-
1
-
-
0030952289
-
Mechanism of angiogenesis
-
Risau W. Mechanism of angiogenesis. Nature 1997; 386:671-4.
-
(1997)
Nature
, vol.386
, pp. 671-674
-
-
Risau, W.1
-
2
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285:1182-6.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
3
-
-
0028929803
-
Angiogenesis in cancer, vascular, rheumatoid and other disease
-
Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1:27-31.
-
(1995)
Nat Med
, vol.1
, pp. 27-31
-
-
Folkman, J.1
-
4
-
-
0021111648
-
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
-
Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983; 219:983-5.
-
(1983)
Science
, vol.219
, pp. 983-985
-
-
Senger, D.R.1
Galli, S.J.2
Dvorak, A.M.3
-
5
-
-
0024384470
-
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
-
Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Bophys Res Commun1989; 161:851-8.
-
(1989)
Biochem Bophys Res Commun
, vol.161
, pp. 851-858
-
-
Ferrara, N.1
Henzel, W.J.2
-
6
-
-
0024801035
-
Vascular permeability factor, an endothelial cell mitogen related to PDGF
-
Keck PJ, Hauser SD, Krivi G, et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989; 246:1309-12.
-
(1989)
Science
, vol.246
, pp. 1309-1312
-
-
Keck, P.J.1
Hauser, S.D.2
Krivi, G.3
-
7
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung DW, Cachianes G, Kuang W-J, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1898; 246:1306-9.
-
(1898)
Science
, vol.246
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.-J.3
-
8
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocrine Rev 1997; 18:4-25.
-
(1997)
Endocrine Rev
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
9
-
-
0028842903
-
Role of VEGF-flt receptor system in normal and tumor angiogenesis
-
Shibuya M. Role of VEGF-Flt receptor system in normal and tumor angiogenesis. Adv Cancer Res 1995; 67:281-316.
-
(1995)
Adv Cancer Res
, vol.67
, pp. 281-316
-
-
Shibuya, M.1
-
11
-
-
33344474964
-
Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
-
Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res 2006; 312:549-60.
-
(2006)
Exp Cell Res
, vol.312
, pp. 549-560
-
-
Shibuya, M.1
Claesson-Welsh, L.2
-
12
-
-
0027197245
-
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
-
Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993; 362:841-4.
-
(1993)
Nature
, vol.362
, pp. 841-844
-
-
Kim, K.J.1
Li, B.2
Winer, J.3
-
13
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86:353-64.
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
14
-
-
0036782278
-
VEGF and the quest for tumour angiogenesis factors
-
Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2002; 2:795-803.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 795-803
-
-
Ferrara, N.1
-
15
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350:2335-42.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
16
-
-
0030026897
-
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
-
Joukov V, Pajusola K, Kaipainen A, et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 1996; 15:290-8.
-
(1996)
EMBO J
, vol.15
, pp. 290-298
-
-
Joukov, V.1
Pajusola, K.2
Kaipainen, A.3
-
17
-
-
0036527585
-
Molecular mechanisms of lymphangio-genesis in health and disease
-
Alitalo K, Carmeliet P. Molecular mechanisms of lymphangio-genesis in health and disease. Cancer Cell 2002; 1:219-27.
-
(2002)
Cancer Cell
, vol.1
, pp. 219-227
-
-
Alitalo, K.1
Carmeliet, P.2
-
18
-
-
17744396472
-
Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphan-giogenesis in transgenic mice
-
Veikkola T, Jussila L, Makinen T, et al. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphan-giogenesis in transgenic mice. EMBO J 2001; 20:1223-31.
-
(2001)
EMBO J
, vol.20
, pp. 1223-1231
-
-
Veikkola, T.1
Jussila, L.2
Makinen, T.3
-
19
-
-
9144236286
-
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
-
Karkkainen MJ, Haiko P, Sainio K, et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 2004; 5:74-80.
-
(2004)
Nat Immunol
, vol.5
, pp. 74-80
-
-
Karkkainen, M.J.1
Haiko, P.2
Sainio, K.3
-
20
-
-
0035126049
-
VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
-
Stacker SA, Caesar C, Baldwin ME, et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nature Med 2001; 7:186-91.
-
(2001)
Nature Med
, vol.7
, pp. 186-191
-
-
Stacker, S.A.1
Caesar, C.2
Baldwin, M.E.3
-
21
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20:4368-80.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
22
-
-
0027979253
-
Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus
-
Lyttle DJ, Fraser KM, Fleming SB, et al. Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus. J Virol 1994; 68:84-92.
-
(1994)
J Virol
, vol.68
, pp. 84-92
-
-
Lyttle, D.J.1
Fraser, K.M.2
Fleming, S.B.3
-
23
-
-
0032553299
-
A novel type of vascular endothelial growth factor: Vegf-E (NZ-7 VEGF) preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain
-
Ogawa S, Oku A, Sawano A, et al. A novel type of Vascular Endothelial Growth Factor: VEGF-E (NZ-7 VEGF) preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain. J Biol Chem 1998; 273:31273-82.
