ASCO Annu Meet Proc 2007;25:18058.
-
(2007)
J Clin Oncol 2007 ASCO Annu Meet Proc
, vol.25
, pp. 18058
-
-
Abrey, L.1
Wen, P.2
Govindan, R.3
-
36
-
-
19944428071
-
Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo
-
Lin B, Catley L, LeBlanc R, et al. Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo. Blood 2005;105:350-7.
-
(2005)
Blood
, vol.105
, pp. 350-357
-
-
Lin, B.1
Catley, L.2
LeBlanc, R.3
-
37
-
-
34548091847
-
Effects of patupilone (epothilone B; EPO906), a novel chemotherapeutic agent, in hepatocellular carcinoma: An in vitro study
-
Mok TS, Choi E, Yau D, et al. Effects of patupilone (epothilone B; EPO906), a novel chemotherapeutic agent, in hepatocellular carcinoma: an in vitro study. Oncology 2006;71:292-6.
-
(2006)
Oncology
, vol.71
, pp. 292-296
-
-
Mok, T.S.1
Choi, E.2
Yau, D.3
-
38
-
-
20144372598
-
Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma
-
O'Reilly T, Wartmann M, Maira SM, et al. Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma. Cancer Chemother Pharmacol 2005;55:307-17.
-
(2005)
Cancer Chemother Pharmacol
, vol.55
, pp. 307-317
-
-
O'Reilly, T.1
Wartmann, M.2
Maira, S.M.3
-
39
-
-
34548385800
-
Phase I clinical study of the novel epothilone B analogue BMS-310705 given on a weekly schedule
-
Sessa C, Perotti A, Lladò A, et al. Phase I clinical study of the novel epothilone B analogue BMS-310705 given on a weekly schedule. Ann Oncol 2007;18:1548-53.
-
(2007)
Ann Oncol
, vol.18
, pp. 1548-1553
-
-
Sessa, C.1
Perotti, A.2
Lladò, A.3
-
40
-
-
60849137011
-
Preclinical pharmacological profile of ABJ879, a novel epothilone B analog with potent and protracted anti-tumor activity
-
abstract 5440
-
Wartmann M, Loretan J, Reuter R, et al. Preclinical pharmacological profile of ABJ879, a novel epothilone B analog with potent and protracted anti-tumor activity. Proc Am Assoc Cancer Res 2004;45:abstract 5440.
-
(2004)
Proc Am Assoc Cancer Res
, vol.45
-
-
Wartmann, M.1
Loretan, J.2
Reuter, R.3
-
41
-
-
33845486692
-
Total synthesis and antitumor activity of ZK-EPO: The first fully synthetic epothilone in clinical development
-
Klar U, Buchmann B, Schwede W, et al. Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development. Angew Chem Int Ed Engl 2006;45:7942-8.
-
(2006)
Angew Chem Int Ed Engl
, vol.45
, pp. 7942-7948
-
-
Klar, U.1
Buchmann, B.2
Schwede, W.3
-
42
-
-
43549102751
-
Phase II trial of the novel epothilone ZK-EPO in patients with platinum resistant ovarian cancer
-
Rustin G, Reed N, Jayson G, et al. Phase II trial of the novel epothilone ZK-EPO in patients with platinum resistant ovarian cancer. J Clin Oncol 2007 ASCO Annu Meet Proc 2007;25:5527.
-
(2007)
J Clin Oncol 2007 ASCO Annu Meet Proc
, vol.25
, pp. 5527
-
-
Rustin, G.1
Reed, N.2
Jayson, G.3
-
43
-
-
39549088960
-
Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel
-
Beer TM, Higano CS, Saleh M, et al. Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel. Invest New Drugs 2007;25:565-70.
-
(2007)
Invest New Drugs
, vol.25
, pp. 565-570
-
-
Beer, T.M.1
Higano, C.S.2
Saleh, M.3
-
44
-
-
60849087162
-
Phase 1 trial of KOS-862 (epothilone D) in combination with carboplatin (C) in patients with solid tumors
-
Monk J, Calero-Villalona M, Dupont J, et al. Phase 1 trial of KOS-862 (epothilone D) in combination with carboplatin (C) in patients with solid tumors. J Clin Oncol 2005 ASCO Annu Meet Proc 2005;23:2049.
