메뉴 건너뛰기




Volumn 153, Issue 2, 2011, Pages 106-116

Advances in oral transmucosal drug delivery

Author keywords

Buccal absorption; Dosage forms; Mucoadhesive; Permeation pathways; Transmucosal

Indexed keywords

BUCCAL ABSORPTION; COMPLEX MOLECULES; DELIVERY SYSTEMS; DOSAGE FORMS; IN-VIVO; LOCAL ENVIRONMENTS; MUCOADHESIVE; ORAL CAVITY; ORAL MUCOSA; RETENTION TIME; TRANSMUCOSAL;

EID: 79960086774     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.01.027     Document Type: Review
Times cited : (437)

References (131)
  • 1
    • 0031597891 scopus 로고    scopus 로고
    • Buccal mucosa as a route for systemic drug delivery: A review
    • A.H. Shojaei Buccal mucosa as a route for systemic drug delivery: a review J Pharm. Pharmaceut. Sci. 1 1998 15 30
    • (1998) J Pharm. Pharmaceut. Sci. , vol.1 , pp. 15-30
    • Shojaei, A.H.1
  • 2
    • 0028123427 scopus 로고
    • Oral cavity as a site for bioadhesive drug delivery
    • R.B. Gandhi, and J.R. Robinson Oral cavity as a site for bioadhesive drug delivery Adv. Drug Deliv. Rev. 13 1994 43 74 (Pubitemid 24032041)
    • (1994) Advanced Drug Delivery Reviews , vol.13 , Issue.1-2 , pp. 43-74
    • Gandhi, R.B.1    Robinson, J.R.2
  • 3
    • 26644444777 scopus 로고    scopus 로고
    • The use of mucoadhesive polymers in buccal drug delivery
    • DOI 10.1016/j.addr.2005.07.003, PII S0169409X05001444, Mucoadhesive Polymers: Strategies, Achievements and Future Challenges
    • N. Salamat-Miller, M. Chittchang, and T.P. Johnston The use of mucoadhesive polymers in buccal drug delivery Adv. Drug Deliv. Rev. 57 2005 1666 1691 (Pubitemid 41443474)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.11 , pp. 1666-1691
    • Salamat-Miller, N.1    Chittchang, M.2    Johnston, T.P.3
  • 4
    • 0026672148 scopus 로고
    • Transport of thyrotropin releasing hormone in rabbit buccal mucosa in vitro
    • M.E. Dowty, K.E. Knuth, B.K. Irons, and J.R. Robinson Transport of thyrotropin releasing hormone in rabbit buccal mucosa in vitro Pharm. Res. 9 1992 1113 1122
    • (1992) Pharm. Res. , vol.9 , pp. 1113-1122
    • Dowty, M.E.1    Knuth, K.E.2    Irons, B.K.3    Robinson, J.R.4
  • 5
    • 1142273199 scopus 로고    scopus 로고
    • Lectin-mediated drug delivery in the oral cavity
    • DOI 10.1016/j.addr.2003.10.016
    • J.D. Smart Lectin-mediated drug delivery in the oral cavity Adv. Drug Deliv. Rev. 56 2004 481 489 (Pubitemid 38210418)
    • (2004) Advanced Drug Delivery Reviews , vol.56 , Issue.4 , pp. 481-489
    • Smart, J.D.1
  • 6
    • 0023388554 scopus 로고
    • The surface area of adult human mouth and thickness of salivary film covering the teeth and oral mucosa
    • L.M.C. Collins, and C. Dawes The surface area of adult human mouth and thickness of salivary film covering the teeth and oral mucosa J. Dent. Res. 66 1987 1300 1302
    • (1987) J. Dent. Res. , vol.66 , pp. 1300-1302
    • Collins, L.M.C.1    Dawes, C.2
  • 8
    • 28044460290 scopus 로고    scopus 로고
    • Buccal drug delivery
    • DOI 10.1517/17425247.2.3.507
    • J.D. Smart Buccal drug delivery Expert Opin. Drug Deliv. 2 2005 507 517 (Pubitemid 41683224)
    • (2005) Expert Opinion on Drug Delivery , vol.2 , Issue.3 , pp. 507-517
    • Smart, J.D.1
  • 9
    • 0347600479 scopus 로고    scopus 로고
    • Overcoming the challenges of noninvasive proteins and peptides delivery
    • M.R. DeFelippis Overcoming the challenges of noninvasive proteins and peptides delivery Am. Pharm. Rev. 6 2003 21 30
    • (2003) Am. Pharm. Rev. , vol.6 , pp. 21-30
    • Defelippis, M.R.1
  • 11
    • 0007394050 scopus 로고
    • 2O) in gastrointestinal contents and the proportion of total body water (T.B.W) in the gastrointestinal tract
    • 2O) in gastrointestinal contents and the proportion of total body water (T.B.W) in the gastrointestinal tract J. Clin. Invest. 36 1957 289 296
    • (1957) J. Clin. Invest. , vol.36 , pp. 289-296
    • Gotch, F.1    Nadell, J.2    Edelman, I.S.3
  • 15
    • 0006367023 scopus 로고    scopus 로고
    • Systemic oral mucosal drug delivery systems and delivery systems
    • M.J. Rathbone, Marcel Dekker Inc New York
    • P. Gilles, F.A. Ghazali, and J. Rathbone Systemic oral mucosal drug delivery systems and delivery systems M.J. Rathbone, Oral Mucosal Drug Delivery, Vol. 74 1996 Marcel Dekker Inc New York 241 285
    • (1996) Oral Mucosal Drug Delivery, Vol. 74 , pp. 241-285
    • Gilles, P.1    Ghazali, F.A.2    Rathbone, J.3
  • 16
    • 0003070827 scopus 로고    scopus 로고
    • Structure and function of the oral mucosa and implications for drug delivery
    • M.J. Rathbone, Marcel Dekker, Inc. New York
    • C.A. Squier, and P.W. Wertz Structure and function of the oral mucosa and implications for drug delivery M.J. Rathbone, Oral Mucosal Drug Delivery, Vol. 74 1996 Marcel Dekker, Inc. New York 1 26
    • (1996) Oral Mucosal Drug Delivery, Vol. 74 , pp. 1-26
    • Squier, C.A.1    Wertz, P.W.2
  • 17
    • 27644473596 scopus 로고    scopus 로고
    • Comparison of the lipid composition of porcine buccal and esophageal permeability barriers
    • DOI 10.1016/j.archoralbio.2005.04.008, PII S0003996905001330
    • I.D. Consuelo, Y. Jacques, G. Pizzolato, R.H. Guy, and F. Falson Comparison of the lipid composition of porcine buccal and esophageal permeability barriers Arch. Oral Biol. 50 2005 981 987 (Pubitemid 41570120)
    • (2005) Archives of Oral Biology , vol.50 , Issue.12 , pp. 981-987
    • Diaz-Del Consuelo, I.1    Jacques, Y.2    Pizzolato, G.-P.3    Guy, R.H.4    Falson, F.5