-
(1998)
J Biol Chem
, vol.273
, pp. 31273-31282
-
-
Ogawa, S.1
Oku, A.2
Sawano, A.3
-
24
-
-
0033556287
-
A novel vascular endothelial growth factor encoded by orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases
-
Meyer M, Clauss M, Lepple-Wienhues A, et al. A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. EMBO J 1999; 18:363-74.
-
(1999)
EMBO J
, vol.18
, pp. 363-374
-
-
Meyer, M.1
Clauss, M.2
Lepple-Wienhues, A.3
-
25
-
-
13044287362
-
Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1
-
Wise LM, Veikkola T, Mercer AA, et al. Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. Proc Natl Acad Sci USA 1999; 96:3071-6.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3071-3076
-
-
Wise, L.M.1
Veikkola, T.2
Mercer, A.A.3
-
26
-
-
0035955692
-
Molecular cloning and expression of a functional snake venom vascular endothelium growth factor (VEGF) from the bothrops insularis pit viper. A new member of the VEGF family of proteins
-
Junqueira de Azevedo IL, Farsky SH, Oliveira ML, et al. Molecular cloning and expression of a functional snake venom vascular endothelium growth factor (VEGF) from the Bothrops insularis pit viper. A new member of the VEGF family of proteins. J Biol Chem 2001; 276:39836-42.
-
(2001)
J Biol Chem
, vol.276
, pp. 39836-39842
-
-
Junqueira De Azevedo, I.L.1
Farsky, S.H.2
Oliveira, M.L.3
-
27
-
-
0033533401
-
Vascular endothelial growth factor VEGF-like heparin-binding protein from the venom of vipera aspis aspis (Aspic viper)
-
Komori Y, Nikai T, Taniguchi K, et al. Vascular endothelial growth factor VEGF-like heparin-binding protein from the venom of Vipera aspis aspis (Aspic viper). Biochemistry 1999; 38:11796-803.
-
(1999)
Biochemistry
, vol.38
, pp. 11796-803
-
-
Komori, Y.1
Nikai, T.2
Taniguchi, K.3
-
28
-
-
0037119446
-
Complete structure of an increasing capillary permeability protein (ICPP) purified from vipera lebetina venom. ICPP is angiogenic via vascular endo-thelial growth factor receptor signalling
-
Gasmi A, Bourcier C, Aloui Z, et al. Complete structure of an increasing capillary permeability protein (ICPP) purified from Vipera lebetina venom. ICPP is angiogenic via vascular endo-thelial growth factor receptor signalling. J Biol Chem 2002; 277:29992-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 29992-29998
-
-
Gasmi, A.1
Bourcier, C.2
Aloui, Z.3
-
29
-
-
8544262237
-
A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential xignaling via VEGF receptor-1
-
Takahashi H, Hattori S, Iwamatsu A, et al. A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential xignaling via VEGF receptor-1. J Biol Chem 2004; 279:46304-14.
-
(2004)
J Biol Chem
, vol.279
, pp. 46304-46314
-
-
Takahashi, H.1
Hattori, S.2
Iwamatsu, A.3
-
30
-
-
0346101800
-
Snake venom vascular endothelial growth factors (VEGFs) exhibit potent activity through their specific recognition of KDR (VEGF receptor 2)
-
Yamazaki Y, Takani K, Atoda H, et al. Snake venom vascular endothelial growth factors (VEGFs) exhibit potent activity through their specific recognition of KDR (VEGF receptor 2). J Biol Chem 2003; 278:51985-8.
-
(2003)
J Biol Chem
, vol.278
, pp. 51985-51988
-
-
Yamazaki, Y.1
Takani, K.2
Atoda, H.3
-
31
-
-
0034648793
-
Vascular-specific growth factors and blood vessel formation
-
Yancopoulos GD, Davis S, Gale NW, et al. Vascular-specific growth factors and blood vessel formation. Nature 2000; 407:242-8.
-
(2000)
Nature
, vol.407
, pp. 242-248
-
-
Yancopoulos, G.D.1
Davis, S.2
Gale, N.W.3
-
32
-
-
0037212712
-
Hepatocyte growth factor: From diagnosis to clinical applications
-
Funakoshi H, Nakamura T. Hepatocyte growth factor: from diagnosis to clinical applications. Clin Chim Acta 2003; 327:1-23.
-
(2003)
Clin Chim Acta
, vol.327
, pp. 1-23
-
-
Funakoshi, H.1
Nakamura, T.2
-
33
-
-
0037423321
-
Angiogenesis-independent endothelial protection of liver: Role of VEGFR-1
-
LeCouter J, Moritz DR, Li B, et al. Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 2003; 299:890-3.
-
(2003)
Science
, vol.299
, pp. 890-893
-
-
LeCouter, J.1
Moritz, D.R.2
Li, B.3
-
34
-
-
0028363506
-
In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells
-
Pepper MS, Wasi S, Ferrara N, et al. In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells. Exp Cell Res 1994; 210:298-305.
-
(1994)
Exp Cell Res
, vol.210
, pp. 298-305
-
-
Pepper, M.S.1
Wasi, S.2
Ferrara, N.3
-
35
-
-
17144402207
-
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
-
Hirakawa S, Kodama S, Kunstfeld R, et al. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 2005; 201:1089-99.