-
(2005)
J Clin Oncol 2005 ASCO Annu Meet Proc
, vol.23
, pp. 2049
-
-
Monk, J.1
Calero-Villalona, M.2
Dupont, J.3
-
45
-
-
54349090609
-
Phase I trial of weekly combination KOS-862 (epothilone D) and trastuzumab in HER-2 overexpressing malignancies
-
Cortes J, Climent M, Gomez P, et al. Phase I trial of weekly combination KOS-862 (epothilone D) and trastuzumab in HER-2 overexpressing malignancies. J Clin Oncol 2006 ASCO Annu Meet Proc 2006;24:2028.
-
(2006)
J Clin Oncol 2006 ASCO Annu Meet Proc
, vol.24
, pp. 2028
-
-
Cortes, J.1
Climent, M.2
Gomez, P.3
-
46
-
-
60849131823
-
Phase 1 and pharmacokinetic (PK) study of weekly KOS-862 (epothilone D) combined with gemcitabine (GEM) in patients (pts) with advanced solid tumors
-
Marshall J, Ramalingam S, Hwang J, et al. Phase 1 and pharmacokinetic (PK) study of weekly KOS-862 (epothilone D) combined with gemcitabine (GEM) in patients (pts) with advanced solid tumors. J Clin Oncol 2005 ASCO Annu Meet Proc 2005;23:2041.
-
(2005)
J Clin Oncol 2005 ASCO Annu Meet Proc
, vol.23
, pp. 2041
-
-
Marshall, J.1
Ramalingam, S.2
Hwang, J.3
-
47
-
-
33745233908
-
Phase II trial of KOS-862 (epothilone D) in anthracycline and taxane pretreated metastatic breast cancer
-
Overmoyer B, Waintraub S, Kaufman P, et al. Phase II trial of KOS-862 (epothilone D) in anthracycline and taxane pretreated metastatic breast cancer. J Clin Oncol 2005 ASCO Annu Meet Proc 2005;23:778.
-
(2005)
J Clin Oncol 2005 ASCO Annu Meet Proc
, vol.23
, pp. 778
-
-
Overmoyer, B.1
Waintraub, S.2
Kaufman, P.3
-
48
-
-
55349115251
-
Phase I trial of KOS-1584 (a novel epothilone) using two weekly dosing schedules
-
Stopeck A, Moulder S, Jones S, et al. Phase I trial of KOS-1584 (a novel epothilone) using two weekly dosing schedules. J Clin Oncol 2007 ASCO Annu Meet Proc 2007;25:2571.
-
(2007)
J Clin Oncol 2007 ASCO Annu Meet Proc
, vol.25
, pp. 2571
-
-
Stopeck, A.1
Moulder, S.2
Jones, S.3
-
49
-
-
31544473618
-
A phase I pharmacokinetic (PK) trial of XAA296A (discodermolide) administered every 3 wks to adult patients with advanced solid malignancies
-
Mita A, Lockhart A, Chen T, et al. A phase I pharmacokinetic (PK) trial of XAA296A (discodermolide) administered every 3 wks to adult patients with advanced solid malignancies. J Clin Oncol 2004 ASCO Annu Meet Proc 2004;22:2025.
-
(2004)
J Clin Oncol 2004 ASCO Annu Meet Proc
, vol.22
, pp. 2025
-
-
Mita, A.1
Lockhart, A.2
Chen, T.3
-
50
-
-
27744476031
-
Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin
-
Madiraju C, Edler MC, Hamel E, et al. Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry 2005;44:15053-63.
-
(2005)
Biochemistry
, vol.44
, pp. 15053-15063
-
-
Madiraju, C.1
Edler, M.C.2
Hamel, E.3
-
51
-
-
34249308550
-
In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent
-
Liu J, Towle MJ, Cheng H, et al. In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent. Anticancer Res 2007;27:1509-18.
-
(2007)
Anticancer Res
, vol.27
, pp. 1509-1518
-
-
Liu, J.1
Towle, M.J.2
Cheng, H.3
-
52
-
-
34247391586
-
Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines
-
Wilmes A, Bargh K, Kelly C, Northcote PT, Miller JH. Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines. Mol Pharmacol 2007;4:269-80.
-
(2007)
Mol Pharmacol
, vol.4
, pp. 269-280
-
-
Wilmes, A.1
Bargh, K.2
Kelly, C.3
Northcote, P.T.4
Miller, J.H.5
-
53
-
-
33751163059
-
Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly
-
Hamel E, Day BW, Miller JH, et al. Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Mol Pharmacol 2006;70:1555-64.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1555-1564
-
-
Hamel, E.1
Day, B.W.2
Miller, J.H.3
-
54
-
-
33846374429
-
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites
-
Buey RM, Calvo E, Barasoain I, et al. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. Nat Chem Biol 2007;3:117-25.