  • 18
    • 0035257183 scopus 로고    scopus 로고
    • A review of saliva: Normal composition, flow, and function
    • DOI 10.1067/mpr.2001.113778
    • S.P. Humphrey, and R.T. Williamson A review of saliva: normal composition, flow and function J. Prosthet. Den. 85 2001 162 169 (Pubitemid 33642446)
    • (2001) Journal of Prosthetic Dentistry , vol.85 , Issue.2 , pp. 162-169
    • Humphrey, S.P.1    Williamson, R.T.2
  • 20
    • 77249103437 scopus 로고    scopus 로고
    • Preclinical assessment of oral mucosal drug delivery systems
    • T.K. Ghosh, W.R. Pfister, CRC Press Boca Raton, FL
    • B. Li, and J.R. Robinson Preclinical assessment of oral mucosal drug delivery systems T.K. Ghosh, W.R. Pfister, Drug delivery to the Oral Cavity: Molecules to Market 2005 CRC Press Boca Raton, FL 41 66
    • (2005) Drug Delivery to the Oral Cavity: Molecules to Market , pp. 41-66
    • Li, B.1    Robinson, J.R.2
  • 21
    • 0021904430 scopus 로고
    • Measurement of blood flow in the oral mucosa and skin of the rhesus monkey using radiolabelled microspheres
    • C.A. Squier, and D. Nanny Measurement of blood flow in the oral mucosa and skin of the rhesus monkey using radiolabelled microspheres Arch. Oral Biol. 30 1985 313 318
    • (1985) Arch. Oral Biol. , vol.30 , pp. 313-318
    • Squier, C.A.1    Nanny, D.2
  • 22
    • 77249093105 scopus 로고    scopus 로고
    • Critical evaluation of permeation enhancers for oral mucosal drug delivery
    • H. Sohi, A. Ahuja, F.J. Ahmad, and R.K. Khar Critical evaluation of permeation enhancers for oral mucosal drug delivery Drug Dev. Ind. Pharm. 36 2010 254 282
    • (2010) Drug Dev. Ind. Pharm. , vol.36 , pp. 254-282
    • Sohi, H.1    Ahuja, A.2    Ahmad, F.J.3    Khar, R.K.4
  • 23
    • 0026564618 scopus 로고
    • Drug delivery via the mucous membranes of the oral cavity
    • D. Harris, and J.R. Robinson Drug delivery via the mucous membranes of the oral cavity J. Pharm. Sci. 81 1992 1 10
    • (1992) J. Pharm. Sci. , vol.81 , pp. 1-10
    • Harris, D.1    Robinson, J.R.2
  • 24
    • 0017033158 scopus 로고
    • The in vitro permeability of skin and buccal mucosa to selected drugs and tritiated water
    • W.R. Galey, H.K. Lonsdale, and S. Nacht The in vitro permeability of skin and buccal mucosa to selected drugs and tritiated water J. Invest. Dermatol. 67 1976 713 717 (Pubitemid 8005953)
    • (1976) Journal of Investigative Dermatology , vol.67 , Issue.6 , pp. 713-717
    • Galey, W.R.1    Lonsdale, H.K.2    Nacht, S.3
  • 26
    • 0018141903 scopus 로고
    • The permeability of epidermis lacking normal membrane-coating granules: An ultrastructural tracer study of Kyrle-Flegel disease
    • C.A. Squier, R.A. Eady, and R.M. Hopps The permeability of epidermis lacking normal membrane-coating granules: an ultrastructural tracer study of Kyrle-Flegel disease J. Invest. Dermatol. 70 1978 361 364 (Pubitemid 8369152)
    • (1978) Journal of Investigative Dermatology , vol.70 , Issue.6 , pp. 361-364
    • Squier, C.A.1    Eady, R.A.J.2    Hopps, R.M.3
  • 27
    • 0021303753 scopus 로고
    • The permeability of mammalian nonkeratinized oral epithelia to horseradish peroxidise applied in vivo and in vitro
    • C.A. Squier, and B.K. Hall The permeability of mammalian nonkeratinized oral epithelia to horseradish peroxidise applied in vivo and in vitro Arch. Oral Biol. 29 1984 45 50
    • (1984) Arch. Oral Biol. , vol.29 , pp. 45-50
    • Squier, C.A.1    Hall, B.K.2
  • 28
    • 0000963946 scopus 로고
    • The gastrointestinal physiology. Salivary, gastric and hepatobiliary secretions
    • J.G. Forte, American Physiological Society Bethesda, MD
    • A. Allen The gastrointestinal physiology. Salivary, gastric and hepatobiliary secretions J.G. Forte, Handbook of Physiology, Vol. III Section 6 1989 American Physiological Society Bethesda, MD 359 382
    • (1989) Handbook of Physiology, Vol. III Section 6 , pp. 359-382
    • Allen, A.1
  • 29
    • 0032403463 scopus 로고    scopus 로고
    • The effect of physical barriers and properties on the oral absorption of particulates
    • DOI 10.1016/S0169-409X(98)00037-4, PII S0169409X98000374
    • D.A. Norris, N. Puri, and P.J. Sinko The effect of physical barriers and properties on the oral absorption of particulates Adv. Drug Deliv. Rev. 34 1998 135 154 (Pubitemid 28535109)
    • (1998) Advanced Drug Delivery Reviews , vol.34 , Issue.2-3 , pp. 135-154
    • Norris, D.A.1    Puri, N.2    Sinko, P.J.3
  • 30
    • 0035858290 scopus 로고    scopus 로고
    • Surface modifications and molecular imprinting of polymers in medical and pharmaceutical applications
    • DOI 10.1016/S0168-3659(01)00259-0, PII S0168365901002590
    • P. Bures, Y. Huang, E. Oral, and N.A. Peppas Surface modifications and molecular imprinting of polymers in medical and pharmaceutical applications J. Control. Release 72 2001 25 33 (Pubitemid 32522341)
    • (2001) Journal of Controlled Release , vol.72 , Issue.1-3 , pp. 25-33
    • Bures, P.1    Huang, Y.2    Oral, E.3    Peppas, N.A.4
  • 33
    • 43249121029 scopus 로고    scopus 로고
    • Gut instincts: Explorations in intestinal physiology and drug delivery
    • E.L. McConnell, H.M. Fadda, and A.W. Basit Gut instincts: explorations in intestinal physiology and drug delivery Int. J. Pharm. 364 2008 213 226
    • (2008) Int. J. Pharm. , vol.364 , pp. 213-226
    • McConnell, E.L.1    Fadda, H.M.2    Basit, A.W.3
  • 34
    • 69149099286 scopus 로고    scopus 로고