-
(2005)
J Exp Med
, vol.201
, pp. 1089-1099
-
-
Hirakawa, S.1
Kodama, S.2
Kunstfeld, R.3
-
36
-
-
16644382257
-
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
-
Storkebaum E, Lambrechts D, Dewerchin M, et al. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Natute Neurosci 2005; 8:85-92.
-
(2005)
Natute Neurosci
, vol.8
, pp. 85-92
-
-
Storkebaum, E.1
Lambrechts, D.2
Dewerchin, M.3
-
37
-
-
2642526164
-
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
-
Azzouz M, Ralph GS, Storkebaum E, et al. VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 2004; 429:413-7.
-
(2004)
Nature
, vol.429
, pp. 413-417
-
-
Azzouz, M.1
Ralph, G.S.2
Storkebaum, E.3
-
38
-
-
33344460695
-
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
-
Le Bras B, Barallobre MJ, Homman-Ludiye J, et al. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nature Neurosci 2006; 9:340-8.
-
(2006)
Nature Neurosci
, vol.9
, pp. 340-348
-
-
Le Bras, B.1
Barallobre, M.J.2
Homman-Ludiye, J.3
-
39
-
-
0343920277
-
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
-
Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380:435-9.
-
(1996)
Nature
, vol.380
, pp. 435-439
-
-
Carmeliet, P.1
Ferreira, V.2
Breier, G.3
-
40
-
-
0030004485
-
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
-
Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996; 380:439-42.
-
(1996)
Nature
, vol.380
, pp. 439-442
-
-
Ferrara, N.1
Carver-Moore, K.2
Chen, H.3
-
41
-
-
25144511910
-
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
-
Takahashi H, Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond) 2005; 109:227-41.
-
(2005)
Clin Sci (Lond)
, vol.109
, pp. 227-241
-
-
Takahashi, H.1
Shibuya, M.2
-
42
-
-
0032875460
-
Mechanism of action and in vivo role of platelet-derived growth factor
-
Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999; 79:1283-316.
-
(1999)
Physiol Rev
, vol.79
, pp. 1283-1316
-
-
Heldin, C.H.1
Westermark, B.2
-
43
-
-
0029965081
-
Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain
-
Soker S, Fidder H, Neufeld G, et al. Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain. J Biol Chem 1996; 271:5761-7.
-
(1996)
J Biol Chem
, vol.271
, pp. 5761-5767
-
-
Soker, S.1
Fidder, H.2
Neufeld, G.3
-
44
-
-
0032549799
-
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
-
Soker S, Takashima S, Miao HQ, et al. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998; 92:735-45.
-
(1998)
Cell
, vol.92
, pp. 735-745
-
-
Soker, S.1
Takashima, S.2
Miao, H.Q.3
-
45
-
-
0036166701
-
Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
-
Maes C, Carmeliet P, Moermans K, et al. Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Mech Dev 2002; 111:61-73.
-
(2002)
Mech Dev
, vol.111
, pp. 61-73
-
-
Maes, C.1
Carmeliet, P.2
Moermans, K.3
-
46
-
-
0032925156
-
Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
-
Carmeliet P, Ng YS, Nuyens D, et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nature Med 1999; 5:495-502.
-
(1999)
Nature Med
, vol.5
, pp. 495-502
-
-
Carmeliet, P.1
Ng, Y.S.2
Nuyens, D.3
-
47
-
-
0037108152
-
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
-
Ruhrberg C, Gerhardt H, Golding M, et al. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev 2002; 16:2684-98.
-
(2002)
Genes Dev
, vol.16
, pp. 2684-2698
-
-
Ruhrberg, C.1
Gerhardt, H.2
Golding, M.3
-
48
-
-
0028221238
-
Vascular endo-thelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells
-
Pertovaara L, Kaipainen A, Mustonen T, et al. Vascular endo-thelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J Biol Chem 1994; 269:6271-4.
-
(1994)
J Biol Chem
, vol.269
, pp. 6271-6274
-
-
Pertovaara, L.1
Kaipainen, A.2
Mustonen, T.3
-
49
-
-
0029805574
-
Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma
-
Warren RS, Yuan H, Matli MR, et al. Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J Biol Chem 1996; 271:29483-8.
-
(1996)
J Biol Chem
, vol.271
, pp. 29483-29488
-
-
Warren, R.S.1
Yuan, H.2
Matli, M.R.3
-
50
-
-
0031940839
-
Vascular endothe-lial growth factor is essential for corpus luteum angiogenesis
-
Ferrara N, Chen H, Davis-Smyth T, et al. Vascular endothe-lial growth factor is essential for corpus luteum angiogenesis. Nature Med 1998; 4:336-40.
-
(1998)
Nature Med
, vol.4
, pp. 336-340
-
-
Ferrara, N.1
Chen, H.2
Davis-Smyth, T.3
-
51
-
-
0037362890
-
HIF hydroxylation and the mammalian oxygen-sensing pathway
-
Safran M, Kaelin WG Jr. HIF hydroxylation and the mammalian oxygen-sensing pathway. J Clin Invest 2003; 111:779-83.
