Salivary mucins in oral mucosal defense

General Pharmacology

Volumn 27, Issue 5, 1996, Pages 761-771

  Slomiany, B L ^a   Murty, V L N ^a   Piotrowski, J ^a   Slomiany, A ^a  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Defense mechanism; Mucus coat; Oral mucosa; Salivary mucin

Indexed keywords

CALCIUM CHANNEL; CARBOHYDRATE; EPIDERMAL GROWTH FACTOR; GLYCOPROTEIN; MEMBRANE RECEPTOR; MUCIN; SIALOMUCIN; SULFOMUCIN; UNCLASSIFIED DRUG;

BACTERIUM; CALCIUM HOMEOSTASIS; CHEMICAL COMPOSITION; DENTAL CARIES; DISEASE PREDISPOSITION; HOST RESISTANCE; HUMAN; MOLECULAR WEIGHT; MOUTH MUCOSA; MUCUS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SALIVA;

EID: 0030198956     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02050-0     Document Type: Review

References (60)

1. Allen A. (1981) Structure and function of gastrointestinal mucus. In: (Edited by Johnson L. R.) Physiology of the Gastrointestinal Tract, vol. 1, pp. 617-639. Raven Press, New York.
2. Cohen R. E. and Levine M. J. (1989) Salivary glycoproteins. In: (Edited by Tenouvo J.) Human Saliva: Clinical Chemistry and Microbiology, vol. 1, pp. 101-130. CRC Press, Boca Raton.
3. Eckhardt A. E., Timpte C. S., Abernethy J. L., Toumadje A. A., Johnson W. C. and Hill R. L. (1987) Structural properties of porcine submaxillary gland apomucin. J. Biol. Chem. 262, 11339-11344.
4. Forstner J. F. (1978) Intestinal mucins in health and disease. Digestion 17, 234-263.
5. Green D. R. J. and Embery G. (1987) Isolation, chemical and biological characterization of sulfated glycoproteins synthesized by rat buccal and palatal minor salivary glands in vivo and in vitro. Arch. Oral Biol. 32, 391-399.
6. Hill H. D., Schwyzer M., Steinman H. M. and Hill R. L. (1977) Ovine sub-maxillary mucin primary structure and peptide substrates of UDP-N-acetylgalactosamine: mucin transferase. J. Biol. Chem. 252, 3799-3804.
7. Hosey M. M. and Lazdunski M. (1988) Calcium channels: pharmacology, structure, and regulation. J. Membr. Biol. 104, 81-105.
8. Ikeno K., Ikeno T., Kuzuya H. and Ishiguro I. (1986) Assay of trypsin-like protease in rat submandibular saliva and gland. Arch. Oral Biol. 31, 357-361.
9. Kass G. E. N., Llopis J., Chow S. C., Duddy S. K. and Orrenius S. (1990) Receptor-operated calcium influx in rat hepatocytes. J. Biol. Chem. 265, 17486-17492.
10. Kawagishi S., Fahim R. E. F., Wong K. H. and Bennick A. (1990) Purification and characterization of subunits of a high molecular weight human salivary mucin. Arch. Oral Biol. 35, 265-272.
11. Klein A., Carnoy C., Wieruszeski J. M., Strecker G., Strang A. M., Van Halbeek M., Roussel P. and Lamblin G. (1992) The broad diversity of neutral and sialylated oligosaccharides derived from human salivary mucins. Biochemistry 31, 6152-6165.
12. 2+ channels. J. Biol. Chem. 265, 11156-11166.
13. Liu J., Fekete Z., Slomiany A. and Slomiany B. L. (1993) Activation of gastric mucosal calcium channels by epidermal growth factor. Int. J. Biochem. 25, 29-35.
14. Loomis R. E., Prakobphol A., Levine M. J., Reddy M. S. and Jones P. C. (1987) Biochemical and biophysical comparison of two mucins from human submandibular-sublingual saliva. Arch. Biochem. Biophys. 258, 452-462.
15. Mandel, I. D. (1982) The functions of saliva. J. Dent. Res. 66, 623-635.
16. Murray P. A., Levine M. J., Tabak L. A. and Reddy M. S. (1982) Specificity of salivary-bacterial interactions. Evidence for a lectin on Streptococcus sanguis with specificity for a NeuAcα2,3Ga1β1,3Ga1NAc sequence. Biochem. Biophys. Res. Commun. 106, 390-396.
17. Murray P. A., Prakobphol A., Lee T., Hoover C. I. and Fisher S. J. (1992) Adherence of oral Streptococci to salivary glycoproteins. Infect. Immun. 60, 31-38.
18. Murty V. L. N., Bilski J., Liau Y. H.; Slomiany A. and Slomiany B. L. (1988) Sulfation in vitro of mucus glycoprotein by submandibular salivary gland: effect of prostaglandin and acetylsalicylic acid. Biochim. Biophys. Acta 966, 287-296.
