Improving sublingual delivery of weak base compounds using pHmax concept: Application to propranolol

European Journal of Pharmaceutical Sciences

Volumn 39, Issue 4, 2010, Pages 272-278

  Wang, Yanfeng ^a   Zuo, Zhong ^a   Chen, Xiao ^b   Tomlinson, Brian ^a   Chow, Moses S S ^c  

^a Prince of Wales Hospital   (Hong Kong)

^b SUN YAT SEN UNIVERSITY   (China)

^c WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Permeability; Pharmacokinetics; Propranolol; Sublingual; Weak base

Indexed keywords

GENERIC DRUG; PROPRANOLOL;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG HALF LIFE; DRUG PENETRATION; DRUG SALIVA LEVEL; DRUG SOLUBILITY; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NORMAL HUMAN; PH; PRIORITY JOURNAL; STEADY STATE; SUBLINGUAL GLAND; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, SUBLINGUAL; ADOLESCENT; ADULT; ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MOUTH MUCOSA; PROPRANOLOL; SWINE; YOUNG ADULT;

EID: 75149187815     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.12.011     Document Type: Article

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