-
(2003)
J Clin Invest
, vol.111
, pp. 779-783
-
-
Safran, M.1
Kaelin Jr., W.G.2
-
52
-
-
0034979159
-
Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis
-
Dor Y, Porat R, Keshet E. Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis. Am J Physiol Cell Physiol 2001; 280:C1367-74
-
(2001)
Am J Physiol Cell Physiol
, vol.280
-
-
Dor, Y.1
Porat, R.2
Keshet, E.3
-
53
-
-
0029103274
-
Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer
-
Liu Y, Cox SR, Morita T, et al. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer. Circ Res 1995; 77:638-43.
-
(1995)
Circ Res
, vol.77
, pp. 638-643
-
-
Liu, Y.1
Cox, S.R.2
Morita, T.3
-
54
-
-
0031000736
-
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
-
Ema M, Taya S, Yokotani N, et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997; 94:4273-8.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4273-4278
-
-
Ema, M.1
Taya, S.2
Yokotani, N.3
-
55
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399:271-5.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
56
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan M, Kondo K, Yang H, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001; 292:464-8.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
-
57
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: Role of the HIF system
-
Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nature Med 2003; 9:677-84.
-
(2003)
Nature Med
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
58
-
-
0026505773
-
Molecular and biological properties of the vascular endothelial growth factor family of proteins
-
Ferrara N, Houck K, Jakeman L, et al. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 1992; 13(1):18-32.
-
(1992)
Endocr Rev
, vol.13
, Issue.1
, pp. 18-32
-
-
Ferrara, N.1
Houck, K.2
Jakeman, L.3
-
59
-
-
1842328560
-
Prognostic value of vascular endothelial growth factor and its receptor flt-1 in squamous cell lung cancer
-
Volm M, Koomagi R, Mattern J. Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. Int J Cancer 1997; 74:64-8.
-
(1997)
Int J Cancer
, vol.74
, pp. 64-68
-
-
Volm, M.1
Koomagi, R.2
Mattern, J.3
-
60
-
-
0029935566
-
Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer
-
Yoshiji H, Gomez DE, Shibuya M, et al. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res 1996; 56:2013-6.
-
(1996)
Cancer Res
, vol.56
, pp. 2013-2016
-
-
Yoshiji, H.1
Gomez, D.E.2
Shibuya, M.3
-
61
-
-
0028216495
-
Vascular permeability factor/endothelial growth factor (VPF/VEGF): Accumulation and expression in human synovial fluids and rheumatoid synovial tissue
-
Jul 1
-
Fava RA, Olsen NJ, Spencer-Green G, et al. Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 1994; Jul 1 180(1):341-6.
-
(1994)
J Exp Med
, vol.180
, Issue.1
, pp. 341-346
-
-
Fava, R.A.1
Olsen, N.J.2
Spencer-Green, G.3
-
62
-
-
3543002277
-
VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis
-
Dong J, Grunstein J, Tejada M, et al. VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J 2004; 23:2800-10.
-
(2004)
EMBO J
, vol.23
, pp. 2800-2810
-
-
Dong, J.1
Grunstein, J.2
Tejada, M.3
-
63
-
-
33644863498
-
Cross-species vascular endo-thelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF
-
Liang WC, Wu X, Peale FV, et al. Cross-species vascular endo-thelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J Biol Chem 2006; 281:951-61.
-
(2006)
J Biol Chem
, vol.281
, pp. 951-961
-
-
Liang, W.C.1
Wu, X.2
Peale, F.V.3
-
64
-
-
0028824336
-
Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121
-
Asano M, Yukita A, Matsumoto T, et al. Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121. Cancer Res 1995; 55:5296-301.
-
(1995)
Cancer Res
, vol.55
, pp. 5296-5301
-
-
Asano, M.1
Yukita, A.2
Matsumoto, T.3
-
65
-
-
0032502843
-
Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor
-
Kong HL, Hecht D, Song W, et al. Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor. Hum Gene Ther 1998; 9:823-33.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 823-833
-
-
Kong, H.L.1
Hecht, D.2
Song, W.3
-
66
-
-
0037143764
-
VEGF-trap: A VEGF blocker with potent antitumor effects
-
Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2002; 99:11393-8.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
-
67
-
-
0034652716
-
ZD4190: An orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy
-
Wedge SR, Ogilvie DJ, Dukes M, et al. ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy. Cancer Res 2000; 60:970-5.
-
(2000)
Cancer Res
, vol.60
, pp. 970-975
-
-
Wedge, S.R.1
Ogilvie, D.J.2
Dukes, M.3
-
68
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
Wood JM, Bold G, Buchdunger E, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 2000; 60:2178-89
-
(2000)
Cancer Res
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
Buchdunger, E.3
-
69
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355:2542-50.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
70
-
-
34447130180
-
FDA drug approval summary: Bevacizumab (Avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsqua-mous non-small cell lung cancer
-
Cohen MH, Gootenberg J, Keegan P, et al. FDA drug approval summary: bevacizumab (Avastin) plus Carboplatin and Paclitaxel as first-line treatment of advanced/metastatic recurrent nonsqua-mous non-small cell lung cancer. Oncologist 2007;12:713-8.
