메뉴 건너뛰기




Volumn 17, Issue 5, 2009, Pages 335-363

Colonic treatments and targets: Issues and opportunities

Author keywords

Bacteria; Cancer; Chronotherapy; Colonic delivery; Fermentation; Gastrointestinal tract; Large intestine; Lymphatics; Microbiota; Peptides; Pharmacogenomics; Proteins; Ulcerative colitis; Vaccine

Indexed keywords

ANTIINFLAMMATORY AGENT; AZATHIOPRINE; AZETIRELIN; BALSALAZIDE; CALCITONIN; CELECOXIB; CHLORAMPHENICOL; CLONAZEPAM; CYTOCHROME P450 ISOENZYME; CYTOTOXIC AGENT; DAIDZEIN; DIGOXIN; DRUG METABOLIZING ENZYME; FLUCYTOSINE; FLUOROURACIL; GLYCOPROTEIN P; HESPERIDIN; INFLIXIMAB; INSULIN; ISOSORBIDE DINITRATE; LEVAMISOLE; LEVODOPA; MESALAZINE; METHAMPHETAMINE; PLACEBO; PROBIOTIC AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; SALAZOSULFAPYRIDINE; UNINDEXED DRUG; ANTINEOPLASTIC AGENT; AUTACOID; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450; NANOPARTICLE; PEPTIDE; PROTEIN;

EID: 69149099286     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860902839502     Document Type: Review
Times cited : (84)

References (283)
  • 1
    • 0027240704 scopus 로고
    • The role of the gastrointestinal microflora in the metabolism of drugs
    • Abu Shamat M. (1993). The role of the gastrointestinal microflora in the metabolism of drugs. Int J Pharm, 97, 1-13.
    • (1993) Int J Pharm , vol.97 , pp. 1-13
    • Abu Shamat, M.1
  • 2
    • 51849168253 scopus 로고
    • Glyceryl trinitrate: Metabolism by the intestinal flora
    • Abu Shamat MS, Beckett AH. (1983). Glyceryl trinitrate: metabolism by the intestinal flora. J Pharm Pharmacol, 35, 71P.
    • (1983) J Pharm Pharmacol , vol.35
    • Abu Shamat, M.S.1    Beckett, A.H.2
  • 4
    • 0028948837 scopus 로고
    • The effect of different concentrations of mannitol in solution on small intestinal transit: Implications for drug absorption
    • Adkin DA, Davis SS, Sparrow RA, Huckle PD, Phillips AJ, Wilding IR. (1995a). The effect of different concentrations of mannitol in solution on small intestinal transit: implications for drug absorption. Pharm Res, 12, 393-396.
    • (1995) Pharm Res , vol.12 , pp. 393-396
    • Adkin, D.A.1    Davis, S.S.2    Sparrow, R.A.3    Huckle, P.D.4    Phillips, A.J.5    Wilding, I.R.6
  • 7
    • 16844376491 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of guar gum-based matrix tablets of rofecoxib for colonic drug delivery
    • Al-Saidan SM, Krishnaiah YS, Satyanarayana V, Rao GS. (2005). In vitro and in vivo evaluation of guar gum-based matrix tablets of rofecoxib for colonic drug delivery. Curr Drug Deliv, 2, 155-163.
    • (2005) Curr Drug Deliv , vol.2 , pp. 155-163
    • Al-Saidan, S.M.1    Krishnaiah, Y.S.2    Satyanarayana, V.3    Rao, G.S.4
  • 8
    • 36749072999 scopus 로고    scopus 로고
    • Towards an oral influenza vaccine: Comparison between intragastric and intracolonic delivery of influenza subunit vaccine in a murine model
    • Amorij JP, Westra TA, Hinrichs WL, Huckriede A, Frijlink HW. (2007). Towards an oral influenza vaccine: comparison between intragastric and intracolonic delivery of influenza subunit vaccine in a murine model. Vaccine, 26, 67-76.
    • (2007) Vaccine , vol.26 , pp. 67-76
    • Amorij, J.P.1    Westra, T.A.2    Hinrichs, W.L.3    Huckriede, A.4    Frijlink, H.W.5
  • 9
    • 0022379640 scopus 로고
    • Oxprenolol absorption in man after single bolus dosing into two segments of the colon compared with that after oral dosing
    • Antonin KH, Bieck P, Scheurlen M, Jedrychowski M, Malchow H. (1985). Oxprenolol absorption in man after single bolus dosing into two segments of the colon compared with that after oral dosing. Br J Clin Pharmacol, 19(Suppl. 2), 137S-142S.
    • (1985) Br J Clin Pharmacol , vol.19 , Issue.SUPPL. 2
    • Antonin, K.H.1    Bieck, P.2    Scheurlen, M.3    Jedrychowski, M.4    Malchow, H.5
  • 10
    • 51649123932 scopus 로고    scopus 로고
    • Polyethylene glycol 400 enhances the bioavailability of a BCS class III drug (ranitidine) in male subjects but not females
    • Ashiru DA, Patel R, Basit AW. (2008). Polyethylene glycol 400 enhances the bioavailability of a BCS class III drug (ranitidine) in male subjects but not females. Pharm Res, 25, 2327-2333.
    • (2008) Pharm Res , vol.25 , pp. 2327-2333
    • Ashiru, D.A.1    Patel, R.2    Basit, A.W.3
  • 12
    • 33645280045 scopus 로고    scopus 로고
    • Physicochemical properties of enteric films prepared from aqueous dispersions and organic solutions
    • Bando H, McGinity JW. (2006a). Physicochemical properties of enteric films prepared from aqueous dispersions and organic solutions. Int J Pharm, 313, 43-48.
    • (2006) Int J Pharm , vol.313 , pp. 43-48
    • Bando, H.1    McGinity, J.W.2
  • 13
    • 33748714320 scopus 로고    scopus 로고
    • Relationship between drug dissolution and leaching of plasticizer for pellets coated with an aqueous Eudragit((R)) S100: L100 dispersion
    • Bando H, McGinity JW. (2006b). Relationship between drug dissolution and leaching of plasticizer for pellets coated with an aqueous Eudragit((R)) S100: L100 dispersion. Int J Pharm, 323, 11-17.
    • (2006) Int J Pharm , vol.323 , pp. 11-17
    • Bando, H.1    McGinity, J.W.2
  • 16
    • 23444440934 scopus 로고    scopus 로고
    • Advances in colonic drug delivery
    • Basit AW. (2005). Advances in colonic drug delivery. Drugs, 65, 1991-2007.
    • (2005) Drugs , vol.65 , pp. 1991-2007
    • Basit, A.W.1
  • 17
    • 0035807469 scopus 로고    scopus 로고
    • Colonic metabolism of ranitidine: Implications for its delivery and absorption
    • Basit AW, Lacey LF. (2001). Colonic metabolism of ranitidine: implications for its delivery and absorption. Int J Pharm, 227, 157-165.
    • (2001) Int J Pharm , vol.227 , pp. 157-165
    • Basit, A.W.1    Lacey, L.F.2
  • 18
    • 0034812650 scopus 로고    scopus 로고
    • The effect of polyethylene glycol 400 on gastrointestinal transit: Implications for the formulation of poorly-water soluble drugs
    • Basit AW, Newton JM, Short MD, Waddington WA, Ell PJ, Lacey LF. (2001). The effect of polyethylene glycol 400 on gastrointestinal transit: implications for the formulation of poorly-water soluble drugs. Pharm Res, 18, 1146-1150.
    • (2001) Pharm Res , vol.18 , pp. 1146-1150
    • Basit, A.W.1    Newton, J.M.2    Short, M.D.3    Waddington, W.A.4    Ell, P.J.5    Lacey, L.F.6
  • 19
    • 0037177374 scopus 로고    scopus 로고
    • Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora
    • Basit AW, Newton JM, Lacey LF. (2002). Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora. Int J Pharm, 237, 23-33.
    • (2002) Int J Pharm , vol.237 , pp. 23-33
    • Basit, A.W.1    Newton, J.M.2    Lacey, L.F.3
  • 20
    • 65849520625 scopus 로고    scopus 로고
    • Microbiota-triggered colonic delivery: Robustness of the polysaccharide approach in the fed state in man
    • Basit AW, Short MD, McConnell EL. (2009). Microbiota-triggered colonic delivery: robustness of the polysaccharide approach in the fed state in man. J Drug Target, 17, 64-71.
    • (2009) J Drug Target , vol.17 , pp. 64-71
    • Basit, A.W.1    Short, M.D.2    McConnell, E.L.3
  • 21
    • 0036155980 scopus 로고    scopus 로고
    • Thalidomide reduces tumour necrosis factor alpha and interleukin 12 production in patients with chronic active Crohn's disease
    • Bauditz J, Wedel S, Lochs H. (2002). Thalidomide reduces tumour necrosis factor alpha and interleukin 12 production in patients with chronic active Crohn's disease. Gut, 50, 196-200.
    • (2002) Gut , vol.50 , pp. 196-200
    • Bauditz, J.1    Wedel, S.2    Lochs, H.3
  • 22
    • 42649142580 scopus 로고    scopus 로고
    • Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: Ex vivo and in vivo studies
    • Bayat A, Dorkoosh FA, Dehpour AR, Moezi L, Larijani B, Junginger HE, Rafiee-Tehrani M. (2008). Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: ex vivo and in vivo studies. Int J Pharm, 356, 259-266.
    • (2008) Int J Pharm , vol.356 , pp. 259-266
    • Bayat, A.1    Dorkoosh, F.A.2    Dehpour, A.R.3    Moezi, L.4    Larijani, B.5    Junginger, H.E.6    Rafiee-Tehrani, M.7
  • 23
    • 0038795405 scopus 로고    scopus 로고
    • Increased toxicity and lack of efficacy of Rofecoxib in combination with chemotherapy for treatment of metastatic colorectal cancer: A phase II study
    • Becerra CR, Frenkel EP, Ashfaq R, Gaynor RB. (2003). Increased toxicity and lack of efficacy of Rofecoxib in combination with chemotherapy for treatment of metastatic colorectal cancer: a phase II study. Int J Cancer, 105, 868-872.
    • (2003) Int J Cancer , vol.105 , pp. 868-872
    • Becerra, C.R.1    Frenkel, E.P.2    Ashfaq, R.3    Gaynor, R.B.4
  • 24
    • 0018173224 scopus 로고
    • Distribution of pellets in the gastrointestinal tract. the influence on transit time exerted by the density or diameter of pellets
    • Bechgaard H, Ladefoged K. (1978). Distribution of pellets in the gastrointestinal tract. The influence on transit time exerted by the density or diameter of pellets. J Pharm Pharmacol, 30, 690-692.
    • (1978) J Pharm Pharmacol , vol.30 , pp. 690-692
    • Bechgaard, H.1    Ladefoged, K.2
  • 26
    • 27944453621 scopus 로고    scopus 로고
    • Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma
    • Bergheim I, Bode C, Parlesak A. (2005a). Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma. BMC Gastroenterol, 5, 34.
    • (2005) BMC Gastroenterol , vol.5 , pp. 34
    • Bergheim, I.1    Bode, C.2    Parlesak, A.3
  • 27
    • 27744539745 scopus 로고    scopus 로고
    • Distribution of cytochrome P450 2C 2E1, 3A4, and 3A5 in human colon mucosa
    • Bergheim I, Bode C, Parlesak A. (2005b). Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa. BMC Clin Pharmacol, 5, 4.
    • (2005) BMC Clin Pharmacol , vol.5 , pp. 4
    • Bergheim, I.1    Bode, C.2    Parlesak, A.3
  • 28
    • 0030016235 scopus 로고    scopus 로고
    • Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis
    • Bertran X, Mane J, Fernandez-Banares F, Castella E, Bartoli R, Ojanguren I, Esteve M, Gassull MA. (1996). Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis. Gut, 38, 899-904.
    • (1996) Gut , vol.38 , pp. 899-904
    • Bertran, X.1    Mane, J.2    Fernandez-Banares, F.3    Castella, E.4    Bartoli, R.5    Ojanguren, I.6    Esteve, M.7    Gassull, M.A.8
  • 30
    • 50049118724 scopus 로고    scopus 로고
    • Oral IL-10 gene delivery in a microsphere- based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease
    • Bhavsar MD, Amiji MM. (2008). Oral IL-10 gene delivery in a microsphere- based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease. Gene Ther, 15, 1200-1209.