    • Colonic treatment and targets: Issues and opportunities
    • E.L. McConnell, F. Lui, and A.W. Basit Colonic treatment and targets: issues and opportunities J. Drug Target. 17 2009 335 363
    • (2009) J. Drug Target. , vol.17 , pp. 335-363
    • McConnell, E.L.1    Lui, F.2    Basit, A.W.3
  • 35
    • 45849149250 scopus 로고    scopus 로고
    • Current status and the future of buccal drug delivery systems
    • DOI 10.1517/17425247.5.5.531
    • S.I. Pather, M.J. Rathbone, and S. Senel Current status and the future of buccal drug delivery systems Expert Opin. Drug Deliv. 5 2008 531 542 (Pubitemid 351877432)
    • (2008) Expert Opinion on Drug Delivery , vol.5 , Issue.5 , pp. 531-542
    • Pather, S.I.1    Rathbone, M.J.2    Senel, S.3
  • 36
    • 0034630914 scopus 로고    scopus 로고
    • TR146 cells grown on filters as a model of human buccal epithelium: V. Enzyme activity of the TR146 cell culture model, human buccal epithelium and porcine buccal epithelium, and permeability of leu-enkephalin
    • H.M. Nielsen, and M.R. Rassing TR146 cells grown on filters as a model of human buccal epithelium: V. Enzyme activity of the TR146 cell culture model, human buccal epithelium and porcine buccal epithelium, and permeability of leu-enkephalin Int. J. Pharm. 200 2000 261 270
    • (2000) Int. J. Pharm. , vol.200 , pp. 261-270
    • Nielsen, H.M.1    Rassing, M.R.2
  • 37
    • 0037148692 scopus 로고    scopus 로고
    • Peptidase activity on the surface of the porcine buccal mucosa
    • DOI 10.1016/S0378-5173(01)00934-6, PII S0378517301009346
    • G.F. Walker, N. Langoth, and A. Bernkop-Schnurch Peptidase activity on the surface of the porcine buccal mucosa Int. J. Pharm. 233 2002 141 147 (Pubitemid 34230426)
    • (2002) International Journal of Pharmaceutics , vol.233 , Issue.1-2 , pp. 141-147
    • Walker, G.F.1    Langoth, N.2    Bernkop-Schnurch, A.3
  • 39
    • 0021987999 scopus 로고
    • The permeability of skin and oral mucosa to water and horseradish peroxidase as related to the thickness of the permeability barrier
    • DOI 10.1111/1523-1747.ep12264711
    • C.A. Squier, and B.K. Hall The permeability of the skin and oral mucosa to water and horseradish peroxidise as related to the thickness of the permeability barrier J. Inv. Dermat. 84 1985 176 179 (Pubitemid 15127885)
    • (1985) Journal of Investigative Dermatology , vol.84 , Issue.3 , pp. 176-179
    • Squier, C.A.1    Hall, B.K.2
  • 40
    • 34547126907 scopus 로고    scopus 로고
    • Transbuccal delivery of 5-Aza-2′-Deoxycytidine: Effects of drug concentration, buffer solution and bile salts on permeation
    • Article 55
    • R. Mahalingam, H. Ravivarapu, S. Redkar, X. Li, and B.R. Jasti Transbuccal delivery of 5-Aza-2′-Deoxycytidine: effects of drug concentration, buffer solution and bile salts on permeation AAPS PharmSciTech 8 2007 E1 E6 Article 55
    • (2007) AAPS PharmSciTech , vol.8
    • Mahalingam, R.1    Ravivarapu, H.2    Redkar, S.3    Li, X.4    Jasti, B.R.5
  • 41
    • 0035183597 scopus 로고    scopus 로고
    • Transbuccal delivery of 2′,3′-dideoxycytidine: In vitro permeation study and histological investigation
    • DOI 10.1016/S0378-5173(01)00865-1, PII S0378517301008651
    • J. Xiang, X. Fang, and X. Li Transbuccal delivery of 2′, 3′-dideoxycytidine: in vitro permeation study and histological investigation Int. J. Pharm. 231 2002 57 66 (Pubitemid 33086819)
    • (2002) International Journal of Pharmaceutics , vol.231 , Issue.1 , pp. 57-66
    • Xiang, J.1    Fang, X.2    Li, X.3
  • 43
    • 0035997043 scopus 로고    scopus 로고
    • Nicotine permeability across the buccal TR146 cell culture model and porcine buccal mucosa in vitro: Effect of pH and concentration
    • DOI 10.1016/S0928-0987(02)00083-0, PII S0928098702000830
    • H.M. Nielsen, and M.R. Rassing Nicotine permeability across the buccal TR146 cell culture model and porcine buccal mucosa in vitro: effect of pH and concentration Eur. J. Pharm. Sci. 16 2002 151 157 (Pubitemid 34786449)
    • (2002) European Journal of Pharmaceutical Sciences , vol.16 , Issue.3 , pp. 151-157
    • Nielsen, H.M.1    Rassing, M.R.2
  • 44
    • 27444440815 scopus 로고    scopus 로고
    • Transbuccal delivery of lamotrigine across porcine buccal mucosa: In vitro determination of routes of buccal transport
    • R. Mashru, V. Sutariya, M. Sankalia, and J. Sankalia Transbuccal delivery of lamotrigine across porcine buccal mucosa: in vitro determination of routes of buccal transport J. Pharm. Pharmaceut. Sci. 8 2005 54 62 (Pubitemid 41528870)
    • (2005) Journal of Pharmacy and Pharmaceutical Sciences , vol.8 , Issue.1 , pp. 54-62
    • Mashru, R.1    Sutariya, V.2    Sankalia, M.3    Sankalia, J.4
  • 45
    • 0031969413 scopus 로고    scopus 로고
    • Perfusion cells for studying regional variation in oral mucosal permeability in humans. 2. A specialized transport mechanism in D-glucose absorption exists in dorsum of tongue
    • DOI 10.1021/js9703028
    • Y. Kurosaki, K. Yano, and T. Kimura Perfusion cells for studying regional variation in oral mucosal permeability in humans. 2. A specialized transport mechanism in D-glucose absorption across cultured dorsum of tongue J. Pharm. Sci. 87 1998 613 615 (Pubitemid 28225627)
    • (1998) Journal of Pharmaceutical Sciences , vol.87 , Issue.5 , pp. 613-615
    • Kurosaki, Y.1    Yano, K.2    Kimura, T.3
  • 47
    • 54949136459 scopus 로고    scopus 로고
    • Evaluation of galantamine transbuccal absorption by reconstituted human oral epithelium and porcine tissue as buccal mucosa models: Part i
