Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

Endocrine-Related Cancer

Volumn 17, Issue 2, 2010, Pages 351-360

  Algire, Carolyn ^a   Amrein, Lilian ^b   Zakikhani, Mahvash ^b   Panasci, Lawrence ^c   Pollak, Michael ^c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENYLATE KINASE; FATTY ACID SYNTHASE; INSULIN; LEPTIN; METFORMIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BNIP3; PROTEIN KINASE B; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CANCER INHIBITION; COLON CARCINOMA; CONTROLLED STUDY; DRUG EFFECT; ENZYME PHOSPHORYLATION; INSULIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; UPREGULATION;

ACETYL-COA CARBOXYLASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; CARCINOMA; COLONIC NEOPLASMS; ENERGY INTAKE; FATTY ACID SYNTHETASE COMPLEX; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MEMBRANE PROTEINS; METFORMIN; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; PROTEIN-SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED;

EID: 77953589054     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1677/ERC-09-0252     Document Type: Article

References (37)

1. Bandyopadhyay S, Zhan R, Wang Y, Pai SK, Hirota S, Hosobe S, Takano Y, Saito K, Furuta E, Iiizumi M et al. 2006 Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells. Cancer Research 66 5934-5940.
2. Becker S, Dossus L & Kaaks R 2009 Obesity related hyperinsulinaemia and hyperglycaemia and cancer development. Archives of Physiology and Biochemistry 115 86-96.
3. Bowker SL, Majumdar SR, Veugelers P & Johnson JA 2006 Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29 254-258.
4. Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B & Thompson CB 2007 Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Research 67 6745-6752.
5. Cahill GF Jr 1971 Obesity and insulin levels. New England Journal of Medicine 284 1268-1269.
6. Calle EE, Rodriguez C, Walker-Thurmond K & Thun MJ 2003 Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. New England Journal of Medicine 348 1625-1638.
7. Cirillo D, Rachiglio AM, la Montagna R, Giordano A & Normanno N 2008 Leptin signaling in breast cancer: an overview. Journal of Cellular Biochemistry 105 956-964.
8. Dignam JJ, Polite BN, Yothers G, Raich P, Colangelo L, O'Connell MJ & Wolmark N 2006 Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. Journal of the National Cancer Institute 98 1647-1654.
9. Dowling RJ, Zakikhani M, Fantus IG, PollakM & Sonenberg N 2007 Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Research 67 10804-10812.
10. Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR & Morris AD 2005 Metformin and reduced risk of cancer in diabetic patients. BMJ 330 1304-1305.
11. Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, Goldfine ID, Belfiore A & Vigneri R 1999 Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Molecular and Cellular Biology 19 3278-3288.
12. Guo XN, Rajput A, Rose R, Hauser J, Beko A, Kuropatwinski K, LeVea C, Hoffman RM, Brattain MG & Wang J 2007 Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. Cancer Research 67 5851-5858.
13. Kalaany NY & Sabatini DM 2009 Tumours with PI3K activation are resistant to dietary restriction. Nature 458 725-731.
14. Kirpichnikov D, McFarlane SI & Sowers JR 2002 Metformin: an update. Annals of Internal Medicine 137 25-33.
15. Leverve XM, Guigas B, Detaille D, Batandier C, Koceir EA, Chauvin C, Fontaine E & Wiernsperger NF 2003 Mitochondrial metabolism and type-2 diabetes: a specific target of metformin. Diabetes & Metabolism 29 6S88-6S94.
16. Ma J, Giovannucci E, Pollak M, Leavitt A, Tao Y, Gaziano JM & Stampfer MJ 2004 A prospective study of plasma C-peptide and colorectal cancer risk in men. Journal of the National Cancer Institute 96 546-553. (Pubitemid 38559579)
17. Menendez JA & Lupu R 2007 Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nature Reviews. Cancer 7 763-777.
18. Meyerhardt JA, Catalano PJ, Haller DG, Mayer RJ, Benson AB III, Macdonald JS & Fuchs CS 2003 Influence of body mass index on outcomes and treatment-related toxicity in patients with colon carcinoma. Cancer 98 484-495.
19. Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Hu FB, Mayer RJ, Nelson H, Whittom R, Hantel A, Thomas J et al. 2007 Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer. Journal of the American Medical Association 298 754-764.
20. Moon HG, Ju YT, Jeong CY, Jung EJ, Lee YJ, Hong SC, Ha WS, Park ST & Choi SK 2008 Visceral obesity may affect oncologic outcome in patients with colorectal cancer. Annals of Surgical Oncology 15 1918-1922.
21. Ogino S, Nosho K, Meyerhardt JA, Kirkner GJ, Chan AT, Kawasaki T, Giovannucci EL, Loda M & Fuchs CS 2008 Cohort study of fatty acid synthase expression and patient survival in colon cancer. Journal of Clinical Oncology 26 5713-5720.
22. Phoenix KN, Vumbaca F & Claffey KP 2009 Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model. Breast Cancer Research and Treatment 113 101-111.
23. Pietinen P, Malila N, Virtanen M, Hartman TJ, Tangrea JA, Albanes D & Virtamo J 1999 Diet and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes and Control 10 387-396.
24. Pollak M 2008 Insulin and insulin-like growth factor signalling in neoplasia. Nature Reviews. Cancer 8 915-928.
25. Pollak M 2009 Do cancer cells care if their host is hungry? Cell Metabolism 9 401-403.
26. Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J & Schulze A 2005 PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24 6465-6481.
27. Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ et al. 2004 High frequency of mutations of the PIK3CA gene in human cancers. Science 304 554. (Pubitemid 38541907)
28. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M & Cantley LC 2005 The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642-1646.
29. Tomimoto A, Endo H, Sugiyama M, Fujisawa T, Hosono K, Takahashi H, Nakajima N, Nagashima Y, Wada K, Nakagama H et al. 2008 Metformin suppresses intestinal polyp growth in ApcMin/C mice. Cancer Science 99 2136-2141.
30. Wang W & Guan KL 2009 AMP-activated protein kinase and cancer. Acta Physiologica 196 55-63.
31. Wei EK, Ma J, Pollak MN, Rifai N, Fuchs CS, Hankinson SE & Giovannucci E 2005 A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women. Cancer Epidemiology, Biomarkers & Prevention 14 850-855.
32. Wei EK, Ma J, Pollak MN, Rifai N, Fuchs CS, Hankinson SE & Giovannucci E 2006 C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women. Cancer Epidemiology, Biomarkers & Prevention 15 750-755.
33. Wolpin BM, Meyerhardt JA, Chan AT, Ng K, Chan JA, Wu K, Pollak MN, Giovannucci EL & Fuchs CS 2009 Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. Journal of Clinical Oncology 27 176-185.
34. Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L, Zhao H, Scavo L, Novosyadlyy R, Kurshan N et al. 2006 Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology 147 5826-5834.
35. Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL & Brown MS 1993 SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75 187-197.
36. Zakikhani M, Dowling R, Fantus IG, Sonenberg N & Pollak M 2006 Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Research 66 10269-10273.
37. Zakikhani M, Dowling RJ, Sonenberg N & Pollak MN 2008 The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prevention Research 1 369-375.