    • (2008) Gene Ther , vol.15 , pp. 1200-1209
    • Bhavsar, M.D.1    Amiji, M.M.2
  • 31
    • 34547899883 scopus 로고    scopus 로고
    • Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP) 1, CYP2 and CYP3 families in 22 different human tissues
    • Bieche I, Narjoz C, Asselah T, Vacher S, Marcellin P, Lidereau R, Beaune P, De Waziers I. (2007). Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues. Pharmacogenet Genomics, 17, 731-742.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 731-742
    • Bieche, I.1    Narjoz, C.2    Asselah, T.3    Vacher, S.4    Marcellin, P.5    Lidereau, R.6    Beaune, P.7    De Waziers, I.8
  • 33
    • 0029897299 scopus 로고    scopus 로고
    • Investigation of nifedipine absorption in different regions of the human gastrointestinal (GI) tract after simultaneous administration of 13C- and 12C-nifedipine
    • Bode H, Brendel E, Ahr G, Fuhr U, Harder S, Staib AH. (1996). Investigation of nifedipine absorption in different regions of the human gastrointestinal (GI) tract after simultaneous administration of 13C- and 12C-nifedipine. Eur J Clin Pharmacol, 50, 195-201.
    • (1996) Eur J Clin Pharmacol , vol.50 , pp. 195-201
    • Bode, H.1    Brendel, E.2    Ahr, G.3    Fuhr, U.4    Harder, S.5    Staib, A.H.6
  • 34
    • 0021245005 scopus 로고
    • Absorption of acetylsalicylic acid from enteric-coated tablets in relation to gastric emptying and in-vivo disintegration
    • Bogentoft C, Alpsten M, Ekenved G. (1984). Absorption of acetylsalicylic acid from enteric-coated tablets in relation to gastric emptying and in-vivo disintegration. J Pharm Pharmacol, 36, 350-351.
    • (1984) J Pharm Pharmacol , vol.36 , pp. 350-351
    • Bogentoft, C.1    Alpsten, M.2    Ekenved, G.3
  • 36
    • 0022413018 scopus 로고
    • Absorption of glibenclamide from different sites of the gastro-intestinal tract
    • Brockmeier D, Grigoleit HG, Leonhardt H. (1985). Absorption of glibenclamide from different sites of the gastro-intestinal tract. Eur J Clin Pharmacol, 29, 193-197.
    • (1985) Eur J Clin Pharmacol , vol.29 , pp. 193-197
    • Brockmeier, D.1    Grigoleit, H.G.2    Leonhardt, H.3
  • 37
    • 0016342516 scopus 로고
    • Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device
    • Brown RL, Gibson JA, Sladen GE, Hicks B, Dawson AM. (1974). Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device. Gut, 15, 999-1004.
    • (1974) Gut , vol.15 , pp. 999-1004
    • Brown, R.L.1    Gibson, J.A.2    Sladen, G.E.3    Hicks, B.4    Dawson, A.M.5
  • 41
    • 38149067809 scopus 로고    scopus 로고
    • Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): A double-blind, randomised controlled trial
    • Buttgereit F, Doering G, Schaeffler A, Witte S, Sierakowski S, Gromnica- Ihle E, Jeka S, Krueger K, Szechinski J, Alten R. (2008). Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial. The Lancet, 371, 205-214.
    • (2008) The Lancet , vol.371 , pp. 205-214
    • Buttgereit, F.1    Doering, G.2    Schaeffler, A.3    Witte, S.4    Sierakowski, S.5    Gromnica- Ihle, E.6    Jeka, S.7    Krueger, K.8    Szechinski, J.9    Alten, R.10
  • 42
    • 0015621623 scopus 로고
    • The demethylation of methamphetamine by intestinal microflora
    • Caldwell J, Hawksworth GM. (1973). The demethylation of methamphetamine by intestinal microflora. J Pharm Pharmacol, 25, 422-424.
    • (1973) J Pharm Pharmacol , vol.25 , pp. 422-424
    • Caldwell, J.1    Hawksworth, G.M.2
  • 43
    • 58149105515 scopus 로고    scopus 로고
    • Probiotics and irritable bowel syndrome: Rationale, mechanisms, and efficacy
    • Camilleri M. (2008). Probiotics and irritable bowel syndrome: rationale, mechanisms, and efficacy. J Clin Gastroenterol, 42(Suppl. 3), S123-S125.
    • (2008) J Clin Gastroenterol , vol.42 , Issue.SUPPL. 3
    • Camilleri, M.1
  • 46
    • 55949135189 scopus 로고    scopus 로고
    • Efficacy of intracolonic administration of low-molecular-weight heparin CB-01-05, compared to other low-molecular-weight heparins and unfractionated heparin, in experimentally induced colitis in rat
    • Celasco G, Moro L, Bozzella R, Mangano K, Quattrocchi C, Aiello C, Donia M, Fagone P, Di Marco R. (2008). Efficacy of intracolonic administration of low-molecular-weight heparin CB-01-05, compared to other low-molecular-weight heparins and unfractionated heparin, in experimentally induced colitis in rat. Dig Dis Sci, 53, 3170-3175.
    • (2008) Dig Dis Sci , vol.53 , pp. 3170-3175
    • Celasco, G.1    Moro, L.2    Bozzella, R.3    Mangano, K.4    Quattrocchi, C.5    Aiello, C.6    Donia, M.7    Fagone, P.8    Di Marco, R.9
  • 47
    • 0346728729 scopus 로고    scopus 로고
    • The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability
    • Chan LMS, Lowes S, Hirst BH. (2004). The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur J Pharm Sci, 21, 25-51.
    • (2004) Eur J Pharm Sci , vol.21 , pp. 25-51
    • Chan, L.M.S.1    Lowes, S.2    Hirst, B.H.3
  • 49
    • 0036081954 scopus 로고    scopus 로고
    • Inulin and oligofructose in the dietary fibre concept
    • Cherbut C. (2002). Inulin and oligofructose in the dietary fibre concept. Br J Nutr, 87(Suppl. 2), S159-S162.
    • (2002) Br J Nutr , vol.87 , Issue.SUPPL. 2
    • Cherbut, C.1
  • 50
    • 0027431325 scopus 로고
    • Gastrointestinal transit of pellets of differing size and density
    • Clarke GM, Newton JM, Short MD. (1993). Gastrointestinal transit of pellets of differing size and density. Int J Pharm, 100, 81-92.
    • (1993) Int J Pharm , vol.100 , pp. 81-92
    • Clarke, G.M.1    Newton, J.M.2    Short, M.D.3
  • 54
    • 0023213832 scopus 로고
    • Fermentation in the human large intestine and the available substrates
    • Cummings JH, Englyst HN. (1987). Fermentation in the human large intestine and the available substrates. Am J Clin Nutr, 45, 1243-1255.
    • (1987) Am J Clin Nutr , vol.45 , pp. 1243-1255
    • Cummings, J.H.1    Englyst, H.N.2
  • 57
    • 37649021327 scopus 로고    scopus 로고
    • Circadian rhythms in arthritis: Hormonal effects on the immune/inflammatory reaction
    • Cutolo M, Straub RH. (2008). Circadian rhythms in arthritis: hormonal effects on the immune/inflammatory reaction. Autoimmun Rev, 7, 23-228.
    • (2008) Autoimmun Rev , vol.7 , pp. 23-228
    • Cutolo, M.1    Straub, R.H.2
  • 58
    • 0015916139 scopus 로고
    • Adverse reactions during salicylazosulfapyridine therapy and relation with drug-metabolism and acetylator phenotype
    • Das KM, Eastwood MA, Mcmanus JPA, Sircus W. (1973). Adverse reactions during salicylazosulfapyridine therapy and relation with drug-metabolism and acetylator phenotype. N Engl J Med, 289, 491-495.
    • (1973) N Engl J Med , vol.289 , pp. 491-495
    • Das, K.M.1    Eastwood, M.A.2    McManus, J.P.A.3    Sircus, W.4
  • 59
    • 0003122723 scopus 로고
    • Small intestinal transit
    • Hardy JG, Davis SS, Wilson CG. (eds.) Chichester, UK: Ellis Horwood Limited
    • Davis SS. (1989). Small intestinal transit. In: Hardy JG, Davis SS, Wilson CG. (eds.) Drug delivery to the gastrointestinal tract. Chichester, UK: Ellis Horwood Limited pp.49-61.
    • (1989) Drug Delivery to the Gastrointestinal Tract , pp. 49-61
    • Davis, S.S.1
  • 60
    • 0022538998 scopus 로고
    • Transit of pharmaceutical dosage forms through the small intestine
    • Davis SS, Hardy JG, Fara JW. (1986). Transit of pharmaceutical dosage forms through the small intestine. Gut, 27, 886-892.
    • (1986) Gut , vol.27 , pp. 886-892
    • Davis, S.S.1    Hardy, J.G.2    Fara, J.W.3
  • 61
    • 0041851676 scopus 로고    scopus 로고
    • Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: Evidence for highly selective acetylation of 5-aminosalicylic acid
    • Delomenie C, Fouix S, Longuemaux S, Brahimi N, Bizet C, Picard B, Denamur E, Dupret JM. (2001). Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol, 183, 3417-3427.
    • (2001) J Bacteriol , vol.183 , pp. 3417-3427
    • Delomenie, C.1    Fouix, S.2    Longuemaux, S.3    Brahimi, N.4    Bizet, C.5    Picard, B.6    Denamur, E.7    Dupret, J.M.8
  • 63
    • 0025042445 scopus 로고
    • The influence of density on the gastrointestinal transit of pellets
    • Devereux JE, Newton JM, Short MB. (1990). The influence of density on the gastrointestinal transit of pellets. J Pharm Pharmacol, 42, 500-501.
    • (1990) J Pharm Pharmacol , vol.42 , pp. 500-501
    • Devereux, J.E.1    Newton, J.M.2    Short, M.B.3
  • 65
    • 0020562203 scopus 로고
    • Colonic release of 5-amino salicylic-acid from an oral preparation in active ulcerative-colitis
    • Dew MJ, Ryder REJ, Evans N, Evans BK, Rhodes J. (1983). Colonic release of 5-amino salicylic-acid from an oral preparation in active ulcerative-colitis. Br J Clin Pharmacol, 16, 185-187.
    • (1983) Br J Clin Pharmacol , vol.16 , pp. 185-187
    • Dew, M.J.1    Ryder, R.E.J.2    Evans, N.3    Evans, B.K.4    Rhodes, J.5
  • 66
    • 0032953259 scopus 로고    scopus 로고
    • The effect of oleic acid on the human ileal brake and its implications for small intestinal transit of tablet formulations
    • Dobson CL, Davis SS, Chauhan S, Sparrow RA, Wilding IR. (1999). The effect of oleic acid on the human ileal brake and its implications for small intestinal transit of tablet formulations. Pharm Res, 16, 92-96.
    • (1999) Pharm Res , vol.16 , pp. 92-96
    • Dobson, C.L.1    Davis, S.S.2    Chauhan, S.3    Sparrow, R.A.4    Wilding, I.R.5
  • 68
    • 0023552944 scopus 로고
    • Role of the intestinal flora in the acetylation of sulfasalazine metabolites
    • Dull BJ, Salata K, Goldman P. (1987). Role of the intestinal flora in the acetylation of sulfasalazine metabolites. Biochem Pharmacol, 36, 3772-3774.
    • (1987) Biochem Pharmacol , vol.36 , pp. 3772-3774
    • Dull, B.J.1    Salata, K.2    Goldman, P.3
  • 69
    • 0027459272 scopus 로고
    • An in vitro in vivo correlation for the disintegration and onset of drug release from enteric-coated pellets
    • Ebel JP, Jay M, Beihn RM. (1993). An in vitro in vivo correlation for the disintegration and onset of drug release from enteric-coated pellets. Pharm Res, 10, 233-238.
    • (1993) Pharm Res , vol.10 , pp. 233-238
    • Ebel, J.P.1    Jay, M.2    Beihn, R.M.3
  • 70
    • 0031563889 scopus 로고    scopus 로고
    • Physiology of the colorectal barrier
    • Edwards C. (1997). Physiology of the colorectal barrier. Adv Drug Deliv Rev, 28, 173-190.
    • (1997) Adv Drug Deliv Rev , vol.28 , pp. 173-190
    • Edwards, C.1
  • 71
    • 0021677458 scopus 로고
    • Role of the intestinal microflora in clonazepam metabolism in the rat
    • Elmer GW, Remmel RP. (1984). Role of the intestinal microflora in clonazepam metabolism in the rat. Xenobiotica, 14, 829-840.
    • (1984) Xenobiotica , vol.14 , pp. 829-840
    • Elmer, G.W.1    Remmel, R.P.2
  • 72
    • 0242489340 scopus 로고    scopus 로고
    • The impact of heparin compounds on cellular inflammatory responses: A construct for future investigation and pharmaceutical development
    • Elsayed E, Becker RC. (2003). The impact of heparin compounds on cellular inflammatory responses: a construct for future investigation and pharmaceutical development. J Thromb Thrombolysis, 15, 11-18.