    • V. De Caro, G. Giandalia, M.G. Siragusa, C. Paderni, G. Campisi, and L.I. Giannola Evaluation of galantamine transbuccal absorption by reconstituted human oral epithelium and porcine tissue as buccal mucosa models: part I Eur. J. Pharm. Biopharm. 70 2008 869 873
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , pp. 869-873
    • De Caro, V.1    Giandalia, G.2    Siragusa, M.G.3    Paderni, C.4    Campisi, G.5    Giannola, L.I.6
  • 49
    • 12244305575 scopus 로고    scopus 로고
    • Buccal permeation of buspirone: Mechanistic studies on transport pathways
    • DOI 10.1002/jps.20208
    • R. Birudaraj, B. Berner, S. Shen, and X. Li Buccal permeation of buspirone: mechanistic studies on transport pathways J. Pharm. Sci. 94 2005 70 78 (Pubitemid 40116371)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.1 , pp. 70-78
    • Birudaraj, R.1    Berner, B.2    Shen, S.3    Li, X.4
  • 50
    • 18744398120 scopus 로고    scopus 로고
    • Effect of pH on in vitro permeation of ondansetron hydrochloride across porcine buccal mucosa
    • DOI 10.1081/PDT-200054437
    • R.C. Mashru, V.B. Sutariya, M.G. Sankalia, and J.M. Sankalia Effect of pH on in vitro permeation of ondansetron hydrochloride across porcine buccal mucosa Pharm. Dev. Tech. 10 2005 241 247 (Pubitemid 40677444)
    • (2005) Pharmaceutical Development and Technology , vol.10 , Issue.2 , pp. 241-247
    • Mashru, R.C.1    Sutariya, V.B.2    Sankalia, M.G.3    Sankalia, J.M.4
  • 51
    • 0030893941 scopus 로고    scopus 로고
    • Carrier-mediated transport of monocarboxylic acids in primary cultured epithelial cells from rabbit oral mucosa
    • DOI 10.1023/A:1012046021028
    • N. Utoguchi, Y. Watanabe, T. Suzuki, J. Maehara, Y. Matsumoto, and M. Matsumoto Carrier-mediated transport of monocarboxylic acids in primary cultured epithelial cells from rabbit oral mucosa Pharm. Res. 14 1997 320 324 (Pubitemid 27160943)
    • (1997) Pharmaceutical Research , vol.14 , Issue.3 , pp. 320-324
    • Utoguchi, N.1    Watanabe, Y.2    Suzuki, T.3    Maehara, J.4    Matsumoto, Y.5    Matsumoto, M.6
  • 52
    • 0032906292 scopus 로고    scopus 로고
    • Carrier-mediated absorption of salicylic acid from hamster cheek pouch mucosa
    • DOI 10.1021/js970412e
    • N. Utoguchi, Y. Watanabe, T. Suzuki, J. Maehara, Y. Matsumoto, and M. Matsumoto Carrier-mediated absorption of salicylic acid from hamster cheek pouch mucosa J. Pharm. Sci. 88 1999 142 146 (Pubitemid 29037382)
    • (1999) Journal of Pharmaceutical Sciences , vol.88 , Issue.1 , pp. 142-146
    • Utoguchi, N.1    Watanabe, Y.2    Takase, Y.3    Suzuki, T.4    Matsumoto, M.5
  • 54
    • 33746468534 scopus 로고    scopus 로고
    • Buccal bioadhesive drug delivery - A promising option for orally less efficient drugs
    • DOI 10.1016/j.jconrel.2006.04.012, PII S0168365906002021
    • Y. Sudhakar, K. Kuotsu, and A.K. Bandyopadhyay Buccal bioadhesive drug delivery - a promising option for orally less efficient drugs J. Control. Release 114 2006 15 40 (Pubitemid 44128620)
    • (2006) Journal of Controlled Release , vol.114 , Issue.1 , pp. 15-40
    • Sudhakar, Y.1    Kuotsu, K.2    Bandyopadhyay, A.K.3
  • 55
    • 79960106178 scopus 로고    scopus 로고
    • accessed on 02/03/2010
    • http://www.intelgenx.com/technologies/quickreleasewafer.html, accessed on 02/03/2010.
  • 56
    • 79960099171 scopus 로고    scopus 로고
    • accessed on 02/03/2010.
    • http://www.bioenvelop.com/english/prd-technology.html, accessed on 02/03/2010.
  • 57
    • 79960082773 scopus 로고    scopus 로고
    • accessed on 02/03/2010
    • http://www.innozen.com, accessed on 02/03/2010.
  • 58
    • 79960090398 scopus 로고    scopus 로고
    • accessed on 02/03/2010.
    • http://www.biofilm.co.uk/cms/index.php?option=com-content&view= article&id=23&Itemid=69, accessed on 02/03/2010.
  • 59
    • 79960097911 scopus 로고    scopus 로고
    • accessed on 02/03/2010.
    • http://www.meldexinternational.com/technology-platforms.asp, accessed on 02/03/2010.
  • 60
    • 79960104994 scopus 로고    scopus 로고
    • accessed on 02/03/2010.
    • http://www.meldexinternational.com/pages/content/index.asp?PageID=50, accessed on 02/03/2010.
  • 61
    • 79960097029 scopus 로고    scopus 로고
    • accessed on 02/03/2010.
    • http://www.meldexinternational.com/pages/content/index.asp?PageID=48, accessed on 02/03/2010.
  • 62
    • 79960106745 scopus 로고    scopus 로고
    • accessed on 02/03/2010.
    • http://www.uluruinc.com/oradisc-a.htm, accessed on 02/03/2010.
  • 63
    • 79960100323 scopus 로고    scopus 로고
    • accessed on 02/03/2010.
    • http://www.monosolrx.com/technology-thinfilm.html, accessed on 02/03/2010.
  • 64
    • 79960108323 scopus 로고    scopus 로고
    • accessed on 02/03/2010.
    • http://www.monosolrx.com/rx-develop.html, accessed on 02/03/2010.
  • 65
    • 79960099524 scopus 로고    scopus 로고
    • accessed on 03/03/2010.
    • http://www.snoreeze.com/the-snoreeze-range/snoreeze-oral-strips, accessed on 03/03/2010.
  • 66
    • 79960097363 scopus 로고    scopus 로고
    • accessed on 03/03/2010.
    • http://www.gwpharm.com/Sativex.aspx, accessed on 03/03/2010.
  • 67
    • 79960080139 scopus 로고    scopus 로고
    • accessed on 30/03/2010.
    • http://www.generex.com/technology.php, accessed on 30/03/2010.
  • 68
    • 79960078111 scopus 로고    scopus 로고
    • accessed on 30/03/2010.
    • http://www.novadel.com/pipeline/index.htm, accessed on 30/03/2010.