-
(2007)
Oncologist
, vol.12
, pp. 713-718
-
-
Cohen, M.H.1
Gootenberg, J.2
Keegan, P.3
-
71
-
-
0005419856
-
Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites yumors
-
Luo JC, Yamaguchi S, Shinkai A, et al. Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites yumors. Cancer Res 1998; 58:2652-60.
-
(1998)
Cancer Res
, vol.58
, pp. 2652-2660
-
-
Luo, J.C.1
Yamaguchi, S.2
Shinkai, A.3
-
72
-
-
0347377779
-
Differential inhibition of fluid accumulation and tumor growth in two mouse ascites tumors by an anti-vascular endothelial growth factor/permeability factor neutralizing antibody
-
Luo J-C, Toyoda M, Shibuya M. Differential inhibition of fluid accumulation and tumor growth in two mouse ascites tumors by an anti-vascular endothelial growth factor/permeability factor neutralizing antibody. Cancer Res 1998; 58:2594-2600.
-
(1998)
Cancer Res
, vol.58
, pp. 2594-2600
-
-
Luo, J.-C.1
Toyoda, M.2
Shibuya, M.3
-
73
-
-
0036344495
-
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-flt1
-
Luttun A, Tjwa M, Moons L, et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nature Med 2002; 8:831-40.
-
(2002)
Nature Med
, vol.8
, pp. 831-840
-
-
Luttun, A.1
Tjwa, M.2
Moons, L.3
-
74
-
-
10744228170
-
Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K/BxN model of rheumatoid arthritis
-
De Bandt M, Ben Mahdi MH, Ollivier V, et al. Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K/BxN model of rheumatoid arthritis. J Immunol 2003; 171:4853-9.
-
(2003)
J Immunol
, vol.171
, pp. 4853-4859
-
-
De Bandt, M.1
Ben Mahdi, M.H.2
Ollivier, V.3
-
75
-
-
33748703844
-
Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocyte/macrophages
-
Murakami M, Iwai S, Hiratsuka S, et al. Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocyte/macrophages. Blood 2006; 108:1849-56.
-
(2006)
Blood
, vol.108
, pp. 1849-1856
-
-
Murakami, M.1
Iwai, S.2
Hiratsuka, S.3
-
76
-
-
0026052391
-
Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor
-
Maglione D, Guerriero V, Viglietto G, et al. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA 1991; 88:9267-71.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 9267-9271
-
-
Maglione, D.1
Guerriero, V.2
Viglietto, G.3
-
77
-
-
19244379078
-
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
-
Carmeliet P, Moons L, Luttun A, et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nature Med 2001; 7:575-83.
-
(2001)
Nature Med
, vol.7
, pp. 575-583
-
-
Carmeliet, P.1
Moons, L.2
Luttun, A.3
-
78
-
-
0035902538
-
Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
-
Aase K, von Euler G, Li X, et al. Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect. Circulation 2001; 104:358-64.
-
(2001)
Circulation
, vol.104
, pp. 358-364
-
-
Aase, K.1
Von Euler, G.2
Li, X.3
-
79
-
-
0034041161
-
Missense mutations interfere with VEGFR-3 signalling in primary lymphoe-dema
-
Karkkainen MJ, Ferrell RE, Lawrence EC, et al. Missense mutations interfere with VEGFR-3 signalling in primary lymphoe-dema. Nature Genet 2000; 25:153-9.
-
(2000)
Nature Genet
, vol.25
, pp. 153-159
-
-
Karkkainen, M.J.1
Ferrell, R.E.2
Lawrence, E.C.3
-
80
-
-
0037423716
-
VEGFR-2-specific ligand VEGF-E induces non-edematous hyper- vascularization in mice
-
Kiba A, Sagara H, Hara T, et al. VEGFR-2-specific ligand VEGF-E induces non-edematous hyper-vascularization in mice. Biochem Biophys Res Commun 2003; 301:371-7.
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 371-377
-
-
Kiba, A.1
Sagara, H.2
Hara, T.3
-
81
-
-
33747382033
-
NZ7/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation
-
NZ7/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation. Arterioscler Thromb Vasc Biol 2006; 26:2019-26.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 2019-2026
-
-
Zheng, Y.1
Murakami, M.2
Takahashi, H.3
-
82
-
-
0032560844
-
VEGF/VPF overex-pression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development
-
Larcher F, Murillas R, Bolontrade M, et al. VEGF/VPF overex-pression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development. Oncogene 1998; 17:303-11.
-
(1998)
Oncogene
, vol.17
, pp. 303-311
-
-
Larcher, F.1
Murillas, R.2
Bolontrade, M.3
-
83
-
-
7144264398
-
Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
-
Detmar M, Brown LF, Schon MP, et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 1998; 111:1-6.
-
(1998)
J Invest Dermatol
, vol.111
, pp. 1-6
-
-
Detmar, M.1
Brown, L.F.2
Schon, M.P.3
-
84
-
-
0025259592
-
Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family
-
Shibuya M, Yamaguchi S, Yamane A, et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 1990; 5:519-24.