    • (2003) J Thromb Thrombolysis , vol.15 , pp. 11-18
    • Elsayed, E.1    Becker, R.C.2
  • 73
    • 33750181267 scopus 로고    scopus 로고
    • Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells
    • Englund G, Rorsman F, Rönnblom A, Karlbom U, Lazorova L, Gråsjö J, Kindmark A, Artursson P. (2006). Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells. Eur J Pharm Sci, 29, 269-277.
    • (2006) Eur J Pharm Sci , vol.29 , pp. 269-277
    • Englund, G.1    Rorsman, F.2    Rönnblom, A.3    Karlbom, U.4    Lazorova, L.5    Gråsjö, J.6    Kindmark, A.7    Artursson, P.8
  • 75
    • 0023693299 scopus 로고
    • Measurement of gastrointestinal pH profiles in normal ambulant human subjects
    • Evans DF, Pye G, Bramley R, Clark AG, Dyson TJ, Hardcastle JD. (1988). Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut, 29, 1035-1041.
    • (1988) Gut , vol.29 , pp. 1035-1041
    • Evans, D.F.1    Pye, G.2    Bramley, R.3    Clark, A.G.4    Dyson, T.J.5    Hardcastle, J.D.6
  • 76
    • 24044527489 scopus 로고    scopus 로고
    • Dissolution of pH responsive formulations in media resembling intestinal fluids: Bicarbonate versus phosphate buffers
    • Fadda HM, Basit AW. (2005). Dissolution of pH responsive formulations in media resembling intestinal fluids: bicarbonate versus phosphate buffers. J Drug Deliv Sci Technol, 15, 273-279.
    • (2005) J Drug Deliv Sci Technol , vol.15 , pp. 273-279
    • Fadda, H.M.1    Basit, A.W.2
  • 78
    • 47049090791 scopus 로고    scopus 로고
    • Impairment of the in vitro drug release behaviour of oral modified release preparations in the presence of alcohol
    • Fadda HM, Mohamed MA, Basit AW (2008b). Impairment of the in vitro drug release behaviour of oral modified release preparations in the presence of alcohol. Int J Pharm, 360, 171-176.
    • (2008) Int J Pharm , vol.360 , pp. 171-176
    • Fadda, H.M.1    Mohamed, M.A.2    Basit, A.W.3
  • 79
    • 58549098228 scopus 로고    scopus 로고
    • Meal-induced acceleration of tablet transit through the human small intestine
    • Fadda HM, McConnell EL, Short M, Basit AW. (2009). Meal-induced acceleration of tablet transit through the human small intestine. Pharm Res, 26, 356-360.
    • (2009) Pharm Res , vol.26 , pp. 356-360
    • Fadda, H.M.1    McConnell, E.L.2    Short, M.3    Basit, A.W.4
  • 81
    • 0027490263 scopus 로고
    • Very low intraluminal colonic pH in patients with active ulcerative colitis
    • Fallingborg J, Christensen LA, Jacobsen BA, Rasmussen SN. (1993). Very low intraluminal colonic pH in patients with active ulcerative colitis. Dig Dis Sci, 38, 1989-1993.
    • (1993) Dig Dis Sci , vol.38 , pp. 1989-1993
    • Fallingborg, J.1    Christensen, L.A.2    Jacobsen, B.A.3    Rasmussen, S.N.4
  • 84
    • 0037285726 scopus 로고    scopus 로고
    • Expression of the peptide transporter hPepT1 in human colon: A potential route for colonic protein nitrogen and drug absorption
    • Ford D, Howard A, Hirst BH. (2003). Expression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorption. Histochem Cell Biol, 119, 37-43.
    • (2003) Histochem Cell Biol , vol.119 , pp. 37-43
    • Ford, D.1    Howard, A.2    Hirst, B.H.3
  • 86
    • 12344249654 scopus 로고    scopus 로고
    • Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: A randomised controlled pilot trial
    • Furrie E, Macfarlane S, Kennedy A, Cummings JH, Walsh SV, O'neil DA, Macfarlane GT. (2005). Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial. Gut, 54, 242-249.
    • (2005) Gut , vol.54 , pp. 242-249
    • Furrie, E.1    MacFarlane, S.2    Kennedy, A.3    Cummings, J.H.4    Walsh, S.V.5    O'Neil, D.A.6    MacFarlane, G.T.7
  • 87
    • 33846536256 scopus 로고    scopus 로고
    • Biodistribution and pharmacokinetics of colon-specific HPMA copolymer-9- aminocamptothecin conjugate in mice
    • Gao SQ, Lu ZR, Kopeckova P, Kopecek J. (2007). Biodistribution and pharmacokinetics of colon-specific HPMA copolymer-9- aminocamptothecin conjugate in mice. J Control Release, 117, 179-185.
    • (2007) J Control Release , vol.117 , pp. 179-185
    • Gao, S.Q.1    Lu, Z.R.2    Kopeckova, P.3    Kopecek, J.4
  • 88
    • 38049165649 scopus 로고    scopus 로고
    • Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats
    • Gao SQ, Sun Y, Kopeckova P, Peterson CM, Kopecek J. (2008). Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats. Pharm Res, 25, 218-226.
    • (2008) Pharm Res , vol.25 , pp. 218-226
    • Gao, S.Q.1    Sun, Y.2    Kopeckova, P.3    Peterson, C.M.4    Kopecek, J.5
  • 89
    • 0025093145 scopus 로고
    • The fermentability of polysaccharides by mixed human faecal bacteria in relation to their suitability as bulk-forming laxatives
    • Gibson GR, Macfarlane S, Cummings JH. (1990). The fermentability of polysaccharides by mixed human faecal bacteria in relation to their suitability as bulk-forming laxatives. Lett Appl Microbiol, 11, 251-254.
    • (1990) Lett Appl Microbiol , vol.11 , pp. 251-254
    • Gibson, G.R.1    MacFarlane, S.2    Cummings, J.H.3
  • 91
    • 13844269344 scopus 로고    scopus 로고
    • Colorectal cancer prevention: Is an ounce of prevention worth a pound of cure?
    • Gill S, Sinicrope FA. (2005). Colorectal cancer prevention: is an ounce of prevention worth a pound of cure? Semin Oncol, 32, 24-34.
    • (2005) Semin Oncol , vol.32 , pp. 24-34
    • Gill, S.1    Sinicrope, F.A.2
  • 92
    • 0015030844 scopus 로고
    • The role of the gut flora in the metabolism of prontosil and neoprontosil in the rat
    • Gingell R, Bridges JW, Williams RT. (1971). The role of the gut flora in the metabolism of prontosil and neoprontosil in the rat. Xenobiotica, 1, 143-156.
    • (1971) Xenobiotica , vol.1 , pp. 143-156
    • Gingell, R.1    Bridges, J.W.2    Williams, R.T.3
  • 94
    • 0022347773 scopus 로고
    • Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon
    • Godbillon J, Evard D, Vidon N, Duval M, Schoeller JP, Bernier JJ, Hirtz J. (1985). Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon. Br J Clin Pharmacol, 19(Suppl. 2), 113S-118S. (Pubitemid 16193630)
    • (1985) British Journal of Clinical Pharmacology , vol.19 , Issue.SUPPL. 2
    • Godbillon, J.1    Evard, D.2    Vidon, N.3
  • 95
    • 0015745640 scopus 로고
    • Contributions of host and intestinal microflora in the metabolism of L-dopa by the rat
    • Goldin BR, Peppercorn MA, Goldman P. (1973). Contributions of host and intestinal microflora in the metabolism of L-dopa by the rat. J Pharmacol Exp Ther, 186, 160-166.
    • (1973) J Pharmacol Exp Ther , vol.186 , pp. 160-166
    • Goldin, B.R.1    Peppercorn, M.A.2    Goldman, P.3
  • 96
    • 0014172961 scopus 로고
    • Studies of intestinal microflora. II. Microorganisms of the small intestine and their relations to oral and fecal flora
    • Gorbach SL, Plaut AG, Nahas L, Weinstein L, Spanknebel G, Levitan R. (1967). Studies of intestinal microflora. II. Microorganisms of the small intestine and their relations to oral and fecal flora. Gastroenterology, 53, 856-867.
    • (1967) Gastroenterology , vol.53 , pp. 856-867
    • Gorbach, S.L.1    Plaut, A.G.2    Nahas, L.3    Weinstein, L.4    Spanknebel, G.5    Levitan, R.6
  • 97
    • 0007394050 scopus 로고
    • Gastrointestinal water and electrolytes. IV. the equilibration of deuterium oxide (D2O) in gastrointestinal contents and the proportion of total body water (T.B.W) in the gastrointestinal tract
    • Gotch F, Nadell J, Edelman IS. (1957). Gastrointestinal water and electrolytes. IV. The equilibration of deuterium oxide (D2O) in gastrointestinal contents and the proportion of total body water (T.B.W) in the gastrointestinal tract. J Clin Investig, 36, 289-296.
    • (1957) J Clin Investig , vol.36 , pp. 289-296
    • Gotch, F.1    Nadell, J.2    Edelman, I.S.3
  • 98
    • 3142588774 scopus 로고    scopus 로고
    • A comparative pharmacology study between the intracolonic and oral routes of 5-FU administration in a colon cancer-bearing Yoshida sarcoma rat model
    • Goto T, Tomizawa N, Kobayashi E, Fujimura A. (2004). A comparative pharmacology study between the intracolonic and oral routes of 5-FU administration in a colon cancer-bearing Yoshida sarcoma rat model. J Pharmacol Sci, 95, 163-173.
    • (2004) J Pharmacol Sci , vol.95 , pp. 163-173
    • Goto, T.1    Tomizawa, N.2    Kobayashi, E.3    Fujimura, A.4
  • 99
    • 0032736840 scopus 로고    scopus 로고
    • Intraluminal nicotine reduces smooth muscle tone and contractile activity in the distal large bowel
    • Green JT, Mckirdy HC, Rhodes J, Thomas GA, Evans BK. (1999). Intraluminal nicotine reduces smooth muscle tone and contractile activity in the distal large bowel. Eur J Gastroenterol Hepatol, 11, 1299-1304.
    • (1999) Eur J Gastroenterol Hepatol , vol.11 , pp. 1299-1304
    • Green, J.T.1    McKirdy, H.C.2    Rhodes, J.3    Thomas, G.A.4    Evans, B.K.5
  • 101
    • 23044472581 scopus 로고    scopus 로고
    • Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract
    • Gutmann H, Hruz P, Zimmermann C, Beglinger C, Drewe J. (2005). Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract. Biochem Pharmacol, 70, 695-699.
    • (2005) Biochem Pharmacol , vol.70 , pp. 695-699
    • Gutmann, H.1    Hruz, P.2    Zimmermann, C.3    Beglinger, C.4    Drewe, J.5
  • 103
    • 0023360306 scopus 로고
    • Gastrointestinal transit of an enteric-coated delayed-release 5-aminosalicylic acid tablet
    • Hardy JG, Healey JN, Lee SW, Reynolds JR. (1987). Gastrointestinal transit of an enteric-coated delayed-release 5-aminosalicylic acid tablet. Aliment Pharmacol Ther, 1, 209-216.
    • (1987) Aliment Pharmacol Ther , vol.1 , pp. 209-216
    • Hardy, J.G.1    Healey, J.N.2    Lee, S.W.3    Reynolds, J.R.4
  • 106
    • 0036291905 scopus 로고    scopus 로고
    • Regional peptide uptake study in the rat intestinal mucosa: Glatiramer acetate as a model drug
    • Haupt S, Gil E, Tirosh R, Klinger E, Gad A, Rubinstein A. (2002). Regional peptide uptake study in the rat intestinal mucosa: glatiramer acetate as a model drug. Pharm Res, 19, 832-837.
    • (2002) Pharm Res , vol.19 , pp. 832-837
    • Haupt, S.1    Gil, E.2    Tirosh, R.3    Klinger, E.4    Gad, A.5    Rubinstein, A.6
  • 107
    • 33646802666 scopus 로고    scopus 로고
    • Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer
    • Haupt S, Zioni T, Gati I, Kleinstern J, Rubinstein A. (2006). Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer. Eur J Pharm Sci, 28, 204-211.
    • (2006) Eur J Pharm Sci , vol.28 , pp. 204-211
    • Haupt, S.1    Zioni, T.2    Gati, I.3    Kleinstern, J.4    Rubinstein, A.5
  • 109
    • 0032784691 scopus 로고    scopus 로고
    • Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system
    • Hebden JM, Wilson CG, Spiller RC, Gilchrist PJ, Blackshaw E, Frier ME, Perkins AC. (1999). Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system. Pharm Res, 16, 1087-1092.