19. Murty V. L. N., Piotrowski J., Slomiany A. and Slomiany B. L. (1995) Identification and characterization of N-acetylhexosaminidase from P. gingivalis. J. Dent. Res. 74, A941.
20. Peppelenbosch M. P., Teroden L. G. F. and deLaat S. W. (1991) Epidermal growth factor-activated calcium and potassium channels. J. Biol. Chem. 266, 19938-19944.
21. Piotrowski J., Czajkowski A., Murty V. L. N., Slomiany A. and Slomiany B. L. (1992) Identification of human salivary protease activity towards mucin: differences with caries. Biochem. Int. 28, 939-947.
22. Piotrowski J., Murty V. L. N., Czajkowski A., Slomiany A., Yotsumoto F., Majka J. and Slomiany B. L. (1994) Association of salivary bacterial aggregating activity with sulfomucin. Biochem. Mol. Biol. Int. 32, 713-721.
23. Piotrowski J., Slomiany A., Murty V. L. N., Fekete Z. and Slomiany B. L. (1991) Inhibition of H. pylori colonization by sulfated gastric mucin. Biochem. Int. 24, 749-756.
24. Reddy M. S., Levine M. J. and Prakobphol A. (1985) Oligosaccharide structures of the low-molecular-weight salivary mucin from a normal individual and one with cystic fibrosis. J. Dent. Res. 64, 33-36.
25. Rivera J., Veidyanathan S., William S. and Kasinathan C. (1995) Characterization of tyrosine sulfation in rat salivary mucin. J. Dent. Res. 74, A1483.
26. Rolla G. and Embery G. (1977) Sulfated glycoproteins in the acquired pellicle and in plaque. Scand. J. Dent. Res. 85, 237-240.
27. Sarosiek J., Bilski J., Murty V. L. N., Slomiany A. and Slomiany B. L. (1988) Role of salivary epidermal growth factor in the maintenance of physicochemical characteristics of oral and gastric mucosal mucus coat. Biochem. Biophys. Res. Commun. 152, 1421-1427.
28. Schachter M. (1980) Kallikreins (kininogenases) - a group of serine proteases with bioregulatory actions. Pharmac. Rev. 31, 1-17.
29. Slomiany A., Jozwiak Z., Takagi A. and Slomiany B. L. (1984) The role of covalently bound fatty acids in the degradation of human gastric mucus glycoproteins. Arch. Biochem. Biophys. 229, 560-567.
30. 35S-labeled oligosaccharides. Biochem. Int. 18, 589-597.
31. Slomiany A., Okazaki K., Tamura S. and Slomiany B. L. (1991b) Identity of mucin's 118kDa link protein with fibronectin fragment. Arch. Biochem. Biophys. 268, 383-388.
32. Slomiany A., Tamura S., Grzelinska E., Piotrowski J. and Slomiany B. L. (1992a) Mucin complexes: characterization of the "link̂ component of submandibular mucus glycoprotein. Int. J. Biochem. 24, 1003-1015.
33. Slomiany A., Witas H., Aono M. and Slomiany B. L. (1983) Covalently linked fatty acids in gastric mucus glycoprotein of cystic fibrosis patients. J. Biol. Chem. 258, 8535-8538.
34. Slomiany B. L., Fekete Z., Liu J., Murty V. L. N. and Slomiany A. (1992b) Activation of dihydropyridine-sensitive parotid salivary gland calcium channels by epidermal growth factor. Arch. Oral Biol. 37, 863-868.
35. Slomiany B. L., Fekete Z., Piotrowski J., Murty V. L. N. and Slomiany A. (1993a) Salivary mucin modulation of buccal mucosal calcium channel activity. Biochem. Mol. Biol. Int. 29, 221-231.
36. Slomiany B. L., Gwozdzinski K., Murty V. L. N. and Slomiany A. (1987b) Buoyant density and viscosity behavior of human salivary mucins. Ann. N. Y. Acad. Sci. 494, 266-269.
37. Slomiany B. L., Liau Y. H., Li Q., Fekete Z. and Slomiany A. (1991a) Role of sulfation in posttranslational processing of rat salivary mucins. Arch. Oral Biol. 36, 785-790.
38. 1-ganglioside regulation of EGF-induced gastric mucosal calcium channel activation. Gen. Pharmac. 23, 799-803.
39. Slomiany B. L., Murty V. L. N., Carter S. R., Tsukada H. and Slomiany A. (1987a) Susceptibility of salivary mucin to proteolysis: differences with caries. Ann. N. Y. Acad. Sci. 494, 356-358.