-
(2007)
Nat Chem Biol
, vol.3
, pp. 117-125
-
-
Buey, R.M.1
Calvo, E.2
Barasoain, I.3
-
55
-
-
0033609037
-
The coral-derived natural products eleutherobin and sarcodictyins A and B: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site
-
Hamel E, Sackett DL, Vourloumis D, Nicolaou KC. The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry 1999;38:5490-8.
-
(1999)
Biochemistry
, vol.38
, pp. 5490-5498
-
-
Hamel, E.1
Sackett, D.L.2
Vourloumis, D.3
Nicolaou, K.C.4
-
56
-
-
33749578369
-
2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules
-
Kamath K, Okouneva T, Larson G, Panda D, Wilson L, Jordan MA. 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol Cancer Ther 2006;5:2225-33.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2225-2233
-
-
Kamath, K.1
Okouneva, T.2
Larson, G.3
Panda, D.4
Wilson, L.5
Jordan, M.A.6
-
57
-
-
25144483821
-
Phase 1study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies
-
Yee KW, Hagey A, Verstovsek S, et al. Phase 1study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies. Clin Cancer Res 2005;11:6615-24.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6615-6624
-
-
Yee, K.W.1
Hagey, A.2
Verstovsek, S.3
-
58
-
-
33646118484
-
NPI-2358 is a tubulin-depolymerizing agent: In-vitro evidence for activity as a tumor vascular-disrupting agent
-
Nicholson B, Lloyd GK, Miller BR, et al. NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs 2006;17:25-31.
-
(2006)
Anticancer Drugs
, vol.17
, pp. 25-31
-
-
Nicholson, B.1
Lloyd, G.K.2
Miller, B.R.3
-
59
-
-
33646831647
-
Vinflunine - an active chemotherapy for treatment of advanced non-small-cell lung cancer previously treated with a platinum-based regimen: Results of a phase II study
-
Bennouna J, Breton JL, Tourani JM, et al. Vinflunine - an active chemotherapy for treatment of advanced non-small-cell lung cancer previously treated with a platinum-based regimen: results of a phase II study. Br J Cancer 2006;94:1383-8.
-
(2006)
Br J Cancer
, vol.94
, pp. 1383-1388
-
-
Bennouna, J.1
Breton, J.L.2
Tourani, J.M.3
-
60
-
-
23144433687
-
The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
-
Jordan MA, Kamath K, Manna T, et al. The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. Mol Cancer Ther 2005;4:1086-95.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1086-1095
-
-
Jordan, M.A.1
Kamath, K.2
Manna, T.3
-
61
-
-
33645352797
-
A multicenter phase II study of the cryptophycin analog LY355703 in patients with platinum-resistant ovarian cancer
-
D'Agostino G, del Campo J, Mellado B, et al. A multicenter phase II study of the cryptophycin analog LY355703 in patients with platinum-resistant ovarian cancer. Int JGynecol Cancer 2006;16:71-6.
-
(2006)
Int JGynecol Cancer
, vol.16
, pp. 71-76
-
-
D'Agostino, G.1
del Campo, J.2
Mellado, B.3
-
62
-
-
33846041131
-
A phase 2 study of TZT-1027, administered weekly to patients with advanced non-small cell lung cancer following treatment with platinum-based chemotherapy
-
Riely GJ, Gadgeel S, Rothman I, et al. A phase 2 study of TZT-1027, administered weekly to patients with advanced non-small cell lung cancer following treatment with platinum-based chemotherapy. Lung Cancer 2007;55:181-5.
-
(2007)
Lung Cancer
, vol.55
, pp. 181-185
-
-
Riely, G.J.1
Gadgeel, S.2
Rothman, I.3
-
63
-
-
60849120423
-
ILX651 administered daily for five days every 3 weeks (qdx5dq3w) in patients (pts) with inoperable locally advanced or metastatic melanoma: Phase II experience
-
McDermott D, Hersh E, Weber J, et al. ILX651 administered daily for five days every 3 weeks (qdx5dq3w) in patients (pts) with inoperable locally advanced or metastatic melanoma: phase II experience. J Clin Oncol 2005 ASCO Annu Meet Proc 2005;23:7556.
-
(2005)
J Clin Oncol 2005 ASCO Annu Meet Proc
, vol.23
, pp. 7556
-
-
McDermott, D.1
Hersh, E.2
Weber, J.3
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