    • (1999) Pharm Res , vol.16 , pp. 1087-1092
    • Hebden, J.M.1    Wilson, C.G.2    Spiller, R.C.3    Gilchrist, P.J.4    Blackshaw, E.5    Frier, M.E.6    Perkins, A.C.7
  • 110
    • 0016745398 scopus 로고
    • The normal colonic bacterial flora
    • Hill MJ, Drasar BS. (1975). The normal colonic bacterial flora. Gut, 16, 318-323.
    • (1975) Gut , vol.16 , pp. 318-323
    • Hill, M.J.1    Drasar, B.S.2
  • 111
    • 33845804228 scopus 로고    scopus 로고
    • Systemic availability of the active metabolite hydroxy-fasudil after administration of fasudil to different sites of the human gastrointestinal tract
    • Hinderling PH, Karara AH, Tao B, Pawula M, Wilding I, Lu M. (2007). Systemic availability of the active metabolite hydroxy-fasudil after administration of fasudil to different sites of the human gastrointestinal tract. J Clin Pharmacol, 47, 19-25.
    • (2007) J Clin Pharmacol , vol.47 , pp. 19-25
    • Hinderling, P.H.1    Karara, A.H.2    Tao, B.3    Pawula, M.4    Wilding, I.5    Lu, M.6
  • 113
    • 0035105837 scopus 로고    scopus 로고
    • Effects of topical tumoricidal agents on port-site recurrence of colon cancer: An experimental study in rats
    • Hoffstetter W, Ortega A, Chiang M, Paik P, Beart RW. (2001). Effects of topical tumoricidal agents on port-site recurrence of colon cancer: an experimental study in rats. J Laparoendosc Adv Surg Tech A, 11, 9-12.
    • (2001) J Laparoendosc Adv Surg Tech A , vol.11 , pp. 9-12
    • Hoffstetter, W.1    Ortega, A.2    Chiang, M.3    Paik, P.4    Beart, R.W.5
  • 114
    • 0014198434 scopus 로고
    • The bacterial degradation of chloramphenicol
    • Holt R. (1967). The bacterial degradation of chloramphenicol. Lancet, 1, 1259-1260.
    • (1967) Lancet , vol.1 , pp. 1259-1260
    • Holt, R.1
  • 116
    • 0028079610 scopus 로고
    • Comparison of the pharmacokinetics of an ondansetron solution ( 8 mg) when administered intravenously, orally, to the colon, and to the rectum
    • Hsyu PH, Pritchard JF, Bozigian HP, Lloyd TL, Griffin RH, Shamburek R, Krishna G, Barr WH. (1994). Comparison of the pharmacokinetics of an ondansetron solution ( 8 mg) when administered intravenously, orally, to the colon, and to the rectum. Pharm Res, 11, 156-159.
    • (1994) Pharm Res , vol.11 , pp. 156-159
    • Hsyu, P.H.1    Pritchard, J.F.2    Bozigian, H.P.3    Lloyd, T.L.4    Griffin, R.H.5    Shamburek, R.6    Krishna, G.7    Barr, W.H.8
  • 117
    • 33846244273 scopus 로고    scopus 로고
    • An investigation into the in vivo performance variability of pH responsive polymers for ileo-colonic drug delivery using gamma scintigraphy in humans
    • Ibekwe VC, Liu F, Fadda HM, Khela MK, Evans DF, Parsons GE, Basit AW. (2006). An investigation into the in vivo performance variability of pH responsive polymers for ileo-colonic drug delivery using gamma scintigraphy in humans. J Pharm Sci, 95, 2760-2766.
    • (2006) J Pharm Sci , vol.95 , pp. 2760-2766
    • Ibekwe, V.C.1    Liu, F.2    Fadda, H.M.3    Khela, M.K.4    Evans, D.F.5    Parsons, G.E.6    Basit, A.W.7
  • 118
    • 46749083350 scopus 로고    scopus 로고
    • Interplay between intestinal pH, transit time and feed status on the in vivo performance of pH responsive ileo-colonic release systems
    • Ibekwe VC, Fadda HM, McConnell EL, Khela MK, Evans DF, Basit AW. (2008a). Interplay between intestinal pH, transit time and feed status on the in vivo performance of pH responsive ileo-colonic release systems. Pharm Res, 25, 1828-1835.
    • (2008) Pharm Res , vol.25 , pp. 1828-1835
    • Ibekwe, V.C.1    Fadda, H.M.2    McConnell, E.L.3    Khela, M.K.4    Evans, D.F.5    Basit, A.W.6
  • 119
    • 50849113050 scopus 로고    scopus 로고
    • A new concept in colonic drug targeting: A combined pH-responsive and bacterially- triggered drug delivery technology
    • Ibekwe VC, Khela MK, Evans DF, Basit AW. (2008b). A new concept in colonic drug targeting: a combined pH-responsive and bacterially- triggered drug delivery technology. Aliment Pharmacol Ther, 28, 911-916.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 911-916
    • Ibekwe, V.C.1    Khela, M.K.2    Evans, D.F.3    Basit, A.W.4
  • 120
    • 0031783879 scopus 로고    scopus 로고
    • Chitosan and its use as a pharmaceutical excipient
    • Illum L. (1998). Chitosan and its use as a pharmaceutical excipient. Pharm Res, 15, 1326-1331.
    • (1998) Pharm Res , vol.15 , pp. 1326-1331
    • Illum, L.1
  • 122
    • 45849138160 scopus 로고    scopus 로고
    • Target-specific drug release to the colon
    • Jain SK, Jain A. (2008). Target-specific drug release to the colon. Expert Opin Drug Deliv, 5, 483-498.
    • (2008) Expert Opin Drug Deliv , vol.5 , pp. 483-498
    • Jain, S.K.1    Jain, A.2
  • 126
    • 29244440892 scopus 로고    scopus 로고
    • Effects of absorption promoters on insulin absorption through colontargeted delivery
    • Katsuma M, Watanabe S, Kawai H, Takemura S, Sako K. (2006). Effects of absorption promoters on insulin absorption through colontargeted delivery. Int J Pharm, 307, 156-162.
    • (2006) Int J Pharm , vol.307 , pp. 156-162
    • Katsuma, M.1    Watanabe, S.2    Kawai, H.3    Takemura, S.4    Sako, K.5
  • 127
    • 0028110221 scopus 로고
    • The effect of food on the in- vivo behavior of enteric-coated starch capsules
    • Kenyon CJ, Cole ET, Wilding IR. (1994). The effect of food on the in- vivo behavior of enteric-coated starch capsules. Int J Pharm, 112, 207-213.
    • (1994) Int J Pharm , vol.112 , pp. 207-213
    • Kenyon, C.J.1    Cole, E.T.2    Wilding, I.R.3
  • 128
    • 0032995635 scopus 로고    scopus 로고
    • A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers-I. Manipulation of drug release using Eudragit (R) L100-55 and Eudragit (R) S100 combinations
    • Khan MZI, Prebeg Z, Kurjakovic N. (1999). A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers-I. Manipulation of drug release using Eudragit (R) L100-55 and Eudragit (R) S100 combinations. J Control Release, 58, 215-222.
    • (1999) J Control Release , vol.58 , pp. 215-222
    • Khan, M.Z.I.1    Prebeg, Z.2    Kurjakovic, N.3
  • 129
    • 0024605050 scopus 로고
    • Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects
    • Khosla R, Davis SS. (1989). Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects. Int J Pharm, 52, 1-10.
    • (1989) Int J Pharm , vol.52 , pp. 1-10
    • Khosla, R.1    Davis, S.S.2
  • 130
    • 58149234000 scopus 로고    scopus 로고
    • N,N'- Bis(5-aminosalicyl)-L-cystine is a potential colon-specific 5-aminosalicylic acid prodrug with dual therapeutic effects in experimental colitis
    • Kim H, Huh J, Jeon H, Choi D, Han J, Kim Y, Jung Y. (2009). N,N'- Bis(5-aminosalicyl)-L-cystine is a potential colon-specific 5-aminosalicylic acid prodrug with dual therapeutic effects in experimental colitis. J Pharm Sci, 98, 159-168.
    • (2009) J Pharm Sci , vol.98 , pp. 159-168
    • Kim, H.1    Huh, J.2    Jeon, H.3    Choi, D.4    Han, J.5    Kim, Y.6    Jung, Y.7
  • 131
    • 0036229852 scopus 로고    scopus 로고
    • Drugs as P-glycoprotein substrates, inhibitors, and inducers
    • Kim RB. (2002). Drugs as P-glycoprotein substrates, inhibitors, and inducers. Drug Metab Rev, 34, 47-54.
    • (2002) Drug Metab Rev , vol.34 , pp. 47-54
    • Kim, R.B.1
  • 132
    • 0030964923 scopus 로고    scopus 로고
    • The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide
    • Kitamura S, Sugihara K, Kuwasako M, Tatsumi K. (1997). The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide. J Pharm Pharmacol, 49, 253-256.
    • (1997) J Pharm Pharmacol , vol.49 , pp. 253-256
    • Kitamura, S.1    Sugihara, K.2    Kuwasako, M.3    Tatsumi, K.4
  • 134
    • 0018603220 scopus 로고
    • Acetamide-a metabolite of metronidazole formed by the intestinal flora
    • Koch RL, Chrystal EJ, Beaulieu BB, Jr, Goldman P. (1979). Acetamide-a metabolite of metronidazole formed by the intestinal flora. Biochem Pharmacol, 28, 3611-3615.
    • (1979) Biochem Pharmacol , vol.28 , pp. 3611-3615
    • Koch, R.L.1    Chrystal, E.J.2    Beaulieu, B.B.3    Goldman Jr. P4
  • 135
    • 0019127339 scopus 로고
    • Role of the intestinal flora in the metabolism of misonidazole
    • Koch RL, Beaulieu BB, Jr, Goldman P. (1980). Role of the intestinal flora in the metabolism of misonidazole. Biochem Pharmacol, 29, 3281-3284.
    • (1980) Biochem Pharmacol , vol.29 , pp. 3281-3284
    • Koch, R.L.1    Beaulieu, B.B.2    Goldman Jr. P3
  • 137
    • 0028606845 scopus 로고
    • Absorption of isosorbide-5-mononitrate at specific sites in the gastrointestinal tract
    • Kramer WG. (1994). Absorption of isosorbide-5-mononitrate at specific sites in the gastrointestinal tract. J Clin Pharmacol, 34, 1218-1221.
    • (1994) J Clin Pharmacol , vol.34 , pp. 1218-1221
    • Kramer, W.G.1
  • 138
    • 0035733814 scopus 로고    scopus 로고
    • Guar gum as a carrier for colon specific delivery; Influence of metronidazole and tinidazole on in vitro release of albendazole from guar gum matrix tablets
    • Krishnaiah YS, Seetha Devi A, Nageswara Rao L, Bhaskar Reddy PR, Karthikeyan RS, Satyanarayana V. (2001). Guar gum as a carrier for colon specific delivery; influence of metronidazole and tinidazole on in vitro release of albendazole from guar gum matrix tablets. J Pharm Pharm Sci, 4, 235-243.
    • (2001) J Pharm Pharm Sci , vol.4 , pp. 235-243
    • Krishnaiah, Y.S.1    Seetha Devi, A.2    Nageswara Rao, L.3    Bhaskar Reddy, P.R.4    Karthikeyan, R.S.5    Satyanarayana, V.6
  • 140
    • 0037006927 scopus 로고    scopus 로고
    • Studies on the development of oral colon targeted drug delivery systems for metronidazole in the treatment of amoebiasis
    • DOI 10.1016/S0378-5173(02)00006-6, PII S0378517302000066
    • Krishnaiah YS, Bhaskar Reddy PR, Satyanarayana V, Karthikeyan RS. (2002b). Studies on the development of oral colon targeted drug delivery systems for metronidazole in the treatment of amoebiasis. Int J Pharm, 236, 43-55. (Pubitemid 34219372)
    • (2002) International Journal of Pharmaceutics , vol.236 , Issue.1-2 , pp. 43-55
    • Krishnaiah, Y.S.R.1    Bhaskar Reddy, P.R.2    Satyanarayana, V.3    Karthikeyan, R.S.4
  • 144
    • 0038268718 scopus 로고    scopus 로고
    • In vivo evaluation of guar gum-based colon-targeted drug delivery systems of ornidazole in healthy human volunteers
    • DOI 10.1080/1061186031000138614
    • Krishnaiah YS, Indira Muzib Y, Bhaskar P. (2003d). In vivo evaluation of guar gum-based colon-targeted drug delivery systems of ornidazole in healthy human volunteers. J Drug Target, 11, 109-115. (Pubitemid 36869184)
    • (2003) Journal of Drug Targeting , vol.11 , Issue.2 , pp. 109-115
    • Krishnaiah, Y.S.R.1    Muzib, Y.I.2    Bhaskar, P.3
  • 145
    • 0038752564 scopus 로고    scopus 로고
    • Studies on the development of colon targeted oral drug delivery systems for ornidazole in the treatment of amoebiasis
    • Krishnaiah YS, Muzib YI, Rao GS, Bhaskar P, Satyanarayana V. (2003e). Studies on the development of colon targeted oral drug delivery systems for ornidazole in the treatment of amoebiasis. Drug Deliv, 10, 111-117.