40. Slomiany B. L., Murty V. L. N., Grabska M., Piotrowski J., Yotsumoto F., Czajkowski A. and Slomiany A. (1993b) Regulation of buccal mucosal calcium channel activity by salivary mucins. Int. J. Biochem. 25, 1281-1289.
41. Slomiany B. L., Murty V. L. N., Mandel I. D., Sengupta S. and Slomiany A. (1990). Effect of lipids on the lactic acid retardation capacity of tooth enamel and cementum pellicles formed in vitro from saliva of caries-resistant and caries-susceptible human adults. Arch. Oral Biol. 35, 175-180.
42. Slomiany B. L., Murty V. L. N., Mandel I. D., Zalesna G. and Slomiany A. (1989a) Physicochemical characteristics of mucus glycoproteins and lipids of the human oral mucosal mucus coat in relation to caries susceptibility. Arch. Oral Biol. 34, 229-237.
43. Slomiany B. L., Murty V. L. N. and Slomiany A. (1985) Salivary lipids in health and disease. Prog. Lipid Res. 24, 311-324.
44. Slomiany B. L., Murty V. L. N. and Slomiany A. (1993c) Structural features of carbohydrate chains in human salivary mucins. Int. J. Biochem. 25, 259-265.
45. Slomiany B. L., Murty V. L. N., Slomiany A., Zielenski J. and Mandel I. D. (1986a) Mucus glycoproteins of human saliva: differences in the associated and covalently bound lipids with caries. Biochim. Biophys. Acta 882, 18-28.
46. Slomiany B. L., Murty V. L. N., Zdebska E., Slomiany A., Gwozdzinski K. and Mandel I. D. (1986b) Tooth surface pellicle lipids and their role in the protection of dental enamel against lactic acid diffusion in man. Arch. Oral Biol. 31, 187-191.
47. Slomiany B. L., Piotrowski J., Czajkowski A., Murty V. L. N. and Slomiany A. (1993f) Characterization of gastric mucosal mucin receptor. Biochem. Mol. Biol. Int. 31, 745-753.
48. Slomiany B. L., Piotrowski J., Czajkowski A., Shovlin F. E. and Slomiany A. (1993e) Differential expression of salivary mucin bacterial aggregating activity with caries status. Int. J. Biochem. 25, 935-940.
49. Slomiany B. L., Piotrowski J., Czajkowski A. and Slomiany A. (1993d) Control of mucin molecular forms expression by salivary protease: differences with caries. Int. J. Biochem. 25, 681-687.
50. Slomiany B. L., Piotrowski J., Majka J., Liau Y. H. and Slomiany A. (1993g) Identification of buccal mucosal mucin receptor. Biochem. Mol. Biol. Int. 31, 1091-1099.
51. 35S-labeled oligosaccharides. Biochem. Biophys. Res. Commun. 157, 61-67.
52. Slomiany B. L., Sarosiek J. and Slomiany A. (1987c) Gastric mucus and the mucosal barrier. Dig. Dis. 5, 125-145.
53. Slomiany A. and Slomiany B. L. (1994) Synthesis, structure and function of gastrointestinal mucin. In: (Edited by Langlois B.) Mucus Dialogue, pp. 32-45, IME, Paris.
54. Sorsa T., Kovunen E., Konttinen Y. T., Saari H., Soumalainen K. and Stenman U. H. (1992) Human salivary trypsin: characterization and protocollagenase action. J. Dent. Res. 71, A1729.
55. Tabak L. A. (1990) Structure and function of human salivary mucins. Oral Biol. Med. 1, 229-234.
56. Tabak L. A., Levine M. J., Jain N. K., Bryant A. R., Cohen R. E., Monte I. D., Zawacki A., Nancollas G. H., Slomiany A. and Slomiany B. L. (1985a). Adsorbtion of human salivary mucins to hydroxyapatite. Arch. Oral Biol. 30, 423-427.
57. Tabak L. A., Mirels L., Monte L. D., Ridall A. L., Levine M. J., Loomis R. E., Lindauer F., Reddy M. S. and Baum B.J. (1985b) Isolation and characterization of a mucin-glycoprotein from rat submandibular glands. Arch. Biochem. Biophys. 242, 383-392.
58. Thibault G. and Genest J. (1981) Tonin, an estroprotease from rat submaxillary glands. Biochem. Biophys. Acta. 660, 23-29.
59. 1) to Hemophilus parainfluenzae. J. Dent. Res. 74, 351-357.
60. Wanatick C., Piotrowski J., Murty V. L. N., Mandel I. D., Slomiany A. and Slomiany B. L. (1990) Evidence for modification of mucin molecular forms by salivary protease. J. Dent. Res. 69, A1032.