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Volumn 24, Issue 13, 2005, Pages 2342-2353

VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis

Author keywords

Actin cytoskeleton; TSAd; Tumor angiogenesis; Tyrosine phosphorylation site; VEGFR 2

Indexed keywords

ACTIN; ADAPTOR PROTEIN; BROXURIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TSAD; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

EID: 22744447871     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600709     Document Type: Article
Times cited : (236)

References (27)
  • 1
    • 0036718947 scopus 로고    scopus 로고
    • Small molecule inhibitors of KDR (VEGFR-2) kinase: An overview of structure activity relationships
    • Boyer SJ (2002) Small molecule inhibitors of KDR (VEGFR-2) kinase: an overview of structure activity relationships. Curr Top Med Chem 2: 973-1000
    • (2002) Curr Top Med Chem , vol.2 , pp. 973-1000
    • Boyer, S.J.1
  • 4
    • 0003477424 scopus 로고    scopus 로고
    • Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation
    • Choi YB, Kim CK, Yun Y (1999) Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation. J Immunol 163: 5242-5249
    • (1999) J Immunol , vol.163 , pp. 5242-5249
    • Choi, Y.B.1    Kim, C.K.2    Yun, Y.3
  • 5
    • 17044458971 scopus 로고    scopus 로고
    • Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites
    • Dixelius J, Makinen T, Wirzenius M, Karkkainen MJ, Wernstedt C, Alitalo K, Claesson-Welsh L (2003) Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites. J Biol Chem 278: 40973-40979
    • (2003) J Biol Chem , vol.278 , pp. 40973-40979
    • Dixelius, J.1    Makinen, T.2    Wirzenius, M.3    Karkkainen, M.J.4    Wernstedt, C.5    Alitalo, K.6    Claesson-Welsh, L.7
  • 6
    • 0033602091 scopus 로고    scopus 로고
    • Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
    • Dougher M, Terman BI (1999) Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Oncogene 18: 1619-1627
    • (1999) Oncogene , vol.18 , pp. 1619-1627
    • Dougher, M.1    Terman, B.I.2
  • 7
    • 0028170578 scopus 로고
    • Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor
    • Dougher-Vermazen M, Hulmes JD, Bohlen P, Terman BI (1994) Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor. Biochem Biophys Res Commun 205: 728-738
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 728-738
    • Dougher-Vermazen, M.1    Hulmes, J.D.2    Bohlen, P.3    Terman, B.I.4
  • 8
    • 0036985699 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications
    • Ferrara N (2002) Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin Oncol 29: 10-14
    • (2002) Semin Oncol , vol.29 , pp. 10-14
    • Ferrara, N.1
  • 9
    • 1842584776 scopus 로고    scopus 로고
    • Newest findings on the oldest oncogene; how activated src does it
    • Frame MC (2004) Newest findings on the oldest oncogene; how activated src does it. J Cell Sci 117: 989-998
    • (2004) J Cell Sci , vol.117 , pp. 989-998
    • Frame, M.C.1
  • 10
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 11
    • 2542455474 scopus 로고    scopus 로고
    • The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration
    • Holmqvist K, Cross MJ, Rolny C, Hagerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M (2004) The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J Biol Chem 279: 22267-22275
    • (2004) J Biol Chem , vol.279 , pp. 22267-22275
    • Holmqvist, K.1    Cross, M.J.2    Rolny, C.3    Hagerkvist, R.4    Rahimi, N.5    Matsumoto, T.6    Claesson-Welsh, L.7    Welsh, M.8
  • 12
    • 0032483374 scopus 로고    scopus 로고
    • Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules
    • Ito N, Wernstedt C, Engstrom U, Claesson-Welsh L (1998) Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules. J Biol Chem 273: 23410-23418
    • (1998) J Biol Chem , vol.273 , pp. 23410-23418
    • Ito, N.1    Wernstedt, C.2    Engstrom, U.3    Claesson-Welsh, L.4
  • 13
    • 1842293350 scopus 로고    scopus 로고
    • Flk-1 expression defines a population of early embryonic hematopoietic precursors