    • (2003) Drug Deliv , vol.10 , pp. 111-117
    • Krishnaiah, Y.S.1    Muzib, Y.I.2    Rao, G.S.3    Bhaskar, P.4    Satyanarayana, V.5
  • 147
    • 48249114027 scopus 로고    scopus 로고
    • Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: Randomized, double-blind, placebo- controlled trial
    • Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M. (2008). Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo- controlled trial. Pediatrics, 122, 8-12.
    • (2008) Pediatrics , vol.122 , pp. 8-12
    • Kukkonen, K.1    Savilahti, E.2    Haahtela, T.3    Juntunen-Backman, K.4    Korpela, R.5    Poussa, T.6    Tuure, T.7    Kuitunen, M.8
  • 148
    • 0037122743 scopus 로고    scopus 로고
    • Role of transporters in the tissueselective distribution and elimination of drugs: Transporters in the liver, small intestine, brain and kidney
    • Kusuhara H, Sugiyama Y. (2002). Role of transporters in the tissueselective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J Control Release, 78, 43-54.
    • (2002) J Control Release , vol.78 , pp. 43-54
    • Kusuhara, H.1    Sugiyama, Y.2
  • 149
    • 0034872426 scopus 로고    scopus 로고
    • Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa
    • Lamprecht A, Schafer U, Lehr CM. (2001). Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res, 18, 788-793.
    • (2001) Pharm Res , vol.18 , pp. 788-793
    • Lamprecht, A.1    Schafer, U.2    Lehr, C.M.3
  • 150
    • 25644442467 scopus 로고    scopus 로고
    • Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats
    • Lamprecht A, Yamamoto H, Takeuchi H, Kawashima Y. (2005). Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats. J Pharmacol Exp Ther, 315, 196-202.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 196-202
    • Lamprecht, A.1    Yamamoto, H.2    Takeuchi, H.3    Kawashima, Y.4
  • 151
    • 0022922798 scopus 로고
    • The number and distribution of lymphoid follicles in the human large intestine
    • Langman JM, Rowland R. (1986). The number and distribution of lymphoid follicles in the human large intestine. J Anat, 149, 189-194.
    • (1986) J Anat , vol.149 , pp. 189-194
    • Langman, J.M.1    Rowland, R.2
  • 152
    • 0026533101 scopus 로고
    • Density of lymphoid follicles in the rectum and at the anorectal junction
    • Langman JM, Rowland R. (1992). Density of lymphoid follicles in the rectum and at the anorectal junction. J Clin Gastroenterol, 14, 81-84.
    • (1992) J Clin Gastroenterol , vol.14 , pp. 81-84
    • Langman, J.M.1    Rowland, R.2
  • 153
    • 33846570911 scopus 로고    scopus 로고
    • Efficacy and safety of thalidomide in children and young adults with intractable inflammatory bowel disease: Long-term results
    • Lazzerini M, Martelossi S, Marchetti F, Scabar A, Bradaschia F, Ronfani L, Ventura A. (2007). Efficacy and safety of thalidomide in children and young adults with intractable inflammatory bowel disease: long-term results. Aliment Pharmacol Ther, 25, 419-427.
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 419-427
    • Lazzerini, M.1    Martelossi, S.2    Marchetti, F.3    Scabar, A.4    Bradaschia, F.5    Ronfani, L.6    Ventura, A.7
  • 154
    • 2442673018 scopus 로고    scopus 로고
    • Absorption of rivastigmine from different regions of the gastrointestinal tract in humans
    • Lee L, Hossain M, Wang Y, Sedek G. (2004a). Absorption of rivastigmine from different regions of the gastrointestinal tract in humans. J Clin Pharmacol, 44, 599-604.
    • (2004) J Clin Pharmacol , vol.44 , pp. 599-604
    • Lee, L.1    Hossain, M.2    Wang, Y.3    Sedek, G.4
  • 155
    • 4043153467 scopus 로고    scopus 로고
    • Antiallergic activity of hesperidin is activated by intestinal microflora
    • Lee NK, Choi SH, Park SH, Park EK, Kim DH. (2004b). Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology, 71, 174-180.
    • (2004) Pharmacology , vol.71 , pp. 174-180
    • Lee, N.K.1    Choi, S.H.2    Park, S.H.3    Park, E.K.4    Kim, D.H.5
  • 156
    • 0031544453 scopus 로고    scopus 로고
    • The in vivo behaviour of enteric naproxen tablets coated with an aqueous dispersion of methacrylic acid copolymer
    • Lehmann K, Brogmann B, Kenyon CJ, Wilding IR. (1997). The in vivo behaviour of enteric naproxen tablets coated with an aqueous dispersion of methacrylic acid copolymer. Stp Pharma Sci, 7, 463-468.
    • (1997) Stp Pharma Sci , vol.7 , pp. 463-468
    • Lehmann, K.1    Brogmann, B.2    Kenyon, C.J.3    Wilding, I.R.4
  • 157
    • 14744272833 scopus 로고    scopus 로고
    • The use of biopharmaceutic classification of drugs in drug discovery and development: Current status and future extension
    • Lennernas H, Abrahamsson B. (2005). The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension. J Pharm Pharmacol, 57, 273-285.
    • (2005) J Pharm Pharmacol , vol.57 , pp. 273-285
    • Lennernas, H.1    Abrahamsson, B.2
  • 159
    • 0019442903 scopus 로고
    • Inactivation of digoxin by the gut flora: Reversal by antibiotic therapy
    • Lindenbaum J, Rund DG, Butler VP, Jr, Tse-Eng D, Saha JR. (1981). Inactivation of digoxin by the gut flora: reversal by antibiotic therapy. N Engl J Med, 305, 789-794.
    • (1981) N Engl J Med , vol.305 , pp. 789-794
    • Lindenbaum, J.1    Rund, D.G.2    Butler, V.P.3    Tse-Eng Jr. D4    Saha, J.R.5
  • 160
    • 57349173031 scopus 로고    scopus 로고
    • A novel concept in enteric coating: A double-coating system providing rapid drug release in the proximal small intestine
    • Liu F, Lizio R, Meier C, Petereit H-U, Blakey P, Basit AW. (2009). A novel concept in enteric coating: a double-coating system providing rapid drug release in the proximal small intestine. J Control Release, 133(2), 119-124.
    • (2009) J Control Release , vol.133 , Issue.2 , pp. 119-124
    • Liu, F.1    Lizio, R.2    Meier, C.3    Petereit, H.-U.4    Blakey, P.5    Basit, A.W.6
  • 164
    • 0029559664 scopus 로고
    • Absorption and presystemic metabolism of nefazodone administered at different regions in the gastrointestinal tract of humans
    • Marathe PH, Salazar DE, Greene DS, Brennan J, Shukla UA, Barbhaiya RH. (1995). Absorption and presystemic metabolism of nefazodone administered at different regions in the gastrointestinal tract of humans. Pharm Res, 12, 1716-1721.
    • (1995) Pharm Res , vol.12 , pp. 1716-1721
    • Marathe, P.H.1    Salazar, D.E.2    Greene, D.S.3    Brennan, J.4    Shukla, U.A.5    Barbhaiya, R.H.6
  • 166
    • 43249121029 scopus 로고    scopus 로고
    • Gut instincts: Explorations in intestinal physiology and drug delivery
    • McConnell EL, Fadda HM, Basit AW. (2008a). Gut instincts: explorations in intestinal physiology and drug delivery. Int J Pharm, 364(2), 213-226.
    • (2008) Int J Pharm , vol.364 , Issue.2 , pp. 213-226
    • McConnell, E.L.1    Fadda, H.M.2    Basit, A.W.3
  • 167
    • 49749098543 scopus 로고    scopus 로고
    • An investigation into the digestion of chitosan (noncrosslinked and crosslinked) by human colonic bacteria
    • McConnell EL, Murdan S, Basit AW. (2008b). An investigation into the digestion of chitosan (noncrosslinked and crosslinked) by human colonic bacteria. J Pharm Sci, 97(9): 3820-3829.
    • (2008) J Pharm Sci , vol.97 , Issue.9 , pp. 3820-3829
    • McConnell, E.L.1    Murdan, S.2    Basit, A.W.3
  • 168
    • 37849024596 scopus 로고    scopus 로고
    • Colonic antigen administration induces significantly higher humoral levels of colonic and vaginal IgA, and serum IgG compared to oral administration
    • McConnell EL, Basit AW, Murdan S. (2008c). Colonic antigen administration induces significantly higher humoral levels of colonic and vaginal IgA, and serum IgG compared to oral administration. Vaccine, 26, 639-646.
    • (2008) Vaccine , vol.26 , pp. 639-646
    • McConnell, E.L.1    Basit, A.W.2    Murdan, S.3
  • 169
    • 49749094364 scopus 로고    scopus 로고
    • An in vivo comparison of intestinal pH and bacteria as physiological trigger mechanisms for colonic targeting in man
    • McConnell EL, Short MD, Basit AW. (2008d). An in vivo comparison of intestinal pH and bacteria as physiological trigger mechanisms for colonic targeting in man. J Control Release, 130, 154-160.
    • (2008) J Control Release , vol.130 , pp. 154-160
    • McConnell, E.L.1    Short, M.D.2    Basit, A.W.3
  • 170
  • 175
    • 0030995879 scopus 로고    scopus 로고
    • Molecular mechanisms of genetic polymorphisms of drug metabolism
    • Meyer UA, Zanger UM. (1997). Molecular mechanisms of genetic polymorphisms of drug metabolism. Ann Rev Pharmacol Toxicol, 37, 269-296.
    • (1997) Ann Rev Pharmacol Toxicol , vol.37 , pp. 269-296
    • Meyer, U.A.1    Zanger, U.M.2
  • 176
    • 1342331543 scopus 로고    scopus 로고
    • An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis
    • Miner P, Wedel M, Bane B, Bradley J. (2004). An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis. Aliment Pharmacol Ther, 19, 281-286.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 281-286
    • Miner, P.1    Wedel, M.2    Bane, B.3    Bradley, J.4
  • 177
    • 33646237136 scopus 로고    scopus 로고
    • Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis
    • Miner PB, Jr, Geary RS, Matson J, Chuang E, Xia S, Baker BF, Wedel MK. (2006a). Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis. Aliment Pharmacol Ther, 23, 1427-1434.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1427-1434
    • Miner, P.B.1    Geary Jr., R.S.2    Matson, J.3    Chuang, E.4    Xia, S.5    Baker, B.F.6    Wedel, M.K.7
  • 178
    • 33646232502 scopus 로고    scopus 로고
    • Safety and efficacy of two dose formulations of alicaforsen enema compared with mesalazine enema for treatment of mild to moderate left-sided ulcerative colitis: A randomized, double-blind, active-controlled trial
    • Miner PB, Jr, Wedel MK, Xia, S, Baker BF. (2006b). Safety and efficacy of two dose formulations of alicaforsen enema compared with mesalazine enema for treatment of mild to moderate left-sided ulcerative colitis: a randomized, double-blind, active-controlled trial. Aliment Pharmacol Ther, 23, 1403-1413.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1403-1413
    • Miner, P.B.1    Wedel Jr., M.K.2    Xia, S.3    Baker, B.F.4
  • 179
    • 59849124388 scopus 로고    scopus 로고
    • Rectal administration of d-alpha tocopherol for active ulcerative colitis: A preliminary report
    • Mirbagheri SA, Nezami BG, Assa S, Hajimahmoodi M. (2008). Rectal administration of d-alpha tocopherol for active ulcerative colitis: a preliminary report. World J Gastroenterol, 14, 5990-5995.
    • (2008) World J Gastroenterol , vol.14 , pp. 5990-5995
    • Mirbagheri, S.A.1    Nezami, B.G.2    Assa, S.3    Hajimahmoodi, M.4
  • 181
    • 47949110575 scopus 로고    scopus 로고
    • Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines
    • Nakamura A, Nakajima M, Yamanaka H, Fujiwara R, Yokoi T. (2008). Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. Drug Metab Dispos, 36, 1461-1464.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1461-1464
    • Nakamura, A.1    Nakajima, M.2    Yamanaka, H.3    Fujiwara, R.4    Yokoi, T.5
  • 183
    • 0037255898 scopus 로고    scopus 로고
    • Biodegradable microspheres targeting mucosal immune-regulating cells: New approach for treatment of inflammatory bowel disease
    • Nakase H, Okazaki K, Tabata Y, Chiba T. (2003). Biodegradable microspheres targeting mucosal immune-regulating cells: new approach for treatment of inflammatory bowel disease. J Gastroenterol, 38(Suppl. 15), 59-62.
