Tyrosine Residues 951 and 1059 of Vascular Endothelial Growth Factor Receptor-2 (KDR) Are Essential for Vascular Permeability Factor/Vascular Endothelial Growth Factor-induced Endothelium Migration and Proliferation, Respectively

Journal of Biological Chemistry

Volumn 276, Issue 35, 2001, Pages 32714-32719

  Zeng, Huiyan ^b   Sanyal, Sohini ^b   Mukhopadhyay, Debabrata ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CALCIUM; CELLS; ENZYMES;

ENDOTHELIAL GROWTH; PHOSPHORYLATION;

BIOCHEMISTRY;

EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHENYLALANINE; PROTEIN TYROSINE KINASE; TYROSINE DERIVATIVE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; CALCIUM; ENDOTHELIAL CELL GROWTH FACTOR; GROWTH FACTOR RECEPTOR; ISOPROTEIN; LYMPHOKINE; RECOMBINANT PROTEIN; TYROSINE; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL MIGRATION; CELL PROLIFERATION; CHIMERA; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MUTANT; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; VASCULAR ENDOTHELIUM; CALCIUM SIGNALING; CELL CULTURE; CELL DIVISION; CELL MOTION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY; UMBILICAL VEIN;

AMINO ACID SUBSTITUTION; CALCIUM; CALCIUM SIGNALING; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; HUMANS; LYMPHOKINES; MUTAGENESIS, SITE-DIRECTED; PROTEIN ISOFORMS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT PROTEINS; TYROSINE; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035980051     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103130200     Document Type: Article

References (36)

1. Folkman, J. (1996) Sci. Am. 275, 150-154
2. Folkman, J. (1971) N. Engl. J. Med. 285, 1182-1186
3. Folkman, J., and Klagsburn, M. (1987) Science 235, 442-447
4. Folkman, J., Watson, K., Ingber, D., and Hanahan, D. (1989) Nature 339, 58-61
5. Dvorak, H. F., Nagy, J. A., Feng, D., Brown, L. F., and Dvorak, A. M. (1999) Curr. Top. Microbiol. Immunol. 237, 97-132
6. Risau, W. (1997) Nature 386, 671-674
7. Benezra, M., Vlodasky, I., Ishai-Michaeli, R., Neufeld, G., and Bar-Shavit, R. (1993) Blood 81, 3324-3331
8. Senger, D. R., Galli, S. J., Dvorak, A. M., Perruzzi, C. A., Harvey, V. S., and Dvorak, H. F. (1983) Science 219, 983-985
9. Vlodavsky, I., Fuks, Z., Ishai-Michaeli, R., Bashkin, P., Levi, E., Korner, G., Bar-Shavit, R., and Klagsbrun, M. (1991) J. Cell. Biochem. 45, 167-176
10. Dvorak, H. F. (1990) Prog. Clin. Biol. Res. 354A, 317-330
11. Dvorak, H. F., Orenstein, N. S., Carvalho, A. C., Churchill, W. H., Dvorak, A. M., Galli, S. J., Feder, J., Bitzer, A. M., Rypysc, J., and Giovinco, P. (1979) J. Immunol. 122, 166-174
12. Dvorak, H. F., Senger, D. R., and Dvorak, A. M. (1984) Dev. Oncol. 22, 96-114
13. Ferrara, N. (1999) Curr. Top. Microbiol. Immunol. 237, 1-30
14. Seghezzi, G., Patel, S., Ren, C. J., Gualandris, A., Pintucci, G., Robbins, E. S., Shapiro, R. L., Galloway, A. C., Rifkin, D. B., and Mignatti, P. (1998) J. Cell Biol. 141, 1659-1673
15. Leung, D. W., Cachianes, G., Kuang, W. J., Goeddel, D. V., and Ferrara, N. (1989) Science 246, 1306-1309
16. Senger, D. R., Perruzzi, C. A., Feder, J., and Dvorak, H. F. (1986) Cancer Res. 46, 5629-5632
17. Gagnon, M. L., Bielenberg, D. R., Gechtman, Z., Miao, H. Q., Takashima, S., Soker, S., and Klagsbrun, M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2573-2578
18. Soker, S., Takashima, S., Miao, H. Q., Neufeld, G., and Klagsbrun, M. (1998) Cell 92, 735-745
19. Fong, G. H., Rossant, J., Gertsenstein, M., and Breitman, M. L. (1995) Nature 376, 66-70
20. Shalaby, F., Ho, J., Stanford, W. L., Fischer, K. D., Schuh, A. C., Schwartz, L., Bernstein, A., and Rossant, J. (1997) Cell 89, 981-990
21. Joukov, V., Sorsa, T., Kumar, V., Jeltsch, M., Claesson-Welsh, L., Cao, Y., Saksela, O., Kalkkinen, N., and Alitalo, K. (1997) EMBO J. 16, 3898-3911
22. Waltenberger, J., Claesson-Welsh, L., Siegbahn, A., Shibuya, M., and Heldin, C. H. (1994) J. Biol. Chem. 269, 26988-26995
23. Petrova, T. V., Makinen, T., and Alitalo, K. (1999) Exp. Cell Res. 253, 117-130
24. Kanno, S., Oda, N., Abe, M., Terai, Y., Ito, M., Shitara, K., Tabayashi, K., Shibuya, M., and Sato, Y. (2000) Oncogene 19, 2138-2146
25. Bernatchez, P. N., Soker, S., and Sirois, M. G. (1999) J. Biol. Chem. 274, 31047-31054
26. Gille, H., Kowalski, J., Li, B., LeCouter, J., Moffat, B., Zioncheck, T. F., Pelletier, N., and Ferrara, N. (2001) J. Biol. Chem. 276, 3222-3230
27. Zeng, H., Dvorak, H. F., and Mukhopadhyay, D. (2001) J. Biol. Chem. 276, 26969-26979
28. Dougher-Vermazen, M., Hulmes, J. D., Bohlen, P., and Terman, B. I. (1994) Biochem. Biophys. Res. Commun. 205, 728-738
29. Ito, N., Wernstedt, C., Engstrom, U., and Claesson-Welsh, L. (1998) J. Biol. Chem. 273, 23410-23418
30. Seetharam, L., Gotoh, N., Maru, Y., Neufeld, G., Yamaguchi, S., and Shibuya, M. (1995) Oncogene 10, 135-147
31. Brock, T. A., Dvorak, H. F., and Senger, D. R. (1991) Am. J. Pathol. 138, 213-221
32. Millauer, B., Shawver, L. K., Plate, K. H., Risau, W., and Ullrich, A. (1994) Nature 367, 576-579
33. Dougher, M., and Terman, B. I. (1999) Oncogene 18, 1619-1627
34. Shibuya, M., Ito, N., and Claesson-Welsh, L. (1999) Curr. Top. Microbiol. Immunol. 237, 59-83
35. Dayanir, V., Meyer, R., Lashkari, K., and Rahimi, N. (2001) J. Bio. Chem. 276, 17686-17692
36. Gerber, H. P., McMurtrey, A., Kowalski, J., Yan, M., Keyt, B. A., Dixit, V., and Ferrara, N. (1998) J. Biol. Chem. 273, 30336-30343