Bioadhesive-based dosage forms: The next generation

Journal of Pharmaceutical Sciences

Volumn 89, Issue 7, 2000, Pages 850-866

  Lee, Jin Whan ^a   Park, Jae Han ^a   Robinson, Joseph R ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIVE AGENT; LECTIN; METHACRYLIC ACID; POLYMER;

CONTROLLED RELEASE FORMULATION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; HYDROGEN BOND; PATIENT COMPLIANCE; SHORT SURVEY;

EID: 0033813758     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200007)89:7<850::AID-JPS2>3.0.CO;2-G     Document Type: Article

References (133)

1. Ointment-type oral mucosal dosage form of Carbopol containing prednisolone for treatment of aphtha
2. Mucosal adhesive dosage forms
3. Fundamental aspects of bioadhesion
4. Bioadhesive polymers as platforms for oral controlled drug delivery: Method to study bioadhesion
5. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues
6. An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery
7. Soluble N-(2-hydroxypropyl)methacrylamide copolymers as a potential oral, controlled-release, drug delivery system 1. bioadhesion to the rat intestine in vitro
8. Bioadhesion by means of specific binding of tomato lectin
9. The potential of fimbrial proteins for delaying intestinal transit of oral drug delivery system
10. Bioadhesive polymers as platforms for oral controlled drug delivery II: Synthesis and evaluation of some swelling water-insoluble bioadhesive polymers
11. Mucoadhesive drug delivery systems
12. Cellulose derivatives and natural products utilized
13. Chemically-modified cellulosic polymers
14. Model for the structure of the gastric mucous gel
15. Scaling concepts and molecular theories of the adhesion of synthetic polymers to glycoproteins
16. On the relationship between the electrostatic and molecular component of the adhesion of elastic particles to a solid surface
17. A surface energy analysis of bioadhesion
18. Theory of the interface between immiscible polymers
19. The influence of structure on autohesion (self-tack) and other forms of diffusion into polymers
20. Autohesion and adhesion of high polymers
21. Theories of adhesion and uses of adhesive: A review
22. Mucoadhesive drug delivery systems
23. Pharmaceutical and medical aspects of bioadhesive systems for drug administration
24. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
25. Composition producing adhesion through hydration
26. Bioadhesive intraoral release systems: Design, testing and analysis
27. The diffusion and solution of gases in highly crosslinked copolymers
28. Physico-chemical properties of water insoluble polymers important to mucin epithelial adhesion
29. Mucosal adhesive preparations
30. Semisolid dosage forms as buccal bioadhesives
31. An investigation into the role of water movement and mucus gel dehydration in mucoadhesion
32. An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop
33. Mucoadhesion of hydroxypropylmethacrylate nanoparticles to rat intestinal ileal segments in vitro
34. Simple rheological method for the in vitro assessment of mucinpolymer bioadhesive bond strength
35. In vivo evaluation of dosage forms: Application of gamma scintigraphy to non-enternal routes of administration
36. Intestinal transit of bioadhesive microspheres in an in situ loop in the rat-a comparative study with copolymers and blends based on poly(acrylic add)
37. Synthesis of a fluorescent chitosan derivative and its application for the study of chitosan-mucin interactions
38. A surface energy analysis of mucoadhesion: Contact angle measurements on polycarbophil and pig intestinal mucosa in physiologically relevant fluids
39. Surface energy analysis of mucoadhesion. II. Prediction of mucoadhesive performance by spreading coefficients
40. A microtensiometer for the analysis of bioadhesive microspheres
41. Investigation of surface properties of some polymers by a thermodynamic and mechanical approach: Possibility of predicting mucoadhesion and biocompatibility
42. Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency
43. Biologically erodible microspheres as potential oral drug delivery systems
44. Enhanced oral uptake of tomato lectin-conjugated nanoparticles in the rat
45. Utilizing bacterial mechanisms of epithelial cell entry: Invasin-induced oral uptake of latex nanoparticles
46. In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery
47. Derivatives of poly(acrylic acid) are able to inhibit trypsin activity
48. Mucoadhesive poly(acrylates) are inhibitors of the intestinal proteases trypsin and carboxypeptidase
49. Mucoadhesive polymers in peroral peptide drug delivery. II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin
50. Nasal administration of insulin using bioadhesive microspheres as a delivery system
51. Microspheres as a nasal delivery system for peptide drugs
52. Possible mechanisms for the enhancement of rectal absorption of hydrophilic drugs and polypeptides by aqueous polyacrylic acid gel
53. Bioadhesive polymers for the peroral delivery of peptide drugs
54. Cell-polarity dependent effect of chelation on the paracellular permeability of confluent Caco-2 cell monolayers
55. Bioadhesive and phase-change polymers for ocular drug delivery
56. Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits
57. Formulation and evaluation of controlled release Eudragit buccal patches
58. In situ-forming gels for ophthalmic drug delivery
59. Precorneal residence time in humans of sodium hyaluronate as measured by gamma scintigraphy
60. Gamma scintigraphic evaluation of precorneal clearance in human volunteers and in rabbits
61. Lectins as molecules and as tools
62. In vitro study of lectin-latex conjugates for specific bioadhesion
63. Chemical aspects of mucus
64. Poly-N-acetyllactosamine-specific tomato lectin interacts with gastric parietal cells