    • (2003) J Gastroenterol , vol.38 , Issue.SUPPL. 15 , pp. 59-62
    • Nakase, H.1    Okazaki, K.2    Tabata, Y.3    Chiba, T.4
  • 185
    • 35448958078 scopus 로고    scopus 로고
    • Gut pH and transit time in ulcerative colitis appear sufficient for complete dissolution of pH-dependent mesalazine-containing capsules
    • Nugent SG, Kumar D, Rampton DS, Yazaki E, Evans DF. (2000). Gut pH and transit time in ulcerative colitis appear sufficient for complete dissolution of pH-dependent mesalazine-containing capsules. Gut, 46, A9.
    • (2000) Gut , vol.46
    • Nugent, S.G.1    Kumar, D.2    Rampton, D.S.3    Yazaki, E.4    Evans, D.F.5
  • 186
    • 0036082325 scopus 로고    scopus 로고
    • Fermentation and bulking capacity of indigestible carbohydrates: The case of inulin and oligofructose
    • Nyman M. (2002). Fermentation and bulking capacity of indigestible carbohydrates: the case of inulin and oligofructose. Br J Nutr, 87(Suppl. 2), S163-S168.
    • (2002) Br J Nutr , vol.87 , Issue.SUPPL. 2
    • Nyman, M.1
  • 187
    • 0035984949 scopus 로고    scopus 로고
    • Lipid-based formulations for intestinal lymphatic delivery
    • O'Driscoll CM. (2002). Lipid-based formulations for intestinal lymphatic delivery. Eur J Pharm Sci, 15, 405-415.
    • (2002) Eur J Pharm Sci , vol.15 , pp. 405-415
    • O'Driscoll, C.M.1
  • 188
    • 0014532783 scopus 로고
    • Distribution of poliovirus antibody in serum, nasopharynx and alimentary tract following segmental immunization of lower alimentary tract with poliovaccine
    • Ogra PL, Karzon DT. (1969). Distribution of poliovirus antibody in serum, nasopharynx and alimentary tract following segmental immunization of lower alimentary tract with poliovaccine. J Immunol, 102, 1423-1430.
    • (1969) J Immunol , vol.102 , pp. 1423-1430
    • Ogra, P.L.1    Karzon, D.T.2
  • 189
    • 0037863063 scopus 로고    scopus 로고
    • Slow acetylator genotypes as a possible risk factor for infectious mononucleosislike syndrome induced by salazosulfapyridine
    • Ohtani T, Hiroi A, Sakurane M, Furukawa F. (2003). Slow acetylator genotypes as a possible risk factor for infectious mononucleosislike syndrome induced by salazosulfapyridine. Br J Dermatol, 148, 1035-1039.
    • (2003) Br J Dermatol , vol.148 , pp. 1035-1039
    • Ohtani, T.1    Hiroi, A.2    Sakurane, M.3    Furukawa, F.4
  • 190
    • 0032470250 scopus 로고    scopus 로고
    • A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs
    • Okuda H, Ogura K, Kato A, Takubo H, Watabe T. (1998). A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. J Pharmacol Exp Therap, 287, 791-799.
    • (1998) J Pharmacol Exp Therap , vol.287 , pp. 791-799
    • Okuda, H.1    Ogura, K.2    Kato, A.3    Takubo, H.4    Watabe, T.5
  • 191
    • 0034090868 scopus 로고    scopus 로고
    • Effect of intrarectal prostaglandin E-2 analogue (enprostil) on trinitrobenzenesulphonic acidinduced colitis in rats
    • Onizuka Y, Murase K, Furusu H, Isomoto H, Mizuta Y, Takeshima F, Makiyama K, Kohno S. (2000). Effect of intrarectal prostaglandin E-2 analogue (enprostil) on trinitrobenzenesulphonic acidinduced colitis in rats. J Int Med Res, 28, 28-35.
    • (2000) J Int Med Res , vol.28 , pp. 28-35
    • Onizuka, Y.1    Murase, K.2    Furusu, H.3    Isomoto, H.4    Mizuta, Y.5    Takeshima, F.6    Makiyama, K.7    Kohno, S.8
  • 192
    • 0344950491 scopus 로고    scopus 로고
    • Pharmacokinetics and delivery of the anti-influenza prodrug oseltamivir to the small intestine and colon using site-specific delivery capsules
    • Oo C, Snell P, Barrett J, Dorr A, Liu B, Wilding I. (2003). Pharmacokinetics and delivery of the anti-influenza prodrug oseltamivir to the small intestine and colon using site-specific delivery capsules. Int J Pharm, 257, 297-299.
    • (2003) Int J Pharm , vol.257 , pp. 297-299
    • Oo, C.1    Snell, P.2    Barrett, J.3    Dorr, A.4    Liu, B.5    Wilding, I.6
  • 194
    • 33751064505 scopus 로고    scopus 로고
    • The impact of tumor location on the histopathologic expression of colorectal cancer
    • Papagiorgis P, Oikonomakis I, Karapanagiotou I, Wexner SD, Nikiteas N. (2006). The impact of tumor location on the histopathologic expression of colorectal cancer. J BUON, 11, 317-321.
    • (2006) J BUON , vol.11 , pp. 317-321
    • Papagiorgis, P.1    Oikonomakis, I.2    Karapanagiotou, I.3    Wexner, S.D.4    Nikiteas, N.5
  • 195
    • 48449091370 scopus 로고    scopus 로고
    • Oral, colonic-release low-molecular-weight heparin: An initial open study of Parnaparin-MMX for the treatment of mild-to-moderate left-sided ulcerative colitis
    • Pastorelli L, Saibeni S, Spina L, Signorelli C, Celasco G, De Franchis R, Vecchi M. (2008). Oral, colonic-release low-molecular-weight heparin: an initial open study of Parnaparin-MMX for the treatment of mild-to-moderate left-sided ulcerative colitis. Aliment Pharmacol Ther, 28, 581-588.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 581-588
    • Pastorelli, L.1    Saibeni, S.2    Spina, L.3    Signorelli, C.4    Celasco, G.5    De Franchis, R.6    Vecchi, M.7
  • 197
    • 34548010039 scopus 로고    scopus 로고
    • Decreased drug penetration in inflamed tissue related to changed mucosal metabolism in experimental colitis
    • Pellequer Y, Weissenborn V, Lamprecht A. (2007). Decreased drug penetration in inflamed tissue related to changed mucosal metabolism in experimental colitis. J Pharm Sci, 96, 2145-2153.
    • (2007) J Pharm Sci , vol.96 , pp. 2145-2153
    • Pellequer, Y.1    Weissenborn, V.2    Lamprecht, A.3
  • 199
    • 0015348162 scopus 로고
    • The role of intestinal bacteria in the metabolism of salicylazosulfapyridine
    • Peppercorn MA, Goldman P. (1972). The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther, 181, 555-562.
    • (1972) J Pharmacol Exp Ther , vol.181 , pp. 555-562
    • Peppercorn, M.A.1    Goldman, P.2
  • 202
    • 33846343643 scopus 로고    scopus 로고
    • The influence of non-disintegrating tablet dimensions and density on their gastric emptying in fasted volunteers
    • Podczeck F, Course NC, Newton JM, Short MB. (2007a). The influence of non-disintegrating tablet dimensions and density on their gastric emptying in fasted volunteers. J Pharm Pharmacol, 59, 23-27.
    • (2007) J Pharm Pharmacol , vol.59 , pp. 23-27
    • Podczeck, F.1    Course, N.C.2    Newton, J.M.3    Short, M.B.4
  • 203
    • 35848951152 scopus 로고    scopus 로고
    • The gastric emptying of food as measured by gamma-scintigraphy and electrical impedance tomography (EIT) and its influence on the gastric emptying of tablets of different dimensions
    • Podczeck F, Mitchell CL, Newton JM, Evans D, Short MB. (2007b). The gastric emptying of food as measured by gamma-scintigraphy and electrical impedance tomography (EIT) and its influence on the gastric emptying of tablets of different dimensions. J Pharm Pharmacol, 59, 1527-1536.
    • (2007) J Pharm Pharmacol , vol.59 , pp. 1527-1536
    • Podczeck, F.1    Mitchell, C.L.2    Newton, J.M.3    Evans, D.4    Short, M.B.5
  • 204
    • 45749116085 scopus 로고    scopus 로고
    • Effect of different doses of thalidomide in experimentally induced inflammatory bowel disease in rats
    • DOI 10.1111/j.1742-7843.2008.00240.x
    • Prakash O, Medhi B, Saikia UN, Pandhi P. (2008). Effect of different doses of thalidomide in experimentally induced inflammatory bowel disease in rats. Basic Clin Pharmacol Toxicol, 103, 9-16. (Pubitemid 351874535)
    • (2008) Basic and Clinical Pharmacology and Toxicology , vol.103 , Issue.1 , pp. 9-16
    • Prakash, O.1    Medhi, B.2    Saikia, U.N.3    Pandhi, P.4
  • 205
    • 52049100954 scopus 로고    scopus 로고
    • What is the evidence for the use of probiotics in functional disorders?
    • Quigley EM. (2008). What is the evidence for the use of probiotics in functional disorders? Curr Gastroenterol Rep, 10, 379-384.
    • (2008) Curr Gastroenterol Rep , vol.10 , pp. 379-384
    • Quigley, E.M.1
  • 206
    • 0030769203 scopus 로고    scopus 로고
    • Reduction of nitrazepam by Clostridium leptuma nitroreductase-producing bacterium isolated from the human intestinal tract
    • Rafii F, Sutherland JB, Hansen EB, Jr, Cerniglia, CE. (1997). Reduction of nitrazepam by Clostridium leptuma nitroreductase-producing bacterium isolated from the human intestinal tract. Clin Infect Dis, 25(Suppl. 2), S121-S122.
    • (1997) Clin Infect Dis , vol.25 , Issue.SUPPL. 2
    • Rafii, F.1    Sutherland, J.B.2    Hansen, E.B.3    Cerniglia Jr., C.E.4
  • 207
    • 2342599731 scopus 로고    scopus 로고
    • Metabolism of daidzein by intestinal bacteria from rhesus monkeys (Macaca mulatta)
    • Rafii F, Hotchkiss C, Heinze TM, Park M. (2004). Metabolism of daidzein by intestinal bacteria from rhesus monkeys (Macaca mulatta). Comp Med, 54, 165-169.
    • (2004) Comp Med , vol.54 , pp. 165-169
    • Rafii, F.1    Hotchkiss, C.2    Heinze, T.M.3    Park, M.4
  • 208
    • 34547683600 scopus 로고    scopus 로고
    • Diversity of the human gastrointestinal tract microbiota revisited
    • DOI 10.1111/j.1462-2920.2007.01369.x
    • Rajilic-Stojanovic M, Smidt H, De Vos WM. (2007). Diversity of the human gastrointestinal tract microbiota revisited. Environ Microbiol, 9, 2125-2136. (Pubitemid 47222128)
    • (2007) Environmental Microbiology , vol.9 , Issue.9 , pp. 2125-2136
    • Rajilic-Stojanovic, M.1    Smidt, H.2    De Vos, W.M.3
  • 209
    • 0033592203 scopus 로고    scopus 로고
    • Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: A randomised trial
    • Rembacken BJ, Snelling AM, Hawkey PM, Chalmers DM, Axon AT. (1999). Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial. Lancet, 354, 635-639.
    • (1999) Lancet , vol.354 , pp. 635-639
    • Rembacken, B.J.1    Snelling, A.M.2    Hawkey, P.M.3    Chalmers, D.M.4    Axon, A.T.5
  • 210
    • 0024333532 scopus 로고
    • Prokinetic agents: A key in the future of gastroenterology
    • Reynolds JC. (1989). Prokinetic agents: a key in the future of gastroenterology. Gastroenterol Clin North Am, 18, 437-457.
    • (1989) Gastroenterol Clin North Am , vol.18 , pp. 437-457
    • Reynolds, J.C.1
  • 213
    • 0030902450 scopus 로고    scopus 로고
    • Utilization of algal polysaccharides by human colonic bacteria, in axenic culture or in association with hydrogenotrophic microorganisms
    • Rochet V, Bernalier A. (1997). Utilization of algal polysaccharides by human colonic bacteria, in axenic culture or in association with hydrogenotrophic microorganisms. Reprod Nutr Dev, 37, 221-229.