  • 69
    • 79960082064 scopus 로고    scopus 로고
    • accessed on 03/03/2010.
    • http://www.biodeliverysciences.com/BEMA.php, accessed on 03/03/2010.
  • 70
    • 79960080657 scopus 로고    scopus 로고
    • accessed on 30/03/2010.
    • http://www.biodeliverysciences.com/pipeline.php, accessed on 30/03/2010.
  • 71
    • 79960100126 scopus 로고    scopus 로고
    • accessed on 30/03/2010.
    • http://www.transcept.com/content/view/39/95/, accessed on 30/03/2010.
  • 72
    • 79960077561 scopus 로고    scopus 로고
    • accessed on 03/03/2010.
    • http://www.biodeliverysciences.com/BEMA-Buprenorphine.php, accessed on 03/03/2010.
  • 73
    • 79960076849 scopus 로고    scopus 로고
    • accessed on 03/03/2010.
    • http://www.biodeliverysciences.com/pipeline.php, accessed on 03/03/2010.
  • 74
    • 79960093291 scopus 로고    scopus 로고
    • accessed on 03/03/2010.
    • http://www.labtec-pharma.com/index.php?article-id=24, accessed on 03/03/2010.
  • 75
    • 79960099340 scopus 로고    scopus 로고
    • http://www.medpharm.co.uk.
  • 76
    • 0032732323 scopus 로고    scopus 로고
    • Evaluation of a novel, natural oligosaccharide gum as a sustained-release and mucoadhesive component of calcitonin buccal tablets
    • H.H. Alur, J.D. Beal, S.I. Pather, A.K. Mitra, and T.P. Johnston Evaluation of a novel, natural oligosaccharide gum as a sustained-release and mucoadhesive component of calcitonin buccal tablets J. Pharm. Sci. 88 1999 1313 1319
    • (1999) J. Pharm. Sci. , vol.88 , pp. 1313-1319
    • Alur, H.H.1    Beal, J.D.2    Pather, S.I.3    Mitra, A.K.4    Johnston, T.P.5
  • 77
    • 0037712690 scopus 로고    scopus 로고
    • Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery
    • DOI 10.1016/S0168-3659(98)00044-3, PII S0168365998000443
    • C.R. Lopez, A. Portero, J.L. Vila-Jato, and M.J. Alonso Design and evaluation of chitosan/ethylcellulose mucoadhsive bilayered devices for buccal drug delivery J. Control. Release 55 1998 143 152 (Pubitemid 28477605)
    • (1998) Journal of Controlled Release , vol.55 , Issue.2-3 , pp. 143-152
    • Remunan-Lopez, C.1    Portero, A.2    Vila-Jato, J.L.3    Alonso, M.J.4
  • 78
    • 0033813758 scopus 로고    scopus 로고
    • Bioadhesive-based dosage forms: The next generation
    • J.W. Lee, J.H. Park, and J.R. Robinson Bioadhesive-based dosage forms: the next generation J. Pharm. Sci. 89 2000 850 866
    • (2000) J. Pharm. Sci. , vol.89 , pp. 850-866
    • Lee, J.W.1    Park, J.H.2    Robinson, J.R.3
  • 79
    • 26644454810 scopus 로고    scopus 로고
    • The basics and underlying mechanisms of mucoadhesion
    • DOI 10.1016/j.addr.2005.07.001, PII S0169409X05001390, Mucoadhesive Polymers: Strategies, Achievements and Future Challenges
    • J.D. Smart The basics and underlying mechanisms of mucoadhesion Adv. Drug Deliv. Rev. 57 2005 1556 1568 (Pubitemid 41443469)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.11 , pp. 1556-1568
    • Smart, J.D.1
  • 80
    • 60749111451 scopus 로고    scopus 로고
    • Mucoadhesive polymeric platforms for controlled drug delivery
    • G.P. Andrews, T.P. Laverty, and D.S. Jones Mucoadhesive polymeric platforms for controlled drug delivery Eur. J. Pharm. Biopharm. 71 2009 505 518
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , pp. 505-518
    • Andrews, G.P.1    Laverty, T.P.2    Jones, D.S.3
  • 81
    • 0032081252 scopus 로고    scopus 로고
    • A theological assessment of the nature of interactions between mucoadhesive polymers and a homogenised mucus gel
    • DOI 10.1016/S0142-9612(98)00037-4, PII S0142961298000374
    • F. Madsen, K. Eberth, and J. Smart A rheological assessment of the nature of interactions between mucoadhesive polymers and a homogenised mucus gel Biomaterials 19 1998 1083 1092 (Pubitemid 28327536)
    • (1998) Biomaterials , vol.19 , Issue.11-12 , pp. 1083-1092
    • Madsen, F.1    Eberth, K.2    Smart, J.D.3
  • 82
    • 26644434124 scopus 로고    scopus 로고
    • Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives
    • DOI 10.1016/j.addr.2005.07.009, PII S0169409X05001432, Mucoadhesive Polymers: Strategies, Achievements and Future Challenges
    • M.I. Ugwoke, R.U. Agu, N. Verbeke, and R. Kinget Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives Adv. Drug Deliv. Rev. 57 2005 1640 1665 (Pubitemid 41443473)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.11 , pp. 1640-1665
    • Ugwoke, M.I.1    Agu, R.U.2    Verbeke, N.3    Kinget, R.4
  • 83
    • 17444372009 scopus 로고    scopus 로고
    • Mucoadhesives in the gastrointestinal tract: Revisiting the literature for novel applications
    • DOI 10.1016/j.ejpb.2005.01.007
    • D. Dodou, P. Breedveld, and P. Wieringa Mucoadhesives in the gastrointestinal tract: revisiting the literature for novel applications Eur. J. Pharm. Biopharm. 60 2005 1 16 (Pubitemid 40545855)
    • (2005) European Journal of Pharmaceutics and Biopharmaceutics , vol.60 , Issue.1 , pp. 1-16
    • Dodou, D.1    Breedveld, P.2    Wieringa, P.A.3
  • 84
    • 0001587789 scopus 로고
    • Effect of interfacial bonding on the strength of adhesion
    • A. Ahagon, and A.N. Gent Effect of interfacial bonding on the strength of adhesion J. Polym. Sci., Part B: Polym. Phys. 13 1975 1285 1300
    • (1975) J. Polym. Sci., Part B: Polym. Phys. , vol.13 , pp. 1285-1300
    • Ahagon, A.1    Gent, A.N.2
  • 86
    • 0031006979 scopus 로고    scopus 로고
    • Mechanisms of buccal mucoadhesion of novel copolymers of acrylic acid and polyethylene glycol monomethylether monomethacrylate
    • DOI 10.1016/S0168-3659(96)01626-4, PII S0168365996016264