65. Potential use of tomato lectin for oral drug delivery. Part 1. Lectin binding to rat small intestine in vitro
66. Immunocytochemical localization of ingested kidney bean (Phaseolus vulgaris) lectin in eat gut
67. Delivery systems for penetration enhancement of peptide and protein drugs: Design considerations
68. Lectins and bacterial invasion factors for controlling endo- and transcytosis of bioadhesive drug carrier systems
69. Lectins for drug delivery within the oral cavity - Investigation of lectin binding to oral mucosa
70. An adhesive drug delivery system based on K99-fimbriae
71. N-(2-hydroxypropyl) methacrylamide copolymers containing pendant saccharide moieties: Synthesis and bioadhesive properties
72. Investigation into the diffusion behaviour of polypeptides in native intestinal mucus with regard to their peroral administration
73. Gastrointestinal transit of a multiple unit formulation (metoprolol CP/ZOK) and a non-disintegrating tablet with the emphasis on the colon
74. Controlled-release drug delivery systems for prolonged gastric residence: An overview
75. Bioadhesive polymers as platforms for oral controlled drug delivery III: Oral delivery of chlorothiazide using a bioadhesive polymer
76. Bioadhesive polymers in peptide drug delivery
77. Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat
78. From sticky stuff to sweet receptors-achievements, limits and novel approaches to bioadhesion
79. Colonic administration, development of drug delivery systems, contribution of bioadhesion
80. Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo
81. Mucoadhesive polymers in peroral peptide drug delivery. Part 4. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro
82. Principle and investigation of the bioadhesion mechanism of solid dosage forms
83. GI transit of potential bioadhesive systems in the rat
84. Oral cavity as a site for bioadhesive drug delivery
85. Buccal absorption of testosterone and its esters using a bioadhesive tablet in dogs
86. Formulation of buccal mucoadhesive dosage form of ergotamine tartrate
87. Bioadhesive polymer buccal patches for buprenorphine controlled delivery: Formulation, in-vitro adhesion and release properties
88. Effect of additives on release of drugs from ointment bases
89. Highly viscous gel ointment containing carbopol for application to the oral mucosa
90. Bioadhesive polymers for controlled drug delivery
91. Formulation and characterization of a buccoadhesive erodible tablet for the treatment of oral lesions
92. Treatment of diseases of the eye with mucoadhesive delivery systems
93. Effect of drug charge type and charge density on corneal transport
94. Lacrimal and instilled fluid dynamics in rabbit eyes
95. Ocular delivery of progesterone using a bioadhesive polymer
96. Temperature-induced gelation pluronic-g-poly(acrylic acid) graft copolymers for prolonged drug delivery to the eye
97. Topical semisolid drug delivery - Kinetics and tolerance of opthalmic hydrogels
98. Pharmacological evaluation of anti-inflammatory pyrrole-acetic acid derivative eye drops
99. Development of a noval soluble opthalmic insert: Evaluation of ocular tolerance in rabbits
100. Long-acting soluble bioadhesive opthalmic drug insert (BODI) containing gentamicin for veterinary use - Optimization and clinical investigation
101. Evaluation of pilocarpine-loaded albumin particles as controlled drug delivery systems for the eye 2. Co-administration with bioadhesive and viscous polymers
102. Ocular sustained delivery of prednisolone using hyaluronic acid benzyl ester films
103. New ophthalmic drug delivery systems
104. Gelrite: A novel ion activated, in situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol
105. The formulation of drug for ocular administration
106. Precorneal clearance of mucoadhesive microspheres from the rabbit eye
107. Route of delivery: Case studies (1) nasal delivery of peptide drugs
108. Bioadhesive and formulation parameters affecting nasal absorption
109. Powder dosage forms of insulin for nasal administration
110. Bioadhesive microspheres as a potential nasal drug delivery system
111. Nasal absorption of desmopressin in rats and sheep: Effect of a bioadhesive microsphere delivery system
112. In vivo evaluation of spray formulations of human insulin for nasal delivery
113. Evaluation of the clearance characteristics of bioadhesive systems in humans
114. Intranasal mucociliary clearance of putative bioadhesive polymer gels
115. Nasal delivery systems and their effect on deposition and absorption
116. Chitosan as a novel nasal delivery system for peptide drugs
117. Enhanced vaginal adsorption of insulin in sheep using lysophosphatidylcholine and a bioadhesive microsphere delivery system
118. Vaginal and reproductive-system treatments using a bioadhesive polymer
119. Bioadhesive patch cervical drug delivery system for the administration of 5-fluorouracil to cervical tissue
120. Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system
121. Prevention of ovariectomy osteopenia in rats after vaginal administration of Hyaff 11 microspheres containing salmon calcitonin
122. A hydrophobically-modified bioadhesive polyelectrolyte hydrogel for drug delivery
123. Mucoadhesive semi-solid formulations for intraoral use containing sucralfate
124. In vivo evaluation of hydrophilic and hydrophobic mucoadhesive semi-solid formulation containing sucralfate and lidocaine for intraoral use
125. Functional polymers and dendrimers: Reactivity, molecular architecture, and interfacial energy
126. Biomolecular materials
127. Mathematical-model of mass-transport through dispersed-phase polymer networks
128. Dual-stimuli-responsive drug release from interpenetrating polymer network-structured hydrogels of gelatin and dextran
129. Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains
130. Bioactive biomaterials