    • (1997) Reprod Nutr Dev , vol.37 , pp. 221-229
    • Rochet, V.1    Bernalier, A.2
  • 215
    • 46749109330 scopus 로고    scopus 로고
    • Determination of mesalazine in whole or partial mesalamine delayed-release tablets recovered from fecal samples of healthy volunteers
    • Safdi AV. (2005). Determination of mesalazine in whole or partial mesalamine delayed-release tablets recovered from fecal samples of healthy volunteers. Am J Gastroenterol, 100, S159.
    • (2005) Am J Gastroenterol , vol.100
    • Safdi, A.V.1
  • 216
    • 33846061033 scopus 로고    scopus 로고
    • Safety and efficacy of oral, colonic-release, Low Molecular Weight Heparin-MMXTM for the treatment of mild to moderate left-sided ulcerative colitis: Preliminary reports of a pilot study
    • AGA Abstract W1227
    • Saibeni S, Spina L, Pastorelli L, De Franchis R, Moro L, Villa R, Bozzella R, Celasco G, Vecchi M. (2006). Safety and efficacy of oral, colonic-release, Low Molecular Weight Heparin-MMXTM for the treatment of mild to moderate left-sided ulcerative colitis: preliminary reports of a pilot study. Gastroenterology, 130, AGA Abstract W1227.
    • (2006) Gastroenterology , vol.130
    • Saibeni, S.1    Spina, L.2    Pastorelli, L.3    De Franchis, R.4    Moro, L.5    Villa, R.6    Bozzella, R.7    Celasco, G.8    Vecchi, M.9
  • 217
    • 29244470553 scopus 로고    scopus 로고
    • Are chitosan formulations mucoadhesive in the human small intestine? An evaluation based on gamma scintigraphy
    • Sakkinen M, Marvola J, Kanerva H, Lindevall K, Ahonen A, Marvola M. (2006). Are chitosan formulations mucoadhesive in the human small intestine? An evaluation based on gamma scintigraphy. Int J Pharm, 307, 285-291.
    • (2006) Int J Pharm , vol.307 , pp. 285-291
    • Sakkinen, M.1    Marvola, J.2    Kanerva, H.3    Lindevall, K.4    Ahonen, A.5    Marvola, M.6
  • 218
    • 0017750010 scopus 로고
    • Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon
    • Salyers AA, West SE, Vercellotti JR, Wilkins TD. (1977). Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon. Appl Environ Microbiol, 34, 529-533.
    • (1977) Appl Environ Microbiol , vol.34 , pp. 529-533
    • Salyers, A.A.1    West, S.E.2    Vercellotti, J.R.3    Wilkins, T.D.4
  • 219
    • 0018161279 scopus 로고
    • Degradation of polysaccharides by intestinal bacterial enzymes
    • Salyers AA, Palmer JK, Wilkins TD. (1978). Degradation of polysaccharides by intestinal bacterial enzymes. Am J Clin Nutr, 31, S128-S130.
    • (1978) Am J Clin Nutr , vol.31
    • Salyers, A.A.1    Palmer, J.K.2    Wilkins, T.D.3
  • 220
    • 0030852411 scopus 로고    scopus 로고
    • Metabolism of azetirelin, a new thyrotropin- releasing hormone (TRH) analogue, by intestinal microorganisms
    • Sasaki I, Tamura T, Shibakawa T, Fujita T, Murakami M, Yamamoto A, Muranishi S. (1997). Metabolism of azetirelin, a new thyrotropin- releasing hormone (TRH) analogue, by intestinal microorganisms. Pharm Res, 14, 1004-1007.
    • (1997) Pharm Res , vol.14 , pp. 1004-1007
    • Sasaki, I.1    Tamura, T.2    Shibakawa, T.3    Fujita, T.4    Murakami, M.5    Yamamoto, A.6    Muranishi, S.7
  • 221
    • 0033621579 scopus 로고    scopus 로고
    • Prostaglandin E-2 inhibits lesion formation in dextran sodium sulphate-induced colitis in rats and reduces the levels of mucosal inflammatory cytokines
    • Sasaki S, Hirata I, Maemura K, Hamamoto N, Murano M, Toshina K, Katsu K. (2000). Prostaglandin E-2 inhibits lesion formation in dextran sodium sulphate-induced colitis in rats and reduces the levels of mucosal inflammatory cytokines. Scand J Immunol, 51, 23-28.
    • (2000) Scand J Immunol , vol.51 , pp. 23-28
    • Sasaki, S.1    Hirata, I.2    Maemura, K.3    Hamamoto, N.4    Murano, M.5    Toshina, K.6    Katsu, K.7
  • 223
    • 0034528031 scopus 로고    scopus 로고
    • Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria
    • Schneider H, Simmering R, Hartmann L, Pforte H, Blaut M. (2000). Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria. J Appl Microbiol, 89, 1027-1037.
    • (2000) J Appl Microbiol , vol.89 , pp. 1027-1037
    • Schneider, H.1    Simmering, R.2    Hartmann, L.3    Pforte, H.4    Blaut, M.5
  • 224
    • 0023521441 scopus 로고
    • Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study
    • Schroeder KW, Tremaine WJ, Ilstrup DM. (1987). Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med, 317, 1625-1629.
    • (1987) N Engl J Med , vol.317 , pp. 1625-1629
    • Schroeder, K.W.1    Tremaine, W.J.2    Ilstrup, D.M.3
  • 226
    • 0346216089 scopus 로고    scopus 로고
    • Concentration-dependent effects of polyethylene glycol 400 on gastrointestinal transit and drug absorption
    • Schulze JD, Waddington WA, Eli PJ, Parsons GE, Coffin MD, Basit AW. (2003). Concentration-dependent effects of polyethylene glycol 400 on gastrointestinal transit and drug absorption. Pharm Res, 20, 1984-1988.
    • (2003) Pharm Res , vol.20 , pp. 1984-1988
    • Schulze, J.D.1    Waddington, W.A.2    Eli, P.J.3    Parsons, G.E.4    Coffin, M.D.5    Basit, A.W.6
  • 229
    • 54049086058 scopus 로고    scopus 로고
    • Presystemic elimination of budesonide in man when administered locally at different levels in the gut, with and without local inhibition by ketoconazole
    • Seidegård J, Nyberg L, Borgå O. (2008). Presystemic elimination of budesonide in man when administered locally at different levels in the gut, with and without local inhibition by ketoconazole. Eur J Pharm Sci, 35, 264-270.
    • (2008) Eur J Pharm Sci , vol.35 , pp. 264-270
    • Seidegård, J.1    Nyberg, L.2    Borgå, O.3
  • 230
    • 33747090656 scopus 로고    scopus 로고
    • Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells
    • Seithel A, Karlsson J, Hilgendorf C, Bjorquist A, Ungell AL. (2006). Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells. Eur J Pharm Sci, 28, 291-299.
    • (2006) Eur J Pharm Sci , vol.28 , pp. 291-299
    • Seithel, A.1    Karlsson, J.2    Hilgendorf, C.3    Bjorquist, A.4    Ungell, A.L.5
  • 231
    • 0025879859 scopus 로고
    • Metabolism of levamisole, an anti-colon cancer drug, by human intestinal bacteria
    • Shu YZ, Kingston DG, Van Tassell RL, Wilkins TD. (1991). Metabolism of levamisole, an anti-colon cancer drug, by human intestinal bacteria. Xenobiotica, 21, 737-750.
    • (1991) Xenobiotica , vol.21 , pp. 737-750
    • Shu, Y.Z.1    Kingston, D.G.2    Van Tassell, R.L.3    Wilkins, T.D.4
  • 232
    • 1542328825 scopus 로고    scopus 로고
    • Amylose formulations for drug delivery to the colon: A comparison of two fermentation models to assess colonic targeting performance in vitro
    • Siew LF, Man SM, Newton JM, Basit AW. (2004). Amylose formulations for drug delivery to the colon: a comparison of two fermentation models to assess colonic targeting performance in vitro. Int J Pharm, 273, 129-134.
    • (2004) Int J Pharm , vol.273 , pp. 129-134
    • Siew, L.F.1    Man, S.M.2    Newton, J.M.3    Basit, A.W.4
  • 233
    • 0028863589 scopus 로고
    • Dextran hydrogels for colon-specific delivery. V. Degradation in human intestinal incubation models
    • Simonsen L, Hovgaard L, Mortensen PB, Brondsted H. (1995). Dextran hydrogels for colon-specific delivery. V. Degradation in human intestinal incubation models. Eur J Pharm Sci, 3, 329-337.
    • (1995) Eur J Pharm Sci , vol.3 , pp. 329-337
    • Simonsen, L.1    Hovgaard, L.2    Mortensen, P.B.3    Brondsted, H.4
  • 234
    • 0242361674 scopus 로고    scopus 로고
    • Intestinal performance of two mesalamine formulations in patients with active ulcerative colitis as assessed by gamma scintigraphy
    • Sinha A, Ball BJ, Connor AL, Nightingale J, Wilding IR. (2003). Intestinal performance of two mesalamine formulations in patients with active ulcerative colitis as assessed by gamma scintigraphy. Pract Gastroenterol, 27, 56-69.
    • (2003) Pract Gastroenterol , vol.27 , pp. 56-69
    • Sinha, A.1    Ball, B.J.2    Connor, A.L.3    Nightingale, J.4    Wilding, I.R.5
  • 236
    • 0037243915 scopus 로고    scopus 로고
    • Microbially triggered drug delivery to the colon
    • Sinha VR, Kumria R. (2003). Microbially triggered drug delivery to the colon. Eur J Pharm Sci, 18, 3-18.
    • (2003) Eur J Pharm Sci , vol.18 , pp. 3-18
    • Sinha, V.R.1    Kumria, R.2
  • 237
    • 0016206503 scopus 로고
    • Metabolism of N-acylated and O-alkylated drugs by the intestinal microflora during anaerobic incubation in vitro
    • Smith GE, Griffiths LA. (1974). Metabolism of N-acylated and O-alkylated drugs by the intestinal microflora during anaerobic incubation in vitro. Xenobiotica, 4, 477-487.
    • (1974) Xenobiotica , vol.4 , pp. 477-487
    • Smith, G.E.1    Griffiths, L.A.2
  • 238
    • 0034834793 scopus 로고    scopus 로고
    • Circadian rhythms and clinical medicine with applications to hypertension
    • Smolensky MH, Haus E. (2001). Circadian rhythms and clinical medicine with applications to hypertension. Am J Hypertens, 14, 280S-290S.
    • (2001) Am J Hypertens , vol.14
    • Smolensky, M.H.1    Haus, E.2
  • 239
    • 35148824741 scopus 로고    scopus 로고
    • Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma
    • Smolensky MH, Lemmer B, Reinberg AE. (2007). Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma. Adv Drug Deliv Rev, 59, 852-882.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 852-882
    • Smolensky, M.H.1    Lemmer, B.2    Reinberg, A.E.3
  • 241
    • 0023106493 scopus 로고
    • Emptying of the terminal ileum in intact humans. Influence of meal residue and ileal motility
    • Spiller RC, Brown ML, Phillips SF. (1987). Emptying of the terminal ileum in intact humans. Influence of meal residue and ileal motility. Gastroenterology, 92, 724-729.
    • (1987) Gastroenterology , vol.92 , pp. 724-729
    • Spiller, R.C.1    Brown, M.L.2    Phillips, S.F.3
  • 242
    • 0022515946 scopus 로고
    • Measurement of theophylline absorption from different regions of the gastrointestinal tract using a remote controlled drug delivery device
    • Staib AH, Loew D, Harder S, Graul EH, Pfab R. (1986). Measurement of theophylline absorption from different regions of the gastrointestinal tract using a remote controlled drug delivery device. Eur J Clin Pharmacol, 30, 691-697.
    • (1986) Eur J Clin Pharmacol , vol.30 , pp. 691-697
    • Staib, A.H.1    Loew, D.2    Harder, S.3    Graul, E.H.4    Pfab, R.5
  • 244
    • 34548381638 scopus 로고    scopus 로고
    • Characterization of orphan human cytochromes P450
    • Stark K, Guengerich FP. (2007). Characterization of orphan human cytochromes P450. Drug Metab Rev, 39, 627-637.
    • (2007) Drug Metab Rev , vol.39 , pp. 627-637
    • Stark, K.1    Guengerich, F.P.2
  • 245
    • 58449117037 scopus 로고    scopus 로고
    • Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia
    • Stocco G, Cheok M, Crews K, Dervieux T, French D, Pei D, Yang W, Cheng C, Pui CH, Relling M, Evans W. (2009). Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Clin Pharmacol Ther, 85, 164-172.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 164-172
    • Stocco, G.1    Cheok, M.2    Crews, K.3    Dervieux, T.4    French, D.5    Pei, D.6    Yang, W.7    Cheng, C.8    Pui, C.H.9    Relling, M.10    Evans, W.11
  • 246
  • 247
    • 0029895328 scopus 로고    scopus 로고
    • Enteral absorption of insulin in rats from mucoadhesive chitosan- coated liposomes
    • Takeuchi H, Yamamoto H, Niwa T, Hino T, Kawashima Y. (1996). Enteral absorption of insulin in rats from mucoadhesive chitosan- coated liposomes. Pharm Res, 13, 896-901.