    • A. Shojaei, and X. Li Mechanisms of buccal mucoadhesion of novel copolymers of acrylic acid and polyethylene glycol monomethylether monomethacrylate J. Control. Release 47 1997 151 161 (Pubitemid 27212342)
    • (1997) Journal of Controlled Release , vol.47 , Issue.2 , pp. 151-161
    • Shojaei, A.H.1    Li, X.2
  • 87
    • 26644437438 scopus 로고    scopus 로고
    • The use of mucoadhesive polymers in ocular drug delivery
    • DOI 10.1016/j.addr.2005.07.005, PII S0169409X05001420, Mucoadhesive Polymers: Strategies, Achievements and Future Challenges
    • A. Ludwig The use of mucoadhesive polymers in ocular drug delivery Adv. Drug Deliv. Rev. 57 2005 1595 1639 (Pubitemid 41443472)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.11 , pp. 1595-1639
    • Ludwig, A.1
  • 88
    • 34250891275 scopus 로고    scopus 로고
    • Mucoadhesive interactions of amphiphilic cationic copolymers based on [2-(methacryloyloxy)ethyl]trimethylammonium chloride
    • DOI 10.1016/j.ijpharm.2007.02.019, PII S0378517307001676
    • N. Fefelova, Z. Nurkeeva, G. Mun, and V. Khutoryanskiy Mucoadhesive interactions of amphiphilic cationic copolymers based on [2- (methacryloyloxy) ethyl] trimethyl ammonium chloride Int. J. Pharm. 339 2007 25 32 (Pubitemid 46977585)
    • (2007) International Journal of Pharmaceutics , vol.339 , Issue.1-2 , pp. 25-32
    • Fefelova, N.A.1    Nurkeeva, Z.S.2    Mun, G.A.3    Khutoryanskiy, V.V.4
  • 89
    • 0032507738 scopus 로고    scopus 로고
    • In vitro evaluation of the mucoadhesive properties of chitosan microspheres
    • DOI 10.1016/S0378-5173(98)00027-1, PII S0378517398000271
    • P. He, S. Davis, and L. Illum In vitro evaluation of the mucoadhesive properties of chitosan microspheres Int. J. Pharm. 166 1998 75 88 (Pubitemid 28239741)
    • (1998) International Journal of Pharmaceutics , vol.166 , Issue.1 , pp. 75-88
    • He, P.1    Davis, S.S.2    Illum, L.3
  • 90
    • 33947165228 scopus 로고    scopus 로고
    • Development of chitosan sponges for buccal administration of insulin
    • DOI 10.1016/j.carbpol.2006.07.028, PII S0144861706003730
    • A. Portero, D. Teijeiro-Osorio, M. Alonso, and C. Remuñán- López Development of chitosan sponges for buccal administration of insulin Carbohydr. Polym. 68 2007 617 625 (Pubitemid 46412455)
    • (2007) Carbohydrate Polymers , vol.68 , Issue.4 , pp. 617-625
    • Portero, A.1    Teijeiro-Osorio, D.2    Alonso, M.J.3    Remunan-Lopez, C.4
  • 91
    • 0034069558 scopus 로고    scopus 로고
    • Characterization of chitosan hydrochloride-mucin interaction by means of viscosimetric and turbidimetric measurements
    • DOI 10.1016/S0928-0987(00)00065-8, PII S0928098700000658
    • S. Rossi, F. Ferrari, M. Bonferoni, and C. Caramella Characterization of chitosan hydrochloride-mucin interaction by means of viscosimetric and turbidimetric measurements Eur. J. Pharm. Sci. 10 2000 251 257 (Pubitemid 30317460)
    • (2000) European Journal of Pharmaceutical Sciences , vol.10 , Issue.4 , pp. 251-257
    • Rossi, S.1    Ferrari, F.2    Bonferoni, M.C.3    Caramella, C.4
  • 92
    • 0033991816 scopus 로고    scopus 로고
    • Chitosan, its derivatives: Potential excipients for peroral peptide delivery systems
    • A. Bernkop-Schnürch Chitosan, its derivatives: potential excipients for peroral peptide delivery systems Int. J. Pharm. 194 2000 1 13
    • (2000) Int. J. Pharm. , vol.194 , pp. 1-13
    • Bernkop-Schnürch, A.1
  • 93
    • 0034734982 scopus 로고    scopus 로고
    • Lectin-mediated mucosal delivery of drugs and microparticles
    • M.A. Clark, B. Hirst, and M. Jepson Lectin-mediated mucosal delivery of drugs and microparticles Adv. Drug Deliv. Rev. 43 2000 207 223
    • (2000) Adv. Drug Deliv. Rev. , vol.43 , pp. 207-223
    • Clark, M.A.1    Hirst, B.2    Jepson, M.3
  • 95
    • 33748786235 scopus 로고    scopus 로고
    • Comparative in vivo mucoadhesion studies of thiomer formulations using magnetic resonance imaging and fluorescence detection
    • DOI 10.1016/j.jconrel.2006.06.023, PII S0168365906003178
    • K. Albrecht, M. Greindl, C. Kremser, C. Wolf, P. Debbage, and A. Bernkop-Schnürch Comparative in vivo mucoadhesion studies of thiomer formulations using magnetic resonance imaging and fluorescence detection J. Control. Release 115 2006 78 84 (Pubitemid 44415072)
    • (2006) Journal of Controlled Release , vol.115 , Issue.1 , pp. 78-84
    • Albrecht, K.1    Greindl, M.2    Kremser, C.3    Wolf, C.4    Debbage, P.5    Bernkop-Schnurch, A.6
  • 96
    • 0347985635 scopus 로고    scopus 로고
    • Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: Synthesis and in vitro evaluation
    • DOI 10.1016/S0939-6411(03)00157-7
    • M. Roldo, M. Hornof, P. Caliceti, and A. Bernkop-Schnürch Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation Eur. J. Pharm. Biopharm. 57 2004 115 121 (Pubitemid 38058810)
    • (2004) European Journal of Pharmaceutics and Biopharmaceutics , vol.57 , Issue.1 , pp. 115-121
    • Roldo, M.1    Hornof, M.2    Caliceti, P.3    Bernkop-Schnurch, A.4
  • 97
    • 0032839408 scopus 로고    scopus 로고
    • An in vitro mucosal model predictive of bioadhesive agents in the oral cavity
    • DOI 10.1016/S0168-3659(99)00117-0, PII S0168365999001170
    • D. Patel, A.W. Smith, N. Grist, P. Barnett, and J.D. Smart In-vitro mucosal model predictive of bioadhesive agents in the oral cavity J. Control. Release 61 1999 175 183 (Pubitemid 29406091)
    • (1999) Journal of Controlled Release , vol.61 , Issue.1-2 , pp. 175-183
    • Patel, D.1    Smith, A.W.2    Grist, N.3    Barnett, P.4    Smart, J.D.5
