Soluble Flt-1 (soluble VEGFR-1), a potent natural antiangiogenic molecule in mammals, is phylogenetically conserved in avians

Biochemical and Biophysical Research Communications

Volumn 291, Issue 3, 2002, Pages 554-559

  Yamaguchi, Sachiko ^a   Iwata, Kumi ^a   Shibuya, Masabumi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Angiogenesis; Avian system; Flt 1; Intron derived sequence; Phylogenetical conservation; Placental development; Soluble Flt 1; Tyrosine kinase receptor; VEGF

Indexed keywords

RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHICKEN; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; HUMAN; INTRON; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; REGULATORY MECHANISM;

AVES; GALLUS GALLUS; MAMMALIA; VERTEBRATA;

EID: 0036290513     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6478     Document Type: Article

References (32)

1. The biology of vascular endothelial growth factor
2. Structure and function of VEGF receptor-1 and -2
3. Endothelial receptor tyrosine kinases involved in angiogenesis
4. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family
5. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
6. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
7. High affinity VEGF binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis
8. Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor (PlGF), which is related to vascular endothelial growth factor (VEGF)
9. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
10. A novel type of vascular endothelial growth factor: VEGF-E (NZ-7 VEGF) preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain
11. A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signaling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases
12. Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1
13. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
14. A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF
15. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
16. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
17. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
18. Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors
19. Localization of VEGF and expression of its receptors flt and KDR in human placenta throughout pregnancy
20. Amniotic fluid - Soluble vascular endothelial growth factor receptor-1 in preeclampsia
21. Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies
22. Developmental regulation of vascular endothelial growth/permeability factor messenger ribonucleic acid levels in and vascularization of the villous placenta during baboon pregnancy
23. Alternative splicing of vascular endothelial growth factor (VEGF)-R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity
24. Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptor-like molecule
25. Molecular cloning of Quek 1 and 2, two quail vascular endothelial growth factor (VEGF) receptor-like molecules
26. Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor
27. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidyl-inositol 3′-kinase activation and endothelial cell migration
28. Flt-1, a receptor for vascular endothelial growth factor, has transforming and morphogenic potentials
29. An oncogenic form of the Flt-1 kinase has a tubulogenic potential in a sinusoidal endothelial cell line
30. The phosphorylated 1169-tyrosine containing region of Flt-1 kinase (VEGFR-1) is a major binding site for PLCγ
31. Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules
32. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-3 and DNA synthesis in vascular endothelial cells