-
(1990)
Oncogene
, vol.5
, pp. 519-524
-
-
Shibuya, M.1
Yamaguchi, S.2
Yamane, A.3
-
85
-
-
0026572345
-
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
-
De Vries C, Escobedo JA, Ueno H, et al. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 1992; 255:989-91.
-
(1992)
Science
, vol.255
, pp. 989-991
-
-
De Vries, C.1
Escobedo, J.A.2
Ueno, H.3
-
86
-
-
0025739016
-
Identification of a new endothelial cell growth factor receptor tyrosine kinase
-
Terman BI, Carrion ME, Kovacs E, et al. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 199; 6:1677-83.
-
Oncogene
, vol.199
, Issue.6
, pp. 1677-1683
-
-
Terman, B.I.1
Carrion, M.E.2
Kovacs, E.3
-
87
-
-
0025998533
-
A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit
-
Matthews W, Jordan CT, Gavin M, et al. A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci USA 1991; 88:9026-30.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 9026-9030
-
-
Matthews, W.1
Jordan, C.T.2
Gavin, M.3
-
88
-
-
0027466849
-
High affinity VEGF binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis
-
Millauer B, Wizigmann-Voos S, Schnurch H, et al. High affinity VEGF binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993; 72:835-46.
-
(1993)
Cell
, vol.72
, pp. 835-846
-
-
Millauer, B.1
Wizigmann-Voos, S.2
Schnurch, H.3
-
89
-
-
0027232628
-
The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor
-
Galland F, Karamysheva A, Pebusque MJ, et al. The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor. Oncogene 1993; 8:1233-40.
-
(1993)
Oncogene
, vol.8
, pp. 1233-1240
-
-
Galland, F.1
Karamysheva, A.2
Pebusque, M.J.3
-
90
-
-
33646228404
-
Distinct genetic interactions between multiple vegf receptors are required for development of different blood vessel types in zebrafish
-
Covassin LD, Villefranc JA, Kacergis MC, et al. Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proc Natl Acad Sci USA 2006; 103:6554-9.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6554-6559
-
-
Covassin, L.D.1
Villefranc, J.A.2
Kacergis, M.C.3
-
91
-
-
0027997863
-
Different signal transduction properties of KDR and flt1, two receptors for vascular endothelial growth factor
-
Waltenberger J, Claesson-Welsh L, Siegbahn A, et al. Different signal transduction properties of KDR and Flt1, two receptors for Vascular Endothelial Growth Factor. J Biol Chem 1994; 269:26988-95.
-
(1994)
J Biol Chem
, vol.269
, pp. 26988-26995
-
-
Waltenberger, J.1
Claesson-Welsh, L.2
Siegbahn, A.3
-
92
-
-
0028798083
-
A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothe-lial growth factor VEGF
-
Seetharam L, Gotoh N, Maru Y, et al. A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothe-lial growth factor VEGF. Oncogene 1995; 10:135-47.
-
(1995)
Oncogene
, vol.10
, pp. 135-147
-
-
Seetharam, L.1
Gotoh, N.2
Maru, Y.3
-
93
-
-
0030050025
-
Flt-1 but not KDR/flk-1 tyrosine kinase is a receptor for placenta growth factor (PlGF), which is related to vascular endothelial growth factor (VEGF)
-
Sawano A, Takahashi T, Yamaguchi S, et al. Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for Placenta Growth Factor (PlGF), which is related to vascular endothelial growth factor (VEGF). Cell Growth Differ 1996; 7:213-21.
-
(1996)
Cell Growth Differ
, vol.7
, pp. 213-221
-
-
Sawano, A.1
Takahashi, T.2
Yamaguchi, S.3
-
94
-
-
0027421333
-
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
-
Kendall RL, Thomas KA. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA 1993; 90:10705-9.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 10705-10709
-
-
Kendall, R.L.1
Thomas, K.A.2
-
95
-
-
0036290513
-
Soluble flt-1 (soluble VEGFR-1), a potent natural anti-angiogenic molecule in mammals, is phylogenetically conserved in avians
-
Yamaguchi S, Iwata K, Shibuya M. Soluble Flt-1 (soluble VEGFR-1), a potent natural anti-angiogenic molecule in mammals, is phylogenetically conserved in avians. Biochem Biophys Res Commun 2002; 291:554-9.
-
(2002)
Biochem Biophys Res Commun
, vol.291
, pp. 554-559
-
-
Yamaguchi, S.1
Iwata, K.2
Shibuya, M.3
-
96
-
-
0029021660
-
Role of the flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
-
Fong GH, Rossant J, Gertsentein M, et al. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995; 376:66-70.
