A review of saliva: Normal composition, flow, and function

Journal of Prosthetic Dentistry

Volumn 85, Issue 2, 2001, Pages 162-169

  Humphrey, Sue P ^a,b   Williamson, Russell T ^a  

^a UNIVERSITY OF KENTUCKY COLLEGE OF DENTISTRY   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BUFFER; MUCIN; SALIVA PROTEIN;

CHEMISTRY; HISTOLOGY; HUMAN; PATHOPHYSIOLOGY; PH; PHYSIOLOGY; REVIEW; SALIVA; SALIVARY GLAND; SECRETION; TASTE; XEROSTOMIA;

ANTI-INFECTIVE AGENTS; BUFFERS; HUMANS; HYDROGEN-ION CONCENTRATION; MUCINS; SALIVA; SALIVARY GLANDS; SALIVARY PROTEINS; SECRETORY RATE; TASTE; XEROSTOMIA;

EID: 0035257183     PISSN: 00223913     EISSN: None     Source Type: Journal    
DOI: 10.1067/mpr.2001.113778     Document Type: Article

References (59)

1. Edgar WM, Saliva: its secretion, composition and functions. Br Dent J 1992;172:305-12.
2. Roth G, Calmes R, editors. Salivary glands and saliva. In: Oral biology. St Louis: CV Mosby; 1981. p.196-236.
3. Edgar WM. Saliva and dental health. Clinical implications of saliva: report of a consensus meeting. Br Dent J 1990;169:96-8.
4. Garrett JR. The proper role of nerves in salivary secretion: a review. J Dent Res 1987;66:387-97.
5. Grant DA, Stern IB, Listgarten MA, editors. Saliva. In: Periodontics. 6th ed. St Louis: CV Mosby; 1988. p.135-46.
6. Dowd FJ. Saliva and dental caries. Dent Clin North Am 1999;43:579-97.
7. Levine MJ. Development of artificial salivas. Crit Rev Oral Biol Med 1993;4:279-86.
8. Levine MJ. Salivary macromolecules. A structure/function synopsis. Ann NY Acad Sci 1993;694:11-6.
9. Tabak LA, Levine MJ, Mandel ID, Ellison SA. Role of salivary mucins in the protection of the oral cavity. J Oral Pathol 1982:11:1-17.
10. Screebny LM, Valdini A. Xerostomia. A neglected symptom. Arch Intern Med 1987:147:1333-7.
11. Ship JA, Fox PC, Baum BJ. How much saliva is enough? 'Normal' function defined. J Am Dent Assoc 1991;122:63-9.
12. Shannon IL. The biochemistry of human saliva in health and disease. In: Rowe WH, editor. Salivary glands and their secretion. Ann Arbor: University of Michigan Press; 1972. p.92-121.
13. Culp DJ, Graham LA, Latchney LR, Hand AR. Rat sublingual gland as a model to study glandular mucous cell secretion. Am J Physiol 1991;260:C1233-44.
14. Dawes C. Rhythms in salivary flow rate and composition. Int J Chronobiol 1974;2:253-79.
15. Rudney JD. Does variability in salivary protein concentrations influence oral microbial ecology and oral health? Crit Rev Oral Biol Med 1995;6:343-67.
16. Moss S. Clinical implications of recent advances in salivary research. J Esthet Dent 1995;7:197-203.
17. Dawes C, MacPherson LM. The distribution of saliva and sucrose around the mouth during the use of chewing gum and the implications for site-specificity of caries and calculus deposition. J Dent Res 1993:72:852-57.
18. Veerman EC, van den Keybus PA, Vissink A, Nieuw Amerongen AV. Human glandular salivas: their separate collection and analysis. Eur J Oral Sci 1996;104:346-52.
19. Dawes C. A mathematical model of salivary clearance of sugar from the oral cavity. Caries Res 1983;17:321-34.
20. Mandel ID. The role of saliva in maintaining oral homeostasis. J Am Dent Assoc 1989;119:298-304.
21. Navazesh M, Christensen C, Brightman V. Clinical criteria for the diagnosis of salivary gland hypofunction. J Dent Res 1992;71:1363-9.
22. Navazesh M, Mulligan RA, Kipnis V, Denny PA, Denny PC. Comparison of whole saliva flow rates and mucin concentrations in healthy Caucasian young and aged adults. J Dent Res 1992;71:1275-8.
23. Denny PC, Denny PA, Klauser DK, Hong SH, Navazesh M, Tabak LA. Age-related changes in mucins from human whole saliva. J Dent Res 1991;70:1320-7.
24. Culp DJ, Richardson LA. Regulation of mucous acinar exocrine secretion with age. J Dent Res 1996;75:575-80.
25. Aguirre A, Testa-Weintraub LA, Banderas JA, Haraszthy GG, Reddy MS, Levine MJ. Sialochemistry: a diagnostic tool? Crit Rev Oral Biol Med 1993;4:343-50.
26. Ship JA, Nolan NE, Puckett SA. Longitudinal analysis of parotid and submandibular salivary flow rates in healthy, different-aged adults. J Gerontol A Biol Sci Med Sci 1995;50:M285-9.
27. Johnson DA. Regulation of salivary glands and their secretions by masticatory, nutritional and hormonal factors. In: Scribney LM, editor. The salivary system. Boca Raton, FL: CBC Press; 1987. p.136-55.