    • (1996) Pharm Res , vol.13 , pp. 896-901
    • Takeuchi, H.1    Yamamoto, H.2    Niwa, T.3    Hino, T.4    Kawashima, Y.5
  • 248
    • 0034512495 scopus 로고    scopus 로고
    • The clinical development of 9-aminocamptothecin
    • Takimoto CH, Thomas R. (2000). The clinical development of 9-aminocamptothecin. Ann N Y Acad Sci, 922, 224-236.
    • (2000) Ann N y Acad Sci , vol.922 , pp. 224-236
    • Takimoto, C.H.1    Thomas, R.2
  • 249
    • 0033616767 scopus 로고    scopus 로고
    • Immunomodulation of experimental autoimmune encephalomyelitis by oral administration of copolymer 1
    • Teitelbaum D, Arnon R, Sela M. (1999). Immunomodulation of experimental autoimmune encephalomyelitis by oral administration of copolymer 1. Proc Natl Acad Sci USA, 96, 3842-3847.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3842-3847
    • Teitelbaum, D.1    Arnon, R.2    Sela, M.3
  • 251
    • 21744436852 scopus 로고    scopus 로고
    • Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract
    • Thorn M, Finnstrom N, Lundgren S, Rane A, Loof L. (2005). Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract. Br J Clin Pharmacol, 60, 54-60.
    • (2005) Br J Clin Pharmacol , vol.60 , pp. 54-60
    • Thorn, M.1    Finnstrom, N.2    Lundgren, S.3    Rane, A.4    Loof, L.5
  • 253
    • 0031051266 scopus 로고    scopus 로고
    • Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat caecal contents: Implications in peptide delivery to the colon
    • Tozaki H, Emi Y, Horisaka E, Fujita T, Yamamoto A, Muranishi S. (1997a). Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat caecal contents: implications in peptide delivery to the colon. J Pharm Pharmacol, 49, 164-168.
    • (1997) J Pharm Pharmacol , vol.49 , pp. 164-168
    • Tozaki, H.1    Emi, Y.2    Horisaka, E.3    Fujita, T.4    Yamamoto, A.5    Muranishi, S.6
  • 254
  • 255
    • 39149108776 scopus 로고    scopus 로고
    • Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update
    • Trevaskis NL, Charman WN, Porter CJ. (2008). Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update. Adv Drug Deliv Rev, 60, 702-716.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 702-716
    • Trevaskis, N.L.1    Charman, W.N.2    Porter, C.J.3
  • 256
    • 43249129320 scopus 로고    scopus 로고
    • Pharmacokinetics of the CYP 3A substrate simvastatin following administration of delayed versus immediate release oral dosage forms
    • Tubic-Grozdanis M, Hilfinger J, Amidon G, Kim J, Kijek P, Staubach P, Langguth P. (2008). Pharmacokinetics of the CYP 3A substrate simvastatin following administration of delayed versus immediate release oral dosage forms. Pharm Res, 25, 1591-1600.
    • (2008) Pharm Res , vol.25 , pp. 1591-1600
    • Tubic-Grozdanis, M.1    Hilfinger, J.2    Amidon, G.3    Kim, J.4    Kijek, P.5    Staubach, P.6    Langguth, P.7
  • 257
    • 0036791174 scopus 로고    scopus 로고
    • Colonic delivery of 4-aminosalicylic acid using amyloseethylcellulose- coated hydroxypropylmethylcellulose capsules
    • Tuleu C, Basit AW, Waddington WA, Ell PJ, Newton JM. (2002). Colonic delivery of 4-aminosalicylic acid using amyloseethylcellulose- coated hydroxypropylmethylcellulose capsules. Aliment Pharmacol Therap, 16, 1771-1779.
    • (2002) Aliment Pharmacol Therap , vol.16 , pp. 1771-1779
    • Tuleu, C.1    Basit, A.W.2    Waddington, W.A.3    Ell, P.J.4    Newton, J.M.5
  • 258
    • 9144236376 scopus 로고    scopus 로고
    • Low-dose balsalazide plus a high-potency probiotic preparation is more effective than balsalazide alone or mesalazine in the treatment of acute mild-to-moderate ulcerative colitis
    • Tursi A, Brandimarte G, Giorgetti GM, Forti G, Modeo ME, Gigliobianco A. (2004). Low-dose balsalazide plus a high-potency probiotic preparation is more effective than balsalazide alone or mesalazine in the treatment of acute mild-to-moderate ulcerative colitis. Med Sci Monit, 10, PI126-PI131.
    • (2004) Med Sci Monit , vol.10
    • Tursi, A.1    Brandimarte, G.2    Giorgetti, G.M.3    Forti, G.4    Modeo, M.E.5    Gigliobianco, A.6
  • 259
    • 33646271377 scopus 로고    scopus 로고
    • A phase II dose ranging, double-blind, placebocontrolled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis
    • Van Deventer SJ, Wedel MK, Baker BF, Xia S, Chuang E, Miner PB, Jr., (2006). A phase II dose ranging, double-blind, placebocontrolled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis. Aliment Pharmacol Ther, 23, 1415-1425.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1415-1425
    • Van Deventer, S.J.1    Wedel, M.K.2    Baker, B.F.3    Xia, S.4    Chuang, E.5    Miner Jr., P.B.6
  • 263
    • 33748304132 scopus 로고    scopus 로고
    • Review article: Genetic susceptibility and application of genetic testing in clinical management of inflammatory bowel disease
    • Vermeire S. (2006). Review article: genetic susceptibility and application of genetic testing in clinical management of inflammatory bowel disease. Aliment Pharmacol Ther, 24(Suppl 3), 2-10.
    • (2006) Aliment Pharmacol Ther , vol.24 , Issue.SUPPL. 3 , pp. 2-10
    • Vermeire, S.1
  • 266
    • 0025903764 scopus 로고
    • Olsalazine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease
    • Wadworth AN, Fitton A. (1991). Olsalazine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease. Drugs, 41, 647-664.
    • (1991) Drugs , vol.41 , pp. 647-664
    • Wadworth, A.N.1    Fitton, A.2
  • 269
    • 42049088505 scopus 로고    scopus 로고
    • Celecoxib inhibits tumor growth and angiogenesis in an orthotopic implantation tumor model of human colon cancer
    • Wang L, Chen W, Xie X, He Y, Bai X. (2008). Celecoxib inhibits tumor growth and angiogenesis in an orthotopic implantation tumor model of human colon cancer. Exp Oncol, 30, 42-51.
    • (2008) Exp Oncol , vol.30 , pp. 42-51
    • Wang, L.1    Chen, W.2    Xie, X.3    He, Y.4    Bai, X.5
  • 271
    • 12344250990 scopus 로고    scopus 로고
    • TARGIT technology: Coated starch capsules for site-specific drug delivery into the lower gastrointestinal tract
    • Watts P, Smith A. (2005). TARGIT technology: coated starch capsules for site-specific drug delivery into the lower gastrointestinal tract. Expert Opin Drug Deliv, 2, 159-167.
    • (2005) Expert Opin Drug Deliv , vol.2 , pp. 159-167
    • Watts, P.1    Smith, A.2
  • 272
    • 0021813284 scopus 로고
    • N-acetylation pharmacogenetics
    • Weber WW, Hein DW. (1985). N-acetylation pharmacogenetics. Pharmacol Rev, 37, 25-79.
    • (1985) Pharmacol Rev , vol.37 , pp. 25-79
    • Weber, W.W.1    Hein, D.W.2
  • 273
    • 20444395842 scopus 로고    scopus 로고
    • Magnetic marker monitoring: An application of biomagnetic measurement instrumentation and principles for the determination of the gastrointestinal behavior of magnetically marked solid dosage forms
    • Weitschies W, Kosch O, Monnikes H, Trahms L. (2005). Magnetic Marker Monitoring: an application of biomagnetic measurement instrumentation and principles for the determination of the gastrointestinal behavior of magnetically marked solid dosage forms. Adv Drug Deliv Rev, 57, 1210-1222.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 1210-1222
    • Weitschies, W.1    Kosch, O.2    Monnikes, H.3    Trahms, L.4
  • 275
    • 24944563655 scopus 로고    scopus 로고
    • The enterion capsule: A novel technology for understanding the biopharmaceutical complexity of new molecular entities (NMEs)
    • Wilding I. (2001). The enterion capsule: a novel technology for understanding the biopharmaceutical complexity of new molecular entities (NMEs). Drug Deliv Technol, 1, 23-24.
    • (2001) Drug Deliv Technol , vol.1 , pp. 23-24
    • Wilding, I.1
  • 278
    • 1542615524 scopus 로고    scopus 로고
    • Assessment of lumiracoxib bioavailability from targeted sites in the human intestine using remotely activated capsules and gamma scintigraphy
    • Wilding IR, Connor AL, Carpenter P, Rordorf C, Branson J, Milosavljev S, Scott G. (2004). Assessment of lumiracoxib bioavailability from targeted sites in the human intestine using remotely activated capsules and gamma scintigraphy. Pharm Res, 21, 443-446.
    • (2004) Pharm Res , vol.21 , pp. 443-446
    • Wilding, I.R.1    Connor, A.L.2    Carpenter, P.3    Rordorf, C.4    Branson, J.5    Milosavljev, S.6    Scott, G.7
  • 279
    • 0033590207 scopus 로고    scopus 로고
    • The role of cyclooxygenases in inflammation, cancer, and development
    • Williams CS, Mann M, Dubois RN. (1999). The role of cyclooxygenases in inflammation, cancer, and development. Oncogene, 18, 7908-7916.
    • (1999) Oncogene , vol.18 , pp. 7908-7916
    • Williams, C.S.1    Mann, M.2    Dubois, R.N.3
  • 280
    • 0024553027 scopus 로고
    • Bimodal release of ibuprofen in a sustainedrelease formulation: A scintigraphic and pharmacokinetic open study in healthy volunteers under different conditions of food intake
    • Wilson CG, Washington N, Greaves JL, Kamali F, Rees JA, Sempik AK, Lampard JF. (1989). Bimodal release of ibuprofen in a sustainedrelease formulation: a scintigraphic and pharmacokinetic open study in healthy volunteers under different conditions of food intake. Int J Pharm, 50, 155-161.
    • (1989) Int J Pharm , vol.50 , pp. 155-161
    • Wilson, C.G.1    Washington, N.2    Greaves, J.L.3    Kamali, F.4    Rees, J.A.5    Sempik, A.K.6    Lampard, J.F.7
  • 281
    • 12244286045 scopus 로고    scopus 로고
    • Effect of colonic lactulose availability on the timing of drug release onset in vivo from a unique colon-specific drug delivery system (CODES)
    • Yang L, Watanabe S, Li J, Chu JS, Katsuma M, Yokohama S, Fix JA. (2003). Effect of colonic lactulose availability on the timing of drug release onset in vivo from a unique colon-specific drug delivery system (CODES). Pharm Res, 20, 429-434.
    • (2003) Pharm Res , vol.20 , pp. 429-434
    • Yang, L.1    Watanabe, S.2    Li, J.3    Chu, J.S.4    Katsuma, M.5    Yokohama, S.6    Fix, J.A.7
  • 282
    • 0033820248 scopus 로고    scopus 로고
    • Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats
    • Yoshisue K, Masuda H, Matsushima E, Ikeda K, Nagayama S, Kawaguchi Y. (2000). Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats. Drug Metab Dispos, 28, 1162-1167.
    • (2000) Drug Metab Dispos , vol.28 , pp. 1162-1167
    • Yoshisue, K.1    Masuda, H.2    Matsushima, E.3    Ikeda, K.4    Nagayama, S.5    Kawaguchi, Y.6
  • 283
    • 13444252326 scopus 로고    scopus 로고
    • Mapping of multidrug resistance gene 1 and multidrug resistance- associated protein isoform 1 to 5 mRNA expression along the human intestinal tract
    • Zimmermann C, Gutmann H, Hruz P, Gutzwiller JP, Beglinger C, Drewe J. (2005). Mapping of multidrug resistance gene 1 and multidrug resistance-associated protein isoform 1 to 5 mRNA expression along the human intestinal tract. Drug Metab Dispos, 33, 219-224.
    • (2005) Drug Metab Dispos , vol.33 , pp. 219-224
    • Zimmermann, C.1    Gutmann, H.2    Hruz, P.3    Gutzwiller, J.P.4    Beglinger, C.5    Drewe, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.