    • Kabrun N, Buhring HJ, Choi K, Ullrich A, Risau W, Keller G (1997) Flk-1 expression defines a population of early embryonic hematopoietic precursors. Development 124: 2039-2048
    • (1997) Development , vol.124 , pp. 2039-2048
    • Kabrun, N.1    Buhring, H.J.2    Choi, K.3    Ullrich, A.4    Risau, W.5    Keller, G.6
  • 14
    • 0033525530 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues
    • Kendall RL, Rutledge RZ, Mao X, Tebben AJ, Hungate RW, Thomas KA (1999) Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J Biol Chem 274: 6453-6460
    • (1999) J Biol Chem , vol.274 , pp. 6453-6460
    • Kendall, R.L.1    Rutledge, R.Z.2    Mao, X.3    Tebben, A.J.4    Hungate, R.W.5    Thomas, K.A.6
  • 15
    • 0842308307 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38
    • Lamalice L, Houle F, Jourdan G, Huot J (2004) Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. Oncogene 23: 434-445
    • (2004) Oncogene , vol.23 , pp. 434-445
    • Lamalice, L.1    Houle, F.2    Jourdan, G.3    Huot, J.4
  • 16
    • 2342445936 scopus 로고    scopus 로고
    • Deregulation of Flk-1/vascular endothelial growth factor receptor-2 in fibroblast growth factor receptor-1-deficient vascular stem cell development
    • Magnusson P, Rolny C, Jakobsson L, Wikner C, Wu Y, Hicklin DJ, Claesson-Welsh L (2004) Deregulation of Flk-1/vascular endothelial growth factor receptor-2 in fibroblast growth factor receptor-1-deficient vascular stem cell development. J Cell Sci 117: 1513-1523
    • (2004) J Cell Sci , vol.117 , pp. 1513-1523
    • Magnusson, P.1    Rolny, C.2    Jakobsson, L.3    Wikner, C.4    Wu, Y.5    Hicklin, D.J.6    Claesson-Welsh, L.7
  • 18
    • 0035242371 scopus 로고    scopus 로고
    • VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase
    • Qi JH, Claesson-Welsh L (2001) VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase. Exp Cell Res 263: 173-182
    • (2001) Exp Cell Res , vol.263 , pp. 173-182
    • Qi, J.H.1    Claesson-Welsh, L.2
  • 20
    • 12844264070 scopus 로고    scopus 로고
    • Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice
    • Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N, Shibuya M (2005) Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci USA 102: 1076-1081
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1076-1081
    • Sakurai, Y.1    Ohgimoto, K.2    Kataoka, Y.3    Yoshida, N.4    Shibuya, M.5
  • 21
    • 0032548933 scopus 로고    scopus 로고
    • Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites
    • Spurkland A, Brinchmann JE, Markussen G, Pedeutour F, Munthe E, Lea T, Vartdal F, Aasheim HC (1998) Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites. J Biol Chem. 273: 4539-4546
    • (1998) J Biol Chem , vol.273 , pp. 4539-4546
    • Spurkland, A.1    Brinchmann, J.E.2    Markussen, G.3    Pedeutour, F.4    Munthe, E.5    Lea, T.6    Vartdal, F.7    Aasheim, H.C.8
  • 23
    • 0035355472 scopus 로고    scopus 로고
    • A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
    • Takahashi T, Yamaguchi S, Chida K, Shibuya M (2001) A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J 20: 2768-2778
    • (2001) EMBO J , vol.20 , pp. 2768-2778
    • Takahashi, T.1    Yamaguchi, S.2    Chida, K.3    Shibuya, M.4
  • 24
  • 26
    • 0035980051 scopus 로고    scopus 로고
    • Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively
    • Zeng H, Sanyal S, Mukhopadhyay D (2001) Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively. J Biol Chem 276: 32714-32719
    • (2001) J Biol Chem , vol.276 , pp. 32714-32719
    • Zeng, H.1    Sanyal, S.2    Mukhopadhyay, D.3
  • 27
    • 0942275690 scopus 로고    scopus 로고
    • KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA
    • Zeng H, Zhao D, Mukhopadhyay D (2002) KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA. J Biol Chem 277: 46791-46798
    • (2002) J Biol Chem , vol.277 , pp. 46791-46798
    • Zeng, H.1    Zhao, D.2    Mukhopadhyay, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.