  • 98
    • 0035966522 scopus 로고    scopus 로고
    • Buccal iontophoretic delivery of atenolol HCl employing a new in vitro three-chamber permeation cell
    • DOI 10.1016/S0168-3659(00)00328-X, PII S016836590000328X
    • J. Jacobsen Buccal iontophoretic delivery of atenolol HCl employing a new in vitro three-chamber permeation cell J. Control. Release 70 2001 83 95 (Pubitemid 32144795)
    • (2001) Journal of Controlled Release , vol.70 , Issue.1-2 , pp. 83-95
    • Jacobsen, J.1
  • 99
    • 77954310097 scopus 로고    scopus 로고
    • Bioavailability in vivo of naltrexone following transbuccal administration by an electronically-controlled intraoral device: A trial on pigs
    • G. Campisi, L.I. Giannola, A.M. Florena, V. De Caro, A. Schumacher, T. Göttsche, C. Paderni, and A. Wolff Bioavailability in vivo of naltrexone following transbuccal administration by an electronically-controlled intraoral device: a trial on pigs J. Control. Release 145 2010 214 220
    • (2010) J. Control. Release , vol.145 , pp. 214-220
    • Campisi, G.1    Giannola, L.I.2    Florena, A.M.3    De Caro, V.4    Schumacher, A.5    Göttsche, T.6    Paderni, C.7    Wolff, A.8
  • 100
    • 0037237845 scopus 로고    scopus 로고
    • Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmitoyl glycol chitosan hydrogels
    • DOI 10.1016/S0939-6411(02)00118-2
    • L. Martin, C.G. Wilson, F. Koosha, and I.F. Uchegbu Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmitoyl glycol chitosan hydrogels Eur. J. Pharm. Biopharm. 55 2003 35 45 (Pubitemid 36120493)
    • (2003) European Journal of Pharmaceutics and Biopharmaceutics , vol.55 , Issue.1 , pp. 35-45
    • Martin, L.1    Wilson, C.G.2    Koosha, F.3    Uchegbu, I.F.4
  • 101
    • 0026419776 scopus 로고
    • Controlled drug release in periodontics: A review of new therapies
    • I.G. Needleman Controlled drug release in periodontics: a review of new therapies Bri. Dent. J. 170 1991 405 408
    • (1991) Bri. Dent. J. , vol.170 , pp. 405-408
    • Needleman, I.G.1
  • 102
    • 0030469411 scopus 로고    scopus 로고
    • Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases
    • DOI 10.1023/A:1016413428473
    • D.S. Jones, A.D. Woolfson, J. Djokic, and W.A. Coulter Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases Pharm. Res. 13 1996 1734 1738 (Pubitemid 26426902)
    • (1996) Pharmaceutical Research , vol.13 , Issue.11 , pp. 1734-1738
    • Jones, D.S.1    Woolfson, A.D.2    Djokic, J.3    Coulter, W.A.4
  • 103
    • 78149339756 scopus 로고    scopus 로고
    • The buccal mucosa as an alternative route for the systemic delivery of risperidone
    • L.B. Heemstra, B.C. Finnin, and J.A. Nicolazzo The buccal mucosa as an alternative route for the systemic delivery of risperidone J. Pharm. Sci. 99 2010 4584 4592
    • (2010) J. Pharm. Sci. , vol.99 , pp. 4584-4592
    • Heemstra, L.B.1    Finnin, B.C.2    Nicolazzo, J.A.3
  • 104
    • 42649104349 scopus 로고    scopus 로고
    • Rheological and functional characterization of new anti-inflammatory delivery systems designed for buccal administration
    • L. Perioli, C. Pagano, S. Mazzitelli, C. Rossi, and C. Nastruzzi Rheological and functional characterization of new anti-inflammatory delivery systems designed for buccal administration Int. J. Pharm. 356 2008 19 28
    • (2008) Int. J. Pharm. , vol.356 , pp. 19-28
    • Perioli, L.1    Pagano, C.2    Mazzitelli, S.3    Rossi, C.4    Nastruzzi, C.5
  • 106
    • 21744458088 scopus 로고    scopus 로고
    • Buccal drug delivery: A challenge already won?
    • DOI 10.1016/j.ddtec.2005.05.018, PII S1740674905000235
    • S. Rossi, G. Sandri, and C.M. Caramella Buccal drug delivery: a challenge already won? Drug Discovery Today 2 2005 59 65 (Pubitemid 40946309)
    • (2005) Drug Discovery Today: Technologies , vol.2 , Issue.1 , pp. 59-65
    • Rossi, S.1    Sandri, G.2    Caramella, C.M.3
  • 108
    • 77952888510 scopus 로고    scopus 로고
    • Construction and in vitro characterization of an optimized porosity-enabled amalgamated matrix for sustained transbuccal drug delivery
    • O.A. Adeleke, V. Pillay, L.C. du Toit, and Y.E. Choonara Construction and in vitro characterization of an optimized porosity-enabled amalgamated matrix for sustained transbuccal drug delivery Int. J. Pharm. 391 2010 79 89
    • (2010) Int. J. Pharm. , vol.391 , pp. 79-89
    • Adeleke, O.A.1    Pillay, V.2    Du Toit, L.C.3    Choonara, Y.E.4
  • 109
    • 0015449031 scopus 로고
    • Solubility of organic hydrochlorides
    • S.F. Kramer, and G.L. Flynn Solubility of organic hydrochlorides Pharm. Res. 61 1972 1896 1904
    • (1972) Pharm. Res. , vol.61 , pp. 1896-1904
    • Kramer, S.F.1    Flynn, G.L.2
  • 111
    • 0037093723 scopus 로고    scopus 로고
    • Buccoadhesive erodible disk for treatment of oro-dental infections: Design and characterisation
    • DOI 10.1016/S0378-5173(02)00059-5, PII S0378517302000595
    • J. Ali, R. Khar, A. Ahuja, and R. Kalra Buccoadhesive erodible disk for treatment of oro-dental infections: design and characterisation Int. J. Pharm. 283 2002 93 103 (Pubitemid 34457878)
    • (2002) International Journal of Pharmaceutics , vol.238 , Issue.1-2 , pp. 93-103
    • Ali, J.1    Khar, R.2    Ahuja, A.3    Kalra, R.4
  • 113
    • 0037413398 scopus 로고    scopus 로고
    • Buccal delivery of thiocolchicoside: In vitro and in vivo permeation studies
    • DOI 10.1016/S0378-5173(02)00545-8, PII S0378517302005458
    • M. Artusi, P. Santi, P. Colombo, and H.E. Junginger Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies Int. J. Pharm. 250 2003 203 213 (Pubitemid 35447950)
