Buccal delivery of thiocolchicoside: In vitro and in vivo permeation studies

International Journal of Pharmaceutics

Volumn 250, Issue 1, 2003, Pages 203-213

  Artusi, M ^a   Santi, P ^a   Colombo, Paolo ^a   Junginger, H E ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Buccal; Enhancers; Formulation; In vitro in vivo; Permeability; Thiocolchicoside

Indexed keywords

MW 563; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; THIOCOLCHICOSIDE; COLCHICINE; DRUG DERIVATIVE;

ADHESION; ADULT; ANIMAL TISSUE; ARTICLE; CHEEK MUCOSA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG UPTAKE; FEMALE; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUTH MUCOSA; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SWINE; TIME; ANIMAL; BUCCAL DRUG ADMINISTRATION; DRUG DELIVERY SYSTEM; METABOLISM;

ADMINISTRATION, BUCCAL; ADULT; ANIMALS; COLCHICINE; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; MALE; MOUTH MUCOSA; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID;

EID: 0037413398     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00545-8     Document Type: Article

References (25)

1. Beckett A.H., Triggs E.J. Buccal absorption of basic drugs and its application as an in vivo model of passive drug transfer through lipid membranes. J. Pharm. Pharmacol. 19:1967;31S-41S.
2. De Vries M.E., Boddè H.E., Verhoef J.C., Ponec M., Craane W.I.H.M., Junginger H.E. Localization of the permeability barrier inside porcine buccal mucosa: a combined in vitro study of drug permeability, electrical resistance and tissue morphology. Int. J. Pharm. 76:1991;25-35.
3. Fuchs E., Green H. Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell. 19:(4):1980;1033-1042.
4. Hoogstraate A.J., Boddè H.E. Methods for assessing the buccal mucosa as a route of drug delivery. Adv. Drug Deliv. 12:1993;99-125.
5. Hoogstraate J.A., Verhoef J.C., Pijpers A., Van Leengoed L.A.M.G., Verheiden J.H.M., Junginger H.E., Boddè H.E. In vivo buccal delivery of the peptide drug buserelin with glycodeoxycholate as an absorption enhancer in pigs. Pharm. Res. 13:1996;1233-1237.
6. Hoogstraate J.A., Verhoef J.C., Tuk B., Pijpers A., Van Leengoed L.A.M.G., Verheiden J.H.M., Junginger H.E., Boddè H.E. In vivo buccal delivery of fluorescein isothiocyanate-dextran 4400 with glycodeoxycholate as an absorption enhancer in pigs. J. Pharm. Sci. 85:1996;457-460.
7. Hoogstraate J.A., Cullander C., Nagelkerke J.F., Spies F., Verhoef J., Junginger A.H.G.J., Boddé H.E. A novel in situ model for continuous observation of transient drug concentration gradients across buccal epithelium at the microscopical level. J. Control. Release. 39:1996;71-78.
8. Janbroers J.M. Review of the toxicology, pharmacodynamics and pharmacokinetics of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions. Acta Ther. 13:1987;221-250.
9. Junginger H.E., Hoogstraate J.A., Verhoef J.C. Recent advances in buccal delivery and absorption - in vitro and in vivo studies. J. Control. Release. 62:1999;149-159.
10. Lesch C.A., Squier C.A., Cruchley A., Williams D.M., Speight P. The permeability of human oral mucosa and skin to water. J. Dent. Res. 68:1989;1345-1349.
11. Rathbone M.J. Human buccal absorption. A method for estimating the transfer kinetics of drugs across the human buccal membrane. Int. J. Pharm. 69:1991;103-108.
12. Ritschel W.A., Ritschel G.B., Forusz H., Kraeling M. Buccal absorption of insulin in dogs. Res. Commun. Chem. Pathol. Pharmacol. 63:1989;53.
13. Sandouk P., Bouvier d'Yvoire M., Chretien P., Tillement J.P., Scherrmann M. Single-dose bioavailability of oral and intramuscular thiocolchicoside in healthy volunteers. Biopharm. Drug Dispos. 15:1994;87-92.
14. Senel S., Hincal A.A. Drug permeation enhancement via buccal route: possibilities and limitations. J. Control. Release. 72:2001;133-144.
15. Senel S., Capan Y., Sargon M.F., Ikinci G., Solpan D., Guven O., Boddé H.E., Hincal A.A. Enhancement of transbuccal permeation of morphine sulphate by sodium glycodeoxycholate in vitro. J. Control. Release. 45:1997;153-162.
16. Squier C.A. The permeability of keratinized and nonkeratinized oral epithelium to horseradish peroxidase. J. Ultrastruct. Res. 43:1973;160-177.
17. Squier C.A. Membrane coating granules in nonkeratinizing oral epithelium. J. Ultrastruct. Res. 60:1977;212-220.
18. Squier C.A., Wertz P.W. Structure and function of the oral mucosa and implications for drug delivery. Rathbone M.J. Oral Mucosal Delivery. 1996;1-26 Marcel Dekker, New York.
19. Steward A., Bayley D.L., Howes C. The effect of enhancers on the buccal absorption of hybrid (BDBB) alpha interferon. Int. J. Pharm. 104:1994;145-149.
20. Veuillez F., Falson Rieg F., Guy R.H., Deshusses J., Buri P. Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity. Int. J. Pharm. 231:2002;1-9.
21. Wertz P.W., Squier C.A. Cellular and molecular basis of barrier function in oral epithelium. Crit. Rev. Ther. Drug Carrier Syst. 8:1991;237-269.
22. Wertz P.W., Hoogstraate A.J., Squier C.A. Biochemical basis of the permeability barrier in skin and oral mucosa. Rathbone M.J. Oral Mucosal Delivery. 1996;27-49 Marcel Dekker, New York.
23. Zhang H., Robinson J.R. Routes of drug transport across oral mucosa. Rathbone M.J. Oral Mucosal Delivery. 1996;51-63 Marcel Dekker, New York.
24. Zhang H., Robinson J.R. In vitro methods for measuring permeability of the oral mucosa. Rathbone M.J. Oral Mucosal Delivery. 1996;85-100 Marcel Dekker, New York.
25. Zhang J., Niu S., Ebert C., Stanley T.H. An in vivo dog model for studying recovery kinetics of the buccal mucosa permeation barrier after exposure to permeation enhancers: apparent evidence of effective enhancement without tissue damage. Int. J. Pharm. 101:1994;15-22.