Biokinetics of buccal spray insulin in patients with type 1 diabetes

Metabolism: Clinical and Experimental

Volumn 54, Issue 7, 2005, Pages 930-934

  Pozzilli, Paolo ^a   Manfrini, Silvia ^a   Costanza, Flavia ^a   Coppolino, Giusy ^a   Cavallo, Maria Gisella ^b   Fioriti, Elvira ^a   Modi, Pankaj ^c  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Generex Biotechnology   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN;

ADULT; ARTICLE; BLOOD GLUCOSE MONITORING; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INTERMETHOD COMPARISON; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STATISTICAL SIGNIFICANCE;

CHEEK; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; INSULIN; MALE;

EID: 20444490840     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2005.02.008     Document Type: Article

References (14)

1. The Diabetes Control and Complications Trial Research Group The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependant diabetes mellitus N Engl J Med 329 1993 977 986
2. G. Nucci, and C. Cobelli Models of subcutaneous insulin kinetics. A critical review Comput Methods Programs Biomed 62 2000 247 257
3. P. Modi, M. Mihic, and A. Lewin The evolving role of oral insulin in the treatment of diabetes using a novel RapidMist System Diabetes Metab Res Rev 18 Suppl 1 2002 S38 S42
4. S. Schwartz, and P. Modi Pharmacodynamics of oral insulin in healthy volunteers Diabetologia 43 2000 776 [abstract]
5. S. Cernea, J. Wohlgelernter, M. Kidron, P. Modi, and I. Raz Pharmacodynamics and pharmacokinetics of dose ranging effects of Oralin versus s.c. regular insulin in healthy volunteers Diabetes 53 Suppl 2 2004 A4 [abstract]
6. P. Modi, J. Guevare-Aguirre, M. Guevara, K. Saavedra, G. Baldeon, and P. Moncayo Oral insulin spray as a meal insulin in treatment of type-2 diabetes Diabetes 51 Suppl 2 2002 439 [abstract]
7. P. Pozzilli, N. Visalli, R. Buzzetti, M.G. Cavallo, G. Marietti, and M. Hawa Metabolic and immune parameters at clinical onset of insulin dependent diabetes: a population based study Metabolism 47 1998 1205 1210
8. J. Mastrototaro The MiniMed continuous glucose monitoring system (CGMS) J Pediatr Endocrinol Metab 12 1999 751 758
9. P.H. de Meijer, J.A. Lutterman, H.J. van Lier, and A. van't Laar The variability of the absorption of subcutaneously injected insulin: effect of injection technique and relation with brittleness Diabet Med 7 1990 499 505
10. L. Heinemann Variability of insulin absorption and insulin action Diabetes Technol Ther 4 2002 673 682
11. L. Heinemann, and J.H. Anderson Measurement of insulin absorption and insulin action Diabetes Technol Ther 6 2004 698 718
12. S.J. Skyler, W.T. Cefalu, I.A. Kourides, W.H. Landschulz, C.C. Balagtas, and S.L. Cheng Efficacy of inhaled human insulin in type 1 diabetes mellitus: a randomized proof of concept study Lancet 357 2001 331 335
13. G.A. Brunner, B. Balent, M. Ellmerer, L. Schaupp, A. Siebenhofer, and J.H. Jendle Dose-response relation of liquid aerosol inhaled insulin in type I diabetic patients (Abstract) Diabetologia 44 2001 305
14. R. Harrison, M. Aye, A.H. Morice, and E.A. Masson Inhaled insulin may be harmful in lung disease Diabetes 51 Suppl 2 2002 195 [abstract]