    • (2003) International Journal of Pharmaceutics , vol.250 , Issue.1 , pp. 203-213
    • Artusi, M.1    Santi, P.2    Colombo, P.3    Junginger, H.E.4
  • 114
    • 0031437929 scopus 로고    scopus 로고
    • Controlled release of lidocaine hydrochloride from buccal mucosa-adhesive films with solid dispersion
    • DOI 10.1016/S0378-5173(97)00241-X, PII S037851739700241X
    • Y. Kohda, H. Kobayashi, Y. Baba, H. Yuasa, T. Ozeki, Y. Kanaya, and E. Sagara Controlled release of lidocaine hydrochloride from buccal mucosa-adhesive films with solid dispersion Int. J. Pharm. 158 1997 147 155 (Pubitemid 28012901)
    • (1997) International Journal of Pharmaceutics , vol.158 , Issue.2 , pp. 147-155
    • Kohda, Y.1    Kobayashi, H.2    Baba, Y.3    Yuasa, H.4    Ozeki, T.5    Kanaya, Y.6    Sagara, E.7
  • 115
    • 0142060267 scopus 로고    scopus 로고
    • Mucoadhesive buccal patches of miconazole nitrate: In vitro/in vivo performance and effect of ageing
    • DOI 10.1016/S0378-5173(03)00371-5
    • N.A. Nafee, F.A. Ismail, N.A. Boraie, and L.M. Mortada Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing Int. J. Pharm. 264 2003 1 14 (Pubitemid 37297629)
    • (2003) International Journal of Pharmaceutics , vol.264 , Issue.1-2 , pp. 1-14
    • Nafee, N.A.1    Ismail, F.A.2    Boraie, N.A.3    Mortada, L.M.4
  • 116
    • 0142245748 scopus 로고    scopus 로고
    • Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride
    • N.A. Nafee, F.A. Ismail, N.A. Boraie, and L.M. Mortada Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride Acta Pharm. 53 2003 199 212 (Pubitemid 37314581)
    • (2003) Acta Pharmaceutica , vol.53 , Issue.3 , pp. 199-212
    • Nafee, N.A.1    Boraie, N.A.2    Ismail, F.A.3    Mortada, L.M.4
  • 117
    • 0035997327 scopus 로고    scopus 로고
    • Bilayer films for mucosal (genetic) immunization via the buccal route in rabbits
    • DOI 10.1023/A:1016454003450
    • Z. Cui, and R.J. Mumper Bilayer films for mucosal (genetic) immunization via the buccal route in rabbits Pharm. Res. 19 2002 947 953 (Pubitemid 34804236)
    • (2002) Pharmaceutical Research , vol.19 , Issue.7 , pp. 947-953
    • Cui, Z.1    Mumper, R.J.2
  • 119
    • 0036913714 scopus 로고    scopus 로고
    • Buccal transmucosal delivery of calcitonin in rabbits using thin-film composites
    • DOI 10.1023/A:1021462012442
    • Z. Cui, and R.J. Mumper Buccal transmucosal delivery of calcitonin in rabbits using thin-film composites Pharm. Res. 19 2002 1901 1906 (Pubitemid 36016040)
    • (2002) Pharmaceutical Research , vol.19 , Issue.12 , pp. 1901-1906
    • Cui, Z.1    Mumper, R.J.2
  • 120
    • 0042347581 scopus 로고    scopus 로고
    • Production and characterization of hot-melt extruded films containing clotrimazole
    • DOI 10.1081/DDC-120021775
    • M.A. Repka, S. Prodduturi, and S.P. Stodghill Production and characterization of hot-melt extruded films containing clotrimazole Drug Dev. Ind. Pharm. 29 2003 757 765 (Pubitemid 36899882)
    • (2003) Drug Development and Industrial Pharmacy , vol.29 , Issue.7 , pp. 757-765
    • Repka, M.A.1    Prodduturi, S.2    Stodghill, S.P.3
  • 121
    • 57149137648 scopus 로고    scopus 로고
    • Mucoadhesive bilayered patches for administration of sumatriptan succinate
    • S.S. Shidhaye, N.S. Saindane, S. Sutar, and V. Kadam Mucoadhesive bilayered patches for administration of sumatriptan succinate AAPS PharmSciTech 9 2008 909 916
    • (2008) AAPS PharmSciTech , vol.9 , pp. 909-916
    • Shidhaye, S.S.1    Saindane, N.S.2    Sutar, S.3    Kadam, V.4
  • 122
    • 0043212012 scopus 로고    scopus 로고
    • Polymeric microspheres for drug delivery to the oral cavity: An in vitro evaluation of mucoadhesive potential
    • DOI 10.1002/jps.10423
    • S. Kockisch, G.D. Rees, S.A. Young, J. Tsibouklis, and J.D. Smart Polymeric microspheres for drug delivery to the oral cavity: an in vitro evaluation of mucoadhesive potential J. Pharm. Sci. 92 2003 1614 1623 (Pubitemid 36929681)
    • (2003) Journal of Pharmaceutical Sciences , vol.92 , Issue.8 , pp. 1614-1623
    • Kockisch, S.1    Rees, G.D.2    Young, S.A.3    Tsibouklis, J.4    Smart, J.D.5
  • 123
    • 2142808711 scopus 로고    scopus 로고
    • In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions
    • DOI 10.1016/j.ijpharm.2004.02.020, PII S0378517304001073
    • S. Kockisch, G.D. Rees, S.A. Young, J. Tsibouklis, and J.D. Smart In-situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions Int. J. Pharm. 276 2004 51 58 (Pubitemid 38542987)
    • (2004) International Journal of Pharmaceutics , vol.276 , Issue.1-2 , pp. 51-58
    • Kockisch, S.1    Rees, G.D.2    Young, S.A.3    Tsibouklis, J.4    Smart, J.D.5
  • 128
    • 30744437915 scopus 로고    scopus 로고
    • Increasing bioavailability of silymarin using a buccal liposomal delivery system: Preparation and experimental design investigation
    • DOI 10.1016/j.ijpharm.2005.11.006, PII S0378517305007398
    • M.S. El-Samaligy, N.N. Afifi, and E.A. Mahmoud Increasing bioavailability of silymarin using a buccal liposomal delivery system: preparation and experimental design investigation Int. J. Pharm. 308 2006 140 148 (Pubitemid 43097245)
    • (2006) International Journal of Pharmaceutics , vol.308 , Issue.1-2 , pp. 140-148
    • El-Samaligy, M.S.1    Afifi, N.N.2    Mahmoud, E.A.3
  • 131
    • 79960106352 scopus 로고    scopus 로고
    • accessed on 23/11/2010.
    • http://www.generex.com/products.php?prod-id=Nzk=, accessed on 23/11/2010.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.