-
(1995)
Nature
, vol.376
, pp. 66-70
-
-
Fong, G.H.1
Rossant, J.2
Gertsentein, M.3
-
97
-
-
0032482978
-
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angio-genesis in mice
-
Hiratsuka S, Minowa O, Kuno J, et al. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angio-genesis in mice. Proc Natl Acad Sci USA 1998; 95:9349-54.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9349-9354
-
-
Hiratsuka, S.1
Minowa, O.2
Kuno, J.3
-
98
-
-
0029929716
-
The vascular endothelial growth factor receptor flt-1 madiates biological activities
-
Clauss M, Weich H, Breier G, et al. The vascular endothelial growth factor receptor Flt-1 madiates biological activities. J Biol Chem 1996; 271:17629-34.
-
(1996)
J Biol Chem
, vol.271
, pp. 17629-17634
-
-
Clauss, M.1
Weich, H.2
Breier, G.3
-
99
-
-
0029867554
-
Migration of human monocytes in response to vascular endothelilal growth factor (VEGF) is mediated via the VEGF receptor flt-1
-
Barleon B, Sozzani S, Zhou D, et al. Migration of human monocytes in response to vascular endothelilal growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 1996; 87:3336-43.
-
(1996)
Blood
, vol.87
, pp. 3336-3343
-
-
Barleon, B.1
Sozzani, S.2
Zhou, D.3
-
100
-
-
0035254646
-
Vascular endothelial growth factor receptor-1 (Flt-1) is a novel cell surface marker for the lineage of monocyte-macrophages in humans
-
Sawano A, Iwai S, Sakurai Y, et al. Vascular endothelial growth factor receptor-1 (Flt-1) is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood 2001; 97:785-91.
-
(2001)
Blood
, vol.97
, pp. 785-791
-
-
Sawano, A.1
Iwai, S.2
Sakurai, Y.3
-
101
-
-
0035114105
-
Involvement of flt-1 tyro-sine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis
-
Hiratsuka S, Maru Y, Okada A, et al. Involvement of Flt-1 tyro-sine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res 2001; 61:1207-13.
-
(2001)
Cancer Res
, vol.61
, pp. 1207-1213
-
-
Hiratsuka, S.1
Maru, Y.2
Okada, A.3
-
102
-
-
0035160312
-
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
-
Lyden D, Hattori K, Dias S, et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature Med 2001; 7:1194-201.
-
(2001)
Nature Med
, vol.7
, pp. 1194-1201
-
-
Lyden, D.1
Hattori, K.2
Dias, S.3
-
103
-
-
0036782035
-
MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung specific metastasis
-
Hiratsuka S, Nakamura K, Iwai S, et al. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung specific metastasis. Cancer Cell 2002; 2:289-300.
-
(2002)
Cancer Cell
, vol.2
, pp. 289-300
-
-
Hiratsuka, S.1
Nakamura, K.2
Iwai, S.3
-
104
-
-
28644432204
-
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
-
Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005; 438:820-7.
-
(2005)
Nature
, vol.438
, pp. 820-827
-
-
Kaplan, R.N.1
Riba, R.D.2
Zacharoulis, S.3
-
105
-
-
20844461824
-
Essential role of vascular endothelial growth factor and flt-1 signals in neointimal formation after periadventitial injury
-
Zhao Q, Egashira K, Hiasa KI, et al. Essential role of vascular endothelial growth factor and Flt-1 signals in neointimal formation after periadventitial injury. Arterioscler Thromb Vasc Biol 2004; 24:2284-9.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 2284-2289
-
-
Zhao, Q.1
Egashira, K.2
Hiasa, K.I.3
-
106
-
-
6444243603
-
Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells
-
Ohtani K, Egashira K, Hiasa KI, et al. Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells. Circulation 2004; 110:2444-52.
-
(2004)
Circulation
, vol.110
, pp. 2444-2452
-
-
Ohtani, K.1
Egashira, K.2
Hiasa, K.I.3
-
107
-
-
0038030642
-
Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia
-
Koga K, Osuga Y, Yoshino O, et al. Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia. J Clin Endocrinol Metab 2003; 88:2348-51.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 2348-2351
-
-
Koga, K.1
Osuga, Y.2
Yoshino, O.3
-
108
-
-
0037373006
-
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
-
Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111:649-58.
-
(2003)
J Clin Invest
, vol.111
, pp. 649-658
-
-
Maynard, S.E.1
Min, J.Y.2
Merchan, J.3
-
109
-
-
10744227199
-
Circulating angiogenic factors and the risk of preeclampsia
-
Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350:672-83.
-
(2004)
N Engl J Med
, vol.350
, pp. 672-683
-
-
Levine, R.J.1
Maynard, S.E.2
Qian, C.3
-
110
-
-
33750430869
-
Corneal avascularity is due to soluble VEGF receptor-1
-
Ambati BK, Nozaki M, Singh N, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature 2006; 443:993-7.
-
(2006)
Nature
, vol.443
, pp. 993-997
-
-
Ambati, B.K.1
Nozaki, M.2
Singh, N.3
-
111
-
-
0029006696
-
Failure of blood-Island formation and vasculogenesis in flk-1-deficient mice
-
Shalaby F, Rossant J, Yamaguchi T P, et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 1995; 376:62-6.