28. Isokangas P, Tiekso J, Alanen P, Makinen KK. Long-term effect of xylitol chewing gum on dental caries. Community Dent Oral Epidemiol 1989;17:200-3.
29. Mandel ID. The function of saliva. J Dent Res 1987;66:623-7.
30. Iontcheva I, Oppenheim FG, Troxler RF. Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins. J Dent Res 1997;76:734-43.
31. Slomiany BL, Murty VL, Poitrowski J, Slomiany A. Salivary mucins in oral mucosal defense. Gen Pharmacol 1996;27:761-71.
32. Tabak LA. Stucture and function of human salivary mucins. Crit Rev Oral Biol Med 1990;1:229-34.
33. Levine MJ, Reddy MS, Tabak LA, Loomis RE, Bergey EJ, Jones PC, et al. Structural aspects of salivary glycoproteins. J Dent Res 1987;66:436-41.
34. Scannapieco FA, Levine MJ. Salivary mucins and dental plaque formation. In: Bowen WH, Tabak LA, editors. Cariology for the nineties. Rochester, NY: University of Rochester Press; 1993. p.87-105.
35. Mandel ID. Impact of saliva on dental caries. Compend Suppl 1989:S476-81.
36. Lagerlof F, Oliveby A. Caries-protective factors in saliva. Adv Dent Res 1994;8:229-38.
37. Stephan RM. Intra-oral hydrogen ion concentrations associated with dental caries activity. J Dent Res 1944;23:257.
38. Edgar WM. The role of saliva in the control of pH changes in human dental plaque. Caries Res 1976;10:241-54.
39. Bibby BG, Mundorff SA, Zero DT, Almekinder KJ. Oral food clearance and the pH of plaque and saliva. J Am Dent Assoc 1986;112:333-7.
40. Rugg-Gunn AJ, Edgar WM, Geddes DA, Jenkins GN. The effect of different meal patterns upon plaque pH in human subjects. Br Dent J 1975;139:351-6.
41. Steinberg LM, Odusola F, Mandel ID. Remineralizing potential, antiplaque and antigingivitis effects of xylitol and sorbitol sweetened chewing gums. Clin Prev Dent 1992;14:31-4.
42. Richardson CF, Johnsson M, Raj PA, Levine MJ, Nancollas GH. The influence of histatin-5 fragments on the mineralization of hydroxyapatite. Arch Oral Biol 1993;38:997-1002.
43. Margolis HC. Enamel-plaque fluid interactions. In: Bowen WH, Tabak LA, editors. Cariology for the nineties. Rochester, NY: University of Rochester Press; 1993. p.173-81.
44. Perinpanayagam HE, ManWuyckhuyse BS, Ji ZS, Tabak LA. Characterization of low-molecular-weight peptides in human parotid saliva. J Dent Res 1995;74:345-50.
45. McNabb PC, Tomasi TB. Host defense mechanisms at mucosal surfaces. Annu Rev Microbiol 1981;35:447-96.
46. Biesbrock AR, Reddy MS, Levine MJ. Interaction of salivary mucin-secretory immunoglobulin A complex with mucosal pathogens. Infect Immun 1991;59:3492-7.
47. Mandel ID. Nonimmunologic aspects of caries resistance. J Dent Res 1976;55:C22-31.
48. Lassiter MO, Newsome AL, Sams LD, Arnold RR. Characterization of lactoferrin interaction with Streptococcus mutans. J Dent Res 1987;66:480-5.
49. Pollock JJ, Lotardo S, Gavai R, Grossbard BL. Lysozyme-protease-inorganic monovalent anion lysis of oral bacterial strains in buffers and stimulated whole saliva. J Dent Res 1987;66:467-74.
50. Cowman RA, Schaefer SJ, Fitzgerald RJ. Specificity of utilization of human salivary proteins for growth by oral streptococci. Caries Res 1979;13:181-9.
51. Carlen A, Borjesson AC, Nikdel K, Olsson J. Composition of pellicles formed in vivo on tooth surfaces in different parts of the dentition, and in vitro on hydroxyapatite. Caries Res 1998;32:447-55.
52. Tenovuo J. Antimicrobial function of human saliva - how important is it for oral health? Acta Odontol Scand 1998;56:250-6.
53. Valdez IH, Fox PC. Interactions of the salivary and gastrointestinal systems. I. The role of saliva in digestion. Dig Dis 1991;9:125-32.
54. Hatton MN, Loomis RE, Levine MJ, Tabak LA. Masticatory lubrication. The role of carbohydrate in the lubricating property of a salivary glycoprotein-albumin complex. Biochem J 1985;230:817-20.
55. Mandel ID. Salivary diagnosis: promises, promises. Ann NY Acad Sci 1993;694:1-10.
56. Slavkin HC. Toward molecularly based diagnostics for the oral cavity. J Am Dent Assoc 1998;129:1138-43.
57. Malamued D. Saliva as a diagnostic fluid. Br Med J 1992;305:207-8.
58. Mandel ID. A contemporary view of salivary research. Crit Rev Oral Biol Med 1993;4:599-604.
59. Zelles T, Purushotham KR, Macauley SP, Oxford GE, Humphreys-Beher MG. Saliva and growth factors: the fountain of youth resides in us all. J Dent Res 1995;74:1826-32.