-
(1995)
Nature
, vol.376
, pp. 62-66
-
-
Shalaby, F.1
Rossant, J.2
Yamaguchi, T.P.3
-
112
-
-
0035355472
-
A single auto-phosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells
-
Takahashi T, Yamaguchi S, Chida K, et al. A Single auto-phosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells. EMBO J 2001; 20:2768-78.
-
(2001)
EMBO J
, vol.20
, pp. 2768-2778
-
-
Takahashi, T.1
Yamaguchi, S.2
Chida, K.3
-
113
-
-
0035980051
-
Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothe-lial growth factor-induced endothelium migration and proliferation, respectively
-
Zeng H, Sanyal S, Mukhopadhyay D. Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothe-lial growth factor-induced endothelium migration and proliferation, respectively. J Biol Chem 2001; 276:32714-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 32714-32719
-
-
Zeng, H.1
Sanyal, S.2
Mukhopadhyay, D.3
-
114
-
-
0033118228
-
VEGF activates protein kinase C-dependent, but ras-independent raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
-
Takahashi T, Ueno H, Shibuya M. VEGF activates Protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 1999; 18:2221-30.
-
(1999)
Oncogene
, vol.18
, pp. 2221-2230
-
-
Takahashi, T.1
Ueno, H.2
Shibuya, M.3
-
115
-
-
22744447871
-
VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis
-
Matsumoto T, Bohman S, Dixelius J, et al. VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. EMBO J 2005; 24:2342-53.
-
(2005)
EMBO J
, vol.24
, pp. 2342-2353
-
-
Matsumoto, T.1
Bohman, S.2
Dixelius, J.3
-
116
-
-
12844264070
-
Essential role of flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice
-
Sakurai Y, Ohgimoto K, Kataoka Y, et al. Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci USA 2005; 102:1076-81.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1076-1081
-
-
Sakurai, Y.1
Ohgimoto, K.2
Kataoka, Y.3
-
117
-
-
0033597718
-
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
-
Carmeliet P, Lampugnani MG, Moons L, et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 1999; 98:147-157.
-
(1999)
Cell
, vol.98
, pp. 147-157
-
-
Carmeliet, P.1
Lampugnani, M.G.2
Moons, L.3
-
118
-
-
0037047090
-
VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells
-
Shay-Salit A, Shushy M, Wolfovitz E, et al. VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. Proc Natl Acad Sci USA 2002; 99: 9462-7.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 9462-9467
-
-
Shay-Salit, A.1
Shushy, M.2
Wolfovitz, E.3
-
120
-
-
0035956947
-
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
-
Fukumura D, Gohongi T, Kadambi A, et al. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci USA 2001; 98:2604-9.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 2604-2609
-
-
Fukumura, D.1
Gohongi, T.2
Kadambi, A.3
-
121
-
-
33748581389
-
Targeted approaches for treating advanced clear cell renal carcinoma
-
van Spronsen DJ, De Mulder PH. Targeted approaches for treating advanced clear cell renal carcinoma. Onkologie 2006; 29:394-402.
-
(2006)
Onkologie
, vol.29
, pp. 394-402
-
-
Van Spronsen, D.J.1
De Mulder, P.H.2
-
122
-
-
33749503264
-
KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties
-
Nakamura K, Taguchi E, Miura T, et al. KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res 2006; 66:9134-42.
-
(2006)
Cancer Res
, vol.66
, pp. 9134-9142
-
-
Nakamura, K.1
Taguchi, E.2
Miura, T.3
-
123
-
-
0032582502
-
Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
-
Dumont DJ, Jussila L, Taipale J, et al. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 1998; 282:946-9.
-
(1998)
Science
, vol.282
, pp. 946-949
-
-
Dumont, D.J.1
Jussila, L.2
Taipale, J.3
-
124
-
-
20444414142
-
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation
-
Morisada T, Oike Y, Yamada Y, et al. Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood 2005; 105:4649-56.
-
(2005)
Blood
, vol.105
, pp. 4649-4656
-
-
Morisada, T.1
Oike, Y.2
Yamada, Y.3
-
125
-
-
0032707249
-
A requirement for neuropilin-1 in embryonic vessel formation
-
Kawasaki T, Kitsukawa T, Bekku Y, et al. A requirement for neuropilin-1 in embryonic vessel formation. Development 1999; 126:4895-902.
-
(1999)
Development
, vol.126
, pp. 4895-4902
-
-
Kawasaki, T.1
Kitsukawa, T.2
Bekku, Y.3
-
126
-
-
0036803751
-
Abnormal lymphatic vessel development in neuropilin 2 mutant mice
-
Yuan L, Moyon D, Pardanaud L, et al. Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development 2002; 129:4797-806.
-
(2002)
Development
, vol.129
, pp. 4797-4806
-
-
Yuan, L.1
Moyon, D.2
Pardanaud, L.3
-
127
-
-
33751504690
-
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
-
Hiratsuka S, Watanabe A, Aburatani H, eta al. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nature Cell Biol 2006; 8:1369-75.
-
(2006)
Nature Cell Biol
, vol.8
, pp. 1369-1375
-
-
Hiratsuka, S.1
Watanabe, A.2
Aburatani, H.3
|